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Serine/threonine phosphatases

 1. Protein phosphatase, catalytic and regulatory subunits
  Protein phosphatase, catalytic subunits
  Protein phosphatase 1, regulatory subunits  specialist advisor
  Protein phosphatase 2, regulatory subunits
  Protein phosphatase 3, regulatory subunits
  Protein phosphatase 4, regulatory subunits
  Protein phosphatase 6, regulatory subunits
 
2. Protein phosphatases, Mg2+/Mn2+ dependent 
 
3. CTD aspartate-based protein phosphatases

 

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1. Protein phosphatase, catalytic and regulatory subunits

Protein phosphatase, catalytic subunits:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme PPP1A PP1A, PP-1A, PP1alpha 11q13
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme PP1B, PP-1B, PP1beta 2p23
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme PP1C, PP1gamma 12q24.1-q24.2
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme PP2Calpha 5q31.1
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme PP2Abeta 8p12
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme CALN, CALNA CNA1, PPP2B 4q24
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme CALNB CALNA2, CNA2, PP2Bbeta 10q22.2
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme CALNA3, PP2Bgamma 8p21.3
PPP4C protein phosphatase 4, catalytic subunit PP4, PPX 16p11.2
PPP5C protein phosphatase 5, catalytic subunit PPP5 PP5 19q13.3
PPP6C protein phosphatase 6, catalytic subunit PP6 9q33.3
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 PPEF PPP7CA Xp22
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 PPP7CB 4q21.1

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Protein phosphatase 1, regulatory subunits:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 12q13.2
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B DARPP-32, FLJ20940 17q12
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C Inhibitor-1-like 2q31.3
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 IPP2 3q29
PPP1R2P6 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 6 7q34
PPP1R3A protein phosphatase 1, regulatory subunit 3A PPP1R3 GM 7q31.1
PPP1R3B protein phosphatase 1, regulatory subunit 3B GL, FLJ14005, PPP1R4 8p23.1
PPP1R3C protein phosphatase 1, regulatory subunit 3C PPP1R5 PTG 10q23-q24
PPP1R3D protein phosphatase 1, regulatory subunit 3D PPP1R6 20q13.3
PPP1R3E protein phosphatase 1, regulatory subunit 3E FLJ00089 14q11.2
PPP1R3F protein phosphatase 1, regulatory subunit 3F Hb2E Xp11.23
PPP1R3G protein phosphatase 1, regulatory subunit 3G 6p25.1
PPP1R7 protein phosphatase 1, regulatory subunit 7 sds22 2q37.3
PPP1R8 protein phosphatase 1, regulatory subunit 8 ard-1, NIPP-1, PRO2047, ARD1, NIPP1 1p35.3
PPP1R9A protein phosphatase 1, regulatory subunit 9A Neurabin-I, KIAA1222, FLJ20068 7q21.3
PPP1R9B protein phosphatase 1, regulatory subunit 9B PPP1R6, PPP1R9 Spn, SPINO 17q21.33
PPP1R10 protein phosphatase 1, regulatory subunit 10 PNUTS, FB19, CAT53, p99 6p21.3
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 TCTE5 HCGV, Tctex5, HCG-V 6p21.3
PPP1R12A protein phosphatase 1, regulatory subunit 12A MYPT1 MBS, M130 12q15-q21
PPP1R12B protein phosphatase 1, regulatory subunit 12B MYPT2 MGC87886, MGC131980, PP1bp55 1q32.1
PPP1R12C protein phosphatase 1, regulatory subunit 12C LENG3 DKFZP434D0412, p84, MBS85, p85 19q13.42
TP53BP2 tumor protein p53 binding protein 2 PPP1R13A, ASPP2, 53BP2 1q41
PPP1R13B protein phosphatase 1, regulatory subunit 13B p53BP2-like, KIAA0771, p85, ASPP1 14q32.33
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A PPP1INL CPI-17 19q13.1
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B PLCB3N SOM172, PNG, PHI-1 11q13
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C CPI17-like, NY-BR-81, KEPI 6q24.3-q25.3
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D CPI17-like, FLJ20251, GBPI-1, MGC119014, MGC119016 15q11.2-q14
PPP1R15A protein phosphatase 1, regulatory subunit 15A GADD34 19q13.2
PPP1R15B protein phosphatase 1, regulatory subunit 15B FLJ14744 1q32.1
PPP1R16A protein phosphatase 1, regulatory subunit 16A MGC14333, MYPT3 8q24.3
PPP1R16B protein phosphatase 1, regulatory subunit 16B KIAA0823, TIMAP, ANKRD4 20q11.23
PPP1R17 protein phosphatase 1, regulatory subunit 17 C7orf16 GSBS 7p15
PPP1R18 protein phosphatase 1, regulatory subunit 18 KIAA1949 phostensin 6p21.3
CCDC8 coiled-coil domain containing 8 DKFZp564K0322, 3M3, PPP1R20 19q13.33
URI1 URI1, prefoldin-like chaperone C19orf2 RMP, NNX3, FLJ10575, URI, PPP1R19 19q12
PPP1R21 protein phosphatase 1, regulatory subunit 21 CCDC128, KLRAQ1 FLJ16566 2p16.3
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 FLJ20420, MINOS3, PPP1R22 7q33
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 MGC13016, PPP1R23, CHCM1 3q21.3
CSMD1 CUB and Sushi multiple domains 1 KIAA1890, PPP1R24 8p23.2
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 FLJ13633, FLJ23349, FLJ14578, PPP1R25 9q34.2
PPP1R26 protein phosphatase 1, regulatory subunit 26 KIAA0649 9q34.3
PPP1R27 protein phosphatase 1, regulatory subunit 27 DYSFIP1 toonin 17q25.3
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 PPP1R28 7p22.3
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 LRRC62, PPP1R29 dJ63G5.3, KIAA1904 22q13.1
GPATCH2 G patch domain containing 2 GPATC2 FLJ10252, CT110, PPP1R30 1q41
HYDIN HYDIN, axonemal central pair apparatus protein DKFZp434D0513, KIAA1864, PPP1R31, CILD5 16q22.2
PPP1R32 protein phosphatase 1, regulatory subunit 32 C11orf66 IIIG9, FLJ32771 11q12.2
KIAA1244 KIAA1244 C6orf92 dJ171N11.1, BIG3, PPP1R33 6q23.3
KIAA0430 KIAA0430 LKAP, PPP1R34, Marf1 16p13.11
PPP1R35 protein phosphatase 1, regulatory subunit 35 C7orf47 MGC22793 7q22.1
PPP1R36 protein phosphatase 1, regulatory subunit 36 C14orf50 14q23.2
PPP1R37 protein phosphatase 1, regulatory subunit 37 LRRC68 19q13.32
SH2D4A SH2 domain containing 4A FLJ20967, SH2A, PPP1R38 8p21
SH3RF2 SH3 domain containing ring finger 2 PPP1R39 FLJ23654, RNF158, Hepp1, POSHER 5q32
TRIM42 tripartite motif containing 42 FLJ40097, PPP1R40 3q23
PPP1R42 protein phosphatase 1, regulatory subunit 42 LRRC67 dtr, TLLR 8q13.1-q13.2
AKAP1 A kinase (PRKA) anchor protein 1 PRKA1 AKAP121, AKAP149, SAKAP84, S-AKAP84, AKAP84, D-AKAP1, PPP1R43, TDRD17 17q22
AKAP11 A kinase (PRKA) anchor protein 11 KIAA0629, AKAP220, PRKA11, FLJ11304, DKFZp781I12161, PPP1R44 13q
AKAP9 A kinase (PRKA) anchor protein 9 KIAA0803, AKAP350, AKAP450, CG-NAP, YOTIAO, HYPERION, PRKA9, MU-RMS-40.16A, PPP1R45, LQT11 7q21-q22
APC adenomatous polyposis coli DP2, DP3, DP2.5, PPP1R46 5q21-q22
AURKA aurora kinase A STK15, STK6 BTAK, AurA, STK7, ARK1, PPP1R47, AIK 20q13
AURKB aurora kinase B STK12 Aik2, IPL1, AurB, AIM-1, ARK2, STK5, PPP1R48 17p13.1
AXIN1 axin 1 PPP1R49 16p13.3
BCL2 B-cell CLL/lymphoma 2 Bcl-2, PPP1R50 18q21.3
BCL2L2 BCL2-like 2 KIAA0271, BCL-W, PPP1R51 14q11.2-q12
BCL2L1 BCL2-like 1 BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS, PPP1R52 20q11.21
BRCA1 breast cancer 1, early onset RNF53, BRCC1, PPP1R53 17q21.31
CASC1 cancer susceptibility candidate 1 LAS1, FLJ10921, PPP1R54 12p12.1
CASC5 cancer susceptibility candidate 5 D40, AF15Q14, CT29, hKNL-1, KNL1, hSpc105, PPP1R55, Spc7 15q14
CASP9 caspase 9, apoptosis-related cysteine peptidase MCH6, ICE-LAP6, APAF-3, PPP1R56 1p36.21
CASP2 caspase 2, apoptosis-related cysteine peptidase NEDD2 ICH1, PPP1R57, MGC2181 7q34-q35
DLG2 discs, large homolog 2 (Drosophila) PSD-93, PSD93, chapsyn-110, PPP1R58 11q21
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 LIN1, Snu40, PPP1R59 16p11.2
CDC25C cell division cycle 25C CDC25 PPP1R60 5q31
CENPE centromere protein E, 312kDa KIF10, PPP1R61 4q24-q25
CEP192 centrosomal protein 192kDa KIAA1569, FLJ10352, PPP1R62 18p11.21
CLCN7 chloride channel, voltage-sensitive 7 CLC-7, OPTA2, CLC7, ClC-7, PPP1R63 16p13
CNST consortin, connexin sorting protein C1orf71 FLJ32001, PPP1R64 1q44
DZIP3 DAZ interacting zinc finger protein 3 hRUL138, PPP1R66 3q13.13
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa EIF2 EIF2beta, PPP1R67 20q11.2
ELL elongation factor RNA polymerase II C19orf17 Men, ELL1, PPP1R68 19p13.1
ZFYVE16 zinc finger, FYVE domain containing 16 KIAA0305, PPP1R69 5q14.1
SH3GLB1 SH3-domain GRB2-like endophilin B1 CGI-61, KIAA0491, Bif-1, PPP1R70 1p22.3
PTK2 protein tyrosine kinase 2 FAK, FADK, FAK1, PPP1R71 8q24.3
CSRNP2 cysteine-serine-rich nuclear protein 2 C12orf22, FAM130A1 C12ORF2, TAIP-12, PPP1R72 12q13.11-q13.12
CSRNP3 cysteine-serine-rich nuclear protein 3 FAM130A2 FLJ32093, TAIP-2, PPP1R73 2q24.3
FER fer (fps/fes related) tyrosine kinase TYK3, PPP1R74 5q21
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) CDEP, PLEKHC2, MGC87400, PPP1R75 13q32.2
FKBP15 FK506 binding protein 15, 133kDa KIAA0674 PPP1R76, FKBP133, WAFL 9q33.1
ZCCHC9 zinc finger, CCHC domain containing 9 DKFZp761J139, PPP1R41 5q14.1

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Protein phosphatase 2, regulatory subunits:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha PR65A, PP2A-Aalpha 19q13
PPP2R1B protein phosphatase 2, regulatory subunit A, beta PR65B, PP2A-Abeta 11q23.1
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha PR52A, PR55A, B55A 8p21.2
PPP2R2B protein phosphatase 2, regulatory subunit B, beta SCA12 PR55-BETA, PR52B 5q32
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma PR52, IMYPNO, MGC33570, PR55G 4p16.1
PPP2R2D protein phosphatase 2, regulatory subunit B, delta MDS026 10q26.3
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha PPP2R3 3q22.2-q22.3
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta PPP2R3L PPP2R3LY, PR48 Xp22.3 and Yp11.3
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma C14orf10 FLJ20644, G4-1, G5PR 14q13.2
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 PTPA, PR53 9q34
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha PR61A, B56A 1q32.2-q32.3
PPP2R5B protein phosphatase 2, regulatory subunit B', beta FLJ35411, B56B, PR61B 11q12
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma B56G, PR61G 14q32.31
PPP2R5D protein phosphatase 2, regulatory subunit B', delta B56D 6p21.1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 14q23.2

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Protein phosphatase 3, regulatory subunits:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha CALNB1, CNB, CNB1 2p14
PPP3R2 protein phosphatase 3, regulatory subunit B, beta PPP3RL 9q31

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Protein phosphatase 4, regulatory subunits:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PPP4R1 protein phosphatase 4, regulatory subunit 1 PP4R1 18p11.22
PPP4R2 protein phosphatase 4, regulatory subunit 2 3q29
PPP4R4 protein phosphatase 4, regulatory subunit 4 KIAA1622 PP4R4, CFAP14 14q32.2

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Protein phosphatase 6, regulatory subunits:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PPP6R1 protein phosphatase 6, regulatory subunit 1 KIAA1115, SAPS1 SAP190 19q13.42
PPP6R2 protein phosphatase 6, regulatory subunit 2 KIAA0685, SAPS2 dJ579N16.1, SAP190 22q13.33
PPP6R3 protein phosphatase 6, regulatory subunit 3 C11orf23, SAPS3 SAPLa, DKFZp781E2374, DKFZp781O2362, DKFZp781E17107, SAP190, SAPL, PP6R3, FLJ11058, FLJ43065, KIAA1558, MGC125711, MGC125712 11q13
ANKRD28 ankyrin repeat domain 28 KIAA0379, PITK, PP6-ARS-A, PPP1R65 3p25.1
ANKRD44 ankyrin repeat domain 44 PP6-ARS-B 2q33.1
ANKRD52 ankyrin repeat domain 52 FLJ34236, PP6-ARS-C 12q13.3

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2. Protein phosphatases, Mg2+/Mn2+ dependent:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A MGC9201, PP2Calpha, PP2CA 14q23.1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B PPC2BETAX, PP2CB, PP2CBETA 2p22.1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D Wip1, PP2C-DELTA 17q23.3
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E POPX1, KIAA1072, PP2CH, CaMKP-N 17q24.2
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F FEM-2, KIAA0015, POPX2, CaMKPase, CAMKP 22q11.22
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G PP2CG, PP2Cgamma 2p23.3
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H ARHCL1 KIAA1157, FLJ13253, NERPP-2C 12q14.1
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J FLJ35951, MGC19531, DKFZp434P1514, PP2Czeta, PPP2CZ 1p13.1
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K DKFZp761G058, PP2Ckappa, hPTMP, PP2Cm, BDP 4q22.1
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L PP2CE 3q26.1
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M PP2Ceta, FLJ32332 3p21.31
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) FLJ40125 19q13.32
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 PPM2C PDP, PDH 8q22.1
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 KIAA1348, PPM2C2 16q22.1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 PLEKHE1, PHLPP KIAA0606, SCOP 18q21.32
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 PHLPPL KIAA0931 16q22.2
ILKAP integrin-linked kinase-associated serine/threonine phosphatase DKFZP434J2031, FLJ10181 2q37.3

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3. CTD aspartate-based protein phosphatases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CTDNEP1 CTD nuclear envelope phosphatase 1 DULLARD HSA011916, NET56 17p13
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 FCP1 18q23
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 NLIIF, SCP1 2q35
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 OS4, SCP2, PSR2 12q14.1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like C3orf8 HYA22, SCP3, PSR1, RBSP3 3p21.3
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 HSPC129, FLJ10523 15q15.3-q21.1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) TIM50L 19q13.2
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 MGC10067, CPUB1 5q33.3

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