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Gene Family: Membrane bound O-acyltransferases (MBOAT)

MBOAT: The MBOAT (membrane bound O-acyl transferase) family of membrane proteins is a family of various acyltransferase enzymes. All family members contain multiple transmembrane domains and most carry two conserved residues which might be active-site residues, a conserved histidine (His) embedded in a hydrophobic stretch of residues and an asparagine (Asn) or histidine within a more hydrophilic region some 30-50 residues upstream. MBOAT enzymes catalyze the transfer of an acyl group from acyl-coenzyme to one of several different substrates. The family is found from bacteria to eukaryotes, and the active region lies outside the membrane. The family may be grouped into four categories, according to function: [Source: Wikipedia]

Genes contained within the family: 8

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MBOAT1 membrane bound O-acyltransferase domain containing 1 OACT1 MGC44669, dJ434O11.1, LPEAT1 6p22.3
MBOAT2 membrane bound O-acyltransferase domain containing 2 OACT2 FLJ14415, FLJ90298 2p25.1
HHATL hedgehog acyltransferase like C3orf3, GUP1 MBOAT3, OACT3, KIAA1173, MSTP002 3p22.1
MBOAT4 membrane bound O-acyltransferase domain containing 4 OACT4 FKSG89, GOAT 8p12
LPCAT3 lysophosphatidylcholine acyltransferase 3 MBOAT5, OACT5 C3F, nessy 12p13.31
HHAT hedgehog acyltransferase FLJ10724, MART-2, MART2, Skn, ski, rasp, sit, GUP2 1q32.2
MBOAT7 membrane bound O-acyltransferase domain containing 7 LENG4 BB1, hMBOA-7, LPLAT 19q13.42
PORCN porcupine O-acyltransferase DHOF MG61, PORC, PPN, por Xp11.23