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Mitogen-activated protein kinase cascade

1. Mitogen-activated protein kinases [MAPK]
2. Mitogen-activated protein kinase kinases [MAP2K]
3. Mitogen-activated protein kinase kinase kinases [MAP3K]
4. Mitogen-activated protein kinase kinase kinase kinases [MAP4K]

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Mitogen-activated protein kinases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MAPK1 mitogen-activated protein kinase 1 PRKM2, PRKM1 ERK, ERK2, p41mapk, MAPK2 22q11.2
MAPK3 mitogen-activated protein kinase 3 PRKM3 ERK1, p44mapk, p44erk1 16p11.2
MAPK4 mitogen-activated protein kinase 4 PRKM4 Erk3-related, Erk4 18q21.1
MAPK6 mitogen-activated protein kinase 6 PRKM6 ERK3, p97MAPK, HsT17250 15q21
MAPK7 mitogen-activated protein kinase 7 PRKM7 BMK1, ERK5 17p11.2
MAPK8 mitogen-activated protein kinase 8 PRKM8 JNK, JNK1, SAPK1 10q11
MAPK9 mitogen-activated protein kinase 9 PRKM9 JNK2, p54a, SAPK 5q35
MAPK10 mitogen-activated protein kinase 10 PRKM10 JNK3, p493F12, p54bSAPK 4q22-q23
MAPK11 mitogen-activated protein kinase 11 PRKM11 p38-2, p38Beta, SAPK2 22q13.33
MAPK12 mitogen-activated protein kinase 12 SAPK3 ERK6, PRKM12, p38gamma, SAPK-3 22q13.3
MAPK13 mitogen-activated protein kinase 13 PRKM13 SAPK4, p38delta 6p21
MAPK14 mitogen-activated protein kinase 14 CSPB1, CSBP1, CSBP2 PRKM14, p38, Mxi2, PRKM15 6p21.3-p21.2
MAPK15 mitogen-activated protein kinase 15 ERK8, ERK7 8q24.3

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Mitogen-activated protein kinase kinases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MAP2K1 mitogen-activated protein kinase kinase 1 PRKMK1 MEK1, MAPKK1 15q22.1-q22.33
MAP2K2 mitogen-activated protein kinase kinase 2 PRKMK2 MEK2 19p13.3
MAP2K3 mitogen-activated protein kinase kinase 3 PRKMK3 MEK3, MKK3, MAPKK3 17q11.2
MAP2K4 mitogen-activated protein kinase kinase 4 SERK1 MEK4, JNKK1, PRKMK4, MKK4 17p12
MAP2K5 mitogen-activated protein kinase kinase 5 PRKMK5 MEK5, MAPKK5, HsT17454 15q22.31
MAP2K6 mitogen-activated protein kinase kinase 6 PRKMK6 MEK6, MKK6, SAPKK3, MAPKK6 17q
MAP2K7 mitogen-activated protein kinase kinase 7 PRKMK7 MKK7, Jnkk2 19p13.3-p13.2

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Mitogen-activated protein kinase kinase kinases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase MEKK1 MEKK, MAPKKK1 5q11.2
MAP3K2 mitogen-activated protein kinase kinase kinase 2 MEKK2 MEKK2B 2q21.1
MAP3K3 mitogen-activated protein kinase kinase kinase 3 MEKK3 MAPKKK3 17q
MAP3K4 mitogen-activated protein kinase kinase kinase 4 MEKK4 MTK1, MAPKKK4, KIAA0213 6q26
MAP3K5 mitogen-activated protein kinase kinase kinase 5 MEKK5 MAPKKK5, ASK1 6q22.33
MAP3K6 mitogen-activated protein kinase kinase kinase 6 MAPKKK6, ASK2, MEKK6 1p36.11
MAP3K7 mitogen-activated protein kinase kinase kinase 7 TAK1 MEKK7 6q15
MAP3K8 mitogen-activated protein kinase kinase kinase 8 COT, ESTF Tpl-2, EST, c-COT, MEKK8 10p11.2
MAP3K9 mitogen-activated protein kinase kinase kinase 9 MLK1 PRKE1, MEKK9 14q24.2
MAP3K10 mitogen-activated protein kinase kinase kinase 10 MLK2 MST, MEKK10 19q13.2
MAP3K11 mitogen-activated protein kinase kinase kinase 11 MLK3, PTK1 SPRK, MEKK11 11q13.1-q13.3
MAP3K12 mitogen-activated protein kinase kinase kinase 12 ZPK MUK, DLK, ZPKP1, MEKK12 12q13.13
MAP3K13 mitogen-activated protein kinase kinase kinase 13 LZK, MEKK13 3q27
MAP3K14 mitogen-activated protein kinase kinase kinase 14 NIK, HSNIK, FTDCR1B, HS 17q21.31
MAP3K15 mitogen-activated protein kinase kinase kinase 15 bA723P2.3, FLJ16518, ASK3 Xp22.12
MAP3K19 mitogen-activated protein kinase kinase kinase 19 YSK4 FLJ23074, RCK 2q21.3

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Mitogen-activated protein kinase kinase kinase kinases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 HPK1 19q13.1-q13.4
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 RAB8IP GCK, BL44 11q13.1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 RAB8IPL1 GLK, MAPKKKK3 2p22.3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 HGK, NIK, FLH21957 2q11.2-q12
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 KHS1, GCKR, KHS 14q11.2-q21

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