Skip to Navigation
New Beta Site!

Please view this page on our new HGNC beta site and let us know what you think via the feedback form.

Gene Family: 5'-nucleotidases

A subset of : Phosphatases

5'-nucleotidase: 5'-nucleotidase ( EC ) is an enzyme which catalyzes the phosphorylytic cleavage of 5'nucleotides. Although originally found in snake venom, the activity of 5'nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides. The enzyme has a wide substrate specificity for nucleotides and has been shown to hydrolyze 5'nucleotides rapidly, ribose-5-phosphate slowly, and other phosphate esters extremely slowly (if at all). [Source: Wikipedia]

Genes contained within the family: 7

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
NT5C 5', 3'-nucleotidase, cytosolic UMPH2 DNT1, DNT-1, PN-I, cdN, dNT-1 17q25
NT5C1A 5'-nucleotidase, cytosolic IA CN-I, CN-IA, CN1A, CN1, MGC119199, MGC119201 1p34.2
NT5C1B 5'-nucleotidase, cytosolic IB AIRP, CN-IB 2p24.2
NT5C2 5'-nucleotidase, cytosolic II NT5B PNT5, GMP, cN-II, SPG65 10q24.32-q24.33
NT5C3A 5'-nucleotidase, cytosolic IIIA NT5C3 UMPH1, PSN1, PN-I, UMPH, P5'N-1, cN-III, p36, POMP, hUMP1 7p14.3
NT5E 5'-nucleotidase ecto NT5 CD73, eN, eNT, CALJA 6q14.3
NT5M 5',3'-nucleotidase, mitochondrial dNT-2, dNT2, mdN 17p11.2