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Gene Family: Aminopeptidases

Aminopeptidase: Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein (N-terminus) or peptide substrates. They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes. [Source: Wikipedia]

Genes contained within the family: 18

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ANPEP alanyl aminopeptidase, membrane CD13, PEPN LAP1, gp150, p150 15q26.1
DNPEP aspartyl aminopeptidase DAP, ASPEP 2q35
ENPEP glutamyl aminopeptidase gp160, CD249 4q25
ERAP1 endoplasmic reticulum aminopeptidase 1 ARTS-1, A-LAP, PILS-AP, KIAA0525, ERAAP1 5q15
ERAP2 endoplasmic reticulum aminopeptidase 2 L-RAP, LRAP 5q15
LAP3 leucine aminopeptidase 3 PEPS LAPEP, LAP 4p15.32
LNPEP leucyl and cystinyl aminopeptidase CAP, PLAP, P-LAP, IRAP 5q15
LVRN laeverin APQ, FLJ90650, AQPEP, TAQPEP 5q23.1
METAP1 methionyl aminopeptidase 1 KIAA0094, MetAP1A, MAP1A 4q23
METAP1D methionyl aminopeptidase type 1D, mitochondrial MAP1D, Metap1l 2q31.1
METAP2 methionyl aminopeptidase 2 MNPEP, p67, MAP2 12q22
NPEPL1 aminopeptidase like 1 FLJ11583, bA261P9.2 20q13.32
NPEPPS aminopeptidase puromycin sensitive PSA, MP100 17q21.32
RNPEP arginyl aminopeptidase APB 1q32.1
XPNPEP1 X-prolyl aminopeptidase 1 XPNPEP, XPNPEPL1, XPNPEPL 10q25.1
XPNPEP2 X-prolyl aminopeptidase 2 Xq26.1
XPNPEP3 X-prolyl aminopeptidase 3 APP3, NPHPL1, ICP55 22q13.2
XWNPEP X-tryptophanyl aminopeptidase reserved


Note that XPNPEP3 and NPEPL1 are putative aminopeptidases based on sequence.