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NLR: Nucleotide-binding domain, leucine rich repeat containing family | |
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| Giving unique and meaningful names to every human gene | ||||||||
Following a 9 months email discussion the following decisions have been made about the nomenclature of this family:
HGNC aims to provide a unique gene symbol, which will be used in all publications. Looking at the publication history of this family HGNC is reluctant to approve the NLR stem for the most highly published genes, as inevitably these genes will continue to be referred to as CARD4/NOD1 etc. Therefore HGNC recommends that the following designations should be used by the community in future publications:
Human gene details in BLUE (approved symbols in upper case), Mouse gene details in BLACK (approved symbols in upper and lower case).
Visit http://www.genenames.org/genefamily/nlr.php for active links to the human gene details
| New approved symbol | New approved name | Previous approved symbol |
Additional alias | Other names and aliases |
Domain organization |
Entrez Gene ID |
Protein sequence |
| CIITA | class II, major histocompatibility complex, transactivator |
MHC2TA |
NLRA |
C2TA |
(CARD)-AD-NACHT-NAD-LRR |
4261 |
NP_000237 |
| CIIta | class II, major histocompatibility complex, transactivator |
Nlra |
C2TA |
(CARD)-AD-NACHT-NAD-LRR |
12265 |
NP_031601 |
|
| NAIP | NLR family, apoptosis inhibitory protein | BIRC1 |
NLRB1 |
CLR5.1 |
BIR3x-NACHT-NAD?-LRR |
4671 |
NP_004527 |
| Naip1 | NLR family, apoptosis inhibitory protein 1 |
Birc1a |
Nlrb1a |
|
BIR3x-NACHT-NAD?-LRR |
17940 |
NP_03269 |
| Naip2 | NLR family, apoptosis inhibitory protein 2 |
Birc1b |
Nlrb1b |
Naip-rs6 |
BIR3x-NACHT-NAD?-LRR |
17948 |
NP_035002 |
| Naip3 | NLR family, apoptosis inhibitory protein 3 |
Birc1c |
Nlrb1c |
Naip-rs5 |
BIR3x-NACHT-NAD?-LRR |
17949 |
U66328 |
| Naip4 | NLR family, apoptosis inhibitory protein 4 |
Birc1d |
Nlrb1d |
Naip-rs2 |
BIR3x-NACHT-NAD?-LRR |
17950 |
U66325 |
| Naip5 | NLR family, apoptosis inhibitory protein 5 |
Birc1e |
Nlrb1e |
Naip-rs3 |
BIR3x-NACHT-NAD?-LRR |
17951 |
NP_03500 |
| Naip6 | NLR family, apoptosis inhibitory protein 6 |
Birc1f |
Nlrb1f |
Naip-rs4 |
BIR3x-NACHT-NAD?-LRR |
17952 |
NP_035001 |
| Naip7 | NLR family, apoptosis inhibitory protein 7 |
Birc1g |
Nlrb1g |
|
BIR3x-NACHT-NAD?-LRR |
53880 |
AAF82749 |
| NOD1 | nucleotide-binding oligomerization domain containing 1 | CARD4 |
NLRC1 |
CLR7.1 |
CARD-NACHT-NAD-LRR |
10392 |
NP_006083 |
| Nod1 | nucleotide-binding oligomerization domain containing 1 | Card4 |
Nlrc1 |
CARD-NACHT-NAD-LRR |
107607 |
NP_766317 |
|
| NOD2 | nucleotide-binding oligomerization domain containing 2 | CARD15 |
NLRC2 |
CD, BLAU, IBD1, PSORAS1; CLR16.3 |
CARD2x-NACHT-NAD-LRR |
64127 |
NP_071445 |
| Nod2 | nucleotide-binding oligomerization domain containing 2 | Card15 |
Nlrc2 |
CARD2x-NACHT-NAD-LRR |
257632 |
NP_665856 |
|
| NLRC3 | NLR family, CARD domain containing 3 | None |
NOD3; CLR16.2 |
CARD-NACHT-NAD-LRR |
197358 |
NP_849172 |
|
| Nlrc3 |
NLR family, CARD domain containing 3 | None |
CLR16.2 |
CARD-NACHT-NAD-LRR |
268857 |
XP_484522 |
|
| NLRC4 | NLR family, CARD domain containing 4 |
CARD12 |
CLAN; CLR2.1, IPAF |
CARD-NACHT-NAD-LRR |
58484 |
NP_067032 |
|
| Nlrc4 |
NLR family, CARD domain containing 4 | Card12 |
CLAN, Ipaf |
CARD-NACHT-NAD-LRR |
268973 |
XP_197335 |
|
| NLRC5 |
NLR family, CARD domain containing 5 | None |
NOD27; CLR16.1 |
CARD-NACHT-NAD-LRR |
84166 |
NP_115582 |
|
| Nlrc5 |
NLR family, CARD domain containing 5 | None |
none |
CARD-NACHT-NAD-LRR |
434341 |
XP_486147 |
|
| NLRX1 |
NLR family member X1 | None |
NOD9; CLR11.3 |
X-NACHT-NAD-LRR |
79671 |
NP_078894 |
|
| Nlrx1 | NLR family member X1 | None |
none |
X-NACHT-NAD-LRR |
270151 |
NP_848507 |
|
| NLRP1 |
NLR family, pyrin domain containing 1 | NALP1 |
DEFCAP; NAC; CARD7; CLR17.1 |
PYD-NACHT-NAD-LRR-FIIND-CARD |
22861 |
NP_127497 |
|
| Nlrp1a |
NLR family, pyrin domain containing 1A | Nalp1 |
Nalp1a |
NACHT-NAD-LRR-FIIND-CARD |
195046 |
NP_001004142 |
|
| Nlrp1b |
NLR family, pyrin domain containing 1B | None |
Nalp1b |
NACHT-?-LRR |
637515 |
NP_001034769 |
|
| Nlrp1c |
NLR family, pyrin domain containing 1C | None |
Nalp1c |
627984 |
NP_001034323 |
||
| NLRP2 |
NLR family, pyrin domain containing 2 | NALP2 |
PYPAF2; NBS1; PAN1; CLR19.9 |
PYD-NACHT-NAD-LRR |
55655 |
NP_060322 |
|
| Nlrp2 |
NLR family, pyrin domain containing 2 | Nalp2 |
Pypaf2, Nbs1, Pan1 |
PYD-NACHT-NAD-LRR |
232827 |
NP_808358 |
|
| NLRP3 |
NLR family, pyrin domain containing 3 | CIAS1 |
PYPAF1, Cryopyrin; CLR1.1, NALP3 |
PYD-NACHT-NAD-LRR |
114548 |
NP_00488 |
|
| Nlrp3 |
NLR family, pyrin domain containing 3 | Cias1 |
Pypaf1, Mmig1, Nalp3 |
PYD-NACHT-NAD-LRR |
216799 |
NP_665826 |
|
| NLRP4 |
NLR family, pyrin domain containing 4 | NALP4 |
PYPAF4;PAN2; RNH2; CLR19.5 |
PYD-NACHT-NAD-LRR |
147945 |
NP_604393 |
|
| Nlrp4a |
NLR family, pyrin domain containing 4A | Nalp4a |
Nalp-eta, Nalp9D |
PYD-NACHT-NAD-LRR |
243880 |
NP_766484 |
|
| Nlrp4b |
NLR family, pyrin domain containing 4B | Nalp4b |
Nalp-gamma, Nalp9E |
PYD-NACHT-NAD-LRR |
210045 |
NP_766069 |
|
| Nlrp4c |
NLR family, pyrin domain containing 4C | Nalp4c |
Nalp-alpha, Rnh2 |
PYD-NACHT-NAD-LRR |
83564 |
NP_113566 |
|
| Nlrp4d |
NLR family, pyrin domain containing 4D | Nalp4d |
Nalp-beta |
PYD-NACHT-NAD-LRR |
384752 |
AAU06316 |
|
| Nlrp4e |
NLR family, pyrin domain containing 4E | Nalp4e |
Nalp-epsilon |
PYD-NACHT-NAD-LRR |
446099 |
NP_001004194 |
|
| Nlrp4f |
NLR family, pyrin domain containing 4F | Nalp4f |
Nalp-kappa, Nalp9F |
PYD-NACHT-NAD-LRR |
97895 |
NP_780499 |
|
| Nlrp4g |
NLR family, pyrin domain containing 4G | Nalp4g |
none |
PYD-NACHT-NAD-LRR |
235779 |
AAH80833 |
|
| NLRP5 |
NLR family, pyrin domain containing 5 | NALP5 |
PYPAF8; MATER, PAN11; CLR19.8 |
PYD-NACHT-NAD-LRR |
126206 |
NP_703148 |
|
| Nlrp5 |
NLR family, pyrin domain containing 5 | Nalp5 |
Mater, Op1 |
NACHT-NAD-LRR |
23968 |
NP_035990 |
|
| NLRP6 |
NLR family, pyrin domain containing 6 | NALP6 |
PYPAF5; PAN3; CLR11.4 |
PYD-NACHT-NAD-LRR |
171389 |
NP_612202 |
|
| Nlrp6 |
NLR family, pyrin domain containing 6 | Nalp6 |
none |
PYD-NACHT-NAD-LRR |
101613 |
AY355343 |
|
| NLRP7 |
NLR family, pyrin domain containing 7 | NALP7 |
PYPAF3; NOD12; PAN7; CLR19.4 |
PYD-NACHT-NAD-LRR |
199713 |
NP_996611 |
|
| NLRP8 |
NLR family, pyrin domain containing 8 | NALP8 |
PAN4; NOD16; CLR19.2 |
PYD-NACHT-NAD-LRR |
126205 |
NP_789781 |
|
| NLRP9 |
NLR family, pyrin domain containing 9 | NALP9 |
NOD6; ; PAN12; CLR19.1 |
PYD-NACHT-NAD-LRR |
338321 |
NP_789790 |
|
| Nlrp9a |
NLR family, pyrin domain containing 9A | Nalp9a |
Nalp-theta |
PYD-NACHT-NAD-LRR |
23300 |
NP_918945 |
|
| Nlrp9b |
NLR family, pyrin domain containing 9B | Nalp9b |
Nalp-delta |
PYD-NACHT-NAD-LRR |
243874 |
NP_918947 |
|
| Nlrp9c |
NLR family, pyrin domain containing 9C | Nalp9c |
Nalp-zeta |
PYD-NACHT-NAD-LRR |
330490 |
NP_918951 |
|
| NLRP10 |
NLR family, pyrin domain containing 10 | NALP10 |
PAN5; NOD8; Pynod; CLR11.1 |
PYD-NACHT-NAD |
338322 |
NP_789791 |
|
| Nlrp10 |
NLR family, pyrin domain containing 10 | Nalp10 |
Pynod |
PYD-NACHT-NAD |
244202 |
NP_780741 |
|
| NLRP11 |
NLR family, pyrin domain containing 11 | NALP11 |
PYPAF6; NOD17; PAN10; CLR19.6 |
PYD-NACHT-NAD-LRR |
204801 |
NP_659444 |
|
| NLRP12 |
NLR family, pyrin domain containing 12 | NALP12 |
PYPAF7; Monarch1; RNO2; PAN6; CLR19.3 |
PYD-NACHT-NAD-LRR |
91662 |
NP_653288 |
|
| Nlrp12 |
NLR family, pyrin domain containing 12 | Nalp12 |
none |
PYD-NACHT-NAD-LRR |
378425 |
XP_355971 |
|
| NLRP13 |
NLR family, pyrin domain containing 13 | NALP13 |
NOD14; PAN13; CLR19.7 |
PYD-NACHT-NAD-LRR |
126204 |
NP_78978 |
|
| NLRP14 |
NLR family, pyrin domain containing 14 | NALP14 |
NOD5; PAN8; ; CLR11.2 |
PYD-NACHT-NAD-LRR |
338323 |
NP_789792 |
|
| Nlrp14 |
NLR family, pyrin domain containing 14 | Nalp14 |
Nalp-iota, GC-LRR, |
PYD-NACHT-NAD-LRR |
76858 |
NP_001002894 |
Abbreviations: CARD, caspase activating and recruitment domain; LRR, leucine-rich repeat; NACHT, domain present in NAIP, CIITA, HET-E, TP-1; BIR, baculovirus inhibitor of apoptosis repeat; PYD, pyrin domain.
Links to previous pages
NACHT domain and LRR First Questionnaire discussion page
NACHT domain and LRR Second Questionnaire discussion page
NACHT domain and LRR Third Questionnaire discussion page
NACHT domain and LRR final discussion page
NHGRI |
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