Interleukins and interleukin receptors

Giving unique and meaningful names to every human gene

We work closely with the IUIS (International Union Of Immunological Societies) Interleukin Nomenclature Committee for all new interleukin designations. Consequently, the Interleukin Nomenclature Committee will be consulted before any new IL numbers are assigned. Please note that the symbols IL14 and IL30 will not be used in the future as approved nomenclature.

Click on the Approved Gene Symbol to retrieve the complete gene record

Approved Symbol	Approved Name	Previous Symbols	Aliases	Chromosome	Accession Numbers	RefSeq IDs
IL1A	interleukin 1, alpha	IL1	IL1F1, IL-1A	2q14	M28983	NM_000575
IL1B	interleukin 1, beta		IL1F2, IL-1B	2q14	M15330	NM_000576
IL1F5	interleukin 1 family, member 5 (delta)		FIL1, FIL1(DELTA), FIL1D, IL1HY1, IL1RP3, IL1L1, IL-1F5	2q14	AF201830	NM_173170
IL1F6	interleukin 1 family, member 6 (epsilon)		FIL1, FIL1E, IL-1F6, IL1(EPSILON)	2q12-q14.1	AF201831	NM_014440
IL1F7	interleukin 1 family, member 7 (zeta)		FIL1, FIL1Z, FIL1(ZETA), IL-1H4, IL-1RP1, IL-1F7	2q12-q14.1	AF201832	NM_014439
IL1F8	interleukin 1 family, member 8 (eta)		FIL1, IL-1H2, IL-1F8	2q14	AF201833	NM_014438
IL1F9	interleukin 1 family, member 9		IL-1H1, IL-1RP2, IL-1F9	2q12-q21	AF200492	NM_019618
IL1F10	interleukin 1 family, member 10 (theta)		FKSG75, IL-1HY2, IL-1F10	2q13	AY026753	NM_173161
IL1R1	interleukin 1 receptor, type I	IL1R, IL1RA	D2S1473, CD121A	2q12	M27492
IL1R2	interleukin 1 receptor, type II	IL1RB	CD121b	2q12	X59770
IL1RAP	interleukin 1 receptor accessory protein		IL-1RAcP, IL1R3, C3orf13	3q28	AB006537
IL1RAPL1	interleukin 1 receptor accessory protein-like 1	IL1RAPL, MRX34, MRX21	OPHN4, TIGIRR-2, IL1R8	Xp22.1-p21.3	AJ243874	NM_014271
IL1RAPL2	interleukin 1 receptor accessory protein-like 2		IL-1R9, TIGIRR-1, IL1RAPL-2, IL1R9	Xq22	AF181285
IL1RL1	interleukin 1 receptor-like 1		ST2, FIT-1, ST2L, ST2V, DER4, T1	2q12	D12764	NM_016232
IL1RL2	interleukin 1 receptor-like 2		IL1R-rp2, IL1RRP2	2q12	U49065	NM_003854
IL1RN	interleukin 1 receptor antagonist		IL1RA, ICIL-1RA, IL1F3, IRAP	2q14.2	M55646	NM_173841
IL2	interleukin 2		IL-2	4q26-q27	U25676
IL2RA	interleukin 2 receptor, alpha	IL2R	CD25	10p15-p14	X01057	NM_000417
IL2RB	interleukin 2 receptor, beta		CD122	22q13	M26062
IL2RG	interleukin 2 receptor, gamma (severe combined immunodeficiency)	SCIDX1, IMD4	CD132	Xq13	D11086
IL3	interleukin 3 (colony-stimulating factor, multiple)		IL-3, MULTI-CSF, MCGF	5q23-q31	M14743	NM_000588
IL3RA	interleukin 3 receptor, alpha (low affinity)		CD123	Xp22.3 and Yp13.3	M74782
IL4	interleukin 4		BSF1, IL-4, BCGF1, BCGF-1	5q23-q31	M23442	NM_000589
IL4R	interleukin 4 receptor		CD124	16p12.1-p11.2	X52425
IL5	interleukin 5 (colony-stimulating factor, eosinophil)		IL-5, EDF, TRF	5q23-q31	X04688	NM_000879
IL5RA	interleukin 5 receptor, alpha	IL5R	CDw125, CD125	3p26-p24	M96652
IL6	interleukin 6 (interferon, beta 2)	IFNB2	IL-6, BSF2, HGF, HSF	7p21-p15	M18403
IL6R	interleukin 6 receptor		CD126	1q21	X12830
IL6RL1	interleukin 6 receptor-like 1			9q22.2
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)		GP130, CD130	5q11	M57230
IL6STP	interleukin 6 signal transducer (gp130, oncostatin M receptor) pseudogene			17p11
IL7	interleukin 7		IL-7	8q12-q13	J04156
IL7R	interleukin 7 receptor		CD127	5p13	M29696
IL8	interleukin 8		SCYB8, LUCT, LECT, MDNCF, TSG-1, CXCL8, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60	4q13-q21	Y00787
IL8RA	interleukin 8 receptor, alpha	CMKAR1	CXCR1, CKR-1, CDw128a, CD181	2q35	U11870	NM_000634
IL8RB	interleukin 8 receptor, beta		CXCR2, CMKAR2, CD182	2q35	U11869
IL8RBP	interleukin 8 receptor, beta pseudogene			2q35	M98335
IL9	interleukin 9		IL-9, HP40, P40	5q31-q35	S63356	NM_000590
IL9R	interleukin 9 receptor		CD129	Xq28 and Yq12	M84747	NM_002186
IL9RP1	interleukin 9 receptor pseudogene 1			9q34
IL9RP2	interleukin 9 receptor pseudogene 2			10p15	L39063
IL9RP3	interleukin 9 receptor pseudogene 3			16p13.3	L39062
IL9RP4	interleukin 9 receptor pseudogene 4			18p11.3		NG_002764
IL10	interleukin 10		CSIF, TGIF, IL10A, IL-10	1q31-q32	M57627	NM_000572
IL10RA	interleukin 10 receptor, alpha	IL10R	HIL-10R, CDW210A	11q23	U00672
IL10RB	interleukin 10 receptor, beta	CRFB4, D21S58, D21S66	CRF2-4, CDW210B, IL-10R2	21q22.1-q22.2	U08988
IL11	interleukin 11		IL-11, AGIF	19q13.3-q13.4	X58377	NM_000641
IL11RA	interleukin 11 receptor, alpha			9p13	Z38102
IL11RB	interleukin 11 receptor, beta			reserved
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	NKSF1	CLMF, IL-12A, p35, NFSK	3p12-q13.2	M65271	NM_000882
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	NKSF2	CLMF, IL-12B, NKSF, CLMF2	5q31.1-q33.1	M65290	NM_002187
IL12RB1	interleukin 12 receptor, beta 1	IL12RB	CD212	19p13.1	U03187
IL12RB2	interleukin 12 receptor, beta 2			1p31.3-p31.2	U64198	NM_001559
IL13	interleukin 13		P600, IL-13, ALRH, BHR1	5q31	U31120	NM_002188
IL13RA1	interleukin 13 receptor, alpha 1		IL-13Ra, NR4, CD213a1	Xq24	U62858	NM_001560
IL13RA2	interleukin 13 receptor, alpha 2		IL-13R, IL13BP, CD213a2	Xq13.1-q28	X95302	NM_000640
IL15	interleukin 15		IL-15	4q31	U14407
IL15RA	interleukin 15 receptor, alpha			10p15.1	U31628	NM_172200, NM_002189
IL15RB	interleukin 15 receptor, beta			reserved
IL16	interleukin 16 (lymphocyte chemoattractant factor)		LCF, IL-16, prIL-16, HsT19289	15q26.3	U82972	NM_172217
IL17A	interleukin 17A	CTLA8, IL17	IL-17A, IL-17	6p12	U32659	NM_002190
IL17B	interleukin 17B		IL-17B, ZCYTO7, IL-20	5q33.1	AF184969
IL17C	interleukin 17C		IL-17C, CX2, IL-21	16q24	AF152099	NM_013278
IL17D	interleukin 17D		IL-22, IL-27, IL-17D, IL27, FLJ30846	13q11	AY078238	NM_138284
IL17F	interleukin 17F		IL-17F, ML-1, ML1	6p12	AF384857
IL17RA	interleukin 17 receptor A	IL17R	hIL-17R, IL-17RA, CDw217, CD217	22q11.1	U58917	NM_014339
IL17RB	interleukin 17 receptor B	IL17BR	IL17RH1, EVI27, CRL4	3p21.1	AF212365	NM_172234
IL17RC	interleukin 17 receptor C		IL17-RL	3p25.3	BC006411	NM_032732
IL17RD	interleukin 17 receptor D		SEF, IL17RLM, FLJ35755, IL-17RD	3p21.1	AF494208	NM_017563
IL17RE	interleukin 17 receptor E		FLJ23658	3p25.3	AF458069	NM_153480
IL18	interleukin 18 (interferon-gamma-inducing factor)		IGIF, IL1F4, IL-1g, IL-18	11q22.2-q22.3	U90434	NM_001562
IL18BP	interleukin 18 binding protein		IL18BPa	11q13	AF110798	NM_173042
IL18R1	interleukin 18 receptor 1		IL1RRP, IL-1Rrp, CD218a	2q12	U43672	NM_003855
IL18RAP	interleukin 18 receptor accessory protein		AcPL, CD218b	2p24.3-p24.1	AF077346	NM_003853
IL19	interleukin 19		IL-19, MDA1, ZMDA1, IL-10C, NG.1	1q32.2	AF192498	NM_153758
IL20	interleukin 20		ZCYTO10, IL10D, IL-20	1q32	AF224266	NM_018724
IL20RA	interleukin 20 receptor, alpha		ZCYTOR7, IL-20R1	6q23.3	AF184971	NM_014432
IL20RB	interleukin 20 receptor beta	FNDC6	DIRS1, IL-20R2, MGC34923	3q22.3	BC033292	NM_144717
IL21	interleukin 21		Za11, IL-21	4q26-q27	AF254069
IL21R	interleukin 21 receptor			16p11	AF254067
IL22	interleukin 22		ILTIF, IL-21, zcyto18, IL-TIF, IL-D110, TIFa, TIFIL-23, IL-22	12q15	AF279437	NM_020525
IL22RA1	interleukin 22 receptor, alpha 1	IL22R	CRF2-9	1p36.11	AF286095
IL22RA2	interleukin 22 receptor, alpha 2		CRF2-S1, IL-22BP	6q24.1-q24.2	AY044429
IL23A	interleukin 23, alpha subunit p19		SGRF, IL23P19, IL-23, IL-23A	12q13.13	AB030000
IL24	interleukin 24	ST16	mda-7, IL10B, Mob-5, C49A, FISP, IL-24	1q32	U16261	NM_006850
IL25	interleukin 25	IL17E	IL-25, IL-17E	14q11.2	AF305200
IL26	interleukin 26		AK155, IL-26	12q15	AJ251549	NM_018402
IL27	interleukin 27	IL30	IL-27, p28	16p11	AY099296
IL27RA	interleukin 27 receptor, alpha		WSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R	19p13.11	AF053004	NM_004843
IL28A	interleukin 28A (interferon, lambda 2)		IL-28A, IFNL2	19q13.13	AY129148
IL28B	interleukin 28B (interferon, lambda 3)		IL-28B, IFNL3	19q13.13	AY129149
IL28RA	interleukin 28 receptor, alpha (interferon, lambda receptor)		CRF2/12, IFNLR, IL-28R1	1p36.11	AY129153	NM_170743
IL29	interleukin 29 (interferon, lambda 1)		IL-29, IFNL1	19q13.13	AY129150
IL31	interleukin 31		IL-31	12q24.31	AY499343
IL31RA	interleukin 31 receptor A		CRL3, GLM-R, CRL, Glmr, IL-31RA	5q11.2	AY499339	NM_139017
IL32	interleukin 32		NK4, TAIF, TAIFb, TAIFd	16p13.3	M59807	NM_004221
IL34	interleukin 34	C16orf77	MGC34647, IL-34	16q22.1	BC029804	NM_152456

NHGRI
	The work of the HGNC is supported by NHGRI grant P41 HG003345, the UK Medical Research Council and the Wellcome Trust.