Ligand-gated ion channels
| 1. 5-HT (serotonin) receptors, ionotropic | 5. Glycine receptors |
| 2. Acetylcholine receptors, nicotinic |
6. Purinergic receptors, ionotropic |
| 3. GABA(A) receptors |
7. Zinc-activated channels |
| 4. Glutamate receptors, ionotropic |
|
| For all Ion channels, see our Ion channels page |
External resources:
- Ligand-gated ion channels IUPHAR DATABASE HGNC approved
- Ligand-Gated Ion Channel database EMBL-EBI
Click on the Approved Gene Symbol to retrieve the complete gene record
5-HT (serotonin) receptors, ionotropic :
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| HTR3A | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | HTR3 | 5-HT3R, 5-HT3A | 11q23.1-q23.2 |
| HTR3B | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic | 5-HT3B | 11q23.1 | |
| HTR3C | 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic | 3q27 | ||
| HTR3D | 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic | 3q27 | ||
| HTR3E | 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic | 3q27 |
Click here to see all 5-HT (serotonin) receptors
Acetylcholine receptors, nicotinic :
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| CHRNA1 | cholinergic receptor, nicotinic, alpha 1 (muscle) | CHRNA | 2q31.1 | |
| CHRNA2 | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 8p21 | ||
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | 15q24 | ||
| CHRNA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) | EBN, EBN1 | BFNC | 20 |
| CHRNA5 | cholinergic receptor, nicotinic, alpha 5 (neuronal) | 15q24 | ||
| CHRNA6 | cholinergic receptor, nicotinic, alpha 6 (neuronal) | 8p22 | ||
| CHRNA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 15q13.3 | ||
| CHRNA9 | cholinergic receptor, nicotinic, alpha 9 (neuronal) | NACHRA9 | 4p14 | |
| CHRNA10 | cholinergic receptor, nicotinic, alpha 10 (neuronal) | 11p15.5 | ||
| CHRNB1 | cholinergic receptor, nicotinic, beta 1 (muscle) | CHRNB | 17p13.1 | |
| CHRNB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) | 1q21.3 | ||
| CHRNB3 | cholinergic receptor, nicotinic, beta 3 (neuronal) | 8p11.21 | ||
| CHRNB4 | cholinergic receptor, nicotinic, beta 4 (neuronal) | 15q24 | ||
| CHRND | cholinergic receptor, nicotinic, delta (muscle) | ACHRD | 2q37.1 | |
| CHRNE | cholinergic receptor, nicotinic, epsilon (muscle) | ACHRE | 17p13.2 | |
| CHRNG | cholinergic receptor, nicotinic, gamma (muscle) | ACHRG | 2q37.1 |
Click here to see all Cholinergic receptors
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| GABRA1 | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | EJM5 | 5q34 | |
| GABRA2 | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 4p12 | ||
| GABRA3 | gamma-aminobutyric acid (GABA) A receptor, alpha 3 | Xq28 | ||
| GABRA4 | gamma-aminobutyric acid (GABA) A receptor, alpha 4 | 4p12 | ||
| GABRA5 | gamma-aminobutyric acid (GABA) A receptor, alpha 5 | 15q12 | ||
| GABRA6 | gamma-aminobutyric acid (GABA) A receptor, alpha 6 | 5q34 | ||
| GABRB1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 | 4p12 | ||
| GABRB2 | gamma-aminobutyric acid (GABA) A receptor, beta 2 | 5q34 | ||
| GABRB3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 15q12 | ||
| GABRD | gamma-aminobutyric acid (GABA) A receptor, delta | 1p36.3 | ||
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | Xq28 | ||
| GABRG1 | gamma-aminobutyric acid (GABA) A receptor, gamma 1 | 4p12 | ||
| GABRG2 | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 5q34 | ||
| GABRG3 | gamma-aminobutyric acid (GABA) A receptor, gamma 3 | 15q12 | ||
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 5q35.1 | ||
| GABRQ | gamma-aminobutyric acid (GABA) A receptor, theta | THETA | Xq28 | |
| GABRR1 | gamma-aminobutyric acid (GABA) A receptor, rho 1 | 6q15 | ||
| GABRR2 | gamma-aminobutyric acid (GABA) A receptor, rho 2 | 6q15 | ||
| GABRR3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 | 3q12.2 |
Click here to see all GABA receptors
Glutamate receptors, ionotropic :
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| GRIA1 | glutamate receptor, ionotropic, AMPA 1 | GLUR1 | GluA1, GLURA | 5q33 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | GLUR2 | GluA2, GLURB | 4q32.1 |
| GRIA3 | glutamate receptor, ionotropic, AMPA 3 | GLUR3 | GluA3, GLURC, MRX94 | Xq25 |
| GRIA4 | glutamate receptor, ionotropic, AMPA 4 | GLUR4 | GluA4, GLURD | 11q22 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | GluD1, KIAA1220 | 10q22 | |
| GRID2 | glutamate receptor, ionotropic, delta 2 | GluD2, GluR-delta-2 | 4q22 | |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | GLUR5 | GluK1 | 21q22 |
| GRIK2 | glutamate receptor, ionotropic, kainate 2 | GLUR6 | GluK2, MRT6 | 6q16.3 |
| GRIK3 | glutamate receptor, ionotropic, kainate 3 | GluK3, GLUR7 | 1p34.3 | |
| GRIK4 | glutamate receptor, ionotropic, kainate 4 | GRIK | GluK4, KA1 | 11q23.3 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | GRIK2 | GluK5, KA2 | 19q13.2 |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | NMDAR1 | GluN1 | 9q34.3 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | NMDAR2A | GluN2A | 16p13.2 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | NMDAR2B | GluN2B | 12p12 |
| GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C | NMDAR2C | GluN2C | 17q25.1 |
| GRIN2D | glutamate receptor, ionotropic, N-methyl D-aspartate 2D | NMDAR2D | GluN2D, EB11, NR2D | 19q13.33 |
| GRIN3A | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | GluN3A | 9q31.1 | |
| GRIN3B | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | GluN3B | 19p13.3 |
Click here to see all Glutamate receptors
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| GLRA1 | glycine receptor, alpha 1 | STHE | 5q33.1 | |
| GLRA2 | glycine receptor, alpha 2 | GLR | Xp22.2 | |
| GLRA3 | glycine receptor, alpha 3 | 4q34.1 | ||
| GLRA4 | glycine receptor, alpha 4 | Xq22.2 |
Purinergic receptors, ionotropic :
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| P2RX1 | purinergic receptor P2X, ligand-gated ion channel, 1 | P2X1 | 17p13.3 | |
| P2RX2 | purinergic receptor P2X, ligand-gated ion channel, 2 | DFNA41 | P2X2 | 12q24.33 |
| P2RX3 | purinergic receptor P2X, ligand-gated ion channel, 3 | P2X3 | 11q12 | |
| P2RX4 | purinergic receptor P2X, ligand-gated ion channel, 4 | P2X4 | 12q24.32 | |
| P2RX5 | purinergic receptor P2X, ligand-gated ion channel, 5 | P2X5 | 17p13.3 | |
| P2RX6 | purinergic receptor P2X, ligand-gated ion channel, 6 | P2RXL1 | P2XM, MGC129625, P2X6 | 22q11.21 |
| P2RX7 | purinergic receptor P2X, ligand-gated ion channel, 7 | P2X7, MGC20089 | 12q24 |
Click here to see all Purinergic receptors
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| ZACN | zinc activated ligand-gated ion channel | LGICZ1 | LGICZ, L2, ZAC, ZAC1 | 17q25.3 |
