Gene Families/Groupings, D to G
Stem symbol schemes
We strongly encourage the development of nomenclature schemes using a "stem" (or "root") symbol for members of a gene family or grouping, with a hierarchical numbering system to distinguish the individual members. This is an efficient and useful way to name large numbers of related genes, and already works well for a number of established gene groupings. When a new gene nomenclature scheme is proposed, we try to contact a number of scientists prominent in that specialist area, to ensure that the majority are in agreement over the symbols (see Specialist Advisors).
Proposals for new gene nomenclature schemes should be sent to: hgnc@genenames.org
Gene families/grouping resources
The pages listed below include finalised HGNC resources, those under review and other sites that do not necessarily contain correct nomenclature. Sites which do use approved nomenclature are shown as HGNC approved. To avoid confusion, the HGNC approved stem symbols are highlighted in bold (within red brackets) and the approved HGNC Gene Family groups without a common "stem" symbol are also highlighted in bold, both are linked to the Nomenclature Database.
The
icon denotes there is a specialist advisor for the Gene Family and links to our specialist advisor page.
Download the HGNC Gene Family dataset
Click here for the complete HGNC Gene Family dataset.
- DDB1 and CUL4 associated factors (DCAF)
- DEAD-boxes (DDX)

- DEAH-boxes (DHX)

- Deafness loci Hereditary Hearing loss Homepage
- Defensins, alpha (DEFA)
- Defensins, beta (DEFB)
- DENN/MADD domain containing (DENND)
- Dishevelled homologs (DVL)
- DNA-binding domain containing
- DNA polymerases
- Dolichyl D-mannosyl phosphate dependent mannosyltransferases
- Dopamine receptors (DRD)
- Dual specificity phosphatases (DUSP)

- Dyneins, axonemal (DN)

- Dyneins, cytoplasmic (DYN)

- EF-hand domain containing (also see: E-F Hand Proteins Data Library)
- Elongator acetyltransferase complex subunits (ELP)
- EMI domain containing (EMID)
- Endogenous Ligands
- Endothelin receptors (EDNR)
- Engulfment and cell motility proteins (ELMO)
- Enhanced RNAi three prime mRNA exonucleases (ERI)
- EPH receptors (EPH)
- Ephrins (EFN)
- ESTHER database Esterases and alpha/beta hydrolase enzymes and relatives
- Exostosin glycosyltransferase family (EXT)
- Exportins (XPO)

- Fanconi anemia, complementation groups (FANC)

- Fatty acid binding protein family
- Fatty acid hydroxylase domain containing
- Fatty acid desaturases (FADS)
- Fatty acid receptors (FFAR)
- Fibrinogen C domain containing
- Fibronectin type III domain containing
- Fibulins (FBLN)
- F-boxes (FBX)
- Fermitins (FERMT)
- Formyl peptide receptors (FPR)
- Forkhead boxes (FOX)

- Frizzled receptors (FZD)
- Fucosyltransferase (FUT)
- GABA receptors
- Galanin receptors (GALR)
- Gamma-glutamyltransferases (GGT)
- Gap junction proteins (connexins) (GJ)

- General transcription factors (GTF)
- General transcription factor IIH complex subunits
- Ghrelin receptors (GHSR)
- Glucagon receptors
- Glutamate receptors (GR)
- Glutathione S-transferases (GST)
- Glutathione S-transferases, soluble
- Glutathione S-transferases, microsomal (MGST)
- Glutathione S-transferases, mitochondrial (kappa) (GSTK)
- Glycerol kinases (GK)
- Glycine receptors (GLRA)
- Glycogen phosphorylases (PYG)
- Glycosyltransferase group 1 domain containing
- Glycosyltransferase family 2 domain containing
- Glycosyltransferase family 6 domain containing
- Glycosyltransferase family 8 domain containing
- Glypicans (GPI-anchored HSPG) (GPC)
- Gonadotropin-releasing hormone receptors (GNRHR)
- Gonadotropin and TSH receptors
- GPN-loop GTPases (GPN)
- G patch domain containing (GPATCH)
- G protein-coupled receptors
- GTPases, IMAP (GIMAP)




