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Voltage-gated ion channels

1. Sodium channels, voltage-gated specialist advisor
 7. Potassium channels, calcium-activated specialist advisor
2. Calcium channels, voltage-gated specialist advisor
 8. Potassium channels, voltage-gated specialist advisor
3. Transient receptor potential cation channels specialist advisor
 9. Potassium channels, inwardly rectifying specialist advisor 
4. CatSper channels
 10. Potassium channels, two-P  specialist advisor
5. Two-pore channels
 11. Hydrogen voltage-gated ion channels
6. Cyclic nucleotide-regulated channels   
   
For all Ion channels, see our Ion channels page  

External resource: Voltage-gated ion channels IUPHAR DATABASE HGNC approved


Click on the Approved Gene Symbol to retrieve the complete gene record

 Sodium channels, voltage-gated :

William A. Catterall, Alan L. Goldin and Stephen G. Waxman. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 2005 57: 397-409. PMID:16382098

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SCN1A sodium channel, voltage-gated, type I, alpha subunit SCN1, FEB3 Nav1.1, GEFSP2, HBSCI, NAC1, SMEI 2q24.3
SCN1B sodium channel, voltage-gated, type I, beta subunit 19q13.12
SCN2A sodium channel, voltage-gated, type II, alpha subunit SCN2A1, SCN2A2 Nav1.2, HBSCII, HBSCI 2q24.3
SCN2B sodium channel, voltage-gated, type II, beta subunit 11q23.3
SCN3A sodium channel, voltage-gated, type III, alpha subunit Nav1.3 2q24
SCN3B sodium channel, voltage-gated, type III, beta subunit HSA243396 11q24.1
SCN4A sodium channel, voltage-gated, type IV, alpha subunit HYKPP Nav1.4, HYPP, SkM1 17q23.3
SCN5A sodium channel, voltage-gated, type V, alpha subunit CMD1E Nav1.5, LQT3, HB1, HBBD, PFHB1, IVF, HB2, HH1, SSS1, CDCD2, CMPD2, ICCD 3p21
SCN7A sodium channel, voltage-gated, type VII, alpha subunit SCN6A Nav2.1, Nav2.2, NaG 2q21-q23
SCN8A sodium channel, voltage gated, type VIII, alpha subunit MED Nav1.6, NaCh6, PN4, CerIII 12q13.1
SCN9A sodium channel, voltage-gated, type IX, alpha subunit Nav1.7, PN1, NE-NA, NENA, ETHA 2q24
SCN10A sodium channel, voltage-gated, type X, alpha subunit Nav1.8, hPN3, SNS, PN3 3p22.2
SCN11A sodium channel, voltage-gated, type XI, alpha subunit SCN12A Nav1.9, NaN, SNS-2 3p22.2

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 Calcium channels, voltage-gated :

William A. Catterall, Edward Perez-Reyes, Terrance P. Snutch and Joerg Striessnig. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels. Pharmacol Rev 2005 57: 411-425. PMID:16382099

Philippe Lory, Roel A. Ophoff and Joseph Nahmias.Towards a unified nomenclature describing voltage-gated calcium channel genes. Hum Genet. 1997 Aug;100(2):149-50. PMID:9254840

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit CACNL1A4, SCA6, MHP1, MHP Cav2.1, EA2, APCA, HPCA, FHM 19p13
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit CACNL1A5 Cav2.2, CACNN 9q34
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit CCHL1A1, CACNL1A1 Cav1.2, CACH2, CACN2, TS, LQT8 12p13.3
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit CCHL1A2, CACNL1A2 Cav1.3, CACH3, CACN4 3p14.3
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit CACNL1A6 Cav2.3, BII, CACH6 1q25.3
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit CSNB2, AIED Cav1.4, JM8, JMC8, CSNBX2, CORDX3, CSNB2A, OA2 Xp11.23
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit Cav3.1, NBR13 17q22
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit Cav3.2 16p13.3
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit Cav3.3 22q13.1
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit HOKPP, MHS5, CACNL1A3 Cav1.1, hypoPP 1q32

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 Transient receptor potential cation channels :

David E. Clapham, David Julius, Craig Montell and Günter Schultz. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels. Pharmacol Rev 2005 57: 427-450. PMID:16382100

Craig Montell, Lutz Birnbaumer, Veit Flockerzi, Rene J. Bindels, Elspeth A. Bruford, Michael J. Caterina, David E. Clapham, Christian Harteneck, Stefan Heller, David Julius, Itaru Kojima, Yasuo Mori, Reinhold Penner, Dirk Prawitt, Andrew M. Scharenberg, Günter Schultz, Nobuyoshi Shimizu and Michael X. Zhu. A Unified Nomenclature for the Superfamily of TRP Cation Channels. Mol Cell. 2002 Feb;9(2):229-31. PMID:11864597

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TRPA1 transient receptor potential cation channel, subfamily A, member 1 ANKTM1 8q13
TRPC1 transient receptor potential cation channel, subfamily C, member 1 HTRP-1 3q23
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene 11p15.4
TRPC3 transient receptor potential cation channel, subfamily C, member 3 4q27
TRPC4 transient receptor potential cation channel, subfamily C, member 4 HTRP4, TRP4 13q13.3
TRPC5 transient receptor potential cation channel, subfamily C, member 5 PPP1R159 Xq23
TRPC6 transient receptor potential cation channel, subfamily C, member 6 FSGS2 TRP6 11q22.1
TRPC7 transient receptor potential cation channel, subfamily C, member 7 5q31.2
TRPM1 transient receptor potential cation channel, subfamily M, member 1 MLSN1 LTRPC1, CSNB1C 15q13.3
TRPM2 transient receptor potential cation channel, subfamily M, member 2 TRPC7 KNP3, LTRPC2, NUDT9L1, NUDT9H, EREG1 21q22.3
TRPM3 transient receptor potential cation channel, subfamily M, member 3 KIAA1616, LTRPC3, GON-2 9q21.11
TRPM4 transient receptor potential cation channel, subfamily M, member 4 FLJ20041 19q13.3
TRPM5 transient receptor potential cation channel, subfamily M, member 5 LTRPC5, MTR1 11p15.5
TRPM6 transient receptor potential cation channel, subfamily M, member 6 HOMG, HSH CHAK2, FLJ22628 9q21.13
TRPM7 transient receptor potential cation channel, subfamily M, member 7 CHAK1, LTRPC7, TRP-PLIK 15q21
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2q37
MCOLN1 mucolipin 1 TRPML1, ML4, MLIV, MST080, MSTP080, TRPM-L1 19p13.2
MCOLN2 mucolipin 2 TRPML2, FLJ36691, TRP-ML2 1p22
MCOLN3 mucolipin 3 TRPML3, FLJ11006, TRP-ML3 1p22.3
PKD1 polycystic kidney disease 1 (autosomal dominant) PBP, Pc-1, TRPP1 16p13.3
PKD2 polycystic kidney disease 2 (autosomal dominant) PKD4, PC2, Pc-2, TRPP2 4q22.1
PKD2L1 polycystic kidney disease 2-like 1 PKD2L, PKDL PCL, TRPP3 10q24.31
PKD2L2 polycystic kidney disease 2-like 2 TRPP5 5q31
TRPV1 transient receptor potential cation channel, subfamily V, member 1 VR1 17p13.3
TRPV2 transient receptor potential cation channel, subfamily V, member 2 VRL, VRL-1, VRL1 17p11.2
TRPV3 transient receptor potential cation channel, subfamily V, member 3 VRL3 17p13.3
TRPV4 transient receptor potential cation channel, subfamily V, member 4 OTRPC4, TRP12, VROAC, VRL-2, VR-OAC, CMT2C 12q24.1
TRPV5 transient receptor potential cation channel, subfamily V, member 5 ECAC1 CaT2 7q34
TRPV6 transient receptor potential cation channel, subfamily V, member 6 ECAC2 CaT1 7q34

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 CatSper channels :

David E. Clapham and David L. Garbers. Nomenclature and Structure-Function Relationships of CatSper and Two-Pore Channels. Pharmacol Rev 2005 57: 451-454. PMID:16382101

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CATSPER1 cation channel, sperm associated 1 CATSPER 11q12.1
CATSPER2 cation channel, sperm associated 2 15q15.3
CATSPER3 cation channel, sperm associated 3 CACRC 5q31.2
CATSPER4 cation channel, sperm associated 4 1p35.3

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Two-pore channels :

David E. Clapham and David L. Garbers. Nomenclature and Structure-Function Relationships of CatSper and Two-Pore Channels. Pharmacol Rev 2005 57: 451-454. PMID:16382101

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TPCN1 two pore segment channel 1 KIAA1169, FLJ20612, TPC1 12q24.21
TPCN2 two pore segment channel 2 TPC2 11q13.1

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 Cyclic nucleotide-regulated channels :

Franz Hofmann, Martin Biel and U. Benjamin Kaupp. Nomenclature and Structure-Function Relationships of Cyclic Nucleotide-Regulated Channels. Pharmacol Rev 2005 57: 455-462. PMID:16382102

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CNGA1 cyclic nucleotide gated channel alpha 1 CNCG1, CNCG RCNC1, RCNCa, CNG1, RP49 4p12
CNGA2 cyclic nucleotide gated channel alpha 2 CNCA1, CNCA CNG2, OCNC1, OCNCa, OCNCALPHA, OCNCalpha, FLJ46312 Xq27
CNGA3 cyclic nucleotide gated channel alpha 3 CNCG3, ACHM2 CCNC1, CCNCa, CNG3 2q11.2
CNGA4 cyclic nucleotide gated channel alpha 4 CNCA2, CNGB2 OCNC2, OCNCb, CNG5 11p15.4
CNGB1 cyclic nucleotide gated channel beta 1 CNCG2, CNCG3L RCNC2, RCNCb, GARP, GAR1, CNGB1B, RP45 16q13
CNGB3 cyclic nucleotide gated channel beta 3 ACHM3, ACHM1, RMCH 8q21.3
HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 BCNG1 BCNG-1, HAC-2 5p12
HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 BCNG2 BCNG-2, HAC-1 19p13
HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 KIAA1535 1q21.2
HCN4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 15q24.1

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 Potassium channels, calcium-activated :

Aguan D. Wei, George A. Gutman, Richard Aldrich, K. George Chandy, Stephan Grissmer and Heike Wulff. Nomenclature and Molecular Relationships of Calcium-Activated Potassium Channels. Pharmacol Rev 2005 57: 463-472. PMID:16382103

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 SLO KCa1.1, mSLO1 10q22
KCNN1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 KCa2.1, hSK1 19p13.1
KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 KCa2.2, hSK2 5q22.3
KCNN3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 KCa2.3, hSK3, SKCA3 1q21.3
KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 KCa3.1, hSK4, hKCa4, hIKCa1 19q13.2
KCNT1 potassium channel, subfamily T, member 1 KCa4.1, KIAA1422 9q34.3
KCNT2 potassium channel, subfamily T, member 2 KCa4.2, SLICK, SLO2.1 1q31.3
KCNU1 potassium channel, subfamily U, member 1 KCa5.1, Slo3, KCNMC1, Kcnma3 8p11.2

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 Potassium channels, voltage-gated:

George A. Gutman, K. George Chandy, Stephan Grissmer, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, and Xiaoliang Wang. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels. Pharmacol Rev 2005 57: 473-508. PMID:16382104

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) AEMK Kv1.1, RBK1, HUK1, MBK1 12p13
KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2 Kv1.2, HK4 1p13
KCNA3 potassium voltage-gated channel, shaker-related subfamily, member 3 Kv1.3, MK3, HLK3, HPCN3 1p13.3
KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4 KCNA4L Kv1.4, HK1, HPCN2 11p14
KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5 Kv1.5, HK2, HPCN1 12p13
KCNA6 potassium voltage-gated channel, shaker-related subfamily, member 6 Kv1.6, HBK2, PPP1R96 12p13
KCNA7 potassium voltage-gated channel, shaker-related subfamily, member 7 Kv1.7, HAK6 19q13.3
KCNA10 potassium voltage-gated channel, shaker-related subfamily, member 10 Kv1.8 1p13.1
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 Kv2.1 20q13.2
KCNB2 potassium voltage-gated channel, Shab-related subfamily, member 2 Kv2.2 8q13.2
KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1 Kv3.1 11p15
KCNC2 potassium voltage-gated channel, Shaw-related subfamily, member 2 Kv3.2 12q14.1
KCNC3 potassium voltage-gated channel, Shaw-related subfamily, member 3 SCA13 Kv3.3 19q13.33
KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4 C1orf30 Kv3.4, HKSHIIIC 1p21
KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1 Kv4.1 Xp11.23
KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2 Kv4.2, RK5, KIAA1044 7q31
KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3 SCA22, SCA19 Kv4.3, KSHIVB 1p13.2
KCNF1 potassium voltage-gated channel, subfamily F, member 1 KCNF Kv5.1, kH1, IK8 2p25
KCNG1 potassium voltage-gated channel, subfamily G, member 1 KCNG Kv6.1, kH2, K13 20q13
KCNG2 potassium voltage-gated channel, subfamily G, member 2 Kv6.2, KCNF2 18q23
KCNG3 potassium voltage-gated channel, subfamily G, member 3 Kv6.3 2p21
KCNG4 potassium voltage-gated channel, subfamily G, member 4 Kv6.4 16q24.1
KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1 Kv10.1, eag, h-eag, eag1 1q32.2
KCNH2 potassium voltage-gated channel, subfamily H (eag-related), member 2 LQT2 Kv11.1, HERG, erg1 7q36.1
KCNH3 potassium voltage-gated channel, subfamily H (eag-related), member 3 Kv12.2, BEC1, elk2 12q13
KCNH4 potassium voltage-gated channel, subfamily H (eag-related), member 4 Kv12.3, elk1 17q21
KCNH5 potassium voltage-gated channel, subfamily H (eag-related), member 5 Kv10.2, H-EAG2, eag2 14q23.1
KCNH6 potassium voltage-gated channel, subfamily H (eag-related), member 6 Kv11.2, erg2, HERG2 17q23.3
KCNH7 potassium voltage-gated channel, subfamily H (eag-related), member 7 Kv11.3, HERG3, erg3 2q24.3
KCNH8 potassium voltage-gated channel, subfamily H (eag-related), member 8 Kv12.1, elk3 3p24.3
KCNQ1 potassium voltage-gated channel, KQT-like subfamily, member 1 LQT, KCNA9 Kv7.1, KCNA8, KVLQT1, JLNS1, LQT1 11p15.5
KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 EBN, EBN1 Kv7.2, ENB1, BFNC, KCNA11, HNSPC 20q13.33
KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3 EBN2 Kv7.3 8q24
KCNQ4 potassium voltage-gated channel, KQT-like subfamily, member 4 DFNA2 Kv7.4 1p34
KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5 Kv7.5 6q14
KCNS1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 Kv9.1 20q12
KCNS2 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 Kv9.2 8q22
KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 Kv9.3 2p24
KCNV1 potassium channel, subfamily V, member 1 Kv8.1 8q23.2
KCNV2 potassium channel, subfamily V, member 2 Kv8.2 9p24.2

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 Potassium channels, inwardly rectifying:

Yoshihiro Kubo, John P. Adelman, David E. Clapham, Lily Y. Jan, Andreas Karschin, Yoshihisa Kurachi, Michel Lazdunski, Colin G. Nichols, Susumu Seino, and Carol A. Vandenberg. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 2005 57: 509-526. PMID:16382105

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNJ1 potassium inwardly-rectifying channel, subfamily J, member 1 Kir1.1, ROMK1 11q24
KCNJ2 potassium inwardly-rectifying channel, subfamily J, member 2 Kir2.1, IRK1, LQT7 17q24.3
KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 Kir3.1, GIRK1, KGA 2q24.1
KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4 Kir2.3, HIR, HRK1, hIRK2, IRK3 22q13.1
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 Kir3.4, CIR, KATP1, GIRK4, LQT13 11q24
KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6 KCNJ7 Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2 21q22.1
KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8 Kir6.1 12p12.1
KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9 Kir3.3, GIRK3 1q23.2
KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10 Kir4.1, Kir1.2 1q23.2
KCNJ11 potassium inwardly-rectifying channel, subfamily J, member 11 Kir6.2, BIR 11p15.1
KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12 KCNJN1 Kir2.2, Kir2.2v, IRK2, hIRK1 17p11.1
KCNJ13 potassium inwardly-rectifying channel, subfamily J, member 13 Kir7.1, Kir1.4, LCA16 2q37
KCNJ14 potassium inwardly-rectifying channel, subfamily J, member 14 Kir2.4, IRK4 19q13
KCNJ15 potassium inwardly-rectifying channel, subfamily J, member 15 Kir4.2, Kir1.3, IRKK 21q22.2
KCNJ16 potassium inwardly-rectifying channel, subfamily J, member 16 Kir5.1, BIR9 17q24.3
KCNJ18 potassium inwardly-rectifying channel, subfamily J, member 18 KIR2.6, TTPP2 17p11.2

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Potassium channels, two-P :

Steve A. N. Goldstein, Douglas A. Bayliss, Donghee Kim, Florian Lesage, Leigh Daniel Plant, and Sindhu Rajan. Nomenclature and Molecular Relationships of Two-P Potassium Channels. Pharmacol Rev 2005 57: 527-540. PMID:16382106

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNK1 potassium channel, subfamily K, member 1 K2p1.1, DPK, TWIK-1 1q42-q43
KCNK2 potassium channel, subfamily K, member 2 K2p2.1, TREK-1 1q41
KCNK3 potassium channel, subfamily K, member 3 K2p3.1, TASK, TASK-1 2p23
KCNK4 potassium channel, subfamily K, member 4 K2p4.1, TRAAK 11q13
KCNK5 potassium channel, subfamily K, member 5 K2p5.1, TASK-2 6p21
KCNK6 potassium channel, subfamily K, member 6 K2p6.1, TWIK-2 19q13.1
KCNK7 potassium channel, subfamily K, member 7 K2p7.1 11q13
KCNK9 potassium channel, subfamily K, member 9 K2p9.1, TASK3, TASK-3 8q24.3
KCNK10 potassium channel, subfamily K, member 10 K2p10.1, TREK-2, TREK2, PPP1R97 14q31
KCNK12 potassium channel, subfamily K, member 12 THIK-2, THIK2, K2p12.1 2p16.3
KCNK13 potassium channel, subfamily K, member 13 K2p13.1, THIK-1, THIK1 14q32.11
KCNK15 potassium channel, subfamily K, member 15 KCNK11, KCNK14 K2p15.1, dJ781B1.1, KT3.3, KIAA0237, TASK5, TASK-5 20q13.12
KCNK16 potassium channel, subfamily K, member 16 K2p16.1, TALK-1, TALK1 6p21.2-p21.1
KCNK17 potassium channel, subfamily K, member 17 K2p17.1, TALK-2, TALK2, TASK4, TASK-4 6p21
KCNK18 potassium channel, subfamily K, member 18 K2p18.1, TRESK-2, TRESK2, TRESK, TRIK 10q26.11

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Hydrogen voltage-gated ion channels :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HVCN1 hydrogen voltage-gated channel 1 MGC15619, Hv1, VSOP 12q24.11

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