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Gene Family: MCM family (MCM)

Also known as : "minichromosome maintenance complex", "minichromosome maintenance replicative helicase", "MCM8-9 complex", "minichromosome maintenance family"
A subset of : DNA helicases

Minichromosome maintenance: Mini chromosome maintenance complex (or minichromosome maintenance protein complex, or mini-chromosome maintenance (MCM) 2-7 helicase complex ) has a role in both the initiation and the elongation phases of eukaryotic DNA replication, specifically the formation and elongation of the replication fork. MCM is a component of the pre-replication complex, which is a component of the licensing factor. MCM is a hexamer of six related polypeptides (MCM2 through MCM7) that form a ring structure. [Source: Wikipedia]

Genes contained within the family: 9

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MCM2 minichromosome maintenance complex component 2 CCNL1, CDCL1 D3S3194, KIAA0030, BM28, cdc19, DFNA70 3q21.3
MCM3 minichromosome maintenance complex component 3 6p12.2
MCM4 minichromosome maintenance complex component 4 CDC21 CDC54, hCdc21, P1-Cdc21, MGC33310 8q11.21
MCM5 minichromosome maintenance complex component 5 CDC46 22q12.3
MCM6 minichromosome maintenance complex component 6 Mis5 2q21.3
MCM7 minichromosome maintenance complex component 7 MCM2 CDC47, PPP1R104 7q22.1
MCM8 minichromosome maintenance 8 homologous recombination repair factor C20orf154 MGC4816, MGC12866, MGC119522, MGC119523, dJ967N21.5, REC 20p12.3
MCM9 minichromosome maintenance 9 homologous recombination repair factor MCMDC1, C6orf61 MGC35304, dJ329L24.3, FLJ20170 6q22.31
MCMDC2 minichromosome maintenance domain containing 2 C8orf45 FLJ25692 8q13.1

Comments

Vertebrates have eight characterised homologous MCM genes: MCM2-7 form a replicative helicase complex, and MCM8 and MCM9 form a dimer involved in homologous recombination repair. The ninth gene to encode an MCM domain is named as MCMDC2, but the function of the encoded protein is currently unknown. MCM10 is not a paralog of MCM2-9 (and therefore not included in this family page) but associates with the MCM2-7 complex to initiate replication. SRF is the vertebrate ortholog of the yeast MCM1 gene, and also is not included here as it is not a paralog of MCM2-9.

Publications

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