Protein tyrosine phosphatases (including dual specificity phosphatases)

Giving unique and meaningful names to every human gene

1. Class I Cys-based PTPs
Classical PTPs:	Dual specificity phosphatases:
Transmembrane receptor-like PTPs	MAP kinase phosphatases
Non-receptor PTPs	Atypical dual specificity phosphatases
	Slingshots
	PRLs
	CDC14s
	PTENs
	Myotubularins
2. Class II Cys-based PTPs
3. Class III Cys-based PTPs
4. Asp-based PTPs

1. Class I Cys-based PTPs

Classical PTPs
Transmembrane receptor-like PTPs:

Click on the Approved Gene Symbol to retrieve the complete gene record

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
PTPRA	protein tyrosine phosphatase, receptor type, A	PTPRL2, PTPA	LRP, HLPR, HPTPA, RPTPA	20p13
PTPRB	protein tyrosine phosphatase, receptor type, B	PTPB		12q15-q21	X54131
PTPRC	protein tyrosine phosphatase, receptor type, C	CD45	LCA, T200, GP180	1q31-q32	Y00062
PTPRD	protein tyrosine phosphatase, receptor type, D		PTPD, HPTP	9p24.1-p23	X54133
PTPRE	protein tyrosine phosphatase, receptor type, E		PTPE	10q26	AF406557
PTPRF	protein tyrosine phosphatase, receptor type, F	LAR		1p34	Y00815
PTPRG	protein tyrosine phosphatase, receptor type, G	PTPG	RPTPG	3p21-p14	L09247	NM_002841
PTPRH	protein tyrosine phosphatase, receptor type, H		SAP-1	19q13.4
PTPRJ	protein tyrosine phosphatase, receptor type, J		DEP1, HPTPeta, CD148	11p11.2	U10886
PTPRK	protein tyrosine phosphatase, receptor type, K		R-PTP-kappa	6q22.2-q22.3	L77886
PTPRM	protein tyrosine phosphatase, receptor type, M	PTPRL1	RPTPU, hR-PTPu	18p11.2	X58288
PTPRN	protein tyrosine phosphatase, receptor type, N		IA-2	2q35-q36.1
PTPRN2	protein tyrosine phosphatase, receptor type, N polypeptide 2		KIAA0387, phogrin, ICAAR, IA-2beta	7q36	AB002385
PTPRO	protein tyrosine phosphatase, receptor type, O		PTPU2, GLEPP1, PTP-U2	12p13-p12	U20489
PTPRQ	protein tyrosine phosphatase, receptor type, Q			12q21.2	AF169351
PTPRR	protein tyrosine phosphatase, receptor type, R	PTPRQ	PTPBR7, PTP-SL, EC-PTP, PCPTP1	12q15	D64053
PTPRS	protein tyrosine phosphatase, receptor type, S			19p13.3	U35234
PTPRT	protein tyrosine phosphatase, receptor type, T		RPTPrho, KIAA0283	20q12-q13	AF043644
PTPRU	protein tyrosine phosphatase, receptor type, U		PTPRO, hPTP-J, PCP-2, FMI, PTP	1p35.3	U71075
PTPRV	protein tyrosine phosphatase, receptor type, V (pseudogene)		OST-PTP, ESP, PTPRVP	1q32.1	AJ629456	XM_086287
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	PTPZ, PTPRZ	PTP18, RPTPB, phosphacan	7q31.3	M93426

Non-receptor PTPs:

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
PTPN1	protein tyrosine phosphatase, non-receptor type 1	PTP1B		20q13.1-q13.2
PTPN2	protein tyrosine phosphatase, non-receptor type 2	PTPT	TCELLPTP, TC-PTP, TCPTP	18p11.3-p11.2	M25393	NM_002828, NM_080422, NM_080423
PTPN3	protein tyrosine phosphatase, non-receptor type 3		PTPH1	9q31
PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)		PTPMEG	2q14.2
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)		STEP, PTPSTEP	11p15.1	BC064807	NM_001039970
PTPN6	protein tyrosine phosphatase, non-receptor type 6		HCP, HCPH, PTP-1C, SHP-1, SHP1	12p13.31		NM_002831
PTPN7	protein tyrosine phosphatase, non-receptor type 7		HEPTP, LC-PTP	1q32.1	BC001746	NM_002832
PTPN9	protein tyrosine phosphatase, non-receptor type 9		MEG2	15q23
PTPN11	protein tyrosine phosphatase, non-receptor type 11	NS1	BPTP3, SH-PTP2, SHP-2, PTP2C, SHP2	12q24.1	D13540
PTPN12	protein tyrosine phosphatase, non-receptor type 12		PTPG1, PTP-PEST	7q11.23
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)		PTP1E, PTP-BAS, PTPL1, PTP-BL	4q21.3
PTPN14	protein tyrosine phosphatase, non-receptor type 14		PEZ	1q32.2	X82676	NM_005401
PTPN18	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)		BDP1	2q21	X79568
PTPN20A	protein tyrosine phosphatase, non-receptor type 20A		bA142I17.1	10q11.22
PTPN20B	protein tyrosine phosphatase, non-receptor type 20B		bA42B19.1, DKFZP566K0524	10q11.22		NM_015605
PTPN20C	protein tyrosine phosphatase, non-receptor type 20C		bA164N7.3	10q11.22		XM_925912
PTPN21	protein tyrosine phosphatase, non-receptor type 21		PTPD1, PTPRL10	14q31	X79510
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	PTPN8	Lyp, Lyp1, Lyp2	1p13.2	AF001846	NM_015967
PTPN23	protein tyrosine phosphatase, non-receptor type 23		DKFZP564F0923, KIAA1471, HD-PTP	3p21.3	AB025194	NM_015466

Dual specificity phosphatases
MAP kinase phosphatases:

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
DUSP1	dual specificity phosphatase 1	PTPN10	HVH1, CL100, MKP-1	5q35.1	X68277	NM_004417
DUSP2	dual specificity phosphatase 2		PAC-1	2q11	L11329	NM_004418
DUSP4	dual specificity phosphatase 4		HVH2, MKP-2, TYP	8p12-p11	U21108	NM_001394
DUSP5	dual specificity phosphatase 5		HVH3	10q25	U16996	NM_004419
DUSP6	dual specificity phosphatase 6		MKP-3, PYST1	12q22-q23	BC037236	NM_001946, NM_022652
DUSP7	dual specificity phosphatase 7		MKP-X, PYST2	3p21	X93921	NM_001947
DUSP8	dual specificity phosphatase 8	C11orf81	HVH-5, HB5, FLJ42958	11p15.5		NM_004420
DUSP9	dual specificity phosphatase 9		MKP-4, MKP4	Xq28	Y08302	NM_001395
DUSP10	dual specificity phosphatase 10		MKP-5, MKP5	1q41	AB026436	NM_007207
DUSP16	dual specificity phosphatase 16		MKP-7, KIAA1700, MKP7	12p13	AB052156	NM_030640
STYXL1	serine/threonine/tyrosine interacting-like 1	DUSP24	MK-STYX	7q11.23	AF069762	NM_016086

Atypical dual specificity phosphatases:

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
DUPD1	dual specificity phosphatase and pro isomerase domain containing 1		DUSP27	10q22.3		XM_291741
DUSP3	dual specificity phosphatase 3	VHR		17q21	BC035701	NM_004090
DUSP11	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)		PIR1	2p13.1	AF023917
DUSP12	dual specificity phosphatase 12		YVH1, DUSP1	1q21-q22	AF119226	NM_007240
DUSP13	dual specificity phosphatase 13		BEDP, TMDP, FLJ32450, DUSP13A, DUSP13B	10q23.1	AB027004
DUSP14	dual specificity phosphatase 14		MKP-L, MKP6	17q12	AF038844	NM_007026
DUSP15	dual specificity phosphatase 15		bA243J16.6, VHY	20q11.21		NM_080611
DUSP18	dual specificity phosphatase 18		DUSP20	22q12.1	AF461689
DUSP19	dual specificity phosphatase 19		SKRP1, DUSP17	2q32.1	AB038770
DUSP21	dual specificity phosphatase 21			Xp11.4-p11.23	AF143321	NM_022076
DUSP22	dual specificity phosphatase 22		MKPX, JSP1, JKAP, VHX	6pter-q22.33	AF165519	NM_020185
DUSP23	dual specificity phosphatase 23		FLJ20442, DUSP25	1q23.1		NM_017823
DUSP26	dual specificity phosphatase 26 (putative)		MGC1136, DUSP24	8p12	AY902194	NM_024025
DUSP28	dual specificity phosphatase 28		VHP, DUSP26	2q37.1	BC036198	NM_001033575
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)		LDE, LD	6q24	AF284580
PTPMT1	protein tyrosine phosphatase, mitochondrial 1		PLIP, DUSP23, MOSP	11p11.2	BC014048	XM_374879
RNGTT	RNA guanylyltransferase and 5'-phosphatase		HCE, HCE1, hCAP	6q16	AF025654
STYX	serine/threonine/tyrosine interacting protein			14q22.1		NM_145251

Slingshots:

Approved Symbol	Approved Name	Aliases	Chromosome	Accession Numbers	RefSeq IDs
SSH1	slingshot homolog 1 (Drosophila)	KIAA1298	12q24.12	BC062341	NM_018984
SSH2	slingshot homolog 2 (Drosophila)	KIAA1725	17q11.2	AB072359	NM_033389
SSH3	slingshot homolog 3 (Drosophila)	FLJ20515, FLJ10928	11q13	AF085851	NM_018276

PRLs:

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
PTP4A1	protein tyrosine phosphatase type IVA, member 1		PTPCAAX1, PRL-1	6q12	U48296
PTP4A2	protein tyrosine phosphatase type IVA, member 2	PTP4A	HU-PP-1, PTPCAAX2, OV-1, ptp-IV1a, PRL-2	1p35	L48723	NM_080391
PTP4A3	protein tyrosine phosphatase type IVA, member 3		PRL-3, PRL-R, PRL3	8q24.3	AF041434	NM_032611

CDC14s:

Approved Symbol	Approved Name	Aliases	Chromosome	Accession Numbers	RefSeq IDs
CDC14A	CDC14 cell division cycle 14 homolog A (S. cerevisiae)	Cdc14A1, Cdc14A2, cdc14	1p21	AF000367	NM_033312
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	Cdc14B1, Cdc14B2, CDC14B3, hCDC14B	9q22.3	AF023158	NM_033331
CDKN3	cyclin-dependent kinase inhibitor 3	KAP, CDI1	14q22	U02681
PTPDC1	protein tyrosine phosphatase domain containing 1	PTP9Q22, FLJ37312	9q22.32	BC051654	NM_177995, NM_152422

PTENs:

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
PTEN	phosphatase and tensin homolog	BZS, MHAM	MMAC1, TEP1, PTEN1	10q23	U92436	NM_000314
TENC1	tensin like C1 domain containing phosphatase (tensin 2)		KIAA1075, C1-TEN, TNS2	12q13.13	AF518729	NM_170754
TNS1	tensin 1	TNS, MXRA6	DKFZp586K0617	2q35-q36	AB209238	NM_022648
TPTE	transmembrane phosphatase with tensin homology		PTEN2	21p11	AF007118
TPTE2	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2		TPIP	13q12.11	AJ421032	NM_199255

Myotubularins:

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
MTM1	myotubularin 1			Xq27.3-q28	U46024	NM_000252
MTMR1	myotubularin related protein 1			Xq28	U58032	NM_003828, NM_176789
MTMR2	myotubularin related protein 2	CMT4B	KIAA1073	11q22	U58033	NM_016156
MTMR3	myotubularin related protein 3		KIAA0371, ZFYVE10, FYVE-DSP1	22q12.2	U58034	NM_021090
MTMR4	myotubularin related protein 4		KIAA0647, ZFYVE11	17q22-q23	AB014547	NM_004687
MTMR6	myotubularin related protein 6			13q12	AF072928	NM_004685
MTMR7	myotubularin related protein 7			8p22	AF073482
MTMR8	myotubularin related protein 8		FLJ20126	Xq11.2-q12	AK000133	NM_017677
MTMR9	myotubularin related protein 9	C8orf9, MTMR8	DKFZp434K171, LIP-STYX	8p23-p22	AJ297823
MTMR10	myotubularin related protein 10		FLJ20313	15q13.3	AK000320	NM_017762
MTMR11	myotubularin related protein 11		CRA	1q12-q21	AK097000	NM_181873
MTMR12	myotubularin related protein 12	PIP3AP	3-PAP, FLJ20476, KIAA1682, 3PAP	5p15.33	AB051469	NM_019061
MTMR14	myotubularin related protein 14	C3orf29	FLJ22405, FLJ90311, hJumpy, hEDTP	3p26	BC001674	NM_022485
MTMR15	myotubularin related protein 15	KIAA1018		15q13.2-q13.3		NM_014967
SBF1	SET binding factor 1		MTMR5	22q13.33	U93181
SBF2	SET binding factor 2	CMT4B2	KIAA1766, MTMR13	11p15.3	AB051553	NM_030962

2. Class II Cys-based PTPs

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
ACP1	acid phosphatase 1, soluble			2p25	M87546

3. Class III Cys-based PTPs

Approved Symbol	Approved Name	Previous Symbols	Chromosome	Accession Numbers	RefSeq IDs
CDC25A	cell division cycle 25 homolog A (S. pombe)		3p21	M81933	NM_001789
CDC25B	cell division cycle 25 homolog B (S. pombe)		20p13		NM_021874
CDC25C	cell division cycle 25 homolog C (S. pombe)	CDC25	5q31	M34065

4. Asp-based PTPs

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
EYA1	eyes absent homolog 1 (Drosophila)	BOR		8q13.3	AJ000098	NM_000503, NM_172060
EYA2	eyes absent homolog 2 (Drosophila)		EAB1	20q13.1		NM_005244
EYA3	eyes absent homolog 3 (Drosophila)		DKFZp686C132	1p36	U81602	NM_001990
EYA4	eyes absent homolog 4 (Drosophila)	DFNA10, CMD1J		6q23	Y17114	NM_004100

NHGRI
	The work of the HGNC is supported by NHGRI grant P41 HG003345, the UK Medical Research Council and the Wellcome Trust.