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Heat shock proteins

Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones. 2009 Jan;14(1):105-11. PMID:18663603

1. HSP70
2. DNAJ (HSP40) specialist advisor 
3. HSPB (small heat shock proteins)
4. HSPC (HSP90)
5. Chaperonins

Click on the Approved Gene Symbol to retrieve the complete gene record

1. HSP70 :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSPA1A heat shock protein family A (Hsp70) member 1A HSPA1 HSP70-1 6p21.3
HSPA1B heat shock protein family A (Hsp70) member 1B HSP70-2 6p21.3
HSPA1L heat shock protein family A (Hsp70) member 1 like HSP70-HOM, hum70t 6p21.3
HSPA2 heat shock protein family A (Hsp70) member 2 14q23
HSPA4 heat shock protein family A (Hsp70) member 4 HS24/P52, HSPH2 5q31.1
HSPA4L heat shock protein family A (Hsp70) member 4 like APG-1, Osp94, HSPH3 4q28
HSPA5 heat shock protein family A (Hsp70) member 5 GRP78 BiP 9q33.3
HSPA6 heat shock protein family A (Hsp70) member 6 HSP70B' 1q23.3
HSPA7 heat shock protein family A (Hsp70) member 7 HSP70B 1q23.3
HSPA8 heat shock protein family A (Hsp70) member 8 HSPA10 HSC71, HSC70, HSP73 11q24.1
HSPA9 heat shock protein family A (Hsp70) member 9 HSPA9B GRP75, PBP74, mot-2, mthsp75 5q31.1
HSPA12A heat shock protein family A (Hsp70) member 12A FLJ13874, KIAA0417 10q25.3
HSPA12B heat shock protein family A (Hsp70) member 12B C20orf60 dJ1009E24.2 20p13
HSPA13 heat shock protein family A (Hsp70) member 13 STCH 21q11.1
HSPA14 heat shock protein family A (Hsp70) member 14 HSP70-4, HSP70L1 10p13
HSPH1 heat shock protein family H (Hsp110) member 1 HSP105B, KIAA0201, HSP105A, NY-CO-25 13q12.3
HYOU1 hypoxia up-regulated 1 ORP150, HSP12A, Grp170 11q23.1-q23.3

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2. DNAJ (HSP40) :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 HSJ2 HSPF4, hdj-2, dj-2, NEDD7 9p13.3
DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 HIRIP4, DNAJ, CPR3, DNJ3 16q12.1
DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 TID1 hTid-1 16p13.3
DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 PRO1472 15q24.1
DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 HSPF1 Hsp40, Sis1, RSPH16B 19p13.12
DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 HSJ1 HSPF3, CMT2T 2q35
DNAJB3 DnaJ heat shock protein family (Hsp40) member B3 HCG3 2q37
DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 HLJ1 1p31.1
DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 Hsc40 9p
DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 LGMD1D MRJ 7q36.3
DNAJB7 DnaJ heat shock protein family (Hsp40) member B7 HSC3 22q13.2
DNAJB8 DnaJ heat shock protein family (Hsp40) member B8 MGC33884, CT156 3q21.3
DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 MDG1 7q31
DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 EDJ, HEDJ, ERdj3 3q27
DNAJB12 DnaJ heat shock protein family (Hsp40) member B12 DJ10, FLJ20027 10q22
DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 TSARG6, RSPH16A 11q13.3
DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 FLJ14281 4q23
DNAJC1 DnaJ heat shock protein family (Hsp40) member C1 DNAJL1, ERdj1, MTJ1 10p11.23
DNAJC2 DnaJ heat shock protein family (Hsp40) member C2 ZRF1 MPP11, MPHOSPH11, ZUO1, zuotin 7q22-q32
DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 PRKRI P58, P58IPK, HP58, ERdj6 13q32
DNAJC4 DnaJ heat shock protein family (Hsp40) member C4 HSPF2 MCG18 11q13
DNAJC5 DnaJ heat shock protein family (Hsp40) member C5 CLN4 FLJ00118, FLJ13070, DNAJC5A 20q13.33
DNAJC5B DnaJ heat shock protein family (Hsp40) member C5 beta MGC26226, CSP-beta 8q13.1
DNAJC5G DnaJ heat shock protein family (Hsp40) member C5 gamma FLJ40417, CSP-gamma 2p23
DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 KIAA0473, PARK19 1p31.3
DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 TTC2 TPR2 17q21.2
DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 SPF31 1p35
DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 JDD1, SB73 10q22.3
DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 FLJ10737 1p36.23
DNAJC12 DnaJ heat shock protein family (Hsp40) member C12 JDP1 10q21.3
DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 RME8, KIAA0678 3q22.1
DNAJC14 DnaJ heat shock protein family (Hsp40) member C14 DNAJ, DRIP78, HDJ3, LIP6, FLJ32792 12q12
DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 DNAJD1 MCJ 13q14.1
DNAJC16 DnaJ heat shock protein family (Hsp40) member C16 KIAA0962 1p36.1
DNAJC17 DnaJ heat shock protein family (Hsp40) member C17 FLJ10634 15q15.1
DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 MGC29463 5q31.2
DNAJC19 DnaJ heat shock protein family (Hsp40) member C19 TIMM14, Tim14, Pam18 3q26.33
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone HSC20, DNAJC20, Jac1 22q12.1
DNAJC21 DnaJ heat shock protein family (Hsp40) member C21 GS3, DNAJA5, JJJ1 5p13.2
DNAJC22 DnaJ heat shock protein family (Hsp40) member C22 wus, FLJ13236 12q13.12
SEC63 SEC63 homolog, protein translocation regulator SEC63L, PRO2507, ERdj2, DNAJC23 6q21
DNAJC24 DnaJ heat shock protein family (Hsp40) member C24 ZCSL3, DPH4 JJJ3 11p14.1
DNAJC25 DnaJ heat shock protein family (Hsp40) member C25 bA16L21.2.1 9q31.3
GAK cyclin G associated kinase DNAJC26 4p16
DNAJC27 DnaJ heat shock protein family (Hsp40) member C27 RBJ RabJS 2p23.3
DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 C21orf55 C21orf78 21q22.11
SACS sacsin molecular chaperone ARSACS, KIAA0730, DKFZp686B15167, DNAJC29, SPAX6, PPP1R138 13q11
DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 WBSCR18 7q11.23
DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 ERdj5, PDIA19 2q32.1

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3. HSPB (small heat shock proteins) :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSPB1 heat shock protein family B (small) member 1 HSP27, HSP28, Hs.76067, Hsp25, CMT2F 7q11.23
HSPB2 heat shock protein family B (small) member 2 Hs.78846, MKBP 11q23.1
HSPB3 heat shock protein family B (small) member 3 HSPL27 5q11.2
CRYAA crystallin alpha A CRYA1 HSPB4 21q22.3
CRYAB crystallin alpha B CRYA2 HSPB5 11q23.1
HSPB6 heat shock protein family B (small) member 6 FLJ32389, Hsp20, PPP1R91 19q13.13
HSPB7 heat shock protein family B (small) member 7 cvHSP 1p36.13
HSPB8 heat shock protein family B (small) member 8 H11, E2IG1, HSP22, HspB8, CMT2L 12q24.23
HSPB9 heat shock protein family B (small) member 9 CT51 17q21.2
ODF1 outer dense fiber of sperm tails 1 ODFPG, ODF27, RT7, HSPB10, CT133 8q22
HSPB11 heat shock protein family B (small) member 11 C1orf41 HSPCO34, PP25, IFT25 1p32

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4. HSPC (HSP90) :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSP90AA1 heat shock protein 90kDa alpha family class A member 1 HSPC1, HSPCA Hsp89, Hsp90, FLJ31884, HSP90N 14q32.33
HSP90AA3P heat shock protein 90kDa alpha family class A member 3, pseudogene HSPCAL1 1q23.1
HSP90AB1 heat shock protein 90kDa alpha family class B member 1 HSPC2, HSPCB 6p12
HSP90B1 heat shock protein 90kDa beta family member 1 TRA1 GP96, GRP94 12q24.2-q24.3
TRAP1 TNF receptor-associated protein 1 HSP75, HSP90L 16p13.3

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5. Chaperonins :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BBS10 Bardet-Biedl syndrome 10 C12orf58 FLJ23560 12q21.2
BBS12 Bardet-Biedl syndrome 12 C4orf24 FLJ35630, FLJ41559 4q27
TCP1 t-complex 1 D6S230E, CCT1, Ccta 6q25-q27
CCT2 chaperonin containing TCP1 subunit 2 Cctb 12q15
CCT3 chaperonin containing TCP1 subunit 3 TRIC5 Cctg 1q23
CCT4 chaperonin containing TCP1 subunit 4 Cctd 2p15
CCT5 chaperonin containing TCP1 subunit 5 KIAA0098 5p15.2
CCT6A chaperonin containing TCP1 subunit 6A CCT6 TTCP20, TCPZ, Cctz, HTR3, TCP20 7p11.2
CCT6B chaperonin containing TCP1 subunit 6B Cctz2, TSA303 17q12
CCT7 chaperonin containing TCP1 subunit 7 Ccth, Nip7-1 2p13.2
CCT8 chaperonin containing TCP1 subunit 8 C21orf112 Cctq, PRED71 21q21.3
HSPD1 heat shock protein family D (Hsp60) member 1 SPG13 GroEL, HSP60 2q33.1
HSPE1 heat shock protein family E (Hsp10) member 1 CPN10, GroES, HSP10, EPF 2q33.1
MKKS McKusick-Kaufman syndrome BBS6 20p12

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