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Gene Family: Erb-b2 receptor tyrosine kinases (ERBB)

Also known as : "ErbB family"

ErbB: The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. In humans, the family includes Her1 (EGFR, ErbB1 ), Her2 (Neu, ErbB2), Her3 (ErbB3), and Her4 (ErbB4). The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease, while excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. [Source: Wikipedia]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
EGFR epidermal growth factor receptor ERBB ERBB1 7p11.2
ERBB2 erb-b2 receptor tyrosine kinase 2 NGL NEU, HER-2, CD340, HER2 17q12
ERBB3 erb-b2 receptor tyrosine kinase 3 LCCS2 HER3 12q13.2
ERBB4 erb-b2 receptor tyrosine kinase 4 ALS19, HER4 2q34