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The HGNC Custom Database Download script serves as a front end for a PostgreSQL database and provides a web-based interface which allows users to select columns of data for output, execute limited SQL queries, and save searches for future reference.

The HGNC Comparison of Orthology Predictions (HCOP) search is a tool that integrates and displays the orthology assertions predicted for a specified human gene, or set of human genes, by eggNOG, Ensembl Compara, HGNC, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, TreeFam and ZFIN. An indication of the reliability of a prediction is provided by the number of databases which concur. HCOP was originally designed to show orthology predictions between human and mouse, but has been expanded to include data from chimp, macaque, rat, dog, horse, cow, pig, opossum, platypus, chicken, anole lizard, xenopus, zebrafish, C. elegans, Drosophila and S. cerevisiae, meaning that there are currently 18 genomes available for comparison in HCOP.

The genenames.org REST web-service is a convenient and quick way of searching and fetching data from our database within a script/program. Users may request results as either XML or JSON making our data easier to parse.

Our search tools allows our users to search over 38000 active gene symbol reports stored within our database quickly and with ease. The search server utilises Apache Solr which offers a powerful full-text search, hit highlighting and faceted searching. With facet searching you can search for a particular keyword and then filter the results by locus group and type.

The search form can be found within the mast head of each page. To use it just enter a search term within the search input box and click on the spy glass icon. By default the results are gene symbol reports however users can click on the drop down to the left of the input box and search the rest of the site instead by selecting "search site". This is the best way for searching parts of our site such as gene families etc. If you are looking to search lists of gene symbols, please use the symbol checker tool.

The symbol checker tool allows the user to type, paste or upload a list of symbols into a search field to check if the symbols are HGNC approved symbols. The results include a ‘match type’ column that shows how each submitted symbol matches the returned HGNC symbol. The user is able to click on the approved symbol to be taken to the relevant Symbol Report to access more information about the gene.

Each gene with an approved HGNC symbol has its own Symbol Report that contains our manually curated data and links to many other external biomedical resources.  The HGNC "core data" is displayed at the top of the page in a separate box and presents the approved nomenclature, the unique HGNC ID number, synonyms, previous nomenclature, locus type and chromosomal location.  The table below the HGNC "core data" provides links to the HGNC's curated gene family page where applicable, and links to information on homologs in other species, nucleotide sequences, gene resources, protein resources, clinical resources, publications and other database links.