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Gene Family: RAF family

RAF kinases & KSR scaffold proteins: This family includes the RAF kinases and the KSR scaffold proteins. All of the genes are related by homology but the KSR genes are 'pseudokinases' and have no kinase function. [Source: HGNC]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ARAF A-Raf proto-oncogene, serine/threonine kinase ARAF1 Xp11.3
BRAF B-Raf proto-oncogene, serine/threonine kinase BRAF1 7q34
KSR1 kinase suppressor of ras 1 KSR RSU2 17q11.2
KSR2 kinase suppressor of ras 2 FLJ25965 12q24.22-q24.23
RAF1 Raf-1 proto-oncogene, serine/threonine kinase Raf-1, c-Raf, CRAF 3p25.2

Publications

25907612