Basic helix-loop-helix proteins
Click on the Approved Gene Symbol to retrieve the complete gene record
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| AHR | aryl hydrocarbon receptor | bHLHe76 | 7p15 | |
| AHRR | aryl-hydrocarbon receptor repressor | AHH, AHHR | KIAA1234, bHLHe77 | 5p15.33 |
| ARNT | aryl hydrocarbon receptor nuclear translocator | HIF-1beta, bHLHe2 | 1q21 | |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | KIAA0307, bHLHe1 | 15q25.1 | |
| ARNTL | aryl hydrocarbon receptor nuclear translocator-like | MOP3, JAP3, BMAL1, PASD3, bHLHe5 | 11p15 | |
| ARNTL2 | aryl hydrocarbon receptor nuclear translocator-like 2 | BMAL2, MOP9, CLIF, PASD9, bHLHe6 | 12p12.2-p11.2 | |
| ASCL1 | achaete-scute complex homolog 1 (Drosophila) | ASH1, HASH1, bHLHa46 | 12q22-q23 | |
| ASCL2 | achaete-scute complex homolog 2 (Drosophila) | ASH2, HASH2, bHLHa45 | 11p15.5 | |
| ASCL3 | achaete-scute complex homolog 3 (Drosophila) | bHLHa42, HASH3, Sgn1 | 11p15.3 | |
| ASCL4 | achaete-scute complex homolog 4 (Drosophila) | HASH4, bHLHa44 | 12q24.11 | |
| ASCL5 | achaete-scute complex homolog 5 (Drosophila) | bHLHa47 | 1q32.1 | |
| ATOH1 | atonal homolog 1 (Drosophila) | HATH1, MATH-1, Math1, bHLHa14 | 4q22 | |
| ATOH7 | atonal homolog 7 (Drosophila) | Math5, bHLHa13 | 10q22.2 | |
| ATOH8 | atonal homolog 8 (Drosophila) | HATH6, FLJ14708, bHLHa21 | 2p11.2 | |
| BHLHA9 | basic helix-loop-helix family, member a9 | bHLHa9, BHLHF42 | 17p13.3 | |
| BHLHA15 | basic helix-loop-helix family, member a15 | BHLHB8 | MIST1, bHLHa15 | 7q21.3 |
| BHLHB9 | basic helix-loop-helix domain containing, class B, 9 | p60TRP, KIAA1701 | Xq23 | |
| BHLHE22 | basic helix-loop-helix family, member e22 | TNRC20, BHLHB5 | CAGL85, Beta3, bHLHe22 | 8q12.1 |
| BHLHE23 | basic helix-loop-helix family, member e23 | BHLHB4 | bA305P22.3, Beta4, bHLHe23 | 20q13.33 |
| BHLHE40 | basic helix-loop-helix family, member e40 | STRA13, BHLHB2 | DEC1, bHLHe40 | 3p26 |
| BHLHE41 | basic helix-loop-helix family, member e41 | BHLHB3 | DEC2, SHARP-1, SHARP1, bHLHe41 | 12p12.1 |
| EPAS1 | endothelial PAS domain protein 1 | MOP2, PASD2, HIF2A, HLF, bHLHe73 | 2p21-p16 | |
| FERD3L | Fer3-like (Drosophila) | NATO3, N-TWIST, bHLHa31 | 7p21.3 | |
| FIGLA | folliculogenesis specific basic helix-loop-helix | bHLHc8 | 2p13.3 | |
| HAND1 | heart and neural crest derivatives expressed 1 | eHand, Thing1, Hxt, bHLHa27 | 5q33 | |
| HAND2 | heart and neural crest derivatives expressed 2 | dHand, Thing2, Hed, bHLHa26 | 4q33 | |
| HELT | helt bHLH transcription factor | HESL, HCM1228, Mgn, bHLHb44, MEGANE | 4q35.1 | |
| HES1 | hairy and enhancer of split 1, (Drosophila) | HRY | FLJ20408, HES-1, Hes1, bHLHb39 | 3q28-q29 |
| HES2 | hairy and enhancer of split 2 (Drosophila) | bHLHb40 | 1p36.31 | |
| HES3 | hairy and enhancer of split 3 (Drosophila) | bHLHb43 | 1p36.31 | |
| HES4 | hairy and enhancer of split 4 (Drosophila) | bHLHb42 | 1p36 | |
| HES5 | hairy and enhancer of split 5 (Drosophila) | bHLHb38 | 1p36 | |
| HES6 | hairy and enhancer of split 6 (Drosophila) | bHLHb41 | 2q37.3 | |
| HES7 | hairy and enhancer of split 7 (Drosophila) | bHLHb37 | 17p13.1 | |
| HEY1 | hairy/enhancer-of-split related with YRPW motif 1 | HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31 | 8q21 | |
| HEY2 | hairy/enhancer-of-split related with YRPW motif 2 | bHLHb32, HERP1, HESR2 | 6q | |
| HEYL | hairy/enhancer-of-split related with YRPW motif-like | bHLHb33, HEY3, HESR3 | 1p34.3 | |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | MOP1, HIF-1alpha, PASD8, HIF1, bHLHe78 | 14q23.2 | |
| HIF3A | hypoxia inducible factor 3, alpha subunit | IPAS, MOP7, PASD7, bHLHe17 | 19q13 | |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | dJ857M17.1.2, bHLHb24 | 20q11 | |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | GIG8, bHLHb26 | 2p25 | |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | HEIR-1, bHLHb25 | 1p36.13-p36.12 | |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | bHLHb27 | 6p22.3 | |
| NCOA1 | nuclear receptor coactivator 1 | SRC1, F-SRC-1, NCoA-1, KAT13A, RIP160, bHLHe74 | 2p23 | |
| NCOA3 | nuclear receptor coactivator 3 | RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3 | 20q12 | |
| NCOA2 | nuclear receptor coactivator 2 | TIF2, GRIP1, NCoA-2, KAT13C, bHLHe75 | 8q13.3 | |
| CLOCK | clock circadian regulator | KIAA0334, KAT13D, bHLHe8 | 4q12 | |
| LYL1 | lymphoblastic leukemia derived sequence 1 | bHLHa18 | 19p13.2 | |
| MAX | MYC associated factor X | bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8 | 14q23 | |
| MESP1 | mesoderm posterior 1 homolog (mouse) | MGC10676, bHLHc5 | 15q26.1 | |
| MESP2 | mesoderm posterior 2 homolog (mouse) | SCDO2, bHLHc6 | 15q26.1 | |
| MITF | microphthalmia-associated transcription factor | WS2A, WS2 | MI, bHLHe32 | 3p14.1-p12.3 |
| MLXIP | MLX interacting protein | MONDOA, KIAA0867, MIR, bHLHe36 | 12q21.31 | |
| MSC | musculin | ABF-1, bHLHa22 | 8q21 | |
| MXD1 | MAX dimerization protein 1 | MAD | MAD1, bHLHc58 | 2p13-p12 |
| MXI1 | MAX interactor 1, dimerization protein | MXD2, MAD2, MXI, bHLHc11 | 10q24-q25 | |
| MXD3 | MAX dimerization protein 3 | MAD3, bHLHc13 | 5q35.3 | |
| MXD4 | MAX dimerization protein 4 | MAD4, MSTP149, MST149, bHLHc12 | 4p16.3 | |
| MNT | MNT, MAX dimerization protein | ROX, MXD6, MAD6, bHLHd3 | 17p13.3 | |
| MLX | MLX, MAX dimerization protein | TCFL4 | MAD7, MXD7, bHLHd13 | 17q21.1 |
| MYC | v-myc myelocytomatosis viral oncogene homolog (avian) | c-Myc, bHLHe39 | 8q24 | |
| MYCL1 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | MYCL | LMYC, bHLHe38 | 1p34.3 |
| MYCL1P1 | v-myc myelocytomatosis viral oncogene homolog 1 pseudogene 1 | MYCL2 | bHLHe38 | Xq22-q28 |
| MYCN | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | NMYC | bHLHe37, N-myc | 2p24.3 |
| MYF5 | myogenic factor 5 | bHLHc2 | 12q21 | |
| MYF6 | myogenic factor 6 (herculin) | MRF4, bHLHc4 | 12q21 | |
| MYOD1 | myogenic differentiation 1 | MYF3 | PUM, MYOD, bHLHc1 | 11p15 |
| MYOG | myogenin (myogenic factor 4) | MYF4 | bHLHc3 | 1q31-q41 |
| NEUROD1 | neuronal differentiation 1 | NEUROD | BETA2, BHF-1, NeuroD, bHLHa3, MODY6 | 2q32 |
| NEUROD2 | neuronal differentiation 2 | NDRF, bHLHa1 | 17q12 | |
| NEUROD4 | neuronal differentiation 4 | Atoh3, ATH-3, MATH-3, bHLHa4 | 12q13.13 | |
| NEUROD6 | neuronal differentiation 6 | Atoh2, NEX1M, Math-2, bHLHa2, Nex1 | 7p15.1 | |
| NEUROG1 | neurogenin 1 | NEUROD3 | AKA, Math4C, ngn1, bHLHa6 | 5q23-q31 |
| NEUROG2 | neurogenin 2 | Atoh4, Math4A, ngn-2, bHLHa8, NGN2 | 4q25 | |
| NEUROG3 | neurogenin 3 | Atoh5, Math4B, ngn3, bHLHa7 | 10q21.3 | |
| NHLH1 | nescient helix loop helix 1 | HEN1 | NSCL, NSCL1, bHLHa35 | 1q22 |
| NHLH2 | nescient helix loop helix 2 | HEN2 | NSCL2, bHLHa34 | 1p12-p11 |
| NPAS1 | neuronal PAS domain protein 1 | MOP5, PASD5, bHLHe11 | 19q13.2-q13.3 | |
| NPAS2 | neuronal PAS domain protein 2 | MOP4, PASD4, bHLHe9 | 2q11.2 | |
| NPAS3 | neuronal PAS domain protein 3 | MOP6, PASD6, bHLHe12 | 14q12-q13 | |
| NPAS4 | neuronal PAS domain protein 4 | PASD10, NXF, Le-PAS, bHLHe79 | 11q13.2 | |
| OLIG1 | oligodendrocyte transcription factor 1 | BHLHB6, bHLHe21 | 21q22.11 | |
| OLIG2 | oligodendrocyte lineage transcription factor 2 | PRKCBP2, BHLHB1 | RACK17, OLIGO2, bHLHe19 | 21q22.11 |
| OLIG3 | oligodendrocyte transcription factor 3 | Bhlhb7, bHLHe20 | 6q23.3 | |
| PTF1A | pancreas specific transcription factor, 1a | PTF1-p48, bHLHa29 | 10p12.31 | |
| SCXA | scleraxis homolog A (mouse) | bHLHa41 | 8q24.3 | |
| SCXB | scleraxis homolog B (mouse) | bHLHa48 | 8q24.3 | |
| SIM1 | single-minded homolog 1 (Drosophila) | bHLHe14 | 6q16.3-q21 | |
| SIM2 | single-minded homolog 2 (Drosophila) | SIM | MGC119447, bHLHe15 | 21q22.2 |
| SOHLH1 | spermatogenesis and oogenesis specific basic helix-loop-helix 1 | C9orf157 | NOHLH, TEB2, bA100C15.3, bHLHe80, SPATA27 | 9q34.3 |
| SOHLH2 | spermatogenesis and oogenesis specific basic helix-loop-helix 2 | FLJ20449, TEB1, bHLHe81, SPATA28 | 13q13.3 | |
| SREBF1 | sterol regulatory element binding transcription factor 1 | SREBP1, bHLHd1, SREBP-1c | 17p11.2 | |
| SREBF2 | sterol regulatory element binding transcription factor 2 | SREBP2, bHLHd2 | 22q13.2 | |
| TAL1 | T-cell acute lymphocytic leukemia 1 | TCL5 | SCL, bHLHa17 | 1p32 |
| TAL2 | T-cell acute lymphocytic leukemia 2 | bHLHa19 | 9q32 | |
| TCF3 | transcription factor 3 | E2A, ITF1, MGC129647, MGC129648, bHLHb21, VDIR, E47 | 19p13.3 | |
| TCF4 | transcription factor 4 | SEF2-1B, ITF2, bHLHb19, E2-2 | 18q21.1 | |
| TCF12 | transcription factor 12 | HEB, HTF4, HsT17266, bHLHb20 | 15q21 | |
| TCF15 | transcription factor 15 (basic helix-loop-helix) | EC2, PARAXIS, bHLHa40 | 20p13 | |
| TCF21 | transcription factor 21 | POD1, bHLHa23 | 6q23-q24 | |
| TCF23 | transcription factor 23 | OUT, bHLHa24 | 2p23.3 | |
| TCF24 | transcription factor 24 | bHLHa25 | 8q13.1 | |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | Figlb, E2BP-1, CHA, bHLHe82 | 20q13.3-qter | |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | AP-4, bHLHc41 | 16p13 | |
| TFE3 | transcription factor binding to IGHM enhancer 3 | TFEA, bHLHe33 | Xp11.22 | |
| TFEB | transcription factor EB | TCFEB, bHLHe35 | 6p21 | |
| TFEC | transcription factor EC | TCFEC, TFECL, bHLHe34 | 7q31.2 | |
| TWIST1 | twist basic helix-loop-helix transcription factor 1 | ACS3, BPES3, TWIST | SCS, H-twist, BPES2, bHLHa38 | 7p21 |
| TWIST2 | twist basic helix-loop-helix transcription factor 2 | DERMO1, Dermo-1, bHLHa39 | 2q37.3 | |
| USF1 | upstream transcription factor 1 | UEF, MLTFI, bHLHb11 | 1q22-q23 | |
| USF2 | upstream transcription factor 2, c-fos interacting | FIP, bHLHb12 | 19q13 |
For a review of this family, see Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. PMC2894270
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