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Gene Family: PDZ domain containing (PDZ)

PDZ domain: The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. Proteins containing PDZ domains play a key role in anchoring receptor proteins in the membrane to cytoskeletal components. PDZ is an acronym combining the first letters of three proteins — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) — which were first discovered to share the domain. PDZ domains have previously been referred to as DHR (Dlg homologous region) or GLGF ( glycine - leucine -glycine- phenylalanine ) domains. Proteins with these domains help hold together and organize signaling complexes at cellular membranes. Protein domains, connected by intrinsically disordered flexible linker regions, induce long-range allostery via protein domain dynamics. PDZ domains also play a highly significant role in the anchoring of cell surface receptors (such as CFTR and FZD7 ) to the actin cytoskeleton via mediators like NHERF and ezrin. In general PDZ domains bind to a short region of the C-terminus of other specific proteins. These short regions bind to the PDZ domain by beta sheet augmentation. This means that the beta sheet in the PDZ domain is extended by the addition of a further beta strand from the tail of the binding partner protein. [Source: Wikipedia]

Genes contained within the family: 152

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AHNAK AHNAK nucleoprotein MGC5395 11q12.3
AHNAK2 AHNAK nucleoprotein 2 C14orf78 14q32.33
APBA1 amyloid beta precursor protein binding family A member 1 MINT1 D9S411E, X11 9q21.12
APBA2 amyloid beta precursor protein binding family A member 2 X11L, MINT2 D15S1518E, LIN-10, MGC:14091, HsT16821 15q13.1
APBA3 amyloid beta precursor protein binding family A member 3 X11L2, mint3 19p13.3
ARHGAP21 Rho GTPase activating protein 21 KIAA1424, ARHGAP10 10p12.1
ARHGAP23 Rho GTPase activating protein 23 KIAA1501 17q12
ARHGEF11 Rho guanine nucleotide exchange factor 11 KIAA0380, GTRAP48, PDZ-RHOGEF 1q23.1
ARHGEF12 Rho guanine nucleotide exchange factor 12 KIAA0382, LARG 11q23.3
CARD11 caspase recruitment domain family member 11 CARMA1, BIMP3 7p22.2
CARD14 caspase recruitment domain family member 14 PSORS2 CARMA2, BIMP2 17q25.3
CASK calcium/calmodulin dependent serine protein kinase TNRC8 LIN2, CAGH39, FGS4 Xp11.4
CNKSR1 connector enhancer of kinase suppressor of Ras 1 CNK1, KSR, CNK 1p36.11
CNKSR2 connector enhancer of kinase suppressor of Ras 2 KIAA0902, CNK2, KSR2 Xp22.12
CNKSR3 CNKSR family member 3 MAGI1 FLJ31349 6q25.2
CYTIP cytohesin 1 interacting protein PSCDBP B3-1, HE, CYBR, CASP, CYTHIP 2q24.1
DEPTOR DEP domain containing MTOR interacting protein DEPDC6 DEP.6, FLJ12428 8q24.12
DLG1 discs large MAGUK scaffold protein 1 SAP97, SAP-97, hdlg, DLGH1, dJ1061C18.1.1 3q29
DLG2 discs large MAGUK scaffold protein 2 PSD-93, PSD93, chapsyn-110, PPP1R58 11q14.1
DLG3 discs large MAGUK scaffold protein 3 NE-Dlg, SAP102, SAP-102, NEDLG, KIAA1232, MRX90, PPP1R82 Xq13.1
DLG4 discs large MAGUK scaffold protein 4 PSD-95, PSD95, SAP90, SAP-90 17p13.1
DLG5 discs large MAGUK scaffold protein 5 P-dlg, KIAA0583 10q22.3
DVL1 dishevelled segment polarity protein 1 1p36.33
DVL2 dishevelled segment polarity protein 2 17p13.1
DVL3 dishevelled segment polarity protein 3 KIAA0208 3q27.1
ERBIN erbb2 interacting protein ERBB2IP LAP2 5q12.3
FRMPD1 FERM and PDZ domain containing 1 KIAA0967, FRMD2 9p13.2
FRMPD3 FERM and PDZ domain containing 3 RP5-1070B1.1, KIAA1817 Xq22.3
GIPC1 GIPC PDZ domain containing family member 1 C19orf3, RGS19IP1 TIP-2, Hs.6454, GIPC, SEMCAP, GLUT1CBP, SYNECTIN, NIP 19p13.12
GIPC2 GIPC PDZ domain containing family member 2 FLJ20075, SEMCAP-2 1p31.1
GIPC3 GIPC PDZ domain containing family member 3 C19orf64, DFNB72, DFNB15 DFNB95 19p13.3
GOPC golgi associated PDZ and coiled-coil motif containing dJ94G16.2, PIST, FIG, GOPC1, CAL 6q22.1
GORASP1 golgi reassembly stacking protein 1 GOLPH5 GRASP65, P65, FLJ23443 3p22.2
GORASP2 golgi reassembly stacking protein 2 GRASP55, GRS2, GOLPH6 2q31.1
GRASP general receptor for phosphoinositides 1 associated scaffold protein Tamalin 12q13.13
GRID2IP Grid2 interacting protein 7p22.1
GRIP1 glutamate receptor interacting protein 1 12q14.3
GRIP2 glutamate receptor interacting protein 2 KIAA1719 3p25.1
HTRA1 HtrA serine peptidase 1 PRSS11 HtrA, IGFBP5-protease, ARMD7 10q26.13
HTRA2 HtrA serine peptidase 2 PRSS25 OMI, PARK13 2p13.1
HTRA3 HtrA serine peptidase 3 Tasp, Prsp 4p16.1
HTRA4 HtrA serine peptidase 4 FLJ90724 8p11.22
IL16 interleukin 16 LCF, IL-16, prIL-16, HsT19289, FLJ42735, FLJ16806 15q25.1
PATJ PATJ, crumbs cell polarity complex component INADL Cipp 1p31.3
LIMK1 LIM domain kinase 1 LIMK 7q11.23
LIMK2 LIM domain kinase 2 22q12.2
LIN7A lin-7 homolog A, crumbs cell polarity complex component MALS-1, TIP-33, LIN-7A, VELI1 12q21.31
LIN7B lin-7 homolog B, crumbs cell polarity complex component MALS-2, LIN-7B, VELI2 19q13.33
LIN7C lin-7 homolog C, crumbs cell polarity complex component MALS-3, Lin7c, LIN-7C, LIN-7-C, VELI3, FLJ11215 11p14
LMO7 LIM domain 7 FBXO20 FBX20, KIAA0858 13q22.2
LRRC7 leucine rich repeat containing 7 KIAA1365, densin-180 1p31.1
MAGIX MAGI family member, X-linked PDZX, JM10, FLJ21687 Xp11.23
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 BAIAP1 BAP1, MAGI-1, TNRC19, AIP3, WWP3 3p14.1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 AIP1, ARIP1, KIAA0705, ACVRIP1, MAGI-2 7q21.11
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 MAGI-3 1p13.2
MAST1 microtubule associated serine/threonine kinase 1 SAST, KIAA0973 19p13.2
MAST2 microtubule associated serine/threonine kinase 2 MAST205, KIAA0807 1p34.1
MAST3 microtubule associated serine/threonine kinase 3 KIAA0561 19p13.11
MAST4 microtubule associated serine/threonine kinase family member 4 KIAA0303 5q12.3
AFDN afadin, adherens junction formation factor MLLT4 AF-6, AF6 6q27
MPDZ multiple PDZ domain crumbs cell polarity complex component MUPP1 9p23
MPP1 membrane palmitoylated protein 1 DXS552E PEMP Xq28
MPP2 membrane palmitoylated protein 2 DLG2 DKFZp761D0712 17q21.31
MPP3 membrane palmitoylated protein 3 DLG3 17q21.31
MPP4 membrane palmitoylated protein 4 DLG6 2q33.1
MPP5 membrane palmitoylated protein 5 PALS1, FLJ12615 14q23.3
MPP6 membrane palmitoylated protein 6 PALS2, VAM-1, p55T 7p15.3
MPP7 membrane palmitoylated protein 7 FLJ32798 10p12.1
MYO18A myosin XVIIIA KIAA0216, MysPDZ 17q11.2
NOS1 nitric oxide synthase 1 NOS nNOS 12q24.22
PARD3 par-3 family cell polarity regulator PAR3, PARD3A, Bazooka, Baz, ASIP, PPP1R118 10p11.22-p11.21
PARD3B par-3 family cell polarity regulator beta ALS2CR19 Par3L, PAR3beta 2q33.3
PARD6A par-6 family cell polarity regulator alpha PAR-6, PAR-6A, TAX40, PAR6alpha, TIP-40 16q22.1
PARD6B par-6 family cell polarity regulator beta PAR-6B 20q13.13
PARD6G par-6 family cell polarity regulator gamma PAR-6G, PAR6gamma 18q23
PCLO piccolo presynaptic cytomatrix protein KIAA0559, DKFZp779G1236, ACZ 7q21.11
PDLIM1 PDZ and LIM domain 1 CLIM1 CLP-36, hCLIM1, CLP36 10q23.33
PDLIM2 PDZ and LIM domain 2 8p21.3
PDLIM3 PDZ and LIM domain 3 ALP 4q35.1
PDLIM4 PDZ and LIM domain 4 RIL 5q31.1
PDLIM5 PDZ and LIM domain 5 LIM, Enh 4q22.3
LDB3 LIM domain binding 3 CMD1C KIAA0613, PDLIM6, ZASP 10q23.2
PDLIM7 PDZ and LIM domain 7 ENIGMA 5q35.3
PDZK1 PDZ domain containing 1 NHERF3, PDZD1 1q21.1
PDZD2 PDZ domain containing 2 PDZK3 KIAA0300 5p13.3
PDZD3 PDZ domain containing 3 PDZK2 FLJ22756, IKEPP 11q23.3
PDZD4 PDZ domain containing 4 PDZK4 KIAA1444, LU1, FLJ34125, PDZRN4L, LNX5 Xq28
FRMPD2B FERM and PDZ domain containing 2B, pseudogene PDZK5B, FRMPD2L2, FRMPD2L1, PDZK5A, FRMPD2P2, FRMPD2P1, PDZD5A, PDZD5B yX59F3.2, bA556L1.2 10q11.22
FRMPD2 FERM and PDZ domain containing 2 PDZD5C, PDZK5C MGC35285 10q11.22
INTU inturned planar cell polarity protein PDZD6, PDZK6 KIAA1284 4q28.1
PDZD7 PDZ domain containing 7 PDZK7, DFNB57 FLJ23209, bA108L7.8 10q24.31
USH1C USH1 protein network component harmonin DFNB18 NY-CO-37, AIE-75, harmonin, PDZ73, NY-CO-38, PDZ-73, PDZD7C 11p15.1
PDZD8 PDZ domain containing 8 PDZK8 bA129M16.2, FLJ34427 10q25.3-q26.11
PDZD9 PDZ domain containing 9 C16orf65 MGC50721 16p12.2
FRMPD4 FERM and PDZ domain containing 4 PDZK10, PDZD10 KIAA0316 Xp22.2
PDZD11 PDZ domain containing 11 PDZK11 Xq13.1
RAPGEF2 Rap guanine nucleotide exchange factor 2 PDZGEF1 PDZ-GEF1, RA-GEF, DKFZP586O1422, KIAA0313 4q32.1
RAPGEF6 Rap guanine nucleotide exchange factor 6 PDZGEF2 RA-GEF-2, PDZ-GEF2 5q31.1
PDZPH1P PDZ and pleckstrin homology domains 1, pseudogene 5q21.2
LNX2 ligand of numb-protein X 2 PDZRN1 MGC46315 13q12.2
LNX1 ligand of numb-protein X 1 LNX PDZRN2, MPDZ 4q12
PDZRN3 PDZ domain containing ring finger 3 KIAA1095, SEMACAP3, LNX3 3p13
PDZRN4 PDZ domain containing ring finger 4 DKFZp434B0417, LNX4, FLJ33777, IMAGE5767589 12q12
WHRN whirlin DFNB31 CIP98, USH2D, PDZD7B 9q32
PICK1 protein interacting with PRKCA 1 PRKCABP dJ1039K5, MGC15204 22q13.1
PPP1R9A protein phosphatase 1 regulatory subunit 9A Neurabin-I, KIAA1222, FLJ20068 7q21.3
PPP1R9B protein phosphatase 1 regulatory subunit 9B PPP1R6, PPP1R9 Spn, SPINO 17q21.33
PREX1 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 KIAA1415, P-REX1 20q13.13
PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 DEPDC2 DEP.2, FLJ12987, P-REX2, PPP1R129 8q13.2
PRX periaxin KIAA1620 19q13.2
PSMD9 proteasome 26S subunit, non-ATPase 9 p27, Rpn4 12q24.31
PTPN3 protein tyrosine phosphatase, non-receptor type 3 PTPH1 9q31
PTPN4 protein tyrosine phosphatase, non-receptor type 4 PTPMEG 2q14.2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 PTP1E, PTP-BAS, PTPL1, PTP-BL 4q21.3
RADIL Rap associating with DIL domain FLJ10324, KIAA1849, RASIP2 7p22.1
RGS3 regulator of G protein signaling 3 C2PA, FLJ20370, PDZ-RGS3 9q32
RGS12 regulator of G protein signaling 12 4p16.3
RHPN1 rhophilin Rho GTPase binding protein 1 KIAA1929, RHPN, ODF5 8q24.3
RHPN2 rhophilin Rho GTPase binding protein 2 19q13.12
RIMS1 regulating synaptic membrane exocytosis 1 RAB3IP2, CORD7 RIM, KIAA0340, RIM1 6q13
RIMS2 regulating synaptic membrane exocytosis 2 RAB3IP3 KIAA0751, RIM2, OBOE 8q22.3
SCRIB scribbled planar cell polarity protein KIAA0147, SCRB1, Vartul 8q24.3
SDCBP syndecan binding protein SYCL, MDA-9 8q12.1
SDCBP2 syndecan binding protein 2 ST-2, SITAC18 20p13
SHANK1 SH3 and multiple ankyrin repeat domains 1 SSTRIP, SPANK-1, synamon 19q13.33
SHANK2 SH3 and multiple ankyrin repeat domains 2 CORTBP1 CTTNBP1, ProSAP1, SHANK, SPANK-3 11q13.3-q13.4
SHANK3 SH3 and multiple ankyrin repeat domains 3 SPANK-2, prosap2, KIAA1650, PSAP2 22q13.33
SHROOM2 shroom family member 2 APXL Xp22.2
SHROOM3 shroom family member 3 ShrmL, SHRM, KIAA1481, APXL3 4q21.1
SHROOM4 shroom family member 4 KIAA1202 Xp11.22
SIPA1 signal-induced proliferation-associated 1 SPA1 11q13.1
SIPA1L1 signal induced proliferation associated 1 like 1 KIAA0440, E6TP1 14q24.1
SIPA1L2 signal induced proliferation associated 1 like 2 KIAA1389 1q42.2
SIPA1L3 signal induced proliferation associated 1 like 3 KIAA0545 19q13.13-q13.2
SLC9A3R1 SLC9A3 regulator 1 NHERF, EBP50, NHERF1 17q25.1
SLC9A3R2 SLC9A3 regulator 2 SIP-1, TKA-1, NHERF-2, E3KARP 16p13.3
SNTA1 syntrophin alpha 1 SNT1 TACIP1, LQT12 20q11.21
SNTB1 syntrophin beta 1 SNT2B1 59-DAP, A1B, BSYN2, TIP-43, SNT2 8q24.12
SNTB2 syntrophin beta 2 SNT2B2, SNTL, D16S2531E EST25263, SNT3 16q22.1
SNTG1 syntrophin gamma 1 SYN4, G1SYN 8q11.21
SNTG2 syntrophin gamma 2 SYN5, G2SYN 2p25.3
SNX27 sorting nexin family member 27 MY014, KIAA0488, MGC20471 1q21.3
STXBP4 syntaxin binding protein 4 Synip, MGC50337 17q22
SYNJ2BP synaptojanin 2 binding protein Arip2 14q24.2
SYNPO2 synaptopodin 2 MYOPODIN 4q26
SYNPO2L synaptopodin 2 like FLJ12921 10q22.2
TAX1BP3 Tax1 binding protein 3 TIP-1 17p13.2
TIAM1 T-cell lymphoma invasion and metastasis 1 21q22.11
TIAM2 T-cell lymphoma invasion and metastasis 2 STEF 6q25.2-q25.3
TJP1 tight junction protein 1 ZO-1, MGC133289, DKFZp686M05161 15q13.1
TJP2 tight junction protein 2 DFNA51 ZO-2, X104, ZO2 9q21.11
TJP3 tight junction protein 3 ZO-3 19p13.3