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Giving unique and meaningful names to every human gene

1. Class I Cys-based PTPs
     Classical PTPs: Dual specificity phosphatases:
     Transmembrane receptor-like PTPs MAP kinase phosphatases
     Non-receptor PTPs Atypical dual specificity phosphatases
  Slingshots
  PRLs
  CDC14s
  PTENs
  Myotubularins
2. Class II Cys-based PTPs
3. Class III Cys-based PTPs
4. Asp-based PTPs

1. Class I Cys-based PTPs

Classical PTPs
Transmembrane receptor-like PTPs:

Click on the Approved Gene Symbol to retrieve the complete gene record

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
PTPRA protein tyrosine phosphatase, receptor type, A PTPRL2, PTPA LRP, HLPR, HPTPA, RPTPA 20p13    
PTPRB protein tyrosine phosphatase, receptor type, B PTPB   12q15-q21 X54131  
PTPRC protein tyrosine phosphatase, receptor type, C CD45 LCA, T200, GP180 1q31-q32 Y00062  
PTPRD protein tyrosine phosphatase, receptor type, D   PTPD, HPTP 9p24.1-p23 X54133  
PTPRE protein tyrosine phosphatase, receptor type, E   PTPE 10q26 AF406557  
PTPRF protein tyrosine phosphatase, receptor type, F LAR   1p34 Y00815  
PTPRG protein tyrosine phosphatase, receptor type, G PTPG RPTPG 3p21-p14 L09247 NM_002841
PTPRH protein tyrosine phosphatase, receptor type, H   SAP-1 19q13.4    
PTPRJ protein tyrosine phosphatase, receptor type, J   DEP1, HPTPeta, CD148 11p11.2 U10886  
PTPRK protein tyrosine phosphatase, receptor type, K   R-PTP-kappa 6q22.2-q22.3 L77886  
PTPRM protein tyrosine phosphatase, receptor type, M PTPRL1 RPTPU, hR-PTPu 18p11.2 X58288  
PTPRN protein tyrosine phosphatase, receptor type, N   IA-2 2q35-q36.1    
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2   KIAA0387, phogrin, ICAAR, IA-2beta 7q36 AB002385  
PTPRO protein tyrosine phosphatase, receptor type, O   PTPU2, GLEPP1, PTP-U2 12p13-p12 U20489  
PTPRQ protein tyrosine phosphatase, receptor type, Q     12q21.2 AF169351  
PTPRR protein tyrosine phosphatase, receptor type, R PTPRQ PTPBR7, PTP-SL, EC-PTP, PCPTP1 12q15 D64053  
PTPRS protein tyrosine phosphatase, receptor type, S     19p13.3 U35234  
PTPRT protein tyrosine phosphatase, receptor type, T   RPTPrho, KIAA0283 20q12-q13 AF043644  
PTPRU protein tyrosine phosphatase, receptor type, U   PTPRO, hPTP-J, PCP-2, FMI, PTP 1p35.3 U71075  
PTPRV protein tyrosine phosphatase, receptor type, V (pseudogene)   OST-PTP, ESP, PTPRVP 1q32.1 AJ629456 XM_086287
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 PTPZ, PTPRZ PTP18, RPTPB, phosphacan 7q31.3 M93426  

Non-receptor PTPs:

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
PTPN1 protein tyrosine phosphatase, non-receptor type 1 PTP1B   20q13.1-q13.2    
PTPN2 protein tyrosine phosphatase, non-receptor type 2 PTPT TCELLPTP, TC-PTP, TCPTP 18p11.3-p11.2 M25393 NM_002828, NM_080422, NM_080423
PTPN3 protein tyrosine phosphatase, non-receptor type 3   PTPH1 9q31    
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)   PTPMEG 2q14.2    
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)   STEP, PTPSTEP 11p15.1 BC064807 NM_001039970
PTPN6 protein tyrosine phosphatase, non-receptor type 6   HCP, HCPH, PTP-1C, SHP-1, SHP1 12p13.31   NM_002831
PTPN7 protein tyrosine phosphatase, non-receptor type 7   HEPTP, LC-PTP 1q32.1 BC001746 NM_002832
PTPN9 protein tyrosine phosphatase, non-receptor type 9   MEG2 15q23    
PTPN11 protein tyrosine phosphatase, non-receptor type 11 NS1 BPTP3, SH-PTP2, SHP-2, PTP2C, SHP2 12q24.1 D13540  
PTPN12 protein tyrosine phosphatase, non-receptor type 12   PTPG1, PTP-PEST 7q11.23    
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)   PTP1E, PTP-BAS, PTPL1, PTP-BL 4q21.3    
PTPN14 protein tyrosine phosphatase, non-receptor type 14   PEZ 1q32.2 X82676 NM_005401
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)   BDP1 2q21 X79568  
PTPN20A protein tyrosine phosphatase, non-receptor type 20A   bA142I17.1 10q11.22    
PTPN20B protein tyrosine phosphatase, non-receptor type 20B   bA42B19.1, DKFZP566K0524 10q11.22   NM_015605
PTPN20C protein tyrosine phosphatase, non-receptor type 20C   bA164N7.3 10q11.22   XM_925912
PTPN21 protein tyrosine phosphatase, non-receptor type 21   PTPD1, PTPRL10 14q31 X79510  
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) PTPN8 Lyp, Lyp1, Lyp2 1p13.2 AF001846 NM_015967
PTPN23 protein tyrosine phosphatase, non-receptor type 23   DKFZP564F0923, KIAA1471, HD-PTP 3p21.3 AB025194 NM_015466

Dual specificity phosphatases
MAP kinase phosphatases:

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
DUSP1 dual specificity phosphatase 1 PTPN10 HVH1, CL100, MKP-1 5q35.1 X68277 NM_004417
DUSP2 dual specificity phosphatase 2   PAC-1 2q11 L11329 NM_004418
DUSP4 dual specificity phosphatase 4   HVH2, MKP-2, TYP 8p12-p11 U21108 NM_001394
DUSP5 dual specificity phosphatase 5   HVH3 10q25 U16996 NM_004419
DUSP6 dual specificity phosphatase 6   MKP-3, PYST1 12q22-q23 BC037236 NM_001946, NM_022652
DUSP7 dual specificity phosphatase 7   MKP-X, PYST2 3p21 X93921 NM_001947
DUSP8 dual specificity phosphatase 8 C11orf81 HVH-5, HB5, FLJ42958 11p15.5   NM_004420
DUSP9 dual specificity phosphatase 9   MKP-4, MKP4 Xq28 Y08302 NM_001395
DUSP10 dual specificity phosphatase 10   MKP-5, MKP5 1q41 AB026436 NM_007207
DUSP16 dual specificity phosphatase 16   MKP-7, KIAA1700, MKP7 12p13 AB052156 NM_030640
STYXL1 serine/threonine/tyrosine interacting-like 1 DUSP24 MK-STYX 7q11.23 AF069762 NM_016086

Atypical dual specificity phosphatases:

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1   DUSP27 10q22.3   XM_291741
DUSP3 dual specificity phosphatase 3 VHR   17q21 BC035701 NM_004090
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)   PIR1 2p13.1 AF023917  
DUSP12 dual specificity phosphatase 12   YVH1, DUSP1 1q21-q22 AF119226 NM_007240
DUSP13 dual specificity phosphatase 13   BEDP, TMDP, FLJ32450, DUSP13A, DUSP13B 10q23.1 AB027004  
DUSP14 dual specificity phosphatase 14   MKP-L, MKP6 17q12 AF038844 NM_007026
DUSP15 dual specificity phosphatase 15   bA243J16.6, VHY 20q11.21   NM_080611
DUSP18 dual specificity phosphatase 18   DUSP20 22q12.1 AF461689  
DUSP19 dual specificity phosphatase 19   SKRP1, DUSP17 2q32.1 AB038770  
DUSP21 dual specificity phosphatase 21     Xp11.4-p11.23 AF143321 NM_022076
DUSP22 dual specificity phosphatase 22   MKPX, JSP1, JKAP, VHX 6pter-q22.33 AF165519 NM_020185
DUSP23 dual specificity phosphatase 23   FLJ20442, DUSP25 1q23.1   NM_017823
DUSP26 dual specificity phosphatase 26 (putative)   MGC1136, DUSP24 8p12 AY902194 NM_024025
DUSP28 dual specificity phosphatase 28   VHP, DUSP26 2q37.1 BC036198 NM_001033575
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)   LDE, LD 6q24 AF284580  
PTPMT1 protein tyrosine phosphatase, mitochondrial 1   PLIP, DUSP23, MOSP 11p11.2 BC014048 XM_374879
RNGTT RNA guanylyltransferase and 5'-phosphatase   HCE, HCE1, hCAP 6q16 AF025654  
STYX serine/threonine/tyrosine interacting protein     14q22.1   NM_145251

Slingshots:

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
SSH1 slingshot homolog 1 (Drosophila)   KIAA1298 12q24.12 BC062341 NM_018984
SSH2 slingshot homolog 2 (Drosophila)   KIAA1725 17q11.2 AB072359 NM_033389
SSH3 slingshot homolog 3 (Drosophila)   FLJ20515, FLJ10928 11q13 AF085851 NM_018276

PRLs:

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
PTP4A1 protein tyrosine phosphatase type IVA, member 1   PTPCAAX1, PRL-1 6q12 U48296  
PTP4A2 protein tyrosine phosphatase type IVA, member 2 PTP4A HU-PP-1, PTPCAAX2, OV-1, ptp-IV1a, PRL-2 1p35 L48723 NM_080391
PTP4A3 protein tyrosine phosphatase type IVA, member 3   PRL-3, PRL-R, PRL3 8q24.3 AF041434 NM_032611

CDC14s:

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)   Cdc14A1, Cdc14A2, cdc14 1p21 AF000367 NM_033312
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)   Cdc14B1, Cdc14B2, CDC14B3, hCDC14B 9q22.3 AF023158 NM_033331
CDKN3 cyclin-dependent kinase inhibitor 3   KAP, CDI1 14q22 U02681  
PTPDC1 protein tyrosine phosphatase domain containing 1   PTP9Q22, FLJ37312 9q22.32 BC051654 NM_177995, NM_152422

PTENs:

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
PTEN phosphatase and tensin homolog BZS, MHAM MMAC1, TEP1, PTEN1 10q23 U92436 NM_000314
TENC1 tensin like C1 domain containing phosphatase (tensin 2)   KIAA1075, C1-TEN, TNS2 12q13.13 AF518729 NM_170754
TNS1 tensin 1 TNS, MXRA6 DKFZp586K0617 2q35-q36 AB209238 NM_022648
TPTE transmembrane phosphatase with tensin homology   PTEN2 21p11 AF007118  
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2   TPIP 13q12.11 AJ421032 NM_199255

Myotubularins:

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
MTM1 myotubularin 1     Xq27.3-q28 U46024 NM_000252
MTMR1 myotubularin related protein 1     Xq28 U58032 NM_003828, NM_176789
MTMR2 myotubularin related protein 2 CMT4B KIAA1073 11q22 U58033 NM_016156
MTMR3 myotubularin related protein 3   KIAA0371, ZFYVE10, FYVE-DSP1 22q12.2 U58034 NM_021090
MTMR4 myotubularin related protein 4   KIAA0647, ZFYVE11 17q22-q23 AB014547 NM_004687
MTMR6 myotubularin related protein 6     13q12 AF072928 NM_004685
MTMR7 myotubularin related protein 7     8p22 AF073482  
MTMR8 myotubularin related protein 8   FLJ20126 Xq11.2-q12 AK000133 NM_017677
MTMR9 myotubularin related protein 9 C8orf9, MTMR8 DKFZp434K171, LIP-STYX 8p23-p22 AJ297823  
MTMR10 myotubularin related protein 10   FLJ20313 15q13.3 AK000320 NM_017762
MTMR11 myotubularin related protein 11   CRA 1q12-q21 AK097000 NM_181873
MTMR12 myotubularin related protein 12 PIP3AP 3-PAP, FLJ20476, KIAA1682, 3PAP 5p15.33 AB051469 NM_019061
MTMR14 myotubularin related protein 14 C3orf29 FLJ22405, FLJ90311, hJumpy, hEDTP 3p26 BC001674 NM_022485
MTMR15 myotubularin related protein 15 KIAA1018   15q13.2-q13.3   NM_014967
SBF1 SET binding factor 1   MTMR5 22q13.33 U93181  
SBF2 SET binding factor 2 CMT4B2 KIAA1766, MTMR13 11p15.3 AB051553 NM_030962

2. Class II Cys-based PTPs

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
ACP1 acid phosphatase 1, soluble     2p25 M87546  

3. Class III Cys-based PTPs

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
CDC25A cell division cycle 25 homolog A (S. pombe)     3p21 M81933 NM_001789
CDC25B cell division cycle 25 homolog B (S. pombe)     20p13   NM_021874
CDC25C cell division cycle 25 homolog C (S. pombe) CDC25   5q31 M34065  

4. Asp-based PTPs

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
EYA1 eyes absent homolog 1 (Drosophila) BOR   8q13.3 AJ000098 NM_000503, NM_172060
EYA2 eyes absent homolog 2 (Drosophila)   EAB1 20q13.1   NM_005244
EYA3 eyes absent homolog 3 (Drosophila)   DKFZp686C132 1p36 U81602 NM_001990
EYA4 eyes absent homolog 4 (Drosophila) DFNA10, CMD1J   6q23 Y17114 NM_004100

The work of the HGNC is supported by NHGRI grant P41 HG003345, the UK Medical Research Council and the Wellcome Trust.