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Giving unique and meaningful names to every human gene

These genes are part of a separate but similar family to the ADAMs so we will maintain the same stem symbol, with the addition of "TS".  However, the gene name is slightly different as there is no proof that the disintegrin is functional. Following an original request from the MEROPS database to standardise our gene names with the use of the term peptidase, in place of both protease and proteinase, we posted a recent "Hot Topic" on our webpage, where the responders also agreed with this move. Hence we have decided to phase out use of the terms 'protease' and 'proteinase' in favour of the umbrella term, 'peptidase'. As such the ADAMTS gene names were revised, with the consent of our Specialist Advisor Dr Apte, on 18th August 2005.

Click on the Approved Gene Symbol to retrieve the complete gene record

Approved Symbol Approved Name Previous Symbols Aliases Chromosome Accession Numbers RefSeq IDs
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1   C3-C5, METH1, KIAA1346 21q21.3 AF060152  
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2   ADAMTS-3, hPCPNI, PCINP, ADAM-TS2, NPI 5q23-q24 AJ003125 NM_014244
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3   KIAA0366, ADAMTS-4 4q21 AB002364  
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4   KIAA0688, ADAMTS-2, ADMP-1 1q31-q32 AB014588 NM_005099
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5   ADMP-2, ADAMTS11 21q21.3 AF142099  
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6   ADAM-TS6 5q13 AF140674 NM_197941
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7   ADAM-TS7, DKFZp434H204 15pter-qter AF140675 NM_014272
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8   METH2, FLJ41712, ADAM-TS8 11q25 AF060153 NM_007037
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9   KIAA1312 3p14.1 AF261918  
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10   ADAM-TS10 19p13.3 AF163762 NM_030957
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12     5q35 AJ250725 NM_030955
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 C9orf8 VWFCP, TTP, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322 9q34 AJ011374 NM_139025
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14     10q21 AF358666 NM_080722
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15     11q25 AJ315733 NM_139055
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16   ADAMTS16s 5p15 AJ315734 NM_139056
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17   FLJ32769, FLJ16363 15q24 AJ315735 NM_139057
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 ADAMTS21   16q23 AJ311903  
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19     5q31 AJ311904 NM_133638
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20   GON-1 12q12 AF488804 NM_025003

The work of the HGNC is supported by NHGRI grant P41 HG003345, the UK Medical Research Council and the Wellcome Trust.