Mitogen-activated protein kinase cascade

1. Mitogen-activated protein kinases [MAPK]

2. Mitogen-activated protein kinase kinases [MAP2K]

3. Mitogen-activated protein kinase kinase kinases [MAP3K]

4. Mitogen-activated protein kinase kinase kinase kinases [MAP4K]

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Mitogen-activated protein kinases:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
MAPK1	mitogen-activated protein kinase 1	PRKM2, PRKM1	ERK, ERK2, p41mapk, MAPK2	22q11.2
MAPK3	mitogen-activated protein kinase 3	PRKM3	ERK1, p44mapk, p44erk1	16p11.2
MAPK4	mitogen-activated protein kinase 4	PRKM4	Erk3-related, Erk4	18q21.1
MAPK6	mitogen-activated protein kinase 6	PRKM6	ERK3, p97MAPK, HsT17250	15q21
MAPK7	mitogen-activated protein kinase 7	PRKM7	BMK1, ERK5	17p11.2
MAPK8	mitogen-activated protein kinase 8	PRKM8	JNK, JNK1, SAPK1	10q11
MAPK9	mitogen-activated protein kinase 9	PRKM9	JNK2, p54a, SAPK	5q35
MAPK10	mitogen-activated protein kinase 10	PRKM10	JNK3, p493F12, p54bSAPK	4q22-q23
MAPK11	mitogen-activated protein kinase 11	PRKM11	p38-2, p38Beta, SAPK2	22q13.33
MAPK12	mitogen-activated protein kinase 12	SAPK3	ERK6, PRKM12, p38gamma, SAPK-3	22q13.3
MAPK13	mitogen-activated protein kinase 13	PRKM13	SAPK4, p38delta	6p21
MAPK14	mitogen-activated protein kinase 14	CSPB1, CSBP1, CSBP2	PRKM14, p38, Mxi2, PRKM15	6p21.3-p21.2
MAPK15	mitogen-activated protein kinase 15		ERK8, ERK7	8q24.3

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Mitogen-activated protein kinase kinases:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
MAP2K1	mitogen-activated protein kinase kinase 1	PRKMK1	MEK1, MAPKK1	15q22.1-q22.33
MAP2K2	mitogen-activated protein kinase kinase 2	PRKMK2	MEK2	19p13.3
MAP2K3	mitogen-activated protein kinase kinase 3	PRKMK3	MEK3, MKK3, MAPKK3	17q11.2
MAP2K4	mitogen-activated protein kinase kinase 4	SERK1	MEK4, JNKK1, PRKMK4, MKK4	17p12
MAP2K5	mitogen-activated protein kinase kinase 5	PRKMK5	MEK5, MAPKK5, HsT17454	15q22.31
MAP2K6	mitogen-activated protein kinase kinase 6	PRKMK6	MEK6, MKK6, SAPKK3, MAPKK6	17q
MAP2K7	mitogen-activated protein kinase kinase 7	PRKMK7	MKK7, Jnkk2	19p13.3-p13.2

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Mitogen-activated protein kinase kinase kinases:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	MEKK1	MEKK, MAPKKK1	5q11.2
MAP3K2	mitogen-activated protein kinase kinase kinase 2	MEKK2	MEKK2B	2q21.1
MAP3K3	mitogen-activated protein kinase kinase kinase 3	MEKK3	MAPKKK3	17q
MAP3K4	mitogen-activated protein kinase kinase kinase 4	MEKK4	MTK1, MAPKKK4, KIAA0213	6q26
MAP3K5	mitogen-activated protein kinase kinase kinase 5	MEKK5	MAPKKK5, ASK1	6q22.33
MAP3K6	mitogen-activated protein kinase kinase kinase 6		MAPKKK6, ASK2, MEKK6	1p36.11
MAP3K7	mitogen-activated protein kinase kinase kinase 7	TAK1	MEKK7	6q15
MAP3K8	mitogen-activated protein kinase kinase kinase 8	COT, ESTF	Tpl-2, EST, c-COT, MEKK8	10p11.2
MAP3K9	mitogen-activated protein kinase kinase kinase 9	MLK1	PRKE1, MEKK9	14q24.2
MAP3K10	mitogen-activated protein kinase kinase kinase 10	MLK2	MST, MEKK10	19q13.2
MAP3K11	mitogen-activated protein kinase kinase kinase 11	MLK3, PTK1	SPRK, MEKK11	11q13.1-q13.3
MAP3K12	mitogen-activated protein kinase kinase kinase 12	ZPK	MUK, DLK, ZPKP1, MEKK12	12q13
MAP3K13	mitogen-activated protein kinase kinase kinase 13		LZK, MEKK13	3q27
MAP3K14	mitogen-activated protein kinase kinase kinase 14		NIK, HSNIK, FTDCR1B, HS	17q21-q22
MAP3K15	mitogen-activated protein kinase kinase kinase 15		bA723P2.3, FLJ16518	Xp22.12
MAP3K19	mitogen-activated protein kinase kinase kinase 19	YSK4	FLJ23074	2q21.3

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Mitogen-activated protein kinase kinase kinase kinases:

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1		HPK1	19q13.1-q13.4
MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	RAB8IP	GCK, BL44	11q13.1
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	RAB8IPL1	GLK, MAPKKKK3	2p22.3
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4		HGK, NIK, FLH21957	2q11.2-q12
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5		KHS1, GCKR, KHS	14q11.2-q21

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