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This is our older gene family page that is no longer maintained. Please go to our new look gene family index to view a complete list of our new maintained gene families. More information can be found in our gene families help page.

We have created a mapping file (Excel) that will map most of the old families to the new. However because we have changed the way we assign families and how we organise them, this file may not map all the old families.

Short chain dehydrogenase/reductase superfamily

Kallberg Y, Oppermann U, Persson B. Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models. FEBS J. 2010 May;277(10):2375-86. PMID:20423462

Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, J├Ârnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. Chem Biol Interact. 2009 Mar 16;178(1-3):94-8. PMID:19027726


1. Classical SDR fold cluster 1
2. Classical SDR fold cluster 2 
3. Classical SDR fold cluster 3 
4. Extended SDR fold 
5. Atypical members 

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Classical SDR fold cluster 1:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 HADH2, MRXS10 ERAB, MHBD, 17b-HSD10, ABAD, SDR5C1, MRPP2, CAMR Xp11.22
HSDL2 hydroxysteroid dehydrogenase like 2 C9orf99 SDR13C1 9q32
BDH2 3-hydroxybutyrate dehydrogenase 2 DHRS6 UCPA-OR, FLJ13261, UNQ6308, PRO20933, SDR15C1 4q24
DECR2 2,4-dienoyl-CoA reductase 2 PDCR, SDR17C1 16p13.3
DECR1 2,4-dienoyl-CoA reductase 1 DECR SDR18C1 8q21.3
DHRS1 dehydrogenase/reductase 1 FLJ25430, MGC20204, SDR19C1 14q12
DCXR dicarbonyl and L-xylulose reductase KIDCR, DCR, SDR20C1 17q25.3
CBR1 carbonyl reductase 1 CBR SDR21C1 21q22.12
CBR3 carbonyl reductase 3 SDR21C2 21q22.12
DHRS11 dehydrogenase/reductase 11 MGC4172, SDR24C1 17q12
DHRS2 dehydrogenase/reductase 2 HEP27, SDR25C1 14q11.2
DHRS4 dehydrogenase/reductase 4 SCAD-SRL, SDR-SRL, humNRDR, FLJ11008, SDR25C2 14q11.2
DHRS4L2 dehydrogenase/reductase 4 like 2 SDR25C3 14q11.2
DHRS4L1 dehydrogenase/reductase 4 like 1 SDR25C4 14q11.2
PECR peroxisomal trans-2-enoyl-CoA reductase HSA250303, TERP, SDR29C1 2q35
HSD17B8 hydroxysteroid 17-beta dehydrogenase 8 FABGL HKE6, D6S2245E, RING2, KE6, H2-KE6, SDR30C1 6p21.32
HPGD 15-hydroxyprostaglandin dehydrogenase SDR36C1 4q34.1
SPR sepiapterin reductase SDR38C1 2p13.2
CBR4 carbonyl reductase 4 FLJ14431, SDR45C1 4q32.3
HSD17B14 hydroxysteroid 17-beta dehydrogenase 14 DHRS10 retSDR3, SDR47C1 19q13.33

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Classical SDR fold cluster 2:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) MDT1, SDR7C1, ARSDR1 14q24.1
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) FLJ30273, SDR7C2, LCA13, RP53 14q24.1
RDH13 retinol dehydrogenase 13 SDR7C3 19q13.42
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) PAN2, SDR7C4 2p24.2
DHRS13 dehydrogenase/reductase 13 MGC23280, SDR7C5 17q11.2
BDH1 3-hydroxybutyrate dehydrogenase 1 BDH SDR9C1 3q29
HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 HSD17, SDR9C2 16q23.3
HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 SDR9C3 16q22.1
DHRS9 dehydrogenase/reductase 9 RDHL, 3alpha-HSD, RETSDR8, RDH15, SDR9C4 2q31.1
RDH5 retinol dehydrogenase 5 RDH1 HSD17B9, SDR9C5 12q13.2
HSD17B6 hydroxysteroid 17-beta dehydrogenase 6 HSE, RODH, SDR9C6 12q13.3
SDR9C7 short chain dehydrogenase/reductase family 9C member 7 SDR-O, RDHS 12q13.3
RDH16 retinol dehydrogenase 16 (all-trans) RODH-4, SDR9C8 12q13.3
HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 EDHB17, EDH17B2 HSD17, MGC138140, SDR28C1 17q21.2
HSD17B1P1 hydroxysteroid 17-beta dehydrogenase 1 pseudogene 1 EDHB17, EDH17B1, HSD17BP1 SDR28C1P1 17q21.2
RDH8 retinol dehydrogenase 8 (all-trans) PRRDH, SDR28C2 19p13.2
HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 PRAP, SDR37C1 1q23.3
DHRS12 dehydrogenase/reductase 12 FLJ13639, SDR40C1 13q14.3
WWOX WW domain containing oxidoreductase FOR, WOX1, SDR41C1 16q23.1-q23.2

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Classical SDR fold cluster 3:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 MFE-2, DBP, SDR8C1 5q23.1
HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 KAR, SDR12C1 11p11.2
HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 SDR12C2 9q22.32
HSDL1 hydroxysteroid dehydrogenase like 1 SDR12C3 16q24.1
DHRS3 dehydrogenase/reductase 3 retSDR1, Rsdr1, SDR1, RDH17, SDR16C1 1p36.21
HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 DHRS8 RetSDR2, 17-BETA-HSD11, 17-BETA-HSDXI, PAN1B, SDR16C2 4q22.1
HSD17B13 hydroxysteroid 17-beta dehydrogenase 13 SCDR9, SDR16C3 4q22.1
RDH10 retinol dehydrogenase 10 SDR16C4 8q21.11
SDR16C5 short chain dehydrogenase/reductase family 16C member 5 RDHE2, RDH-E2, EPHD-2 8q12.1
SDR16C6P short chain dehydrogenase/reductase family 16C member 6, pseudogene SDR16C6 8q12.1
HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 HSD11B, HSD11 SDR26C1 1q32.2
HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like SCDR10, SDR26C2 19p13.3
DHRS7B dehydrogenase/reductase 7B DKFZp566O084, MGC8916, CGI-93, SDR32C1 17p11.2
DHRS7C dehydrogenase/reductase 7C SDR32C2 17p13.1
DHRS7 dehydrogenase/reductase 7 retDSR4, SDR34C1 14q23.1
KDSR 3-ketodihydrosphingosine reductase FVT1 DHSR, SDR35C1 18q21.33

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Extended SDR fold:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GALE UDP-galactose-4-epimerase SDR1E1 1p36.11
TGDS TDP-glucose 4,6-dehydratase TDPGD, SDR2E1 13q32.1
GMDS GDP-mannose 4,6-dehydratase GMD, SDR3E1 6p25.3
TSTA3 tissue specific transplantation antigen P35B FX, P35B, SDR4E1 8q24.3
UXS1 UDP-glucuronate decarboxylase 1 FLJ23591, UGD, SDR6E1 2q12.2
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 HSDB3, HSD3B SDR11E1 1p12
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 SDR11E2 1p12
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 C(27)-3BETA-HSD, SDR11E3 16p11.2
TDH L-threonine dehydrogenase (pseudogene) FLJ25033, SDR14E1P 8p23.1
NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 NDUFS2L SDR22E1, CI-39k 12p13.3
MAT2B methionine adenosyltransferase 2B MATIIbeta, SDR23E1 5q34
NSDHL NAD(P) dependent steroid dehydrogenase-like XAP104, H105e3, SDR31E1 Xq28
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 HSPC105 16q23.3
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 16p12.1

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Atypical members:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
FAR1 fatty acyl-CoA reductase 1 MLSTD2 FLJ22728, SDR10E1 11p15.3
FAR2 fatty acyl-CoA reductase 2 MLSTD1 FLJ10462, SDR10E2 12p11.22
FASN fatty acid synthase FAS, SDR27X1 17q25.3
QDPR quinoid dihydropteridine reductase DHPR, PKU2, SDR33C1 4p15.32
SDR39U1 short chain dehydrogenase/reductase family 39U member 1 C14orf124 HCDI 14q12
BLVRB biliverdin reductase B FLR SDR43U1 19q13.2
HTATIP2 HIV-1 Tat interactive protein 2 TIP30, CC3, FLJ26963, SDR44U1 11p15.1
NMRAL1 NmrA like redox sensor 1 FLJ25918, HSCARG, SDR48A1 16p13.3

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