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Giving unique and meaningful names to every human gene

NEW - December 2006: The HGNC is in the process of reviewing the nomenclature of all human histone genes. We, therefore, welcome and encourage input from the research community in order to establish a histone nomenclature system that will ideally be used by researchers in future publications, and incorporated into our database, the Histone Sequence Database, and all the major genome databases.

To comment on the problems of the currrent nomenclature system and/or to propose a new nomenclature system, please consult the table below and email hgnc@genenames.org; please also direct your colleagues to this page. Unless specified your email will be added to our discussion page to facilitate discussion amongst the research community.

For a review of the current replication-dependent histone gene nomenclature see Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. The human and mouse replication-dependent histone genes. Genomics. 2002 Nov;80(5):487- 98; PMID:12408966 (PDF).

Symbols in bold are those commonly used in the literature

Rows highlighted in blue are mouse-specific histone genes (with MGNC approved nomenclature) with no known human equivalent

Replication-independent histone genes
HGNC approved gene symbol
HGNC approved gene name
HGNC previous symbols
HGNC aliases*
HGNC record accession
HGNC record RefSeq
GeneID
Location
Coordinates
Mouse ortholog**
Notes
H1 histone family, member 0
H1FV H10
22q13.1
+ve
36531005- 36533643
H1 histone family, member N, testis-specific
HANP1, H1T2
12q13.11
+ve
47009030- 47010329
H1 histone family, member O, oocyte-specific
3q21.3
+ve
130744747- 30752894
H1 histone family, member X
MGC15959, MGC8350, H1X
3q21.3
-ve
130516794- 130517435
H2A histone family, member B1
Xq28
+ve
153766511- 153767027
n/a
H2A histone family, member B2
Xq28
+ve
154263622- 154264138
n/a
H2A histone family, member B3
H2AFB
Xq28
-ve
154342274- 154342790
n/a
Mouse ortholog MGI:3644875?
H2A histone family, member J
FLJ10903, MGC921
12p12.3
+ve
14818672- 14819612
HIST4# cluster?
H2A histone family, member V
H2AV MGC10170, MGC10831, MGC1947
7p13
-ve
44840457- 44849479
H2A histone family, member V, pseudogene
HsT19970
15q26.1
-ve
91077818- 91078511
n/a
H2A histone family, member X
H2AX
11q23.3
-ve
11846979- 118471387
H2A histone family, member Y
macroH2A1.2
5q31.1
-ve
134697224- 134763476
H2A histone family, member Y2
macroH2A2
10q22.1
+ve
71482558- 71542021
H2afy3 H2A histone family, member Y3       n/a  
H2A histone family, member Z
H2AZ
4q24
-ve
101088266- 101090454
H2A histone family, member Z, pseudogene
21q22.3
-ve
44291043- 44291359
n/a
H2A histone family, member Z, pseudogene 2
8q13.3
-ve
71178179- 71178968
n/a
H2B histone family, member M
Xq22.2
+ve
103181172- 103183676
n/a
H2B histone family, member O
H2B/o
1q21.2
-ve
148081679- 148081727
n/a
HIST2# cluster?
H2B histone family, member S
21q22.3
+ve
43809548- 43809928
n/a
H2bfs is an alias for mouse Hist1h2bc
H2B histone family, member W, testis-specific
Xq22.2
-ve
103153940- 103154888
n/a
H3 histone, family 3A
H3F3 H3.3A
1q42.12
+ve
224317002- 224326323
HIST3# cluster?
H3 histone, family 3A, pseudogene 1
HsT18159
15q15.1
-ve
38030864- 38031144
n/a
H3 histone, family 3A, pseudogene 2
H3F3CP
14q11.2
+ve
22833625- 22834849
n/a
H3f3a-ps1 H3 histone, family 3A, pseudogene 1       n/a  
H3f3a-ps2 H3 histone, family 3A, pseudogene 2       n/a  
H3 histone, family 3B (H3.3B)
H3.3B
17q25.1
-ve
71284908- 71288179
H4 histone, family 3
3q13.13
-ve
110609902- 110612777
n/a
Rename as H3F3P?
Replication-dependent histone genes
HGNC approved gene symbol
HGNC approved gene name
HGNC previous symbols
HGNC aliases
HGNC record accession
HGNC record RefSeq
GeneID
Location
Coordinates
MGI ID
Notes
histone cluster 1, H1a
H1F1 H1.1
6p22.1
-ve
26124840- 26126459
histone cluster 1, H1b
H1F5 H1.5
6p22.1
-ve
27942606- 27943286
histone cluster 1, H1c
H1F2 H1.2
6p21.3
-ve
26163994- 26164635
histone cluster 1, H1d
H1F3 H1.3
6p21.3
-ve
26342475- 26343140
histone cluster 1, H1e
H1F4 H1.4
6p22.1
+ve
26264598- 26265257
histone cluster 1, H1, pseudogene 1
dJ34B20.16, FLJ39701, H1F6P
6p22.1
+ve
26303773- 26303978
n/a
histone cluster 1, H1, pseudogene 2
H3FEP pH3/e
6p22.1
+ve
26124180- 26125048
n/a
histone cluster 1, H1t
H1FT H1t
6p22.1
-ve
26215677- 26216297
histone cluster 1, H2aa
bA317E16.2, H2AFR
6p22.2
-ve
25834339- 25834734
histone cluster 1, H2ab
H2AFM H2A/m
6p22.1
-ve
26141383- 2614177
histone cluster 1, H2ac
H2AFL
6p22.1
+ve
26232352- 26232948
histone cluster 1, H2ad
H2AFG H2A/g, H2A.3
6p22.1
-ve
26307058- 26307450
histone cluster 1, H2ae
H2AFA H2A/a, H2A.1
6p22.1
+ve
26325182- 26325574
Hist1h2af histone cluster 1, H2af         n/a    
histone cluster 1, H2ag
H2AFP pH2A/f, H2A/p, H2A.1b
6p22.1
+ve
27208800- 27211049
histone cluster 1, H2ah
H2AFALii, dJ86C11.1, H2A/S
6p22.1
+ve
27222887- 27223273
histone cluster 1, H2ai
H2AFC H2A/c
6p22.1
+ve
27883956- 27884458
histone cluster 1, H2aj
H2AFE H2A/E
6p22.1
-ve
27890111- 27890497
histone cluster 1, H2ak
H2AFD H2A/d
6p22.1
-ve
27913704- 27914096
histone cluster 1, H2al
H2AFI H2A/i, dJ193B12.9
6p22.1
+ve
27941112- 27941504
n/a
histone cluster 1, H2am
H2AFN H2A/n, H2A.1
6p22.1
-ve
27968514- 27968906
n/a
Hist1h2an histone cluster 1, H2an       n/a    
Hist1h2ao histone cluster 1, H2ao       n/a    
histone cluster 1, H2a, pseudogene 1
bA317E16.5, H2AFSP
6p22.2
+ve
25840672- 25841018
n/a
histone cluster 1, H2a, pseudogene 2
H2AFTP dJ139G21.2, H2A/T
6p22.2
-ve
25990233- 25990602
n/a
histone cluster 1, H2a, pseudogene 3
dJ34B20.8, H2AFUP
6p22.1
+ve
26341329- 26341462
n/a
histone cluster 1, H2a, pseudogene 4
H2AFK, H2AFKP pH2A/k, dJ34B20.2
6p22.1
-ve
26380400- 26380747
n/a
histone cluster 1, H2a, pseudogene 5
H2AFFP pH2A/f
6p22.1
+ve
26152107- 26152757
n/a
histone cluster 1, H2ba
bA317E16.3, STBP, TSH2B, H2BFU
6p22.2
+ve
25835116- 25835499
histone cluster 1, H2bb
H2BFF H2B/f
6p22.1
-ve
26151484- 26151864
histone cluster 1, H2bc
H2BFL H2B/l, H2B.1
6p22.1
-ve
26231731- 26232108
histone cluster 1, H2bd
H2BFB H2B/b
6p22.1
+ve
26266353- 26279556
n/a
histone cluster 1, H2be
H2BFH H2B/h, H2B.h
6p22.1
+ve
26292002- 26292387
histone cluster 1, H2bf
H2BFG H2B/g
6p22.1
+ve
26307766- 26308146
histone cluster 1, H2bg
H2BFA H2B/a, H2B.1A
6p21.3
-ve
26324470- 26324850
histone cluster 1, H2bh
H2BFJ H2B/j
6p21.3
+ve
26359858- 26360238
histone cluster 1, H2bi
H2BFK H2B/k
6p22.1
+ve
26381183- 26381563
n/a
histone cluster 1, H2bj
H2BFR H2B/r
6p22.1
-ve
27208128- 27208508
histone cluster 1, H2bk
H2BFT H2BFAiii
6p22.1
-ve
27221799- 27222935
histone cluster 1, H2bl
H2BFC H2B/c, dJ97D16.4
6p22.1
-ve
27882906- 27884042
histone cluster 1, H2bm
H2BFE H2B/e, dJ160A22.3
6p22.1
+ve
27890421- 27891557
histone cluster 1, H2bn
H2BFD H2B/d
6p22.1
+ve
27914039- 27915175
histone cluster 1, H2bo
H2BFN H2B/n, H2B.2
6p22.1
+ve
27968840- 27969976
n/a
Hist1h2bp histone cluster 1, H2bp       n/a    
histone cluster 1, H2b, pseudogene 1
bA317E16.4, H2BFVP
6p22.2
-ve
25839990- 25840369
n/a
histone cluster 1, H2b, pseudogene 2
H2BFIP pH2B/i
6p22.1
-ve
27939819- 27940158
n/a
histone cluster 1, H3a
H3FA H3/A
6p22.1
+ve
26128287- 26129513
histone cluster 1, H3b
H3FL H3/l
6p22.1
-ve
26139857- 26140267
histone cluster 1, H3c
H3FC H3/c, H3.1
6p22.1
+ve
26153618- 26154028
histone cluster 1, H3d
H3FB H3/b
6p22.1
-ve
26305047- 26305457
histone cluster 1, H3e
H3FD H3/d, H3.1
6p22.1
+ve
26333362- 26333772
histone cluster 1, H3f
H3FI H3/i
6p22.1
-ve
26358402- 26358812
histone cluster 1, H3g
H3FH H3/h
6p22.1
-ve
26379181- 26379591
histone cluster 1, H3h
H3FK H3/k, H3F1K
6p22.1
+ve
27885821- 27887057
histone cluster 1, H3i
H3FF H3/f, H3.f
6p22.1
-ve
27947662- 27948072
histone cluster 1, H3j
H3FJ H3/j
6p22.1
-ve
27966139- 27966549
n/a
histone cluster 1, H3, pseudogene 1
dJ45P21.6, H3F3AP1
6p22.1
-ve
26430083- 26430499
n/a
histone cluster 1, H4a
H4FA
6p22.1
+ve
26129575- 26130504
histone cluster 1, H4b
H4FI H4/I
6p22.1
-ve
26135148- 26135456
histone cluster 1, H4c
H4FG H4/g, dJ221C16.1
6p22.1
+ve
26212155- 26212466
histone cluster 1, H4d
H4FB H4/b
6p22.1
-ve
26296972- 26297283
histone cluster 1, H4e
H4FJ H4/j
6p22.1
+ve
26312852- 26313163
n/a
histone cluster 1, H4f
H4FC H4/c, H4
6p22.1
+ve
26348633- 26348944
histone cluster 1, H4g
H4FL H4/l
6p22.1
-ve
26354888- 26355184
n/a
histone cluster 1, H4h
H4FH H4/h
6p22.1
-ve
26393320- 26393716
histone cluster 1, H4i
H4FM H4/m
6p22.1
+ve
27214346- 27215639
histone cluster 1, H4j
H4FE H4/e
6p22.1
+ve
27899765- 27899976
histone cluster 1, H4k
H4FD H4/d
6p22.1
-ve
27906372- 27907897
histone cluster 1, H4l
H4FK H4.k, H4/k
6p22.1
-ve
27948956- 27949267
n/a
Hist1h4m histone cluster 1, H4m         n/a    
histone cluster 1, H4, pseudogene 1
H4FFP pH4/f, dJ97D16.3
6p22.1
+ve
27882638- 27883282
n/a
Hist2h2aa1 histone cluster 2, H2aa1         n/a    
Hist2h2aa2 histone cluster 2, H2aa2         n/a    
histone cluster 2, H2aa3
H2AFO, HIST2H2AA H2A.2, H2A/q
1q21.2
-ve
148080108- 148081280
n/a
histone cluster 2, H2aa4
H2A/r
1q21.2
+ve
148089252- 148089815
n/a
histone cluster 2, H2ab
1q21.2
-ve
148125698- 148126090
histone cluster 2, H2ac
H2A, H2AFQ H2A/q
1q21.2
+ve
148124776- 148125894
histone cluster 2, H2ba
1
n/a
Pseudogene?
Blats to 3
locations
histone cluster 2, H2bb
1
Pseudogene?
Blats to 3 locations
histone cluster 2, H2bc
H2B/t
1q21.2
-ve
148088210- 148089343
n/a
Pseudogene?
histone cluster 2, H2bd
H2B/s
1q21.2
+ve
148080973- 148081985
n/a
Pseudogene?
histone cluster 2, H2be
H2B, H2BFQ H2B/q, H2B.1
1q21.2
-ve
148124058- 148125194
histone cluster 2, H2bf
1q21.2
-ve
148050122- 148050502
n/a
histone cluster 2, H3a
H3/n, H3/o
1q21.2
+ve
148090318- 148091640
n/a
Pseudogene?
histone cluster 2, H3b
HIST2H3PS1
AF531306
-mouse sequence?
Only two
HIST2H3 loci?
Withdraw HIST2H3B?