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This is our older gene family page that is no longer maintained. Please go to our new look gene family index to view a complete list of our new maintained gene families. More information can be found in our gene families help page.

We have created a mapping file (Excel) that will map most of the old families to the new. However because we have changed the way we assign families and how we organise them, this file may not map all the old families.

Voltage-gated ion channels

1. Sodium channels, voltage-gated specialist advisor
 7. Potassium channels, calcium-activated specialist advisor
2. Calcium channels, voltage-gated specialist advisor
 8. Potassium channels, voltage-gated specialist advisor
3. Transient receptor potential cation channels specialist advisor
 9. Potassium channels, inwardly rectifying specialist advisor 
4. CatSper channels
 10. Potassium channels, two-P  specialist advisor
5. Two-pore channels
 11. Hydrogen voltage-gated ion channels
6. Cyclic nucleotide-regulated channels   
   
For all Ion channels, see our Ion channels page  

External resource: Voltage-gated ion channels IUPHAR DATABASE HGNC approved


Click on the Approved Gene Symbol to retrieve the complete gene record

 Sodium channels, voltage-gated :

William A. Catterall, Alan L. Goldin and Stephen G. Waxman. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 2005 57: 397-409. PMID:16382098

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SCN1A sodium voltage-gated channel alpha subunit 1 SCN1, FEB3 Nav1.1, GEFSP2, HBSCI, NAC1, SMEI 2q24.3
SCN1B sodium voltage-gated channel beta subunit 1 19q13.11
SCN2A sodium voltage-gated channel alpha subunit 2 SCN2A1, SCN2A2 Nav1.2, HBSCII, HBSCI 2q24.3
SCN2B sodium voltage-gated channel beta subunit 2 11q23.3
SCN3A sodium voltage-gated channel alpha subunit 3 Nav1.3 2q24.3
SCN3B sodium voltage-gated channel beta subunit 3 HSA243396 11q24.1
SCN4A sodium voltage-gated channel alpha subunit 4 HYKPP Nav1.4, HYPP, SkM1 17q23.3
SCN5A sodium voltage-gated channel alpha subunit 5 CMD1E Nav1.5, LQT3, HB1, HBBD, PFHB1, IVF, HB2, HH1, SSS1, CDCD2, CMPD2, ICCD 3p22.2
SCN7A sodium voltage-gated channel alpha subunit 7 SCN6A Nav2.1, Nav2.2, NaG 2q24.3
SCN8A sodium voltage-gated channel alpha subunit 8 MED Nav1.6, NaCh6, PN4, CerIII 12q13.1
SCN9A sodium voltage-gated channel alpha subunit 9 Nav1.7, PN1, NE-NA, NENA, ETHA 2q24.3
SCN10A sodium voltage-gated channel alpha subunit 10 Nav1.8, hPN3, SNS, PN3 3p22.2
SCN11A sodium voltage-gated channel alpha subunit 11 SCN12A Nav1.9, NaN, SNS-2 3p22.2

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 Calcium channels, voltage-gated :

William A. Catterall, Edward Perez-Reyes, Terrance P. Snutch and Joerg Striessnig. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels. Pharmacol Rev 2005 57: 411-425. PMID:16382099

Philippe Lory, Roel A. Ophoff and Joseph Nahmias.Towards a unified nomenclature describing voltage-gated calcium channel genes. Hum Genet. 1997 Aug;100(2):149-50. PMID:9254840

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CACNA1A calcium voltage-gated channel subunit alpha1 A CACNL1A4, SCA6, MHP1, MHP Cav2.1, EA2, APCA, HPCA, FHM 19p13.13
CACNA1B calcium voltage-gated channel subunit alpha1 B CACNL1A5 Cav2.2, CACNN 9q34.3
CACNA1C calcium voltage-gated channel subunit alpha1 C CCHL1A1, CACNL1A1 Cav1.2, CACH2, CACN2, TS, LQT8 12p13.33
CACNA1D calcium voltage-gated channel subunit alpha1 D CCHL1A2, CACNL1A2 Cav1.3, CACH3, CACN4 3p21.1
CACNA1E calcium voltage-gated channel subunit alpha1 E CACNL1A6 Cav2.3, BII, CACH6 1q25.3
CACNA1F calcium voltage-gated channel subunit alpha1 F CSNB2, AIED Cav1.4, JM8, JMC8, CSNBX2, CORDX3, CSNB2A, OA2 Xp11.23
CACNA1G calcium voltage-gated channel subunit alpha1 G Cav3.1, NBR13 17q21.33
CACNA1H calcium voltage-gated channel subunit alpha1 H Cav3.2 16p13.3
CACNA1I calcium voltage-gated channel subunit alpha1 I Cav3.3 22q13.1
CACNA1S calcium voltage-gated channel subunit alpha1 S HOKPP, MHS5, CACNL1A3 Cav1.1, hypoPP 1q32.1

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 Transient receptor potential cation channels :

David E. Clapham, David Julius, Craig Montell and Günter Schultz. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels. Pharmacol Rev 2005 57: 427-450. PMID:16382100

Craig Montell, Lutz Birnbaumer, Veit Flockerzi, Rene J. Bindels, Elspeth A. Bruford, Michael J. Caterina, David E. Clapham, Christian Harteneck, Stefan Heller, David Julius, Itaru Kojima, Yasuo Mori, Reinhold Penner, Dirk Prawitt, Andrew M. Scharenberg, Günter Schultz, Nobuyoshi Shimizu and Michael X. Zhu. A Unified Nomenclature for the Superfamily of TRP Cation Channels. Mol Cell. 2002 Feb;9(2):229-31. PMID:11864597

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TRPA1 transient receptor potential cation channel subfamily A member 1 ANKTM1 8q21.11
TRPC1 transient receptor potential cation channel subfamily C member 1 HTRP-1 3q23
TRPC2 transient receptor potential cation channel subfamily C member 2, pseudogene 11p15.4
TRPC3 transient receptor potential cation channel subfamily C member 3 4q27
TRPC4 transient receptor potential cation channel subfamily C member 4 HTRP4, TRP4 13q13.3
TRPC5 transient receptor potential cation channel subfamily C member 5 PPP1R159 Xq23
TRPC6 transient receptor potential cation channel subfamily C member 6 FSGS2 TRP6 11q22.1
TRPC7 transient receptor potential cation channel subfamily C member 7 5q31.1
TRPM1 transient receptor potential cation channel subfamily M member 1 MLSN1 LTRPC1, CSNB1C 15q13.3
TRPM2 transient receptor potential cation channel subfamily M member 2 TRPC7 KNP3, LTRPC2, NUDT9L1, NUDT9H, EREG1 21q22.3
TRPM3 transient receptor potential cation channel subfamily M member 3 KIAA1616, LTRPC3, GON-2 9q21.12-q21.13
TRPM4 transient receptor potential cation channel subfamily M member 4 FLJ20041 19q13.3
TRPM5 transient receptor potential cation channel subfamily M member 5 LTRPC5, MTR1 11p15.5
TRPM6 transient receptor potential cation channel subfamily M member 6 HOMG, HSH CHAK2, FLJ22628 9q21.13
TRPM7 transient receptor potential cation channel subfamily M member 7 CHAK1, LTRPC7, TRP-PLIK 15q21.2
TRPM8 transient receptor potential cation channel subfamily M member 8 2q37.1
MCOLN1 mucolipin 1 TRPML1, ML4, MLIV, MST080, MSTP080, TRPM-L1 19p13.2
MCOLN2 mucolipin 2 TRPML2, FLJ36691, TRP-ML2 1p22.3
MCOLN3 mucolipin 3 TRPML3, FLJ11006, TRP-ML3 1p22.3
PKD1 polycystin 1, transient receptor potential channel interacting PBP, Pc-1, TRPP1 16p13.3
PKD2 polycystin 2, transient receptor potential cation channel PKD4, PC2, Pc-2, TRPP2 4q22.1
PKD2L1 polycystin 2 like 1, transient receptor potential cation channel PKD2L, PKDL PCL, TRPP3 10q24.31
PKD2L2 polycystin 2 like 2, transient receptor potential cation channel TRPP5 5q31.2
TRPV1 transient receptor potential cation channel subfamily V member 1 VR1 17p13.2
TRPV2 transient receptor potential cation channel subfamily V member 2 VRL, VRL-1, VRL1 17p11.2
TRPV3 transient receptor potential cation channel subfamily V member 3 VRL3 17p13.2
TRPV4 transient receptor potential cation channel subfamily V member 4 OTRPC4, TRP12, VROAC, VRL-2, VR-OAC, CMT2C 12q24.11
TRPV5 transient receptor potential cation channel subfamily V member 5 ECAC1 CaT2 7q34
TRPV6 transient receptor potential cation channel subfamily V member 6 ECAC2 CaT1 7q34

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 CatSper channels :

David E. Clapham and David L. Garbers. Nomenclature and Structure-Function Relationships of CatSper and Two-Pore Channels. Pharmacol Rev 2005 57: 451-454. PMID:16382101

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CATSPER1 cation channel sperm associated 1 CATSPER 11q13.1
CATSPER2 cation channel sperm associated 2 15q15.3
CATSPER3 cation channel sperm associated 3 CACRC 5q31.1
CATSPER4 cation channel sperm associated 4 1p36.11

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Two-pore channels :

David E. Clapham and David L. Garbers. Nomenclature and Structure-Function Relationships of CatSper and Two-Pore Channels. Pharmacol Rev 2005 57: 451-454. PMID:16382101

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TPCN1 two pore segment channel 1 KIAA1169, FLJ20612, TPC1 12q24.13
TPCN2 two pore segment channel 2 TPC2 11q13.3

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 Cyclic nucleotide-regulated channels :

Franz Hofmann, Martin Biel and U. Benjamin Kaupp. Nomenclature and Structure-Function Relationships of Cyclic Nucleotide-Regulated Channels. Pharmacol Rev 2005 57: 455-462. PMID:16382102

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CNGA1 cyclic nucleotide gated channel alpha 1 CNCG1, CNCG RCNC1, RCNCa, CNG1, RP49 4p12
CNGA2 cyclic nucleotide gated channel alpha 2 CNCA1, CNCA CNG2, OCNC1, OCNCa, OCNCALPHA, OCNCalpha, FLJ46312 Xq28
CNGA3 cyclic nucleotide gated channel alpha 3 CNCG3, ACHM2 CCNC1, CCNCa, CNG3 2q11.2
CNGA4 cyclic nucleotide gated channel alpha 4 CNCA2, CNGB2 OCNC2, OCNCb, CNG5 11p15.4
CNGB1 cyclic nucleotide gated channel beta 1 CNCG2, CNCG3L RCNC2, RCNCb, GARP, GAR1, CNGB1B, RP45 16q21
CNGB3 cyclic nucleotide gated channel beta 3 ACHM3, ACHM1, RMCH 8q21.3
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 BCNG1 BCNG-1, HAC-2 5p12
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 BCNG2 BCNG-2, HAC-1 19p13.3
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 KIAA1535 1q22
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 15q24.1

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 Potassium channels, calcium-activated :

Aguan D. Wei, George A. Gutman, Richard Aldrich, K. George Chandy, Stephan Grissmer and Heike Wulff. Nomenclature and Molecular Relationships of Calcium-Activated Potassium Channels. Pharmacol Rev 2005 57: 463-472. PMID:16382103

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNMA1 potassium calcium-activated channel subfamily M alpha 1 SLO KCa1.1, mSLO1 10q22.3
KCNN1 potassium calcium-activated channel subfamily N member 1 KCa2.1, hSK1 19p13.11
KCNN2 potassium calcium-activated channel subfamily N member 2 KCa2.2, hSK2 5q22.3
KCNN3 potassium calcium-activated channel subfamily N member 3 KCa2.3, hSK3, SKCA3 1q21.3
KCNN4 potassium calcium-activated channel subfamily N member 4 KCa3.1, hSK4, hKCa4, hIKCa1, IK 19q13.31
KCNT1 potassium sodium-activated channel subfamily T member 1 KCa4.1, KIAA1422, SLACK, Slo2.2 9q34.3
KCNT2 potassium sodium-activated channel subfamily T member 2 KCa4.2, SLICK, SLO2.1 1q31.3
KCNU1 potassium calcium-activated channel subfamily U member 1 KCa5.1, Slo3, KCNMC1, Kcnma3 8p11.23

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 Potassium channels, voltage-gated:

George A. Gutman, K. George Chandy, Stephan Grissmer, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, and Xiaoliang Wang. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels. Pharmacol Rev 2005 57: 473-508. PMID:16382104

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNA1 potassium voltage-gated channel subfamily A member 1 AEMK Kv1.1, RBK1, HUK1, MBK1 12p13.32
KCNA2 potassium voltage-gated channel subfamily A member 2 Kv1.2, HK4 1p13.3
KCNA3 potassium voltage-gated channel subfamily A member 3 Kv1.3, MK3, HLK3, HPCN3 1p13.3
KCNA4 potassium voltage-gated channel subfamily A member 4 KCNA4L Kv1.4, HK1, HPCN2 11p14.1
KCNA5 potassium voltage-gated channel subfamily A member 5 Kv1.5, HK2, HPCN1 12p13.32
KCNA6 potassium voltage-gated channel subfamily A member 6 Kv1.6, HBK2, PPP1R96 12p13
KCNA7 potassium voltage-gated channel subfamily A member 7 Kv1.7, HAK6 19q13.33
KCNA10 potassium voltage-gated channel subfamily A member 10 Kv1.8 1p13.3
KCNB1 potassium voltage-gated channel subfamily B member 1 Kv2.1 20q13.13
KCNB2 potassium voltage-gated channel subfamily B member 2 Kv2.2 8q21.11
KCNC1 potassium voltage-gated channel subfamily C member 1 Kv3.1 11p15.1
KCNC2 potassium voltage-gated channel subfamily C member 2 Kv3.2 12q21.1
KCNC3 potassium voltage-gated channel subfamily C member 3 SCA13 Kv3.3 19q13.33
KCNC4 potassium voltage-gated channel subfamily C member 4 C1orf30 Kv3.4, HKSHIIIC 1p13.3
KCND1 potassium voltage-gated channel subfamily D member 1 Kv4.1 Xp11.23
KCND2 potassium voltage-gated channel subfamily D member 2 Kv4.2, RK5, KIAA1044 7q31.31
KCND3 potassium voltage-gated channel subfamily D member 3 SCA22, SCA19 Kv4.3, KSHIVB 1p13.2
KCNF1 potassium voltage-gated channel modifier subfamily F member 1 KCNF Kv5.1, kH1, IK8 2p25.1
KCNG1 potassium voltage-gated channel modifier subfamily G member 1 KCNG Kv6.1, kH2, K13 20q13.13
KCNG2 potassium voltage-gated channel modifier subfamily G member 2 Kv6.2, KCNF2 18q23
KCNG3 potassium voltage-gated channel modifier subfamily G member 3 Kv6.3 2p21
KCNG4 potassium voltage-gated channel modifier subfamily G member 4 Kv6.4 16q24.1
KCNH1 potassium voltage-gated channel subfamily H member 1 Kv10.1, eag, h-eag, eag1 1q32.2
KCNH2 potassium voltage-gated channel subfamily H member 2 LQT2 Kv11.1, HERG, erg1 7q36.1
KCNH3 potassium voltage-gated channel subfamily H member 3 Kv12.2, BEC1, elk2 12q13.12
KCNH4 potassium voltage-gated channel subfamily H member 4 Kv12.3, elk1 17q21.2
KCNH5 potassium voltage-gated channel subfamily H member 5 Kv10.2, H-EAG2, eag2 14q23.2
KCNH6 potassium voltage-gated channel subfamily H member 6 Kv11.2, erg2, HERG2 17q23.3
KCNH7 potassium voltage-gated channel subfamily H member 7 Kv11.3, HERG3, erg3 2q24.2
KCNH8 potassium voltage-gated channel subfamily H member 8 Kv12.1, elk3 3p24.3
KCNQ1 potassium voltage-gated channel subfamily Q member 1 LQT, KCNA9 Kv7.1, KCNA8, KVLQT1, JLNS1, LQT1 11p15.5-p15.4
KCNQ2 potassium voltage-gated channel subfamily Q member 2 EBN, EBN1 Kv7.2, ENB1, BFNC, KCNA11, HNSPC 20q13.33
KCNQ3 potassium voltage-gated channel subfamily Q member 3 EBN2 Kv7.3 8q24.22
KCNQ4 potassium voltage-gated channel subfamily Q member 4 DFNA2 Kv7.4 1p34.2
KCNQ5 potassium voltage-gated channel subfamily Q member 5 Kv7.5 6q13
KCNS1 potassium voltage-gated channel modifier subfamily S member 1 Kv9.1 20q13.12
KCNS2 potassium voltage-gated channel modifier subfamily S member 2 Kv9.2 8q22.2
KCNS3 potassium voltage-gated channel modifier subfamily S member 3 Kv9.3 2p24.2
KCNV1 potassium voltage-gated channel modifier subfamily V member 1 Kv8.1 8q23.2
KCNV2 potassium voltage-gated channel modifier subfamily V member 2 Kv8.2 9p24.2

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 Potassium channels, inwardly rectifying:

Yoshihiro Kubo, John P. Adelman, David E. Clapham, Lily Y. Jan, Andreas Karschin, Yoshihisa Kurachi, Michel Lazdunski, Colin G. Nichols, Susumu Seino, and Carol A. Vandenberg. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 2005 57: 509-526. PMID:16382105

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNJ1 potassium voltage-gated channel subfamily J member 1 Kir1.1, ROMK1 11q24.3
KCNJ2 potassium voltage-gated channel subfamily J member 2 Kir2.1, IRK1, LQT7 17q24.3
KCNJ3 potassium voltage-gated channel subfamily J member 3 Kir3.1, GIRK1, KGA 2q24.1
KCNJ4 potassium voltage-gated channel subfamily J member 4 Kir2.3, HIR, HRK1, hIRK2, IRK3 22q13.1
KCNJ5 potassium voltage-gated channel subfamily J member 5 Kir3.4, CIR, KATP1, GIRK4, LQT13 11q24.3
KCNJ6 potassium voltage-gated channel subfamily J member 6 KCNJ7 Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2 21q22.13
KCNJ8 potassium voltage-gated channel subfamily J member 8 Kir6.1 12p12.1
KCNJ9 potassium voltage-gated channel subfamily J member 9 Kir3.3, GIRK3 1q23.2
KCNJ10 potassium voltage-gated channel subfamily J member 10 Kir4.1, Kir1.2 1q23.2
KCNJ11 potassium voltage-gated channel subfamily J member 11 Kir6.2, BIR 11p15.1
KCNJ12 potassium voltage-gated channel subfamily J member 12 KCNJN1 Kir2.2, Kir2.2v, IRK2, hIRK1 17p11.2
KCNJ13 potassium voltage-gated channel subfamily J member 13 Kir7.1, Kir1.4, LCA16 2q37.1
KCNJ14 potassium voltage-gated channel subfamily J member 14 Kir2.4, IRK4 19q13.33
KCNJ15 potassium voltage-gated channel subfamily J member 15 Kir4.2, Kir1.3, IRKK 21q22.13-q22.2
KCNJ16 potassium voltage-gated channel subfamily J member 16 Kir5.1, BIR9 17q24.3
KCNJ18 potassium voltage-gated channel subfamily J member 18 KIR2.6, TTPP2 17p11.2

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Potassium channels, two-P :

Steve A. N. Goldstein, Douglas A. Bayliss, Donghee Kim, Florian Lesage, Leigh Daniel Plant, and Sindhu Rajan. Nomenclature and Molecular Relationships of Two-P Potassium Channels. Pharmacol Rev 2005 57: 527-540. PMID:16382106

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNK1 potassium two pore domain channel subfamily K member 1 K2p1.1, DPK, TWIK-1 1q42.2
KCNK2 potassium two pore domain channel subfamily K member 2 K2p2.1, TREK-1 1q41
KCNK3 potassium two pore domain channel subfamily K member 3 K2p3.1, TASK, TASK-1 2p23.3
KCNK4 potassium two pore domain channel subfamily K member 4 K2p4.1, TRAAK 11q13.1
KCNK5 potassium two pore domain channel subfamily K member 5 K2p5.1, TASK-2 6p21.2
KCNK6 potassium two pore domain channel subfamily K member 6 K2p6.1, TWIK-2 19q13.2
KCNK7 potassium two pore domain channel subfamily K member 7 K2p7.1 11q13.1
KCNK9 potassium two pore domain channel subfamily K member 9 K2p9.1, TASK3, TASK-3 8q24.3
KCNK10 potassium two pore domain channel subfamily K member 10 K2p10.1, TREK-2, TREK2, PPP1R97 14q31.3
KCNK12 potassium two pore domain channel subfamily K member 12 THIK-2, THIK2, K2p12.1 2p16.3
KCNK13 potassium two pore domain channel subfamily K member 13 K2p13.1, THIK-1, THIK1 14q32.11
KCNK15 potassium two pore domain channel subfamily K member 15 KCNK11, KCNK14 K2p15.1, dJ781B1.1, KT3.3, KIAA0237, TASK5, TASK-5 20q13.12
KCNK16 potassium two pore domain channel subfamily K member 16 K2p16.1, TALK-1, TALK1 6p21.2
KCNK17 potassium two pore domain channel subfamily K member 17 K2p17.1, TALK-2, TALK2, TASK4, TASK-4 6p21.2
KCNK18 potassium two pore domain channel subfamily K member 18 K2p18.1, TRESK-2, TRESK2, TRESK, TRIK 10q25.3

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Hydrogen voltage-gated ion channels :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HVCN1 hydrogen voltage gated channel 1 MGC15619, Hv1, VSOP 12q24.11

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