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Gene Family: Nucleoporins (NUP)

Also known as : "Nuclear pore complex components", "NPC components"

Nucleoporins: The nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nuclear pores in turn allow the transport of water-soluble molecules across the nuclear envelope. Nucleoporins, a family of around 30 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nucleoporin 62 is the most abundant member of this family. Nucleoporins are able to transport molecules across the nuclear envelope at a very high rate. A single NPC is able to transport 60,000 protein molecules across the nuclear envelope every minute. [Source: Wikipedia]

Genes contained within the family: 32

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AAAS aladin WD repeat nucleoporin 12q13.13
AHCTF1 AT-hook containing transcription factor 1 ELYS 1q44
DDX19A DEAD-box helicase 19A DDX19L FLJ11126 16q22.1
DDX19B DEAD-box helicase 19B DDX19 DBP5 16q22.1
GLE1 GLE1, RNA export mediator GLE1L, LCCS1 hGLE1 9q34.11
NDC1 NDC1 transmembrane nucleoporin TMEM48 FLJ10407, NET3 1p32.3
NUP35 nucleoporin 35 MP44 2q32.1
NUP37 nucleoporin 37 MGC5585, FLJ22618 12q23.2
NUP43 nucleoporin 43 bA350J20.1, FLJ13287 6q25.1
NUP50 nucleoporin 50 NPAP60L 22q13.31
NUP54 nucleoporin 54 4q21.1
NUP58 nucleoporin 58 NUPL1 KIAA0410, NUP45 13q12.13
NUP62 nucleoporin 62 p62, DKFZp547L134, IBSN, SNDI, MGC841, FLJ20822, FLJ43869 19q13.33
NUP85 nucleoporin 85 NUP75, FLJ12549 17q25
NUP88 nucleoporin 88 MGC8530 17p13.2
NUP93 nucleoporin 93 KIAA0095 16q13
NUP98 nucleoporin 98 NUP96 11p15.4
NUP107 nucleoporin 107 NUP84 12q15
NUP133 nucleoporin 133 FLJ10814 1q42.13
NUP153 nucleoporin 153 HNUP153 6p22.3
NUP155 nucleoporin 155 KIAA0791, N155 5p13.2
NUP160 nucleoporin 160 KIAA0197, FLJ22583 11p11.2
NUP188 nucleoporin 188 KIAA0169 9q34.11
NUP205 nucleoporin 205 C7orf14 KIAA0225 7q33
NUP210 nucleoporin 210 GP210, POM210, FLJ22389, KIAA0906 3p25.1
NUP214 nucleoporin 214 CAIN, CAN, D9S46E, N214 9q34.13
RANBP2 RAN binding protein 2 ANE1 NUP358, ADANE 2q13
POM121 POM121 transmembrane nucleoporin KIAA0618, DKFZP586G1822, DKFZP586P2220, POM121A 7q11.23
RAE1 ribonucleic acid export 1 Mnrp41 20q13.31
SEC13 SEC13 homolog, nuclear pore and COPII coat complex component D3S1231E, SEC13L1 SEC13R, npp-20 3p25.3
SEH1L SEH1 like nucleoporin SEH1A, SEH1B, Seh1, SEC13L 18p11.21
TPR translocated promoter region, nuclear basket protein 1q31.1

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