Chromatin-modifying enzymes [KDM-KAT-KMT]
Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell. 2007 Nov 16;131(4):633-6. PMID:18022353
| 1. K-demethylases [KDM] |
| 2. K-acetyltransferases [KAT] |
| 3. K-methyltransferases [KMT] |
Click on the Approved Gene Symbol to retrieve the complete gene record
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| KDM1A | lysine (K)-specific demethylase 1A | AOF2, KDM1 | KIAA0601, BHC110, LSD1 | 1p36.12 |
| KDM1B | lysine (K)-specific demethylase 1B | C6orf193, AOF1 | FLJ34109, FLJ33898, dJ298J15.2, bA204B7.3, FLJ43328, LSD2 | 6p22.3 |
| KDM2A | lysine (K)-specific demethylase 2A | FBXL11 | KIAA1004, FBL11, LILINA, DKFZP434M1735, FBL7, FLJ00115, CXXC8, JHDM1A | 11q13.1 |
| KDM2B | lysine (K)-specific demethylase 2B | FBXL10 | PCCX2, CXXC2, Fbl10, JHDM1B | 12q24.31 |
| KDM3A | lysine (K)-specific demethylase 3A | JMJD1, JMJD1A | TSGA, KIAA0742, JHMD2A | 2p11.2 |
| KDM3B | lysine (K)-specific demethylase 3B | C5orf7, JMJD1B | KIAA1082, NET22 | 5q31 |
| KDM4A | lysine (K)-specific demethylase 4A | JMJD2, JMJD2A | KIAA0677, JHDM3A | 1p34.1 |
| KDM4B | lysine (K)-specific demethylase 4B | JMJD2B | KIAA0876 | 19p13.3 |
| KDM4C | lysine (K)-specific demethylase 4C | JMJD2C | GASC1, KIAA0780 | 9p24-p23 |
| KDM4D | lysine (K)-specific demethylase 4D | JMJD2D | FLJ10251 | 11q21 |
| KDM4E | lysine (K)-specific demethylase 4E | KDM4DL | JMJD2E | 11q21 |
| KDM5A | lysine (K)-specific demethylase 5A | RBBP2, JARID1A | 12p11 | |
| KDM5B | lysine (K)-specific demethylase 5B | JARID1B | RBBP2H1A, PLU-1, CT31 | 1q32.1 |
| KDM5C | lysine (K)-specific demethylase 5C | SMCX, JARID1C | DXS1272E, XE169 | Xp11.22-p11.21 |
| KDM5D | lysine (K)-specific demethylase 5D | HYA, HY, SMCY, JARID1D | KIAA0234 | Yq11 |
| KDM6A | lysine (K)-specific demethylase 6A | UTX | Xp11.2 | |
| KDM6B | lysine (K)-specific demethylase 6B | JMJD3 | KIAA0346 | 17p13.1 |
| JHDM1D | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) | KIAA1718 | 7q34 | |
| PHF8 | PHD finger protein 8 | ZNF422, KIAA1111, JHDM1F | Xp11.22 | |
| PHF2 | PHD finger protein 2 | KIAA0662, JHDM1E, CENP-35 | 9q22 | |
| KDM8 | lysine (K)-specific demethylase 8 | JMJD5 | FLJ13798 | 16p12.1 |
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| HAT1 | histone acetyltransferase 1 | KAT1 | 2q31.2-q33.1 | |
| KAT2A | K(lysine) acetyltransferase 2A | GCN5L2 | GCN5, PCAF-b | 17q12-q21 |
| KAT2B | K(lysine) acetyltransferase 2B | PCAF | P/CAF, GCN5, GCN5L | 3p24 |
| CREBBP | CREB binding protein | RSTS | RTS, CBP, KAT3A | 16p13.3 |
| EP300 | E1A binding protein p300 | p300, KAT3B | 22q13.2 | |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF2A, BA2R, CCG1, CCGS, DYT3 | NSCL2, TAFII250, KAT4, DYT3/TAF1 | Xq13.1 |
| KAT5 | K(lysine) acetyltransferase 5 | HTATIP | TIP60, PLIP, cPLA2, HTATIP1, ESA1 | 11q13 |
| KAT6A | K(lysine) acetyltransferase 6A | ZNF220, RUNXBP2, MYST3 | MOZ | 8p11 |
| KAT6B | K(lysine) acetyltransferase 6B | MYST4 | querkopf, qkf, Morf, MOZ2 | 10q22.2 |
| KAT7 | K(lysine) acetyltransferase 7 | MYST2 | HBOA, HBO1 | 17q21.32 |
| KAT8 | K(lysine) acetyltransferase 8 | MYST1 | MOF, FLJ14040, hMOF | 16p11.1 |
| ELP3 | elongation protein 3 homolog (S. cerevisiae) | FLJ10422, KAT9 | 8p21.1 | |
| GTF3C4 | general transcription factor IIIC, polypeptide 4, 90kDa | TFIIIC90, KAT12 | 9q34.3 | |
| NCOA1 | nuclear receptor coactivator 1 | SRC1, F-SRC-1, NCoA-1, KAT13A, RIP160, bHLHe74 | 2p23 | |
| NCOA3 | nuclear receptor coactivator 3 | RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3 | 20q12 | |
| NCOA2 | nuclear receptor coactivator 2 | TIF2, GRIP1, NCoA-2, KAT13C, bHLHe75 | 8q13.3 | |
| CLOCK | clock homolog (mouse) | KIAA0334, KAT13D, bHLHe8 | 4q12 |
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | SUV39H | KMT1A | Xp11.23 |
| SUV39H2 | suppressor of variegation 3-9 homolog 2 (Drosophila) | FLJ23414, KMT1B | 10p13 | |
| EHMT2 | euchromatic histone-lysine N-methyltransferase 2 | C6orf30, BAT8 | G9A, Em:AF134726.3, NG36/G9a, KMT1C | 6p21.3 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | Eu-HMTase1, FLJ12879, KIAA1876, bA188C12.1, KMT1D | 9 | |
| SETDB1 | SET domain, bifurcated 1 | KG1T, KIAA0067, ESET, KMT1E | 1q21 | |
| SETDB2 | SET domain, bifurcated 2 | C13orf4 | CLLD8, CLLL8, KMT1F | 13q14 |
| MLL | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | TRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A, KMT2A | 11q23 | |
| MLL3 | myeloid/lymphoid or mixed-lineage leukemia 3 | KIAA1506, HALR, KMT2C | 7q36 | |
| MLL2 | myeloid/lymphoid or mixed-lineage leukemia 2 | TNRC21 | ALR, MLL4, CAGL114, KMT2D | 12q13.12 |
| MLL5 | myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) | HDCMC04P, KMT2E | 7q22.1 | |
| SETD1A | SET domain containing 1A | KIAA0339, Set1, KMT2F | 16p11.2 | |
| SETD1B | SET domain containing 1B | KIAA1076, Set1B, KMT2G | 12q24.31 | |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | huASH1, ASH1, ASH1L1, KMT2H | 1q22 | |
| SETD2 | SET domain containing 2 | HYPB, HIF-1, KIAA1732, FLJ23184, KMT3A | 3p21.31 | |
| NSD1 | nuclear receptor binding SET domain protein 1 | STO | ARA267, FLJ22263, KMT3B | 5q35 |
| SMYD2 | SET and MYND domain containing 2 | HSKM-B, ZMYND14, KMT3C | 1q32.3 | |
| SMYD1 | SET and MYND domain containing 1 | BOP, ZMYND22, KMT3D | 2p11.1 | |
| SMYD3 | SET and MYND domain containing 3 | ZNFN3A1, ZMYND1 | KMT3E | 1q44 |
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | KIAA1814, DOT1, KMT4 | 19p13.3 | |
| SETD8 | SET domain containing (lysine methyltransferase) 8 | SET8, SET07, PR-Set7, KMT5A | 12q24.31 | |
| SUV420H1 | suppressor of variegation 4-20 homolog 1 (Drosophila) | CGI-85, KMT5B | 11q13.2 | |
| SUV420H2 | suppressor of variegation 4-20 homolog 2 (Drosophila) | MGC2705, KMT5C | 19q13.42 | |
| EZH2 | enhancer of zeste homolog 2 (Drosophila) | EZH1, ENX-1, KMT6, KMT6A | 7q35-q36 | |
| EZH1 | enhancer of zeste homolog 1 (Drosophila) | KIAA0388, KMT6B | 17q21.1-q21.3 | |
| SETD7 | SET domain containing (lysine methyltransferase) 7 | KIAA1717, SET7, SET7/9, Set9, KMT7 | 4q31.1 | |
| PRDM2 | PR domain containing 2, with ZNF domain | RIZ, RIZ1, RIZ2, KMT8, MTB-ZF, HUMHOXY1 | 1p36 |
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