Serine/threonine phosphatases

1. Protein phosphatase, catalytic and regulatory subunits

Protein phosphatase, catalytic subunits

Protein phosphatase 1, regulatory subunits

Protein phosphatase 2, regulatory subunits

Protein phosphatase 3, regulatory subunits

Protein phosphatase 4, regulatory subunits

Protein phosphatase 6, regulatory subunits

2. Protein phosphatases, Mg2+/Mn2+ dependent

3. CTD aspartate-based protein phosphatases

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1. Protein phosphatase, catalytic and regulatory subunits

Protein phosphatase, catalytic subunits:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	PPP1A	PP1A, PP-1A, PP1alpha	11q13
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme		PP1B, PP-1B, PP1beta	2p23
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme		PP1C, PP1gamma	12q24.1-q24.2
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme		PP2Calpha	5q31.1
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme		PP2Abeta	8p12
PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	CALN, CALNA	CNA1, PPP2B	4q24
PPP3CB	protein phosphatase 3, catalytic subunit, beta isozyme	CALNB	CALNA2, CNA2, PP2Bbeta	10q22.2
PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme		CALNA3, PP2Bgamma	8p21.3
PPP4C	protein phosphatase 4, catalytic subunit		PP4, PPX	16p11.2
PPP5C	protein phosphatase 5, catalytic subunit	PPP5	PP5	19q13.3
PPP6C	protein phosphatase 6, catalytic subunit		PP6	9q33.3
PPEF1	protein phosphatase, EF-hand calcium binding domain 1	PPEF	PPP7CA	Xp22
PPEF2	protein phosphatase, EF-hand calcium binding domain 2		PPP7CB	4q21.1

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Protein phosphatase 1, regulatory subunits:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
PPP1R1A	protein phosphatase 1, regulatory (inhibitor) subunit 1A			12q13.2
PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B		DARPP-32, FLJ20940	17q12
PPP1R1C	protein phosphatase 1, regulatory (inhibitor) subunit 1C		Inhibitor-1-like	2q31.3
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2		IPP2	3q29
PPP1R2P6	protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 6			7q34
PPP1R3A	protein phosphatase 1, regulatory subunit 3A	PPP1R3	GM	7q31.1
PPP1R3B	protein phosphatase 1, regulatory subunit 3B		GL, FLJ14005, PPP1R4	8p23.1
PPP1R3C	protein phosphatase 1, regulatory subunit 3C	PPP1R5	PTG	10q23-q24
PPP1R3D	protein phosphatase 1, regulatory subunit 3D	PPP1R6		20q13.3
PPP1R3E	protein phosphatase 1, regulatory subunit 3E		FLJ00089	14q11.2
PPP1R3F	protein phosphatase 1, regulatory subunit 3F		Hb2E	Xp11.23
PPP1R3G	protein phosphatase 1, regulatory subunit 3G			6p25.1
PPP1R7	protein phosphatase 1, regulatory subunit 7		sds22	2q37.3
PPP1R8	protein phosphatase 1, regulatory subunit 8		ard-1, NIPP-1, PRO2047, ARD1, NIPP1	1p35.3
PPP1R9A	protein phosphatase 1, regulatory subunit 9A		Neurabin-I, KIAA1222, FLJ20068	7q21.3
PPP1R9B	protein phosphatase 1, regulatory subunit 9B	PPP1R6, PPP1R9	Spn, SPINO	17q21.33
PPP1R10	protein phosphatase 1, regulatory subunit 10		PNUTS, FB19, CAT53, p99	6p21.3
PPP1R11	protein phosphatase 1, regulatory (inhibitor) subunit 11	TCTE5	HCGV, Tctex5, HCG-V	6p21.3
PPP1R12A	protein phosphatase 1, regulatory subunit 12A	MYPT1	MBS, M130	12q15-q21
PPP1R12B	protein phosphatase 1, regulatory subunit 12B	MYPT2	MGC87886, MGC131980, PP1bp55	1q32.1
PPP1R12C	protein phosphatase 1, regulatory subunit 12C	LENG3	DKFZP434D0412, p84, MBS85, p85	19q13.42
TP53BP2	tumor protein p53 binding protein, 2		PPP1R13A, ASPP2, 53BP2	1q41
PPP1R13B	protein phosphatase 1, regulatory subunit 13B		p53BP2-like, KIAA0771, p85, ASPP1	14q32.33
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	PPP1INL	CPI-17	19q13.1
PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B	PLCB3N	SOM172, PNG, PHI-1	11q13
PPP1R14C	protein phosphatase 1, regulatory (inhibitor) subunit 14C		CPI17-like, NY-BR-81, KEPI	6q24.3-q25.3
PPP1R14D	protein phosphatase 1, regulatory (inhibitor) subunit 14D		CPI17-like, FLJ20251, GBPI-1, MGC119014, MGC119016	15q11.2-q14
PPP1R15A	protein phosphatase 1, regulatory subunit 15A		GADD34	19q13.2
PPP1R15B	protein phosphatase 1, regulatory subunit 15B		FLJ14744	1q32.1
PPP1R16A	protein phosphatase 1, regulatory subunit 16A		MGC14333, MYPT3	8q24.3
PPP1R16B	protein phosphatase 1, regulatory subunit 16B		KIAA0823, TIMAP, ANKRD4	20q11.23
PPP1R17	protein phosphatase 1, regulatory subunit 17	C7orf16	GSBS	7p15
PPP1R18	protein phosphatase 1, regulatory subunit 18	KIAA1949	phostensin	6p21.3
URI1	URI1, prefoldin-like chaperone	C19orf2	RMP, NNX3, FLJ10575, URI, PPP1R19	19q12
CCDC8	coiled-coil domain containing 8		DKFZp564K0322, 3M3, PPP1R20	19q13.33
PPP1R21	protein phosphatase 1, regulatory subunit 21	CCDC128, KLRAQ1	FLJ16566	2p16.3
CHCHD3	coiled-coil-helix-coiled-coil-helix domain containing 3		FLJ20420, MINOS3, PPP1R22	7q33
CHCHD6	coiled-coil-helix-coiled-coil-helix domain containing 6		MGC13016, PPP1R23, CHCM1	3q21.3
CSMD1	CUB and Sushi multiple domains 1		KIAA1890, PPP1R24	8p23.2
DDX31	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31		FLJ13633, FLJ23349, FLJ14578, PPP1R25	9q34.2
PPP1R26	protein phosphatase 1, regulatory subunit 26	KIAA0649		9q34.3
PPP1R27	protein phosphatase 1, regulatory subunit 27	DYSFIP1	toonin	17q25.3
ELFN1	extracellular leucine-rich repeat and fibronectin type III domain containing 1	PPP1R28		7p22.3
ELFN2	extracellular leucine-rich repeat and fibronectin type III domain containing 2	LRRC62, PPP1R29	dJ63G5.3, KIAA1904	22q13.1
GPATCH2	G patch domain containing 2	GPATC2	FLJ10252, CT110, PPP1R30	1q41
HYDIN	HYDIN, axonemal central pair apparatus protein		DKFZp434D0513, KIAA1864, PPP1R31	16q22.2
PPP1R32	protein phosphatase 1, regulatory subunit 32	C11orf66	IIIG9, FLJ32771	11q12.2
KIAA1244	KIAA1244	C6orf92	dJ171N11.1, BIG3, PPP1R33	6q23.3
KIAA0430	KIAA0430		LKAP, PPP1R34, Marf1	16p13.11
PPP1R35	protein phosphatase 1, regulatory subunit 35	C7orf47	MGC22793	7q22.1
PPP1R36	protein phosphatase 1, regulatory subunit 36	C14orf50		14q23.2
PPP1R37	protein phosphatase 1, regulatory subunit 37	LRRC68		19q13.32
SH2D4A	SH2 domain containing 4A		FLJ20967, SH2A, PPP1R38	8p21
SH3RF2	SH3 domain containing ring finger 2	PPP1R39	FLJ23654, RNF158, Hepp1, POSHER	5q32
TRIM42	tripartite motif containing 42		FLJ40097, PPP1R40	3q23
PPP1R42	protein phosphatase 1, regulatory subunit 42	LRRC67	dtr, TLLR	8q13.1-q13.2
AKAP1	A kinase (PRKA) anchor protein 1	PRKA1	AKAP121, AKAP149, SAKAP84, S-AKAP84, AKAP84, D-AKAP1, PPP1R43, TDRD17	17q22
AKAP11	A kinase (PRKA) anchor protein 11		KIAA0629, AKAP220, PRKA11, FLJ11304, DKFZp781I12161, PPP1R44	13q
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9		KIAA0803, AKAP350, AKAP450, CG-NAP, YOTIAO, HYPERION, PRKA9, MU-RMS-40.16A, PPP1R45, LQT11	7q21-q22
APC	adenomatous polyposis coli		DP2, DP3, DP2.5, PPP1R46	5q21-q22
AURKA	aurora kinase A	STK15, STK6	BTAK, AurA, STK7, ARK1, PPP1R47, AIK	20q13
AURKB	aurora kinase B	STK12	Aik2, IPL1, AurB, AIM-1, ARK2, STK5, PPP1R48	17p13.1
AXIN1	axin 1		PPP1R49	16p13.3
BCL2	B-cell CLL/lymphoma 2		Bcl-2, PPP1R50	18q21.3
BCL2L2	BCL2-like 2		KIAA0271, BCL-W, PPP1R51	14q11.2-q12
BCL2L1	BCL2-like 1		BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS, PPP1R52	20q11.21
BRCA1	breast cancer 1, early onset		RNF53, BRCC1, PPP1R53	17q21.31
CASC1	cancer susceptibility candidate 1		LAS1, FLJ10921, PPP1R54	12p12.1
CASC5	cancer susceptibility candidate 5		D40, AF15Q14, CT29, hKNL-1, KNL1, hSpc105, PPP1R55	15q14
CASP9	caspase 9, apoptosis-related cysteine peptidase		MCH6, ICE-LAP6, APAF-3, PPP1R56	1p36.21
CASP2	caspase 2, apoptosis-related cysteine peptidase	NEDD2	ICH1, PPP1R57	7q34-q35
DLG2	discs, large homolog 2 (Drosophila)		PSD-93, PSD93, chapsyn-110, PPP1R58	11q21
CD2BP2	CD2 (cytoplasmic tail) binding protein 2		LIN1, Snu40, PPP1R59	16p11.2
CDC25C	cell division cycle 25C	CDC25	PPP1R60	5q31
CENPE	centromere protein E, 312kDa		KIF10, PPP1R61	4q24-q25
CEP192	centrosomal protein 192kDa		KIAA1569, FLJ10352, PPP1R62	18p11.21
CLCN7	chloride channel, voltage-sensitive 7		CLC-7, OPTA2, CLC7, ClC-7, PPP1R63	16p13
CNST	consortin, connexin sorting protein	C1orf71	FLJ32001, PPP1R64	1q44
DZIP3	DAZ interacting zinc finger protein 3		hRUL138, PPP1R66	3q13.13
EIF2S2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	EIF2	EIF2beta, PPP1R67	20q11.2
ELL	elongation factor RNA polymerase II	C19orf17	Men, ELL1, PPP1R68	19p13.1
ZFYVE16	zinc finger, FYVE domain containing 16		KIAA0305, PPP1R69	5q14.1
SH3GLB1	SH3-domain GRB2-like endophilin B1		CGI-61, KIAA0491, Bif-1, PPP1R70	1p22.3
PTK2	protein tyrosine kinase 2		FAK, FADK, FAK1, PPP1R71	8q24.3
CSRNP2	cysteine-serine-rich nuclear protein 2	C12orf22, FAM130A1	C12ORF2, TAIP-12, PPP1R72	12q13.11-q13.12
CSRNP3	cysteine-serine-rich nuclear protein 3	FAM130A2	FLJ32093, TAIP-2, PPP1R73	2q24.3
FER	fer (fps/fes related) tyrosine kinase		TYK3, PPP1R74	5q21
FARP1	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)		CDEP, PLEKHC2, MGC87400, PPP1R75	13q32.2
FKBP15	FK506 binding protein 15, 133kDa	KIAA0674	PPP1R76	9q33.1
ZCCHC9	zinc finger, CCHC domain containing 9		DKFZp761J139, PPP1R41	5q14.1

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Protein phosphatase 2, regulatory subunits:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha		PR65A, PP2A-Aalpha	19q13
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta		PR65B, PP2A-Abeta	11q23.1
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha		PR52A, PR55A, B55A	8p21.2
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	SCA12	PR55-BETA, PR52B	5q32
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma		PR52, IMYPNO, MGC33570, PR55G	4p16.1
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta		MDS026	10q26.3
PPP2R3A	protein phosphatase 2, regulatory subunit B'', alpha	PPP2R3		3q22.2-q22.3
PPP2R3B	protein phosphatase 2, regulatory subunit B'', beta	PPP2R3L	PPP2R3LY, PR48	Xp22.3 and Yp11.3
PPP2R3C	protein phosphatase 2, regulatory subunit B'', gamma	C14orf10	FLJ20644, G4-1, G5PR	14q13.2
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4		PTPA, PR53	9q34
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha		PR61A, B56A	1q32.2-q32.3
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta		FLJ35411, B56B, PR61B	11q12
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma		B56G, PR61G	14q32.31
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta		B56D	6p21.1
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform			14q23.2

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Protein phosphatase 3, regulatory subunits:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha		CALNB1, CNB, CNB1	2p14
PPP3R2	protein phosphatase 3, regulatory subunit B, beta		PPP3RL	9q31

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Protein phosphatase 4, regulatory subunits:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
PPP4R1	protein phosphatase 4, regulatory subunit 1		PP4R1	18p11.22
PPP4R2	protein phosphatase 4, regulatory subunit 2			3q29
PPP4R4	protein phosphatase 4, regulatory subunit 4	KIAA1622	PP4R4	14q32.2

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Protein phosphatase 6, regulatory subunits:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
PPP6R1	protein phosphatase 6, regulatory subunit 1	KIAA1115, SAPS1	SAP190	19q13.42
PPP6R2	protein phosphatase 6, regulatory subunit 2	KIAA0685, SAPS2	dJ579N16.1, SAP190	22q13.33
PPP6R3	protein phosphatase 6, regulatory subunit 3	C11orf23, SAPS3	SAPLa, DKFZp781E2374, DKFZp781O2362, DKFZp781E17107, SAP190, SAPL, PP6R3, FLJ11058, FLJ43065, KIAA1558, MGC125711, MGC125712	11q13
ANKRD28	ankyrin repeat domain 28		KIAA0379, PITK, PP6-ARS-A, PPP1R65	3p25.1
ANKRD44	ankyrin repeat domain 44		PP6-ARS-B	2q33.1
ANKRD52	ankyrin repeat domain 52		FLJ34236, PP6-ARS-C	12q13.3

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2. Protein phosphatases, Mg2+/Mn2+ dependent:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A		MGC9201, PP2Calpha, PP2CA	14q23.1
PPM1B	protein phosphatase, Mg2+/Mn2+ dependent, 1B		PPC2BETAX, PP2CB, PP2CBETA	2p22.1
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D		Wip1, PP2C-DELTA	17q23.3
PPM1E	protein phosphatase, Mg2+/Mn2+ dependent, 1E		POPX1, KIAA1072, PP2CH, CaMKP-N	17q24.2
PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F		FEM-2, KIAA0015, POPX2, CaMKPase, CAMKP	22q11.22
PPM1G	protein phosphatase, Mg2+/Mn2+ dependent, 1G		PP2CG, PP2Cgamma	2p23.3
PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H	ARHCL1	KIAA1157, FLJ13253, NERPP-2C	12q14.1
PPM1J	protein phosphatase, Mg2+/Mn2+ dependent, 1J		FLJ35951, MGC19531, DKFZp434P1514, PP2Czeta, PPP2CZ	1p13.1
PPM1K	protein phosphatase, Mg2+/Mn2+ dependent, 1K		DKFZp761G058, PP2Ckappa, hPTMP, PP2Cm, BDP	4q22.1
PPM1L	protein phosphatase, Mg2+/Mn2+ dependent, 1L		PP2CE	3q26.1
PPM1M	protein phosphatase, Mg2+/Mn2+ dependent, 1M		PP2Ceta, FLJ32332	3p21.31
PPM1N	protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)		FLJ40125	19q13.32
PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	PPM2C	PDP, PDH	8q22.1
PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2		KIAA1348, PPM2C2	16q22.1
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	PLEKHE1, PHLPP	KIAA0606, SCOP	18q21.32
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	PHLPPL	KIAA0931	16q22.2
ILKAP	integrin-linked kinase-associated serine/threonine phosphatase		DKFZP434J2031, FLJ10181	2q37.3

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3. CTD aspartate-based protein phosphatases:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
CTDNEP1	CTD nuclear envelope phosphatase 1	DULLARD	HSA011916, NET56	17p13
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1		FCP1	18q23
CTDSP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1		NLIIF, SCP1	2q35
CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2		OS4, SCP2, PSR2	12q14.1
CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	C3orf8	HYA22, SCP3, PSR1, RBSP3	3p21.3
CTDSPL2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2		HSPC129, FLJ10523	15q15.3-q21.1
TIMM50	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)		TIM50L	19q13.2
UBLCP1	ubiquitin-like domain containing CTD phosphatase 1		MGC10067, CPUB1	5q33.3

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