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Gene Family: Flotillins (FLOT)

Flotilins: Flotillins are ubiquitous and highly conserved proteins. They were initially discovered as being associated with specific caveolin-independent cholesterol- and glycosphingolipid-enriched membrane microdomains and as being expressed during axon regeneration. Flotillins have a role in a large number of physiopathological processes, mainly through their function in membrane receptor clustering and in the regulation of clathrin-independent endocytosis. [Source: Bodin et al., 2014]

Genes contained within the family: 2

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
FLOT1 flotillin 1 6p21.33
FLOT2 flotillin 2 M17S1 ESA, ESA1, ECS-1, ECS1 17q11.2