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Newer gene family pages are available

This is our older gene family page that is no longer maintained. Please go to our new look gene family index to view a complete list of our new maintained gene families. More information can be found in our gene families help page.

We have created a mapping file (Excel) that will map most of the old families to the new. However because we have changed the way we assign families and how we organise them, this file may not map all the old families.

Chromatin-modifying enzymes

Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell. 2007 Nov 16;131(4):633-6. PMID:18022353

1. K-demethylases
2. K-acetyltransferases
3. K-methyltransferases

Click on the Approved Gene Symbol to retrieve the complete gene record


Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KDM1A lysine demethylase 1A AOF2, KDM1 KIAA0601, BHC110, LSD1 1p36.12
KDM1B lysine demethylase 1B C6orf193, AOF1 FLJ34109, FLJ33898, dJ298J15.2, bA204B7.3, FLJ43328, LSD2 6p22.3
KDM2A lysine demethylase 2A FBXL11 KIAA1004, FBL11, LILINA, DKFZP434M1735, FBL7, FLJ00115, CXXC8, JHDM1A 11q13.2
KDM2B lysine demethylase 2B FBXL10 PCCX2, CXXC2, Fbl10, JHDM1B 12q24.31
KDM3A lysine demethylase 3A JMJD1, JMJD1A TSGA, KIAA0742, JHMD2A 2p11.2
KDM3B lysine demethylase 3B C5orf7, JMJD1B KIAA1082, NET22 5q31.2
KDM4A lysine demethylase 4A JMJD2, JMJD2A KIAA0677, JHDM3A, TDRD14A 1p34.2-p34.1
KDM4B lysine demethylase 4B JMJD2B KIAA0876, TDRD14B 19p13.3
KDM4C lysine demethylase 4C JMJD2C GASC1, KIAA0780, TDRD14C 9p24.1
KDM4D lysine demethylase 4D JMJD2D FLJ10251 11q21
KDM4E lysine demethylase 4E KDM4DL JMJD2E 11q21
KDM5A lysine demethylase 5A RBBP2, JARID1A 12p13.33
KDM5B lysine demethylase 5B JARID1B RBBP2H1A, PLU-1, CT31, PPP1R98 1q32.1
KDM5C lysine demethylase 5C SMCX, JARID1C, MRX13 DXS1272E, XE169 Xp11.22
KDM5D lysine demethylase 5D HYA, HY, SMCY, JARID1D KIAA0234 Yq11.223
KDM6A lysine demethylase 6A UTX Xp11.3
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked KDM6AL Yq11.221
KDM6B lysine demethylase 6B JMJD3 KIAA0346 17p13.1
KDM7A lysine demethylase 7A JHDM1D KIAA1718 7q34
PHF8 PHD finger protein 8 ZNF422, KIAA1111, JHDM1F Xp11.22
PHF2 PHD finger protein 2 KIAA0662, JHDM1E, CENP-35 9q22.31
KDM8 lysine demethylase 8 JMJD5 FLJ13798 16p12.1

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Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HAT1 histone acetyltransferase 1 KAT1 2q31.1
KAT2A lysine acetyltransferase 2A GCN5L2 GCN5, PCAF-b 17q21.2
KAT2B lysine acetyltransferase 2B PCAF P/CAF, GCN5, GCN5L 3p24.3
CREBBP CREB binding protein RSTS RTS, CBP, KAT3A 16p13.3
EP300 E1A binding protein p300 p300, KAT3B 22q13.2
TAF1 TATA-box binding protein associated factor 1 TAF2A, BA2R, CCG1, CCGS, DYT3 NSCL2, TAFII250, KAT4, DYT3/TAF1 Xq13.1
KAT5 lysine acetyltransferase 5 HTATIP TIP60, PLIP, cPLA2, HTATIP1, ESA1, ZC2HC5 11q13.1
KAT6A lysine acetyltransferase 6A ZNF220, RUNXBP2, MYST3 MOZ, ZC2HC6A 8p11.21
KAT6B lysine acetyltransferase 6B MYST4 querkopf, qkf, Morf, MOZ2, ZC2HC6B 10q22.2
KAT7 lysine acetyltransferase 7 MYST2 HBOA, HBO1, ZC2HC7 17q21.33
KAT8 lysine acetyltransferase 8 MYST1 MOF, FLJ14040, hMOF, ZC2HC8 16p11.2
ELP3 elongator acetyltransferase complex subunit 3 FLJ10422, KAT9 8p21.1
GTF3C4 general transcription factor IIIC subunit 4 TFIIIC90, KAT12 9q34.13
NCOA1 nuclear receptor coactivator 1 SRC1, F-SRC-1, NCoA-1, KAT13A, RIP160, bHLHe74 2p23.3
NCOA3 nuclear receptor coactivator 3 RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3 20q13.12
NCOA2 nuclear receptor coactivator 2 TIF2, GRIP1, NCoA-2, KAT13C, bHLHe75 8q13.3
CLOCK clock circadian regulator KIAA0334, KAT13D, bHLHe8 4q12

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Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SUV39H1 suppressor of variegation 3-9 homolog 1 SUV39H KMT1A Xp11.23
SUV39H2 suppressor of variegation 3-9 homolog 2 FLJ23414, KMT1B 10p13
EHMT2 euchromatic histone lysine methyltransferase 2 C6orf30, BAT8 G9A, Em:AF134726.3, NG36/G9a, KMT1C 6p21.33
EHMT1 euchromatic histone lysine methyltransferase 1 Eu-HMTase1, FLJ12879, KIAA1876, bA188C12.1, KMT1D 9q34.3
SETDB1 SET domain bifurcated 1 KG1T, KIAA0067, ESET, KMT1E, TDRD21 1q21.3
SETDB2 SET domain bifurcated 2 C13orf4 CLLD8, CLLL8, KMT1F 13q14.2
KMT2A lysine methyltransferase 2A MLL TRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A 11q23.3
KMT2B lysine methyltransferase 2B KIAA0304, MLL2, TRX2, HRX2, WBP7, MLL1B, MLL4, CXXC10 19q13.12
KMT2C lysine methyltransferase 2C MLL3 KIAA1506, HALR 7q36.1
KMT2D lysine methyltransferase 2D TNRC21, MLL2 ALR, MLL4, CAGL114 12q13.12
KMT2E lysine methyltransferase 2E MLL5 HDCMC04P 7q22.3
SETD1A SET domain containing 1A KIAA0339, Set1, KMT2F 16p11.2
SETD1B SET domain containing 1B KIAA1076, Set1B, KMT2G 12q24.31
ASH1L ASH1 like histone lysine methyltransferase huASH1, ASH1, ASH1L1, KMT2H 1q22
SETD2 SET domain containing 2 HYPB, HIF-1, KIAA1732, FLJ23184, KMT3A 3p21.31
NSD1 nuclear receptor binding SET domain protein 1 STO ARA267, FLJ22263, KMT3B 5q35.3
SMYD2 SET and MYND domain containing 2 HSKM-B, ZMYND14, KMT3C 1q32.3
SMYD1 SET and MYND domain containing 1 BOP, ZMYND22, KMT3D 2p11.2
SMYD3 SET and MYND domain containing 3 ZNFN3A1, ZMYND1 KMT3E 1q44
DOT1L DOT1 like histone lysine methyltransferase KIAA1814, DOT1, KMT4 19p13.3
KMT5A lysine methyltransferase 5A SETD8 SET8, SET07, PR-Set7 12q24.31
KMT5B lysine methyltransferase 5B SUV420H1 CGI-85 11q13.2
KMT5C lysine methyltransferase 5C SUV420H2 MGC2705 19q13.42
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit EZH1, ENX-1, KMT6, KMT6A 7q36.1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit KIAA0388, KMT6B 17q21.2
SETD7 SET domain containing lysine methyltransferase 7 KIAA1717, SET7, SET7/9, Set9, KMT7 4q31.1
PRDM2 PR/SET domain 2 RIZ, RIZ1, RIZ2, KMT8, MTB-ZF, HUMHOXY1 1p36.21

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