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SH2 domain containing

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Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase ABL JTK7, c-ABL, p150 9q34.1
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase ABLL ARG 1q25.2
BCAR3 breast cancer anti-estrogen resistance 3 NSP2, SH2D3B 1p22.1
BLK BLK proto-oncogene, Src family tyrosine kinase MGC10442 8p23-p22
BLNK B-cell linker SLP65, Ly57, SLP-65, BLNK-s, BASH, bca 10q23.2-q23.33
BMX BMX non-receptor tyrosine kinase ETK, PSCTK3 Xp22.2
BTK Bruton agammaglobulinemia tyrosine kinase AGMX1, IMD1 ATK, XLA, PSCTK1 Xq21.33-q22
CHN1 chimerin 1 CHN, DURS2 RhoGAP2, ARHGAP2, n-chimerin 2q31-q32.1
CHN2 chimerin 2 ARHGAP3, RhoGAP3 7p15.3
CISH cytokine inducible SH2-containing protein CIS, G18, CIS-1, SOCS 3p21.3
CLNK cytokine-dependent hematopoietic cell linker MIST 4p16.1
CRK v-crk avian sarcoma virus CT10 oncogene homolog 17p13
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 22q11.21
CSK c-src tyrosine kinase 15q24.1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides BAM32 4q25-q27
FER fer (fps/fes related) tyrosine kinase TYK3, PPP1R74 5q21
FES FES proto-oncogene, tyrosine kinase FPS 15q26.1
FGR FGR proto-oncogene, Src family tyrosine kinase SRC2 c-fgr, p55c-fgr 1p36.2-p36.1
FRK fyn-related Src family tyrosine kinase PTK5 RAK, GTK 6q21-q22.3
FYN FYN proto-oncogene, Src family tyrosine kinase SYN, SLK, MGC45350 6q21
GRAP GRB2-related adaptor protein 17p11.2
GRAP2 GRB2-related adaptor protein 2 Grf40, GrbX, GRBLG, GADS, Mona 22q13.2
GRAPL GRB2-related adaptor protein-like 17p11.2
GRB2 growth factor receptor-bound protein 2 NCKAP2 17q24-q25
GRB7 growth factor receptor-bound protein 7 17q12
GRB10 growth factor receptor-bound protein 10 7p12.2
GRB14 growth factor receptor-bound protein 14 2q22-q24
HCK HCK proto-oncogene, Src family tyrosine kinase JTK9 20q11-q12
HSH2D hematopoietic SH2 domain containing ALX, HSH2, FLJ14886 19p13.12
INPP5D inositol polyphosphate-5-phosphatase, 145kDa SHIP, hp51CN 2q37.1
INPPL1 inositol polyphosphate phosphatase-like 1 SHIP2 11q23
ITK IL2-inducible T-cell kinase EMT, PSCTK2, LYK 5q31-q32
JAK2 Janus kinase 2 JTK10 9p24
LCK LCK proto-oncogene, Src family tyrosine kinase 1p34.3
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) SLP76 SLP-76 5q35.1
LYN LYN proto-oncogene, Src family tyrosine kinase JTK8 8q13
MATK megakaryocyte-associated tyrosine kinase HYLTK, CTK, HYL, Lsk, CHK, HHYLTK, DKFZp434N1212, MGC1708, MGC2101 19p13.3
NCK1 NCK adaptor protein 1 NCK NCKalpha 3q21
NCK2 NCK adaptor protein 2 NCKbeta 2q12
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GRB1, p85-ALPHA, p85 5q13.1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) P85B, p85 19p13.11
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) p55 1p34.1
PLCG1 phospholipase C, gamma 1 PLC1 PLC148, PLC-II, PLCgamma1, NCKAP3 20q12-q13.1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 16q24.1
PTK6 protein tyrosine kinase 6 BRK 20q13.3
PTPN6 protein tyrosine phosphatase, non-receptor type 6 HCP, HCPH, PTP-1C, SHP-1, SHP1 12p13.31
PTPN11 protein tyrosine phosphatase, non-receptor type 11 NS1 BPTP3, SH-PTP2, SHP-2, PTP2C, SHP2 12q24.1
RASA1 RAS p21 protein activator (GTPase activating protein) 1 RASA GAP, CM-AVM, p120GAP, p120RASGAP 5q13
SH2B1 SH2B adaptor protein 1 FLJ30542, SH2B 16p11.2
SH2B2 SH2B adaptor protein 2 APS 7q22.1
SH2B3 SH2B adaptor protein 3 LNK, IDDM20 12q24.12
SH2D1A SH2 domain containing 1A IMD5, LYP XLP, MTCP1, DSHP, XLPD, EBVS, SAP Xq25
SH2D1B SH2 domain containing 1B EAT2 1q23.3
SH2D2A SH2 domain containing 2A TSAd, F2771 1q21
SH2D3A SH2 domain containing 3A NSP1 19p13.3
SH2D3C SH2 domain containing 3C NSP3 9q33.1-q33.3
SH2D4A SH2 domain containing 4A FLJ20967, SH2A, PPP1R38 8p21
SH2D4B SH2 domain containing 4B 10q23.1
SH2D6 SH2 domain containing 6 FLJ35993 2p11.2
SH2D7 SH2 domain containing 7 LOC646892 15q25.1
SH3BP2 SH3-domain binding protein 2 RES4-23, CRBM 4p16.3
SHB Src homology 2 domain containing adaptor protein B 9p13.2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 SHC p66 1q21
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 SLI, SCK, SHCB 19p13.3
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 N-Shc, NSHC, SHCC 9q22.1
SHC4 SHC (Src homology 2 domain containing) family, member 4 RaLP 15q21.1-q21.2
SHD Src homology 2 domain containing transforming protein D 19p13.3
SHE Src homology 2 domain containing E 1q21.3
SHF Src homology 2 domain containing F 15q21.1
SLA Src-like-adaptor SLA1 8q24.22
SLA2 Src-like-adaptor 2 C20orf156 FLJ21992, SLAP-2 20q11.23
SOCS1 suppressor of cytokine signaling 1 SOCS-1, SSI-1, JAB, TIP3, Cish1 16p13.13
SOCS2 suppressor of cytokine signaling 2 STATI2, SSI2, SOCS-2, SSI-2, CIS2, Cish2 12q
SOCS3 suppressor of cytokine signaling 3 SSI-3, CIS3, SOCS-3, Cish3 17q25.3
SOCS4 suppressor of cytokine signaling 4 SOCS7 14q22.1
SOCS5 suppressor of cytokine signaling 5 KIAA0671, SOCS-5, CIS6, CISH6, Cish5 2p21
SOCS6 suppressor of cytokine signaling 6 SOCS4 CIS4, SSI4, HSPC060, STATI4, STAI4, Cish4 18q22
SOCS7 suppressor of cytokine signaling 7 NAP4, NCKAP4 17q21.1
SRC SRC proto-oncogene, non-receptor tyrosine kinase SRC1 ASV, c-src 20q12-q13
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites C20orf148 SRM, dJ697K14.1 20q13.33
STAP1 signal transducing adaptor family member 1 STAP-1, BRDG1 4q13.2
STAT1 signal transducer and activator of transcription 1, 91kDa STAT91, ISGF-3 2q32.2-q32.3
STAT2 signal transducer and activator of transcription 2, 113kDa STAT113 12q13.2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) APRF 17q21
STAT4 signal transducer and activator of transcription 4 2q32.2-q32.3
STAT5A signal transducer and activator of transcription 5A STAT5 MGF 17q11.2
STAT5B signal transducer and activator of transcription 5B 17q11.2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced D12S1644, IL-4-STAT 12q13
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) KIAA0162, SPT6H 17q11.2
SYK spleen tyrosine kinase 9q22
TEC tec protein tyrosine kinase PSCTK4 4p12
TENC1 tensin like C1 domain containing phosphatase (tensin 2) KIAA1075, C1-TEN, TNS2 12q13.13
TNS1 tensin 1 TNS, MXRA6 DKFZp586K0617, PPP1R155 2q35-q36
TNS3 tensin 3 TENS1 TEM6, H_NH0549I23.2, FLJ13732 7p12.3
TNS4 tensin 4 CTEN 17q21.2
TXK TXK tyrosine kinase PTK4 TKL, PSCTK5, BTKL, RLK 4p12
VAV1 vav 1 guanine nucleotide exchange factor VAV 19p13.2
VAV2 vav 2 guanine nucleotide exchange factor 9q34.1
VAV3 vav 3 guanine nucleotide exchange factor 1p13.3
YES1 YES proto-oncogene 1, Src family tyrosine kinase Yes, c-yes, HsT441 18p11.31-p11.21
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa SRK ZAP-70, STD 2q11-q13

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