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G protein-coupled receptors [GPCR]

Main GPCR categories:  
 Class A GPCRs, rhodopsin-type   
 Class B GPCRs, secretin-type  Specialist advisors:specialist advisor
 Class C GPCRs, glutamate-type   
 Class F GPCRs, frizzled-type   
 Unclassified GPCRs   

External resources:

GPCRDB Information system for G protein-coupled receptors
IUPHAR DATABASE  HGNC approved
Guide to Receptors and Channels (GRAC) database British Pharmacological Society HGNC approved

 

Detail of GPCR categories below. Click on the GPCR of interest to retrieve the gene symbols for that category:


Class A GPCRs, rhodopsin-type (links go to GPCRA page) 

  1)  Olfactory receptors
 10) Nucleotide-like receptors
links to [OR] page that has been divided into families
 10a) Adenosine receptors 
   10b) Purinergic receptors, P2Y 
 2) Amine receptors  11)   Opsin receptors 
 2a) Adrenoceptors
 12)   Prokineticin receptors
2a.1) Adrenoceptors, alpha
 13)   Relaxin family peptide receptors  
2a.2) Adrenoceptors, beta
 14)   Resolvin receptors    
 2b) 5-HT (serotonin) receptors, G protein-coupled only
 15)   Protease activated receptors  
 2c) Cholinergic receptors, muscarinic
 16) Short Peptide receptors 
 2d) Dopamine receptors
 16a)  Angiotensin receptors 
 2e) Histamine receptors
 16b)  Bombesin receptors 
 2f) Trace amine receptors    16c)  Bradykinin receptors 
 3)  Chemokine receptors   
 16d)  Cholecystokinin receptors 
3.1) Chemokine (C-C motif) receptors
 16e)  Endothelin receptors 
3.2) Chemokine (X-C motif) receptors
 16f)  Galanin receptors 
3.3) Chemokine (C-X-3C motif) receptors
 16g)  Gonadotropin-releasing hormone receptors  
3.4) Chemokine (C-X-C motif) receptors
 16h)  Hypocretin (orexin) receptors   
 4)  Complement component receptors     16i)   MCH receptors
 5)  Formyl peptide receptors     16j)   Melanocortin receptors 
 6)  Gonadotropin and TSH receptors
 16k)  Motilin receptors
 7)  Hydroxy-carboxylic acid receptors
 16l)   Neuromedin U receptors
 8) Lipid-like receptors
 16m) Neuropeptide receptors 
 8a) Cannabinoid receptors
 16m.1) Neuropeptide FF/neuropeptide AF receptors
 8b) Fatty acid receptors
 16m.2) Neuropeptide S receptors
 8c) Leukotriene receptors
 16m.3) Neuropeptide W/neuropeptide B receptors
 8d) Lysophospholipid receptors
 16m.4) Neuropeptide Y receptors
8d.1) Lysophosphatidic acid receptors    16n)  Neurotensin receptors
8d.2) Sphingosine 1-phosphate receptors    16o)  Opioid receptors 
 8e) Prostanoid receptors     16p)  RF amide peptide receptors 
 8f) Platelet-activating factor receptors     16q)  Somatostatin receptors  
 9)  Melatonin receptors   
 16r)  Tachykinin receptors 
16s) Vasopressin/Oxytocin receptors
16t)  Ghrelin receptors
17)  Class A GPCR, orphans

  

Class B GPCRs, secretin-type  (links go to GPCRB page)

1. VIP and PACAP (ADCYAP1) receptors 
2. Calcitonin receptors 
3. Corticotropin-releasing factor receptors 
4. Glucagon receptors 
5. Parathyroid hormone receptors 
6. Class B GPCR, orphans

 

Class C GPCRs, glutamate-type  (links go to GPCRC page)

1. Calcium-sensing receptors 
2. GABA(B) receptors 
3. Glutamate receptors, metabotropic 
4. Class C GPCR, orphans

 

Class F GPCRs, Frizzled-type  (links go to GPCRF page)

1. Frizzled-type receptors

 

Unclassified GPCRs  (links go to GPCRU page)

1.  Taste receptors
2.  Vomeronasal receptors, type 1 
3.  Adiponectin receptors 
4.  Non signalling 7TM receptors   
5.  7TM orphan receptors  

 

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