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Chromatin-modifying enzymes

Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell. 2007 Nov 16;131(4):633-6. PMID:18022353

1. K-demethylases
2. K-acetyltransferases
3. K-methyltransferases

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K-demethylases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KDM1A lysine (K)-specific demethylase 1A AOF2, KDM1 KIAA0601, BHC110, LSD1 1p36.12
KDM1B lysine (K)-specific demethylase 1B C6orf193, AOF1 FLJ34109, FLJ33898, dJ298J15.2, bA204B7.3, FLJ43328, LSD2 6p22.3
KDM2A lysine (K)-specific demethylase 2A FBXL11 KIAA1004, FBL11, LILINA, DKFZP434M1735, FBL7, FLJ00115, CXXC8, JHDM1A 11q13.1
KDM2B lysine (K)-specific demethylase 2B FBXL10 PCCX2, CXXC2, Fbl10, JHDM1B 12q24.31
KDM3A lysine (K)-specific demethylase 3A JMJD1, JMJD1A TSGA, KIAA0742, JHMD2A 2p11.2
KDM3B lysine (K)-specific demethylase 3B C5orf7, JMJD1B KIAA1082, NET22 5q31
KDM4A lysine (K)-specific demethylase 4A JMJD2, JMJD2A KIAA0677, JHDM3A, TDRD14A 1p34.1
KDM4B lysine (K)-specific demethylase 4B JMJD2B KIAA0876, TDRD14B 19p13.3
KDM4C lysine (K)-specific demethylase 4C JMJD2C GASC1, KIAA0780, TDRD14C 9p24-p23
KDM4D lysine (K)-specific demethylase 4D JMJD2D FLJ10251 11q21
KDM4E lysine (K)-specific demethylase 4E KDM4DL JMJD2E 11q21
KDM5A lysine (K)-specific demethylase 5A RBBP2, JARID1A 12p13.33
KDM5B lysine (K)-specific demethylase 5B JARID1B RBBP2H1A, PLU-1, CT31, PPP1R98 1q32.1
KDM5C lysine (K)-specific demethylase 5C SMCX, JARID1C, MRX13 DXS1272E, XE169 Xp11.22-p11.21
KDM5D lysine (K)-specific demethylase 5D HYA, HY, SMCY, JARID1D KIAA0234 Yq11
KDM6A lysine (K)-specific demethylase 6A UTX Xp11.2
KDM6B lysine (K)-specific demethylase 6B JMJD3 KIAA0346 17p13.1
KDM7A lysine (K)-specific demethylase 7A JHDM1D KIAA1718 7q34
PHF8 PHD finger protein 8 ZNF422, KIAA1111, JHDM1F Xp11.22
PHF2 PHD finger protein 2 KIAA0662, JHDM1E, CENP-35 9q22
KDM8 lysine (K)-specific demethylase 8 JMJD5 FLJ13798 16p12.1

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K-acetyltransferases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HAT1 histone acetyltransferase 1 KAT1 2q31.2-q33.1
KAT2A K(lysine) acetyltransferase 2A GCN5L2 GCN5, PCAF-b 17q12-q21
KAT2B K(lysine) acetyltransferase 2B PCAF P/CAF, GCN5, GCN5L 3p24
CREBBP CREB binding protein RSTS RTS, CBP, KAT3A 16p13.3
EP300 E1A binding protein p300 p300, KAT3B 22q13.2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa TAF2A, BA2R, CCG1, CCGS, DYT3 NSCL2, TAFII250, KAT4, DYT3/TAF1 Xq13.1
KAT5 K(lysine) acetyltransferase 5 HTATIP TIP60, PLIP, cPLA2, HTATIP1, ESA1, ZC2HC5 11q13
KAT6A K(lysine) acetyltransferase 6A ZNF220, RUNXBP2, MYST3 MOZ, ZC2HC6A 8p11
KAT6B K(lysine) acetyltransferase 6B MYST4 querkopf, qkf, Morf, MOZ2, ZC2HC6B 10q22.2
KAT7 K(lysine) acetyltransferase 7 MYST2 HBOA, HBO1, ZC2HC7 17q21.32
KAT8 K(lysine) acetyltransferase 8 MYST1 MOF, FLJ14040, hMOF, ZC2HC8 16p11.1
ELP3 elongator acetyltransferase complex subunit 3 FLJ10422, KAT9 8p21.1
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa TFIIIC90, KAT12 9q34.3
NCOA1 nuclear receptor coactivator 1 SRC1, F-SRC-1, NCoA-1, KAT13A, RIP160, bHLHe74 2p23
NCOA3 nuclear receptor coactivator 3 RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3 20q12
NCOA2 nuclear receptor coactivator 2 TIF2, GRIP1, NCoA-2, KAT13C, bHLHe75 8q13.3
CLOCK clock circadian regulator KIAA0334, KAT13D, bHLHe8 4q12

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K-methyltransferases:

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) SUV39H KMT1A Xp11.23
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) FLJ23414, KMT1B 10p13
EHMT2 euchromatic histone-lysine N-methyltransferase 2 C6orf30, BAT8 G9A, Em:AF134726.3, NG36/G9a, KMT1C 6p21.3
EHMT1 euchromatic histone-lysine N-methyltransferase 1 Eu-HMTase1, FLJ12879, KIAA1876, bA188C12.1, KMT1D 9q34.3
SETDB1 SET domain, bifurcated 1 KG1T, KIAA0067, ESET, KMT1E, TDRD21 1q21
SETDB2 SET domain, bifurcated 2 C13orf4 CLLD8, CLLL8, KMT1F 13q14
KMT2A lysine (K)-specific methyltransferase 2A MLL TRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A 11q23
KMT2B lysine (K)-specific methyltransferase 2B KIAA0304, MLL2, TRX2, HRX2, WBP7, MLL1B, MLL4 19q13.1
KMT2C lysine (K)-specific methyltransferase 2C MLL3 KIAA1506, HALR 7q36
KMT2D lysine (K)-specific methyltransferase 2D TNRC21, MLL2 ALR, MLL4, CAGL114 12q13.12
KMT2E lysine (K)-specific methyltransferase 2E MLL5 HDCMC04P 7q22.1
SETD1A SET domain containing 1A KIAA0339, Set1, KMT2F 16p11.2
SETD1B SET domain containing 1B KIAA1076, Set1B, KMT2G 12q24.31
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) huASH1, ASH1, ASH1L1, KMT2H 1q22
SETD2 SET domain containing 2 HYPB, HIF-1, KIAA1732, FLJ23184, KMT3A 3p21.31
NSD1 nuclear receptor binding SET domain protein 1 STO ARA267, FLJ22263, KMT3B 5q35
SMYD2 SET and MYND domain containing 2 HSKM-B, ZMYND14, KMT3C 1q32.3
SMYD1 SET and MYND domain containing 1 BOP, ZMYND22, KMT3D 2p11.1
SMYD3 SET and MYND domain containing 3 ZNFN3A1, ZMYND1 KMT3E 1q44
DOT1L DOT1-like histone H3K79 methyltransferase KIAA1814, DOT1, KMT4 19p13.3
SETD8 SET domain containing (lysine methyltransferase) 8 SET8, SET07, PR-Set7, KMT5A 12q24.31
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) CGI-85, KMT5B 11q13.2
SUV420H2 suppressor of variegation 4-20 homolog 2 (Drosophila) MGC2705, KMT5C 19q13.42
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit EZH1, ENX-1, KMT6, KMT6A 7q35-q36
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit KIAA0388, KMT6B 17q21.1-q21.3
SETD7 SET domain containing (lysine methyltransferase) 7 KIAA1717, SET7, SET7/9, Set9, KMT7 4q31.1
PRDM2 PR domain containing 2, with ZNF domain RIZ, RIZ1, RIZ2, KMT8, MTB-ZF, HUMHOXY1 1p36

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