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Newer gene family pages are available

This is our older gene family page that is no longer maintained. Please go to our new look gene family index to view a complete list of our new maintained gene families. More information can be found in our gene families help page.

We have created a mapping file (Excel) that will map most of the old families to the new. However because we have changed the way we assign families and how we organise them, this file may not map all the old families.

I-set domain containing

For all immunoglobulin domain categories, see the Immunoglobulin superfamily domain page

Click on the Approved Gene Symbol to retrieve the complete gene record

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ADAMTSL1 ADAMTS like 1 C9orf94 ADAMTSR1, FLJ35283 9p22.2-p22.1
ADAMTSL3 ADAMTS like 3 KIAA1233, punctin-2 15q25.2
ALPK2 alpha kinase 2 HAK 18q21.31-q21.32
ALPK3 alpha kinase 3 MAK, KIAA1330, Midori 15q25.3
TRIO trio Rho guanine nucleotide exchange factor ARHGEF23 5p15.2
KALRN kalirin, RhoGEF kinase HAPIP duo, Hs.8004, TRAD, DUET, Kalirin, ARHGEF24 3q21.1-q21.2
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF KIAA1556, UNC89, KIAA1639, ARHGEF30 1q42.13
BOC BOC cell adhesion associated, oncogene regulated CDON2 3q13.2
BSG basigin (Ok blood group) OK EMMPRIN, CD147 19p13.3
CADM2 cell adhesion molecule 2 IGSF4D NECL3, Necl-3, SynCAM2 3p12.1
CD101 CD101 molecule IGSF2 V7 1p13.1
CDON cell adhesion associated, oncogene regulated ORCAM, CDO, CDON1 11q24.2
CEACAM5 carcinoembryonic antigen related cell adhesion molecule 5 CEA CD66e 19q13.2
CEACAM20 carcinoembryonic antigen related cell adhesion molecule 20 UNQ9366 19q13.31
CHL1 cell adhesion molecule L1 like CALL, L1CAM2, FLJ44930, MGC132578 3p26.3
CLMP CXADR like membrane protein ASAM, FLJ22415, ACAM 11q24.1
CNTN1 contactin 1 F3, GP135 12q12
CNTN2 contactin 2 TAX, AXT TAG-1, TAX1 1q32.1
CNTN3 contactin 3 PANG BIG-1 3p12.3
CNTN4 contactin 4 BIG-2 3p26.3-p26.2
CNTN5 contactin 5 NB-2, hNB-2 11q22.1
CNTN6 contactin 6 NB-3 3p26.3
DSCAM DS cell adhesion molecule CHD2-42, CHD2-52 21q22.2
DSCAML1 DS cell adhesion molecule like 1 KIAA1132 11q23.3
EMB embigin MGC71745 5q11.1
HMCN1 hemicentin 1 ARMD1 FBLN6, FIBL6, FIBL-6 1q25.3-q31.1
HMCN2 hemicentin 2 DKFZp434P0216, FLJ23816 9q34.11
FGFR1 fibroblast growth factor receptor 1 FLT2, KAL2 H2, H3, H4, H5, CEK, FLG, BFGFR, N-SAM, CD331 8p11.23
FGFR2 fibroblast growth factor receptor 2 KGFR, BEK, CFD1, JWS CEK3, TK14, TK25, ECT1, K-SAM, CD332 10q26.13
FGFR3 fibroblast growth factor receptor 3 ACH CEK2, JTK4, CD333 4p16.3
FGFR4 fibroblast growth factor receptor 4 JTK2, CD334 5q35.2
FGFRL1 fibroblast growth factor receptor-like 1 4p16.3
FLT1 fms related tyrosine kinase 1 FLT VEGFR1 13q12.3
FLT4 fms related tyrosine kinase 4 VEGFR3, PCL 5q35.3
FSTL4 follistatin like 4 KIAA1061 5q31.1
FSTL5 follistatin like 5 DKFZp566D234, KIAA1263 4q32.2
ADGRF5 adhesion G protein-coupled receptor F5 GPR116 DKFZp564O1923, KIAA0758 6p12.3
ADGRA3 adhesion G protein-coupled receptor A3 GPR125 FLJ38547, PGR21 4p15.2
HEPACAM2 HEPACAM family member 2 FLJ38683 7q21.2
HSPG2 heparan sulfate proteoglycan 2 SJS1 perlecan, PRCAN 1p36.12
DCC DCC netrin 1 receptor IGDCC1, NTN1R1 18q21.2
NEO1 neogenin 1 NGN, HsT17534, IGDCC2, NTN1R2 15q24.1
IGDCC3 immunoglobulin superfamily DCC subclass member 3 PUNC HsT18880 15q22.31
IGDCC4 immunoglobulin superfamily DCC subclass member 4 NOPE, LOC57722 15q22.31
PRTG protogenin FLJ25756, IGDCC5 15q21.3
IGFBP7 insulin like growth factor binding protein 7 MAC25, IGFBP-7, PSF, FSTL2 4q12
IGFBPL1 insulin like growth factor binding protein like 1 bA113O24.1 9p13.1
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 DKFZp434B1231, EEF1A2BP1 1q32.1
OPCML opioid binding protein/cell adhesion molecule like OPCM, OBCAM, IGLON1 11q25
NTM neurotrimin HNT, NTRI, IGLON2 11q25
LSAMP limbic system-associated membrane protein LAMP, IGLON3 3q13.31
NEGR1 neuronal growth regulator 1 KILON, MGC46680, Ntra, IGLON4 1p31.1
IGSF5 immunoglobulin superfamily member 5 JAM4 21q22.2
IGSF9 immunoglobulin superfamily member 9 KIAA1355, Nrt1, IGSF9A 1q23.2
IGSF9B immunoglobulin superfamily member 9B KIAA1030 11q25
IGSF10 immunoglobulin superfamily member 10 FLJ25972, CMF608 3q25.1
IGSF11 immunoglobulin superfamily member 11 BT-IgSF, MGC35227, Igsf13, VSIG3, CT119 3q13.32
IGSF22 immunoglobulin superfamily member 22 FLJ37794, IGFN2 11p15.1
IL1R1 interleukin 1 receptor type 1 IL1R, IL1RA D2S1473, CD121A 2q11.2-q12.1
IL1RAPL1 interleukin 1 receptor accessory protein like 1 IL1RAPL, MRX34, MRX21, MRX10 OPHN4, TIGIRR-2, IL1R8 Xp21.3-p21.2
IL1RL1 interleukin 1 receptor like 1 ST2, FIT-1, ST2L, ST2V, DER4, T1, IL33R 2q12.1
ISLR immunoglobulin superfamily containing leucine rich repeat HsT17563 15q24.1
JAM2 junctional adhesion molecule 2 C21orf43 VE-JAM, JAM-B, JAMB, CD322 21q21.3
KAZALD1 Kazal type serine peptidase inhibitor domain 1 FKSG40, FKSG28 10q24.31
KDR kinase insert domain receptor FLK1, VEGFR, VEGFR2, CD309 4q12
KIRREL kin of IRRE like (Drosophila) NEPH1 1q23.1
KIRREL2 kin of IRRE like 2 (Drosophila) NLG1, NEPH3, FILTRIN, DKFZp564A1164, MGC15718 19q13.12
KIRREL3 kin of IRRE like 3 (Drosophila) NEPH2, KIAA1867, KIRRE 11q24.2
L1CAM L1 cell adhesion molecule HSAS1, SPG1, HSAS, MASA, MIC5, S10 CD171 Xq28
LINGO1 leucine rich repeat and Ig domain containing 1 LRRN6A FLJ14594, LERN1 15q24.3
LINGO2 leucine rich repeat and Ig domain containing 2 LRRN6C LERN3 9p21.2-p21.1
LINGO3 leucine rich repeat and Ig domain containing 3 LRRN6B LERN2 19p13.3
LINGO4 leucine rich repeat and Ig domain containing 4 LRRN6D 1q21.3
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 KIAA1484, SALM2 19q13.2
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 KIAA1246, SALM1 FIGLER2 6p21.2-p21.1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 MGC2656, SALM4, FIGLER1 19q13.13
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 MGC3103, SALM3., FIGLER6 11q13.1
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 C14orf146 FIGLER8, SALM5 14q21.1
LRIG1 leucine rich repeats and immunoglobulin like domains 1 LIG-1, DKFZP586O1624, LIG1 3p14.1
LRIG2 leucine rich repeats and immunoglobulin like domains 2 KIAA0806 1p13.2
LRIG3 leucine rich repeats and immunoglobulin like domains 3 FLJ90440, KIAA3016 12q14.1
LRIT1 leucine rich repeat, Ig-like and transmembrane domains 1 LRRC21 PAL, DKFZP434K091, FIGLER9 10q23.1
LRIT2 leucine rich repeat, Ig-like and transmembrane domains 2 LRRC22 AC022389.4 10q23.1
LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 FLJ44691, FIGLER4, CSNB1F 4q25
LRRC4 leucine rich repeat containing 4 NAG14 7q32.1
LRRC4B leucine rich repeat containing 4B LRIG4 DKFZp761A179, HSM 19q13.33
LRRC4C leucine rich repeat containing 4C KIAA1580, NGL-1 11p12
LRRC24 leucine rich repeat containing 24 LRRC14OS 8q24.3
LRRN1 leucine rich repeat neuronal 1 FIGLER3 3p26.2
LRRN2 leucine rich repeat neuronal 2 LRRN5 GAC1, LRANK1, FIGLER7 1q32.1
LRRN3 leucine rich repeat neuronal 3 NLRR3, FLJ11129, FIGLER5 7q31.1
MAG myelin associated glycoprotein GMA SIGLEC4A, SIGLEC-4A, S-MAG 19q13.1
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 GPIM, MAMDC3 6p21.2
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 MAMDC1 14q21.3
MERTK MER proto-oncogene, tyrosine kinase mer, RP38, c-Eyk, Tyro12 2q13
MFAP3 microfibrillar associated protein 3 5q33.2
MFAP3L microfibrillar associated protein 3 like KIAA0626, NYD-sp9 4q33
MUSK muscle associated receptor tyrosine kinase 9q31.3
MXRA5 matrix remodeling associated 5 DKFZp564I1922 Xp22.33
MYBPC1 myosin binding protein C, slow type 12q23.2
MYBPC2 myosin binding protein C, fast type MYBPCF, MYBPC, MGC163408 19q13.33
MYBPC3 myosin binding protein C, cardiac CMH4 MYBP-C, FHC 11p11.2
MYBPH myosin binding protein H 1q32.1
MYBPHL myosin binding protein H like 1p13.3
MYLK myosin light chain kinase MLCK, smMLCK, MYLK1, MLCK1 3q21.1
MYOM1 myomesin 1 18p11.31
MYOM2 myomesin 2 8p23.3
MYOM3 myomesin 3 FLJ35961 1p36.11
MYOT myotilin TTID, LGMD1A, LGMD1 5q31.2
MYPN myopalladin MYOP 10q21.3
NCAM1 neural cell adhesion molecule 1 NCAM, CD56 11q23.2
NCAM2 neural cell adhesion molecule 2 NCAM21, MGC51008 21q21.1
NEXN nexilin F-actin binding protein nexilin, NELIN 1p31.1
NFASC neurofascin NRCAML, KIAA0756, FLJ46866, NF 1q32.1
NPTN neuroplastin SDFR1 SDR1, GP55, GP65, np65, np55 15q24.1
NRCAM neuronal cell adhesion molecule KIAA0343, Bravo 7q31.1
NRG1 neuregulin 1 HGL, NRG1-IT2 HRG, NDF, GGF 8p12
NRG2 neuregulin 2 Don-1, NTAK, HRG2 5q31.2
NTRK2 neurotrophic receptor tyrosine kinase 2 TRKB 9q21.33
NTRK3 neurotrophic receptor tyrosine kinase 3 TRKC 15q25.3
OBSL1 obscurin like 1 KIAA0657 2q35
PALLD palladin, cytoskeletal associated protein KIAA0992, SIH002, CGI-151 4q32.3
PAPLN papilin, proteoglycan like sulfated glycoprotein MGC50452 14q24.2
PDGFRA platelet derived growth factor receptor alpha CD140a, PDGFR2, GAS9 4q12
PDGFRB platelet derived growth factor receptor beta PDGFR JTK12, CD140b, PDGFR1 5q32
PDGFRL platelet derived growth factor receptor like PRLTS 8p22
PTK7 protein tyrosine kinase 7 (inactive) CCK4 6p21.1
PTPRD protein tyrosine phosphatase, receptor type D PTPD, HPTP 9p24.1-p23
PTPRF protein tyrosine phosphatase, receptor type F LAR 1p34.2
PTPRM protein tyrosine phosphatase, receptor type M PTPRL1 RPTPU, hR-PTPu 18p11.23
PTPRS protein tyrosine phosphatase, receptor type S 19p13.3
NECTIN3 nectin cell adhesion molecule 3 PVRL3 nectin-3, PPR3, PVRR3, DKFZP566B0846, CDw113, CD113 3q13.13
PXDN peroxidasin KIAA0230, PRG2, MG50, D2S448, D2S448E, PXN 2p25.3
PXDNL peroxidasin like FLJ25471, PMR1 8q11.22-q11.23
ROBO1 roundabout guidance receptor 1 DUTT1, FLJ21882, SAX3 3p12.3
ROBO2 roundabout guidance receptor 2 KIAA1568 3p12.3
ROBO3 roundabout guidance receptor 3 HGPPS RBIG1, FLJ21044, HGPS 11q24.2
ROBO4 roundabout guidance receptor 4 FLJ20798, MRB, ECSM4 11q24.2
ROR1 receptor tyrosine kinase like orphan receptor 1 NTRKR1 1p31.3
ROR2 receptor tyrosine kinase like orphan receptor 2 NTRKR2, BDB, BDB1 9q22.31
SDK1 sidekick cell adhesion molecule 1 FLJ31425 7p22.2
SDK2 sidekick cell adhesion molecule 2 FLJ10832, KIAA1514 17q25.1
SEMA3C semaphorin 3C SEMAE SemE 7q21.11
SIGLEC1 sialic acid binding Ig like lectin 1 SN SIGLEC-1, CD169, FLJ00051, FLJ00055, FLJ00073, FLJ32150, dJ1009E24.1, sialoadhesin 20p13
SIGLEC6 sialic acid binding Ig like lectin 6 CD33L, CD33L1 OB-BP1, SIGLEC-6, CD327 19q13.41
SIGLEC11 sialic acid binding Ig like lectin 11 19q13.33
SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) SIGLECL1 SLG, S2V, Siglec-XII, Siglec-12, Siglec-L1 19q13.41
SIGLEC16 sialic acid binding Ig like lectin 16 (gene/pseudogene) SIGLECP16 Siglec-P16 19q13.33
SPEG SPEG complex locus APEG1 MGC12676, KIAA1297, SPEGalpha, SPEGbeta, BPEG 2q35
TMIGD1 transmembrane and immunoglobulin domain containing 1 TMIGD UNQ9372 17q11.2
TTN titin CMD1G CMPD4, FLJ32040, TMD, CMH9, LGMD2J, MYLK5 2q31.2
TYRO3 TYRO3 protein tyrosine kinase RSE Dtk, Brt, Tif, Sky, Etk-2, Rek 15q15.1
UNC5A unc-5 netrin receptor A KIAA1976, UNC5H1 5q35.2
UNC5B unc-5 netrin receptor B UNC5H2, p53RDL1 10q22.1
UNC5C unc-5 netrin receptor C 4q22.3
UNC5D unc-5 netrin receptor D KIAA1777, Unc5h4 8p12
VCAM1 vascular cell adhesion molecule 1 CD106 1p21.2
VSIG2 V-set and immunoglobulin domain containing 2 CTXL, CTH 11q24.2
VSIG10 V-set and immunoglobulin domain containing 10 12q24.23
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 C16orf12 RJD2, WFIKKN, WFDC20A 16p13.3
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 WFIKKNRP, WFDC20B 17q21.33

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