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Gene Family: Diacylglycerol kinases (DGK)

Diacylglycerol kinase: Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA) utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low allowing DAG to be used for glycerophospholipid biosynthesis but on receptor activation of the phosphoinositide pathway, DGK activity increases driving the conversion of DAG to PA. As both lipids are thought to function as bioactive lipid signaling molecules with distinct cellular targets, DGK therefore occupies an important position, effectively serving as a switch by terminating the signalling of one lipid while simultaneously activating signalling by another. In bacteria, DGK is very small (13 to 15 kD) membrane protein which seems to contain three transmembrane domains. The best conserved region is a stretch of 12 residues which are located in a cytoplasmic loop between the second and third transmembrane domains. Some Gram-positive bacteria also encode a soluble diacylglycerol kinase capable of reintroducing DAG into the phospholipid biosynthesis pathway. DAG accumulates in Gram-positive bacteria as a result of the transfer of glycerol-1-phosphate moieties from phosphatidylglycerol to lipotechoic acid. [Source: Wikipedia]

Genes contained within the family: 10

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DGKA diacylglycerol kinase alpha DAGK, DAGK1 DGK-alpha 12q13.2
DGKB diacylglycerol kinase beta DAGK2 KIAA0718, DGK, DGK-BETA 7p21.2
DGKD diacylglycerol kinase delta KIAA0145, DGKdelta 2q37.1
DGKE diacylglycerol kinase epsilon DAGK6, DGK 17q22
DGKG diacylglycerol kinase gamma DAGK3 3q27.2-q27.3
DGKH diacylglycerol kinase eta DGKeta 13q14.11
DGKI diacylglycerol kinase iota DGK-IOTA 7q33
DGKK diacylglycerol kinase kappa Xp11.22
DGKQ diacylglycerol kinase theta DAGK4 DAGK, DAGK7 4p16.3
DGKZ diacylglycerol kinase zeta DAGK5, hDGKzeta, DGK-ZETA, DAGK6 11p11.2