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Protein tyrosine phosphatases, including dual specificity phosphatases

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1. Class I Cys-based PTPs
Classical PTPs:
Transmembrane receptor-like PTP
Non-receptor PTPs
Dual specificity phosphatases
MAP kinase phosphatase
Atypical dual specificity phosphatases
Slingshots
PRLs
CDC14
PTENs
Myotubularins

2. Class II Cys-based PTPs

3. Class III Cys-based PTP

4. Asp-based PTPs

Click on the Approved Gene Symbol to retrieve the complete gene record

1. Class I Cys-based PTPs

Classical PTPs
Transmembrane receptor-like PTPs:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PTPRA protein tyrosine phosphatase, receptor type, A PTPRL2, PTPA LRP, HLPR, HPTPA, RPTPA 20p13
PTPRB protein tyrosine phosphatase, receptor type, B PTPB 12q15-q21
PTPRC protein tyrosine phosphatase, receptor type, C CD45 LCA, T200, GP180 1q31-q32
PTPRD protein tyrosine phosphatase, receptor type, D PTPD, HPTP 9p24.1-p23
PTPRE protein tyrosine phosphatase, receptor type, E PTPE 10q26
PTPRF protein tyrosine phosphatase, receptor type, F LAR 1p34
PTPRG protein tyrosine phosphatase, receptor type, G PTPG RPTPG 3p21-p14
PTPRH protein tyrosine phosphatase, receptor type, H SAP-1 19q13.4
PTPRJ protein tyrosine phosphatase, receptor type, J DEP1, HPTPeta, CD148 11p11.2
PTPRK protein tyrosine phosphatase, receptor type, K R-PTP-kappa 6q22.2-q22.3
PTPRM protein tyrosine phosphatase, receptor type, M PTPRL1 RPTPU, hR-PTPu 18p11.2
PTPRN protein tyrosine phosphatase, receptor type, N IA-2 2q35-q36.1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 KIAA0387, phogrin, ICAAR, IA-2beta 7q36
PTPRO protein tyrosine phosphatase, receptor type, O PTPU2, GLEPP1, PTP-U2, PTP-oc, NPHS6 12p13-p12
PTPRQ protein tyrosine phosphatase, receptor type, Q DFNB84 12q21.31
PTPRR protein tyrosine phosphatase, receptor type, R PTPRQ PTPBR7, PTP-SL, EC-PTP, PCPTP1 12q15
PTPRS protein tyrosine phosphatase, receptor type, S 19p13.3
PTPRT protein tyrosine phosphatase, receptor type, T RPTPrho, KIAA0283 20q12-q13
PTPRU protein tyrosine phosphatase, receptor type, U PTPRO, hPTP-J, PCP-2, FMI, PTP 1p35.3
PTPRVP protein tyrosine phosphatase, receptor type, V, pseudogene PTPRV OST-PTP, ESP 1q32.1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 PTPZ, PTPRZ PTP18, RPTPB, phosphacan 7q31.3

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Non-receptor PTPs:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PTPN1 protein tyrosine phosphatase, non-receptor type 1 PTP1B 20q13.1-q13.2
PTPN2 protein tyrosine phosphatase, non-receptor type 2 PTPT TCELLPTP, TC-PTP, TCPTP 18p11.3-p11.2
PTPN3 protein tyrosine phosphatase, non-receptor type 3 PTPH1 9q31
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) PTPMEG 2q14.2
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) STEP, PTPSTEP 11p15.1
PTPN6 protein tyrosine phosphatase, non-receptor type 6 HCP, HCPH, PTP-1C, SHP-1, SHP1 12p13.31
PTPN7 protein tyrosine phosphatase, non-receptor type 7 HEPTP, LC-PTP 1q32.1
PTPN9 protein tyrosine phosphatase, non-receptor type 9 MEG2 15q23
PTPN11 protein tyrosine phosphatase, non-receptor type 11 NS1 BPTP3, SH-PTP2, SHP-2, PTP2C, SHP2 12q24.1
PTPN12 protein tyrosine phosphatase, non-receptor type 12 PTPG1, PTP-PEST 7q11.23
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) PTP1E, PTP-BAS, PTPL1, PTP-BL 4q21.3
PTPN14 protein tyrosine phosphatase, non-receptor type 14 PEZ 1q32.2
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) BDP1 2q21
PTPN20A protein tyrosine phosphatase, non-receptor type 20A bA142I17.1, CT126 10q11.22
PTPN20B protein tyrosine phosphatase, non-receptor type 20B bA42B19.1, DKFZP566K0524 10q11.22
PTPN20CP protein tyrosine phosphatase, non-receptor type 20C, pseudogene PTPN20C bA164N7.3 10q11.22
PTPN21 protein tyrosine phosphatase, non-receptor type 21 PTPD1, PTPRL10 14q31
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) PTPN8 Lyp, Lyp1, Lyp2 1p13.2
PTPN23 protein tyrosine phosphatase, non-receptor type 23 DKFZP564F0923, KIAA1471, HD-PTP 3p21.3

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Dual specificity phosphatases

MAP kinase phosphatases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DUSP1 dual specificity phosphatase 1 PTPN10 HVH1, CL100, MKP-1 5q35.1
DUSP2 dual specificity phosphatase 2 PAC-1 2q11
DUSP4 dual specificity phosphatase 4 HVH2, MKP-2, TYP 8p12-p11
DUSP5 dual specificity phosphatase 5 HVH3 10q25
DUSP6 dual specificity phosphatase 6 MKP-3, PYST1 12q22-q23
DUSP7 dual specificity phosphatase 7 MKP-X, PYST2 3p21
DUSP8 dual specificity phosphatase 8 C11orf81 HVH-5, HB5, FLJ42958 11p15.5
DUSP9 dual specificity phosphatase 9 MKP-4, MKP4 Xq28
DUSP10 dual specificity phosphatase 10 MKP-5, MKP5 1q41
DUSP16 dual specificity phosphatase 16 MKP-7, KIAA1700, MKP7 12p13
STYXL1 serine/threonine/tyrosine interacting-like 1 DUSP24 MK-STYX 7q11.23

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Atypical dual specificity phosphatases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 DUSP27 10q22.3
DUSP3 dual specificity phosphatase 3 VHR 17q21
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) PIR1 2p13.1
DUSP12 dual specificity phosphatase 12 YVH1, DUSP1 1q21-q22
DUSP13 dual specificity phosphatase 13 BEDP, TMDP, FLJ32450, DUSP13A, DUSP13B 10q23.1
DUSP14 dual specificity phosphatase 14 MKP-L, MKP6 17q12
DUSP15 dual specificity phosphatase 15 bA243J16.6, VHY 20q11.21
DUSP18 dual specificity phosphatase 18 DUSP20 22q12.1
DUSP19 dual specificity phosphatase 19 SKRP1, DUSP17 2q32.1
DUSP21 dual specificity phosphatase 21 Xp11.4-p11.23
DUSP22 dual specificity phosphatase 22 MKPX, JSP1, JKAP, VHX 6p25.3
DUSP23 dual specificity phosphatase 23 FLJ20442, DUSP25 1q23.1
DUSP26 dual specificity phosphatase 26 (putative) MGC1136, DUSP24 8p12
DUSP28 dual specificity phosphatase 28 VHP, DUSP26 2q37.1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) LDE, LD 6q24
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 PLIP, DUSP23, MOSP 11p11.2
RNGTT RNA guanylyltransferase and 5'-phosphatase HCE, HCE1, hCAP 6q16
STYX serine/threonine/tyrosine interacting protein 14q22.1

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Slingshots:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SSH1 slingshot protein phosphatase 1 KIAA1298 12q24.12
SSH2 slingshot protein phosphatase 2 KIAA1725 17q11.2
SSH3 slingshot protein phosphatase 3 FLJ20515, FLJ10928 11q13

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PRLs:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PTP4A1 protein tyrosine phosphatase type IVA, member 1 PTPCAAX1, PRL-1 6q12
PTP4A2 protein tyrosine phosphatase type IVA, member 2 PTP4A HU-PP-1, PTPCAAX2, OV-1, ptp-IV1a, PRL-2 1p35
PTP4A3 protein tyrosine phosphatase type IVA, member 3 PRL-3, PRL-R, PRL3 8q24.3

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CDC14s:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CDC14A cell division cycle 14A Cdc14A1, Cdc14A2, cdc14 1p21
CDC14B cell division cycle 14B Cdc14B1, Cdc14B2, CDC14B3, hCDC14B 9q22.3
CDKN3 cyclin-dependent kinase inhibitor 3 KAP, CDI1 14q22
PTPDC1 protein tyrosine phosphatase domain containing 1 PTP9Q22, FLJ37312 9q22.32

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PTENs:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PTEN phosphatase and tensin homolog BZS, MHAM MMAC1, TEP1, PTEN1 10q23
TENC1 tensin like C1 domain containing phosphatase (tensin 2) KIAA1075, C1-TEN, TNS2 12q13.13
TNS1 tensin 1 TNS, MXRA6 DKFZp586K0617, PPP1R155 2q35-q36
TPTE transmembrane phosphatase with tensin homology PTEN2, CT44 21p11
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 TPIP 13q12.11

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Myotubularins:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MTM1 myotubularin 1 Xq27.3-q28
MTMR1 myotubularin related protein 1 Xq28
MTMR2 myotubularin related protein 2 CMT4B KIAA1073 11q22
MTMR3 myotubularin related protein 3 KIAA0371, ZFYVE10, FYVE-DSP1 22q12.2
MTMR4 myotubularin related protein 4 KIAA0647, ZFYVE11 17q22-q23
SBF1 SET binding factor 1 MTMR5, DENND7A 22q13.33
MTMR6 myotubularin related protein 6 13q12
MTMR7 myotubularin related protein 7 8p22
MTMR8 myotubularin related protein 8 FLJ20126 Xq11.2-q12
MTMR9 myotubularin related protein 9 C8orf9, MTMR8 DKFZp434K171, LIP-STYX 8p23-p22
MTMR10 myotubularin related protein 10 FLJ20313 15q13.3
MTMR11 myotubularin related protein 11 CRA 1q12-q21
MTMR12 myotubularin related protein 12 PIP3AP 3-PAP, FLJ20476, KIAA1682, 3PAP 5p15.33
SBF2 SET binding factor 2 CMT4B2 KIAA1766, MTMR13, DENND7B 11p15.3
MTMR14 myotubularin related protein 14 C3orf29 FLJ22405, FLJ90311, hJumpy, hEDTP 3p26

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2. Class II Cys-based PTPs

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ACP1 acid phosphatase 1, soluble 2p25

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3. Class III Cys-based PTPs

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CDC25A cell division cycle 25A 3p21
CDC25B cell division cycle 25B 20p13
CDC25C cell division cycle 25C CDC25 PPP1R60 5q31

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4. Asp-based PTPs

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
EYA1 EYA transcriptional coactivator and phosphatase 1 BOR 8q13.3
EYA2 EYA transcriptional coactivator and phosphatase 2 EAB1 20q13.1
EYA3 EYA transcriptional coactivator and phosphatase 3 DKFZp686C132 1p36
EYA4 EYA transcriptional coactivator and phosphatase 4 DFNA10, CMD1J 6q23

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