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Heat shock proteins

Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones. 2009 Jan;14(1):105-11. PMID:18663603

1. HSP70
2. DNAJ (HSP40) specialist advisor 
3. HSPB (small heat shock proteins)
4. HSPC (HSP90)
5. Chaperonins

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1. HSP70 :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSPA1A heat shock 70kDa protein 1A HSPA1 HSP70-1 6p21.3
HSPA1B heat shock 70kDa protein 1B HSP70-2 6p21.3
HSPA1L heat shock 70kDa protein 1-like HSP70-HOM, hum70t 6p21.3
HSPA2 heat shock 70kDa protein 2 14q23
HSPA4 heat shock 70kDa protein 4 HS24/P52, HSPH2 5q31.1
HSPA4L heat shock 70kDa protein 4-like APG-1, Osp94, HSPH3 4q28
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) GRP78 BiP 9q33.3
HSPA6 heat shock 70kDa protein 6 (HSP70B') 1q23.3
HSPA7 heat shock 70kDa protein 7 (HSP70B) 1q23.3
HSPA8 heat shock 70kDa protein 8 HSPA10 HSC71, HSC70, HSP73 11q24.1
HSPA9 heat shock 70kDa protein 9 (mortalin) HSPA9B GRP75, PBP74, mot-2, mthsp75 5q31.1
HSPA12A heat shock 70kDa protein 12A FLJ13874, KIAA0417 10q25.3
HSPA12B heat shock 70kD protein 12B C20orf60 dJ1009E24.2 20p13
HSPA13 heat shock protein 70kDa family, member 13 STCH 21q11.1
HSPA14 heat shock 70kDa protein 14 HSP70-4, HSP70L1 10p13
HSPH1 heat shock 105kDa/110kDa protein 1 HSP105B, KIAA0201, HSP105A, NY-CO-25 13q12.2-q13.3
HYOU1 hypoxia up-regulated 1 ORP150, HSP12A, Grp170 11q23.1-q23.3

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2. DNAJ (HSP40) :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 HSJ2 HSPF4, hdj-2, dj-2, NEDD7 9p13.3
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 HIRIP4, DNAJ, CPR3, DNJ3 16q12.1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 TID1 hTid-1 16p13.3
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 PRO1472 15q24.1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 HSPF1 Hsp40, Sis1, RSPH16B 19p13.2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 HSJ1 HSPF3 2q32-q34
DNAJB3 DnaJ (Hsp40) homolog, subfamily B, member 3 HCG3 2q37
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 HLJ1 1p31.1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 Hsc40 9p
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 MRJ 7q36.3
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 HSC3 22q13.2
DNAJB8 DnaJ (Hsp40) homolog, subfamily B, member 8 MGC33884 3q21.3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 MDG1 7q31
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 EDJ, HEDJ, ERdj3 3q27
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 DJ10, FLJ20027 10q22
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 TSARG6, RSPH16A 11q13.3
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 FLJ14281 4q23
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 DNAJL1, ERdj1, MTJ1 10p11.23
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 ZRF1 MPP11, MPHOSPH11, ZUO1, zuotin 7q22-q32
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 PRKRI P58, P58IPK, HP58 13q32
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 HSPF2 MCG18 11q13
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 CLN4 FLJ00118, FLJ13070, DNAJC5A 20q13.33
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta MGC26226, CSP-beta 8q13.1
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma FLJ40417, CSP-gamma 2p23
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 KIAA0473 1p31.3
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 TTC2 TPR2 17q11.2
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 SPF31 1p35
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 JDD1, SB73 10q22.3
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 FLJ10737 1p36.23
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 JDP1 10q21.3
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 RME8, KIAA0678 3q22.1
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 DNAJ, DRIP78, HDJ3, LIP6, FLJ32792 12q12
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 DNAJD1 MCJ 13q14.1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 KIAA0962 1p36.1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 FLJ10634 15q15.1
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 MGC29463 5q31.2
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 TIMM14, Tim14, Pam18 3q26.33
HSCB HscB iron-sulfur cluster co-chaperone homolog (E. coli) HSC20, DNAJC20, Jac1 22q12.1
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 GS3, DNAJA5, JJJ1 5p13-p12
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 wus, FLJ13236 12q13.12
SEC63 SEC63 homolog (S. cerevisiae) SEC63L, PRO2507, ERdj2, DNAJC23 6q21
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 ZCSL3, DPH4 JJJ3 11p14.1
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 bA16L21.2.1 9q31.3
GAK cyclin G associated kinase DNAJC26 4p16
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 RBJ RabJS 2p23.3
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 C21orf55 C21orf78 21q22.11
SACS spastic ataxia of Charlevoix-Saguenay (sacsin) ARSACS, KIAA0730, DKFZp686B15167, DNAJC29 13q11
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 WBSCR18 7q11.23
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 ERdj5, PDIA19 2q32.1

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3. HSPB (small heat shock proteins) :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSPB1 heat shock 27kDa protein 1 HSP27, HSP28, Hs.76067, Hsp25 7q11.23
HSPB2 heat shock 27kDa protein 2 Hs.78846, MKBP 11q22-q23
HSPB3 heat shock 27kDa protein 3 HSPL27 5q11.2
CRYAA crystallin, alpha A CRYA1 HSPB4 21q22.3
CRYAB crystallin, alpha B CRYA2 HSPB5 11q22.3-q23.1
HSPB6 heat shock protein, alpha-crystallin-related, B6 FLJ32389, Hsp20 19q13.13
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) cvHSP 1p36.23-p34.3
HSPB8 heat shock 22kDa protein 8 H11, E2IG1, HSP22, HspB8 12q24.23
HSPB9 heat shock protein, alpha-crystallin-related, B9 CT51 17q21
ODF1 outer dense fiber of sperm tails 1 ODFPG, ODF27, RT7, HSPB10, CT133 8q22
HSPB11 heat shock protein family B (small), member 11 C1orf41 HSPCO34, PP25, IFT25 1p32

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4. HSPC (HSP90) :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 HSPC1, HSPCA Hsp89, Hsp90, FLJ31884, HSP90N 14q32.33
HSP90AA3P heat shock protein 90kDa alpha (cytosolic), class A member 3, pseudogene HSPCAL1 1q23.1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 HSPC2, HSPCB 6p12
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 TRA1 GP96, GRP94 12q24.2-q24.3
TRAP1 TNF receptor-associated protein 1 HSP75, HSP90L 16p13.3

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5. Chaperonins :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BBS10 Bardet-Biedl syndrome 10 C12orf58 FLJ23560 12q21.2
BBS12 Bardet-Biedl syndrome 12 C4orf24 FLJ35630, FLJ41559 4q27
TCP1 t-complex 1 D6S230E, CCT1, Ccta 6q25-q27
CCT2 chaperonin containing TCP1, subunit 2 (beta) Cctb 12q14
CCT3 chaperonin containing TCP1, subunit 3 (gamma) TRIC5 Cctg 1q23
CCT4 chaperonin containing TCP1, subunit 4 (delta) Cctd 2p15
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) KIAA0098 5p15.2
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) CCT6 TTCP20, TCPZ, Cctz, HTR3, TCP20 7p11.2
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) Cctz2, TSA303 17q
CCT7 chaperonin containing TCP1, subunit 7 (eta) Ccth, Nip7-1 2p13.2
CCT8 chaperonin containing TCP1, subunit 8 (theta) C21orf112 Cctq, PRED71 21q21.3
HSPD1 heat shock 60kDa protein 1 (chaperonin) SPG13 GROEL, HSP60 2q33.1
HSPE1 heat shock 10kDa protein 1 (chaperonin 10) CPN10, GROES 2q33.1
MKKS McKusick-Kaufman syndrome BBS6 20p12

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