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Intermediate filaments

Intermediate Filament Families:

External resource: Human Intermediate Filament Database

Click on the Approved Gene Symbol to retrieve the complete gene record

Type I. Keratins (acidic)

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome Specialist Database Links
KRT9 keratin 9 EPPK, K9, CK-9 17q21.2 Intermediate Filament DB COSMIC Orphanet
KRT10 keratin 10 KPP K10, CK10 17q21.2 Intermediate Filament DB COSMIC Orphanet
KRT12 keratin 12 K12 17q21.2 Intermediate Filament DB COSMIC Orphanet
KRT13 keratin 13 K13, CK13, MGC3781, MGC161462 17q21.2 Intermediate Filament DB COSMIC Orphanet
KRT14 keratin 14 EBS3, EBS4 17q21.2 Intermediate Filament DB COSMIC Orphanet
KRT15 keratin 15 K15, CK15, K1CO 17q21.2 Intermediate Filament DB COSMIC
KRT16 keratin 16 NEPPK 17q21.2 Intermediate Filament DB COSMIC Orphanet
KRT17 keratin 17 PCHC1 17q21.2 Intermediate Filament DB COSMIC Orphanet
KRT18 keratin 18 12q13 Intermediate Filament DB COSMIC
KRT19 keratin 19 K19, CK19, K1CS, MGC15366 17q21.2 Intermediate Filament DB COSMIC
KRT20 keratin 20 CK20, K20, MGC35423 17q21.2 Intermediate Filament DB COSMIC
KRT23 keratin 23 (histone deacetylase inducible) K23, DKFZP434G032, HAIK1, CK23, MGC26158 17q21.2 Intermediate Filament DB COSMIC
KRT24 keratin 24 FLJ20261, MGC138169, MGC138173 17q21.2 Intermediate Filament DB COSMIC
KRT25 keratin 25 KRT25A 17q21.2 Intermediate Filament DB COSMIC
KRT26 keratin 26 KRT25B 17q21.2 Intermediate Filament DB COSMIC
KRT27 keratin 27 KRT25C 17q21.2 Intermediate Filament DB COSMIC
KRT28 keratin 28 KRT25D 17q21.2 Intermediate Filament DB COSMIC
KRT31 keratin 31 KRTHA1 Ha-1 17q21.2 Intermediate Filament DB COSMIC
KRT32 keratin 32 KRTHA2 Ha-2 17q21.2 Intermediate Filament DB COSMIC
KRT33A keratin 33A KRTHA3A Ha-3I, Krt1-3 17q21.2 Intermediate Filament DB COSMIC
KRT33B keratin 33B KRTHA3B Ha-3II 17q21.2 Intermediate Filament DB COSMIC
KRT34 keratin 34 KRTHA4 Ha-4 17q21.2 Intermediate Filament DB COSMIC
KRT35 keratin 35 KRTHA5 Ha-5 17q21.2 Intermediate Filament DB COSMIC
KRT36 keratin 36 KRTHA6 17q21.2 Intermediate Filament DB COSMIC
KRT37 keratin 37 KRTHA7 17q21.2 Intermediate Filament DB COSMIC
KRT38 keratin 38 KRTHA8 17q21.2 Intermediate Filament DB COSMIC
KRT39 keratin 39 KA35 17q21.2 Intermediate Filament DB COSMIC
KRT40 keratin 40 FLJ36600, KA36 17q21.2 Intermediate Filament DB COSMIC

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Type II. Keratins (basic)

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome Specialist Database Links
KRT1 keratin 1 EHK1 KRT1A 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT2 keratin 2 KRT2A KRTE 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT3 keratin 3 CK3, K3 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT4 keratin 4 CYK4 CK4, K4 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT5 keratin 5 EBS2 KRT5A 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT6A keratin 6A KRT6C, KRT6D CK6C, K6C, CK6D, K6D 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT6B keratin 6B KRTL1 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT6C keratin 6C KRT6E 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT7 keratin 7 K7, CK7, K2C7, SCL 12q13.13 Intermediate Filament DB COSMIC
KRT8 keratin 8 CARD2, K8, CK8, CYK8, K2C8, KO 12q13.13 Intermediate Filament DB COSMIC
KRT71 keratin 71 KRT6IRS, KRT6IRS1, K6IRS1 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT72 keratin 72 K6IRS2, KRT6IRS2, KRT6, K6irs 12q13.13 Intermediate Filament DB COSMIC
KRT73 keratin 73 KRT6IRS3, K6IRS3 12q13.13 Intermediate Filament DB COSMIC
KRT74 keratin 74 K6IRS4, KRT5C, KRT6IRS4 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT75 keratin 75 K6HF 12q13.13 Intermediate Filament DB COSMIC
KRT76 keratin 76 HUMCYT2A, KRT2B, KRT2P 12q13.13 Intermediate Filament DB COSMIC
KRT77 keratin 77 KRT1B 12q13.13 Intermediate Filament DB COSMIC
KRT78 keratin 78 K5B 12q13.13 Intermediate Filament DB COSMIC
KRT79 keratin 79 K6L, KRT6L 12q13.13 COSMIC
KRT80 keratin 80 KB20 12q13.13 Intermediate Filament DB COSMIC
KRT81 keratin 81 KRTHB1 Hb-1 12q13 Intermediate Filament DB COSMIC Orphanet
KRT82 keratin 82 KRTHB2 Hb-2 12q13 Intermediate Filament DB COSMIC
KRT83 keratin 83 KRTHB3 Hb-3 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT84 keratin 84 KRTHB4 Hb-4 12q13 Intermediate Filament DB COSMIC
KRT85 keratin 85 KRTHB5 Hb-5 12q13.13 Intermediate Filament DB COSMIC Orphanet
KRT86 keratin 86 KRTHB6 MNX, Hb6 12q13 Intermediate Filament DB COSMIC Orphanet

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Type III.

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome Specialist Database Links
DES desmin CMD1I, CSM1, CSM2 2q35 Intermediate Filament DB COSMIC Orphanet
GFAP glial fibrillary acidic protein FLJ45472 17q21 Intermediate Filament DB COSMIC Orphanet
PRPH peripherin NEF4 PRPH1 12q12-q13 Intermediate Filament DB COSMIC Orphanet
SYNC syncoilin, intermediate filament protein SYNC1 SYNCOILIN 1p35.1 Intermediate Filament DB COSMIC
VIM vimentin 10p13 Intermediate Filament DB COSMIC Orphanet

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Type IV. 

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome Specialist Database Links
INA internexin neuronal intermediate filament protein, alpha NEF5 NF-66 10q24 Intermediate Filament DB COSMIC
NEFH neurofilament, heavy polypeptide 22q12.2 Intermediate Filament DB COSMIC Orphanet
NEFL neurofilament, light polypeptide NFL, CMT1F, CMT2E, NF68, PPP1R110 8p21.2 Intermediate Filament DB COSMIC Orphanet
NEFM neurofilament, medium polypeptide NEF3 NFM, NF-M 8p21 Intermediate Filament DB COSMIC
NES nestin FLJ21841 1q23 Intermediate Filament DB COSMIC
SYNM synemin, intermediate filament protein DMN KIAA0353, SYN 15q26.3 Intermediate Filament DB COSMIC

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Type V. Lamins

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome Specialist Database Links
LMNA lamin A/C LMN1, CMD1A, LGMD1B, PRO1, LMNL1 HGPS 1q22 Intermediate Filament DB COSMIC Orphanet
LMNB1 lamin B1 5q23.2 Intermediate Filament DB COSMIC Orphanet
LMNB2 lamin B2 LMN2 19p13.3 Intermediate Filament DB COSMIC Orphanet

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Type VI. Eye lens intermediate filaments

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome Specialist Database Links
BFSP1 beaded filament structural protein 1, filensin CP94, CP115, LIFL-H, filensin 20p12.1 Intermediate Filament DB COSMIC Orphanet
BFSP2 beaded filament structural protein 2, phakinin CP47, CP49, LIFL-L, phakinin 3q22.1 Intermediate Filament DB COSMIC Orphanet

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Intermediate filament family orphans.

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome Specialist Database Links
IFFO1 intermediate filament family orphan 1 IFFO HOM-TES-103 12p13.31 COSMIC
IFFO2 intermediate filament family orphan 2 1p36.13 COSMIC

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