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Short chain dehydrogenase/reductase superfamily

Kallberg Y, Oppermann U, Persson B. Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models. FEBS J. 2010 May;277(10):2375-86. PMID:20423462

Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, J├Ârnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. Chem Biol Interact. 2009 Mar 16;178(1-3):94-8. PMID:19027726


1. Classical SDR fold cluster 1
2. Classical SDR fold cluster 2 
3. Classical SDR fold cluster 3 
4. Extended SDR fold 
5. Atypical members 

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Classical SDR fold cluster 1:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 HADH2, MRXS10 ERAB, MHBD, 17b-HSD10, ABAD, SDR5C1, MRPP2, CAMR Xp11.2
HSDL2 hydroxysteroid dehydrogenase like 2 C9orf99 SDR13C1 9q32
BDH2 3-hydroxybutyrate dehydrogenase, type 2 DHRS6 UCPA-OR, FLJ13261, UNQ6308, PRO20933, SDR15C1 4q24
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal PDCR, SDR17C1 16p13.3
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial DECR SDR18C1 8q21.3
DHRS1 dehydrogenase/reductase (SDR family) member 1 FLJ25430, MGC20204, SDR19C1 14q11.2
DCXR dicarbonyl/L-xylulose reductase KIDCR, DCR, SDR20C1 17q25.3
CBR1 carbonyl reductase 1 CBR SDR21C1 21q22.1
CBR3 carbonyl reductase 3 SDR21C2 21q22.2
DHRS11 dehydrogenase/reductase (SDR family) member 11 MGC4172, SDR24C1 17q12
DHRS2 dehydrogenase/reductase (SDR family) member 2 HEP27, SDR25C1 14q11.2
DHRS4 dehydrogenase/reductase (SDR family) member 4 SCAD-SRL, SDR-SRL, humNRDR, FLJ11008, SDR25C2 14q11.2
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 SDR25C3 14q11.2
DHRS4L1 dehydrogenase/reductase (SDR family) member 4 like 1 SDR25C4 14q11.2
PECR peroxisomal trans-2-enoyl-CoA reductase HSA250303, TERP, SDR29C1 2q35
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 FABGL HKE6, D6S2245E, RING2, KE6, H2-KE6, SDR30C1 6p21.3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) SDR36C1 4q34-q35
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) SDR38C1 2p14-p12
CBR4 carbonyl reductase 4 FLJ14431, SDR45C1 4q32.3
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 DHRS10 retSDR3, SDR47C1 19q13.33

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Classical SDR fold cluster 2:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) MDT1, SDR7C1, ARSDR1 14q24.1
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) FLJ30273, SDR7C2, LCA13, RP53 14q24.1
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) SDR7C3 19q13.42
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) PAN2, SDR7C4 2p24.2
DHRS13 dehydrogenase/reductase (SDR family) member 13 MGC23280, SDR7C5 17q11.2
BDH1 3-hydroxybutyrate dehydrogenase, type 1 BDH SDR9C1 3q29
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 HSD17, SDR9C2 16q24.1-q24.2
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 SDR9C3 16q22
DHRS9 dehydrogenase/reductase (SDR family) member 9 RDHL, 3alpha-HSD, RETSDR8, RDH15, SDR9C4 2q31.1
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) RDH1 HSD17B9, SDR9C5 12q13-q14
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 HSE, RODH, SDR9C6 12q13.3
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 SDR-O, RDHS 12q13.3
RDH16 retinol dehydrogenase 16 (all-trans) RODH-4, SDR9C8 12q13.3
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 EDHB17, EDH17B2 HSD17, MGC138140, SDR28C1 17q11-q21
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 EDHB17, EDH17B1, HSD17BP1 SDR28C1P1 17q11-q21
RDH8 retinol dehydrogenase 8 (all-trans) PRRDH, SDR28C2 19p13.2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 PRAP, SDR37C1 1q23
DHRS12 dehydrogenase/reductase (SDR family) member 12 FLJ13639, SDR40C1 13q14.3
WWOX WW domain containing oxidoreductase FOR, WOX1, SDR41C1 16q23.3-q24.1

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Classical SDR fold cluster 3:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 MFE-2, DBP, SDR8C1 5q2
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 KAR, SDR12C1 11q11
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 SDR12C2 9q22
HSDL1 hydroxysteroid dehydrogenase like 1 SDR12C3 16q24
DHRS3 dehydrogenase/reductase (SDR family) member 3 retSDR1, Rsdr1, SDR1, RDH17, SDR16C1 1p36.1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 DHRS8 RetSDR2, 17-BETA-HSD11, 17-BETA-HSDXI, PAN1B, SDR16C2 4q22.1
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 SCDR9, SDR16C3 4q22.1
RDH10 retinol dehydrogenase 10 (all-trans) SDR16C4 8q21.11
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 RDHE2, RDH-E2 8q12.1
SDR16C6P short chain dehydrogenase/reductase family 16C, member 6, pseudogene SDR16C6 8q12.1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 HSD11B, HSD11 SDR26C1 1q32-q41
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like SCDR10, SDR26C2 19p13.3
DHRS7B dehydrogenase/reductase (SDR family) member 7B DKFZp566O084, MGC8916, CGI-93, SDR32C1 17p12
DHRS7C dehydrogenase/reductase (SDR family) member 7C SDR32C2 17p13.1
DHRS7 dehydrogenase/reductase (SDR family) member 7 retDSR4, SDR34C1 14q23.1
KDSR 3-ketodihydrosphingosine reductase FVT1 DHSR, SDR35C1 18q21

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Extended SDR fold:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GALE UDP-galactose-4-epimerase SDR1E1 1p36-p35
TGDS TDP-glucose 4,6-dehydratase TDPGD, SDR2E1 13q32.1
GMDS GDP-mannose 4,6-dehydratase GMD, SDR3E1 6p25
TSTA3 tissue specific transplantation antigen P35B FX, P35B, SDR4E1 8q24.3
UXS1 UDP-glucuronate decarboxylase 1 FLJ23591, UGD, SDR6E1 2q12.2
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 HSDB3, HSD3B SDR11E1 1p12
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 SDR11E2 1p12
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 C(27)-3BETA-HSD, SDR11E3 16p11.2
TDH L-threonine dehydrogenase (pseudogene) FLJ25033, SDR14E1P 8p23.1
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa NDUFS2L SDR22E1, CI-39k 12p13.3
MAT2B methionine adenosyltransferase II, beta MATIIbeta, SDR23E1 5q34-q35
NSDHL NAD(P) dependent steroid dehydrogenase-like XAP104, H105e3, SDR31E1 Xq28
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 HSPC105 16q23.3
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 16p12.1

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Atypical members:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
FAR1 fatty acyl CoA reductase 1 MLSTD2 FLJ22728, SDR10E1 11p15.2
FAR2 fatty acyl CoA reductase 2 MLSTD1 FLJ10462, SDR10E2 12p11.23
FASN fatty acid synthase FAS, SDR27X1 17q25
QDPR quinoid dihydropteridine reductase DHPR, PKU2, SDR33C1 4p15.31
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 C14orf124 HCDI 14q12
BLVRB biliverdin reductase B (flavin reductase (NADPH)) FLR SDR43U1 19q13.1-q13.2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa TIP30, CC3, FLJ26963, SDR44U1 11p15.1
NMRAL1 NmrA-like family domain containing 1 FLJ25918, HSCARG, SDR48A1 16p13.3

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