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Gene Family: RecQ like helicases (RECQL)

Also known as : "RecQ helicases"
A subset of : DNA helicases

RecQ helicase: RecQ helicase is a family of helicase enzymes initially found in Escherichia coli that has been shown to be important in genome maintenance. They function through catalyzing the reaction ATP + H 2 O → ADP + P and thus driving the unwinding of paired DNA and translocating in the 3' to 5' direction. These enzymes can also drive the reaction NTP + H 2 O → NDP + P to drive the unwinding of either DNA or RNA. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
RECQL RecQ like helicase RecQ1, RecQL1 12p12.1
WRN Werner syndrome RecQ like helicase RECQL2, RECQ3 8p12
BLM Bloom syndrome RecQ like helicase RECQ2, BS, RECQL3 15q26.1
RECQL4 RecQ like helicase 4 RecQ4 8q24.3
RECQL5 RecQ like helicase 5 RecQ5, FLJ90603 17q25