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Gene Family: Bromodomain containing (BRD)

Bromodomain: A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones. Bromodomains, as the “readers” of lysine acetylation, are responsible in transducing the signal carried by acetylated lysine residues and translating it into various normal or abnormal phenotypes. Their affinity is higher for regions where multiple acetylation sites exist in proximity. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha helices each separated by loop regions of variable lengths that form a hydrophobic pocket that recognizes the acetyl lysine. [Source: Wikipedia]

Family contains the following subsets

Genes contained within the family: 38

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ATAD2 ATPase family, AAA domain containing 2 PRO2000, DKFZp667N1320, MGC5254, MGC29843, CT137, ANCCA 8q24.13
ATAD2B ATPase family, AAA domain containing 2B KIAA1240 2p24.1-p23.3
BAZ1A bromodomain adjacent to zinc finger domain 1A hACF1, ACF1, WALp1, WCRF180 14q13.1-q13.2
BAZ1B bromodomain adjacent to zinc finger domain 1B WBSCR9, WBSCR10 WSTF 7q11.23
BAZ2A bromodomain adjacent to zinc finger domain 2A KIAA0314, TIP5, WALp3 12q13.3
BAZ2B bromodomain adjacent to zinc finger domain 2B WALp4 2q24.2
BPTF bromodomain PHD finger transcription factor FALZ FAC1, NURF301 17q24.2
BRD1 bromodomain containing 1 BRL, BRPF2 22q13.33
BRD7 bromodomain containing 7 CELTIX1, BP75 16q12.1
BRD8 bromodomain containing 8 SMAP, p120 5q31.2
BRD9 bromodomain containing 9 FLJ13441 5p15.33
BRPF1 bromodomain and PHD finger containing 1 BR140 3p25.3
BRPF3 bromodomain and PHD finger containing 3 KIAA1286 6p21.31
BRWD1 bromodomain and WD repeat domain containing 1 C21orf107, WDR9 FLJ11315, N143, DCAF19 21q22.2
BRWD3 bromodomain and WD repeat domain containing 3 FLJ38568, MRX93 Xq21.1
CECR2 CECR2, histone acetyl-lysine reader KIAA1740 22q11.1-q11.21
CREBBP CREB binding protein RSTS RTS, CBP, KAT3A 16p13.3
EP300 E1A binding protein p300 p300, KAT3B 22q13.2
KAT2A lysine acetyltransferase 2A GCN5L2 GCN5, PCAF-b 17q21.2
KAT2B lysine acetyltransferase 2B PCAF P/CAF, GCN5, GCN5L 3p24.3
KMT2A lysine methyltransferase 2A MLL TRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A 11q23.3
ASH1L ASH1 like histone lysine methyltransferase huASH1, ASH1L1, ASH1, KMT2H 1q22
PBRM1 polybromo 1 BAF180, PB1 3p21.1
PHIP pleckstrin homology domain interacting protein WDR11 ndrp, FLJ20705, DCAF14, BRWD2 6q14.1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 SNF2L2 BAF190, hSNF2a, hBRM, Sth1p, SNF2LA, BRM, SNF2, SWI2 9p24.3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 SNF2L4 hSNF2b, BRG1, BAF190, SNF2, SWI2, SNF2-BETA, SNF2LB, FLJ39786 19p13.2
SP100 SP100 nuclear antigen 2q37.1
SP110 SP110 nuclear body protein IFI41, IFI75 2q37.1
SP140 SP140 nuclear body protein LYSP100-B, LYSP100-A 2q37.1
SP140L SP140 nuclear body protein like 2q37.1
TAF1 TATA-box binding protein associated factor 1 TAF2A, BA2R, CCG1, CCGS, DYT3 NSCL2, TAFII250, KAT4, DYT3/TAF1 Xq13.1
TAF1L TATA-box binding protein associated factor 1 like 9p21.1
TRIM24 tripartite motif containing 24 TIF1 hTIF1, Tif1a, RNF82, TIF1A 7q33-q34
TRIM28 tripartite motif containing 28 TIF1B, KAP1, TF1B, RNF96, PPP1R157 19q13.4
TRIM33 tripartite motif containing 33 TIF1GAMMA, FLJ11429, KIAA1113, TIFGAMMA, RFG7, TF1G, TIF1G, PTC7 1p13.2
TRIM66 tripartite motif containing 66 C11orf29 KIAA0298, TIF1D 11p15.4
ZMYND8 zinc finger MYND-type containing 8 PRKCBP1 RACK7 20q13.12
ZMYND11 zinc finger MYND-type containing 11 BS69 10p15.3

Genes contained within subsets

Publications

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