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This is our older gene family page that is no longer maintained. Please go to our new look gene family index to view a complete list of our new maintained gene families. More information can be found in our gene families help page.

We have created a mapping file (Excel) that will map most of the old families to the new. However because we have changed the way we assign families and how we organise them, this file may not map all the old families.

Endogenous ligands

Click on the Approved Gene Symbol to retrieve the complete gene record

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ADCYAP1 adenylate cyclase activating polypeptide 1 PACAP 18p11
ADIPOQ adiponectin, C1Q and collagen domain containing ACDC ACRP30, AdipoQ, apM1, GBP28, adiponectin 3q27
ADM adrenomedullin AM 11p15.4
ADM2 adrenomedullin 2 AM2, FLJ21135 22q13.33
AGRP agouti related neuropeptide Agrt, ART, ASIP2 16q22
AGT angiotensinogen SERPINA8 1q42.2
AMH anti-Mullerian hormone MIS 19p13.3
ANXA1 annexin A1 ANX1, LPC1 9q21.13
APELA apelin receptor early endogenous ligand Ende, ELA, tdl 4q32.3
APLN apelin apelin, XNPEP2 Xq25
APP amyloid beta precursor protein AD1 21q21.2
AREG amphiregulin SDGF, AREGB 4q13.3
ARF1 ADP ribosylation factor 1 1q42.13
ARHGDIB Rho GDP dissociation inhibitor beta RAP1GN1, GDIA2, GDID4 Ly-GDI, RhoGDI2 12p12.3
ARTN artemin NBN, EVN, ENOVIN 1p34.1
AVP arginine vasopressin ARVP ADH 20p13
BDNF brain-derived neurotrophic factor 11p14.1
BID BH3 interacting domain death agonist 22q11.2
BMP2 bone morphogenetic protein 2 BMP2A 20p12
BMP4 bone morphogenetic protein 4 BMP2B 14q22-q23
BMP5 bone morphogenetic protein 5 6p12.1
BMP6 bone morphogenetic protein 6 VGR VGR1 6p24-p23
BMP7 bone morphogenetic protein 7 OP-1 20q13
BMP8A bone morphogenetic protein 8a 1p35-p32
BMP8B bone morphogenetic protein 8b BMP8 OP-2 1p35-p32
BMP10 bone morphogenetic protein 10 2p13.2
C3 complement component 3 CPAMD1, ARMD9, C3a, C3b 19p13.3-p13.2
C5 complement component 5 CPAMD4, C5a, C5b 9q33-q34
CALCA calcitonin related polypeptide alpha CALC1 11p15.2
CALCB calcitonin related polypeptide beta CALC2 FLJ30166, CGRP-II 11p15.2
CALM1 calmodulin 1 (phosphorylase kinase, delta) CALML2 CAMI, PHKD, DD132 14q32.11
CALM2 calmodulin 2 (phosphorylase kinase, delta) PHKD, CAMII 2p21.3-p21.1
CALM3 calmodulin 3 (phosphorylase kinase, delta) PHKD 19q13.2-q13.3
CAMP cathelicidin antimicrobial peptide CAP18, FALL39, FALL-39, LL37 3p21.3
CCK cholecystokinin 3p22.1
CCL1 C-C motif chemokine ligand 1 SCYA1 I-309, TCA3, P500, SISe 17q11.2
CCL2 C-C motif chemokine ligand 2 SCYA2 MCP1, MCP-1, MCAF, SMC-CF, GDCF-2, HC11, MGC9434 17q11.2-q21.1
CCL3 C-C motif chemokine ligand 3 SCYA3 G0S19-1, LD78ALPHA, MIP-1-alpha 17q12
CCL4 C-C motif chemokine ligand 4 LAG1, SCYA4 MIP-1-beta, Act-2, AT744.1 17q12
CCL5 C-C motif chemokine ligand 5 D17S136E, SCYA5 RANTES, SISd, TCP228, MGC17164 17q12
CCL7 C-C motif chemokine ligand 7 SCYA6, SCYA7 MCP-3, NC28, FIC, MARC, MCP3 17q11.2-q12
CCL8 C-C motif chemokine ligand 8 SCYA8 MCP-2, HC14 17q11.2
CCL11 C-C motif chemokine ligand 11 SCYA11 eotaxin, MGC22554 17q21.1-q21.2
CCL13 C-C motif chemokine ligand 13 SCYA13 MCP-4, NCC-1, SCYL1, CKb10, MGC17134 17q11.2
CCL14 C-C motif chemokine ligand 14 SCYA14 HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF 17q12
CCL15 C-C motif chemokine ligand 15 SCYA15 HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B 17q12
CCL16 C-C motif chemokine ligand 16 SCYA16 NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1 17q12
CCL17 C-C motif chemokine ligand 17 SCYA17 TARC, ABCD-2 16q13
CCL19 C-C motif chemokine ligand 19 SCYA19 ELC, MIP-3b, exodus-3, CKb11 9p13
CCL20 C-C motif chemokine ligand 20 SCYA20 LARC, MIP-3a, exodus-1, ST38, CKb4 2q36.3
CCL21 C-C motif chemokine ligand 21 SCYA21 SLC, exodus-2, TCA4, CKb9, 6Ckine, ECL 9p13
CCL22 C-C motif chemokine ligand 22 SCYA22 MDC, STCP-1, ABCD-1, DC/B-CK, A-152E5.1, MGC34554 16q13
CCL23 C-C motif chemokine ligand 23 SCYA23 Ckb-8, MPIF-1, MIP-3, CKb8 17q12
CCL24 C-C motif chemokine ligand 24 SCYA24 Ckb-6, MPIF-2, eotaxin-2, MPIF2 7q11.23
CCL25 C-C motif chemokine ligand 25 SCYA25 TECK, Ckb15 19p13.2
CCL26 C-C motif chemokine ligand 26 SCYA26 MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1 7q11.2
CCL27 C-C motif chemokine ligand 27 SCYA27 ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK 9p13
CCL28 C-C motif chemokine ligand 28 SCYA28, MEC, CCK1 5p12
CD40LG CD40 ligand HIGM1, IMD3, TNFSF5 CD40L, TRAP, gp39, hCD40L, CD154 Xq26
CD274 CD274 molecule PDCD1LG1 B7-H, B7H1, PD-L1, PDL1, B7-H1 9p24.1
CFLAR CASP8 and FADD like apoptosis regulator CASP8AP1 CASH, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT, c-FLIP 2q33-q34
CGA glycoprotein hormones, alpha polypeptide HCG, GPHa, GPHA1, FSHA, LHA, TSHA 6q14.3
CGB3 chorionic gonadotropin beta subunit 3 CGB 19q13.33
CNTN1 contactin 1 F3, GP135 12q12
COPA coatomer protein complex subunit alpha HEP-COP 1q23.2
CORT cortistatin MGC32686 1p36.22
CRH corticotropin releasing hormone CRF, CRH1 8q13
CSF3 colony stimulating factor 3 GCSF, G-CSF, C17orf33 MGC45931 17q11.2-q12
CTSG cathepsin G CG 14q12
CX3CL1 C-X3-C motif chemokine ligand 1 SCYD1 NTN, C3Xkine, ABCD-3, CXC3C, CXC3, fractalkine, neurotactin 16q13
CXCL1 C-X-C motif chemokine ligand 1 MGSA, GRO1, FSP SCYB1, GROa, MGSA-a, NAP-3 4q13.3
CXCL2 C-X-C motif chemokine ligand 2 GRO2 SCYB2, GROb, MIP-2a, MGSA-b, CINC-2a 4q13.3
CXCL3 C-X-C motif chemokine ligand 3 GRO3 SCYB3, GROg, MIP-2b, CINC-2b 4q21
CXCL5 C-X-C motif chemokine ligand 5 SCYB5 ENA-78 4q13.3
CXCL6 C-X-C motif chemokine ligand 6 SCYB6 GCP-2, CKA-3 4q13.3
CXCL8 C-X-C motif chemokine ligand 8 IL8 SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1 4q13-q21
CXCL9 C-X-C motif chemokine ligand 9 CMK, MIG SCYB9, Humig, crg-10 4q21
CXCL10 C-X-C motif chemokine ligand 10 INP10, SCYB10 IFI10, IP-10, crg-2, mob-1, C7, gIP-10 4q21
CXCL11 C-X-C motif chemokine ligand 11 SCYB9B, SCYB11 H174, b-R1, I-TAC, IP-9 4q21
CXCL12 C-X-C motif chemokine ligand 12 SDF1A, SDF1B, SDF1 SCYB12, SDF-1a, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1 10q11.1
CXCL13 C-X-C motif chemokine ligand 13 SCYB13 BLC, BCA-1, BLR1L, ANGIE, ANGIE2 4q21
CXCL16 C-X-C motif chemokine ligand 16 SR-PSOX, CXCLG16, SRPSOX 17p13
DEFB4A defensin beta 4A DEFB102, DEFB2, DEFB4 SAP1, HBD-2, DEFB-2 8p23.1
EDN1 endothelin 1 ET1 6p24.1
EDN2 endothelin 2 ET2 1p34
EDN3 endothelin 3 ET3 20q13.2-q13.3
EPO erythropoietin EP 7q21
F2 coagulation factor II, thrombin 11p11.2
FASLG Fas ligand APT1LG1, TNFSF6 FasL, CD178 1q23
FGA fibrinogen alpha chain 4q28
FGB fibrinogen beta chain 4q28
FGF1 fibroblast growth factor 1 FGFA AFGF, ECGF, ECGFA, ECGFB, HBGF1, ECGF-beta, FGF-alpha, GLIO703 5q31.3-q33.2
FGF2 fibroblast growth factor 2 FGFB 4q26
FGF4 fibroblast growth factor 4 HSTF1 K-FGF, HBGF-4, HST, HST-1, KFGF 11q13.3
FGF5 fibroblast growth factor 5 4q21
FGF6 fibroblast growth factor 6 12p13
FGF7 fibroblast growth factor 7 KGF 15q21.2
FGF8 fibroblast growth factor 8 AIGF 10q25-q26
FGF9 fibroblast growth factor 9 13q11-q12
FGG fibrinogen gamma chain 4q28
FLT3LG fms related tyrosine kinase 3 ligand 19q13.3
FN1 fibronectin 1 MSF, CIG, LETS, GFND2, FINC 2q34
FSHB follicle stimulating hormone beta subunit 11p14.1
GAL galanin and GMAP prepropeptide GALN GMAP, GAL-GMAP, GLNN 11q13.2
GALP galanin like peptide 19q13.42
GAST gastrin GAS 17q21.2
GCG glucagon GLP1, GLP2, GRPP 2q36-q37
GDF1 growth differentiation factor 1 19p13.11
GDF2 growth differentiation factor 2 BMP-9, BMP9 10q11.22
GDF3 growth differentiation factor 3 12p13.1
GDF9 growth differentiation factor 9 5q31.1
GDF10 growth differentiation factor 10 BMP-3b 10q11.22
GDNF glial cell derived neurotrophic factor ATF1, ATF2, HFB1-GDNF 5p13.1-p12
GH1 growth hormone 1 GH-N, GHN, GH, hGH-N 17q23.3
GH2 growth hormone 2 GH-V, GHV, GHL, hGH-V 17q23.3
GHRH growth hormone releasing hormone GHRF 20q11.2
GHRL ghrelin/obestatin prepropeptide MTLRP, ghrelin, obestatin 3p25.3
GIP gastric inhibitory polypeptide 17q21.3-q22
GNRH1 gonadotropin releasing hormone 1 GRH, GNRH, LHRH 8p21-p11.2
GNRH2 gonadotropin releasing hormone 2 20p13
GRP gastrin releasing peptide 18q21.1-q21.32
GUCA2A guanylate cyclase activator 2A GUCA2 STARA 1p35-p34
GUCA2B guanylate cyclase activator 2B 1p34-p33
HCRT hypocretin (orexin) neuropeptide precursor PPOX, OX 17q21
HEBP1 heme binding protein 1 HEBP, HBP 12p13.2
HTT huntingtin HD IT15 4p16.3
IAPP islet amyloid polypeptide AMYLIN, DAP, IAP 12p12.1
ICAM1 intercellular adhesion molecule 1 BB2, CD54 19p13.2
ICAM2 intercellular adhesion molecule 2 CD102 17q23.3
ICOSLG inducible T-cell costimulator ligand ICOSL KIAA0653, GL50, B7-H2, B7RP-1, B7H2, B7RP1, ICOS-L, CD275 21q22.3
IGF1 insulin like growth factor 1 IGF1A, IGFI, IGF-I 12q23.2
IL1A interleukin 1 alpha IL1 IL1F1, IL-1A, IL1-ALPHA 2q14
IL1B interleukin 1 beta IL1F2, IL-1B, IL1-BETA 2q14
IL1RN interleukin 1 receptor antagonist IL1RA, ICIL-1RA, IL1F3, IRAP, IL-1RN, MGC10430 2q14.2
IL11 interleukin 11 IL-11, AGIF 19q13.3-q13.4
INHBA inhibin beta A subunit 7p15-p13
INHBB inhibin beta B subunit 2q14.2
INSL3 insulin like 3 RLNL RLF, MGC119818, MGC119819 19p13.11
INSL5 insulin like 5 1p31.3
KISS1 KiSS-1 metastasis-suppressor 1q32
KNG1 kininogen 1 KNG, BDK BK 3q27.3
LGALS1 galectin 1 GBP 22q13.1
LGALS3 galectin 3 LGALS2 MAC-2, GALIG 14q22.3
LGALS3BP galectin 3 binding protein MAC-2-BP, 90K, BTBD17B, TANGO10B, M2BP, gp90, CyCAP 17q25
LHB luteinizing hormone beta polypeptide LSH-B, CGB4, hLHB 19q13.3
LRRC4B leucine rich repeat containing 4B LRIG4 DKFZp761A179, HSM 19q13.33
MLN motilin 6p21.31
MMP1 matrix metallopeptidase 1 CLG 11q22.2
MMP13 matrix metallopeptidase 13 CLG3 11q22.3
MT-RNR2 mitochondrially encoded 16S RNA MTRNR2 HN mitochondria
NCAN neurocan CSPG3 19p12
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 DKFZp686O24166, B7-H6 11p15.1
NDP NDP, norrin cystine knot growth factor EVR2 norrin Xp11.4-p11.3
NGF nerve growth factor NGFB 1p13.1
NMS neuromedin S 2q11.2
NMU neuromedin U 4q12
NPB neuropeptide B PPL7, PPNPB 17q25.3
NPFF neuropeptide FF-amide peptide precursor FMRFAL 12q13.13
NPPA natriuretic peptide A ANP, PND 1p36.21
NPPB natriuretic peptide B 1p36.2
NPPC natriuretic peptide C CNP 2q37.1
NPS neuropeptide S 10q26.2
NPVF neuropeptide VF precursor C7orf9 RFRP 7p15.3
NPW neuropeptide W PPL8 16p13.3
NPY neuropeptide Y PYY4 7p15.3
NRTN neurturin NTN 19p13.3
NTF3 neurotrophin 3 NGF2 12p13
NTF4 neurotrophin 4 NTF5 NT-4/5, GLC1O 19q13.3
NTS neurotensin 12q21.31
OXT oxytocin/neurophysin I prepropeptide OT OXT-NPI, OT-NPI 20p13
PDCD1LG2 programmed cell death 1 ligand 2 PD-L2, Btdc, PDL2, bA574F11.2, CD273, B7-DC 9p24.2
PDYN prodynorphin SCA23 PENKB, ADCA 20p13
PENK proenkephalin 8q12.1
PMCH pro-melanin concentrating hormone MCH 12q23.2
PNOC prepronociceptin PPNOC, N/OFQ, NOP 8p21
POMC proopiomelanocortin MSH, POC, CLIP, ACTH, NPP, LPH 2p23
PPBP pro-platelet basic protein THBGB1 SCYB7, TGB, NAP-2-L1, LA-PF4, MDGF, LDGF, Beta-TG, CTAP3, CXCL7, PBP, b-TG1, TGB1, CTAPIII, NAP-2 4q12-q13
PPY pancreatic polypeptide PNP 17q21.31
PRLH prolactin releasing hormone PRH 2q37.3
PROC protein C, inactivator of coagulation factors Va and VIIIa 2q13-q14
PROK1 prokineticin 1 PK1, PRK1, EGVEGF 1p21
PROK2 prokineticin 2 PK2, BV8, MIT1, KAL4 3p21.1
PSAP prosaposin SAP1, GLBA 10q21-q22
PSPN persephin PSP 19p13.3
PTH parathyroid hormone PTH1 11p15.3
PTH2 parathyroid hormone 2 TIP39 19q13.33
PTHLH parathyroid hormone-like hormone PTHRP, HHM, PLP, PTHR 12p12.1-p11.2
PTN pleiotrophin NEGF1 HBNF, HBGF8 7q33
PYY peptide YY PYY1 17q21.1
QRFP pyroglutamylated RFamide peptide 26RFa, P518 9q34.12
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) TC-25, p21-Rac1, Rac-1 7p22
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) EN-7 22q13.1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 17q25.3
RARRES2 retinoic acid receptor responder 2 TIG2, HP10433 7q36.1
RB1 RB transcriptional corepressor 1 OSRC RB, PPP1R130 13q14.2
RGS2 regulator of G-protein signaling 2 G0S8 1q31
RLN1 relaxin 1 H1 9p24.1
RLN2 relaxin 2 H2, RLXH2, bA12D24.1.1, bA12D24.1.2 9p24.1
RLN3 relaxin 3 ZINS4, RXN3, H3 19p13.2
RSPO1 R-spondin 1 FLJ40906, RSPONDIN 1p34.2
RSPO2 R-spondin 2 MGC35555 8q23.1
RSPO3 R-spondin 3 THSD2 FLJ14440 6q22.33
RSPO4 R-spondin 4 C20orf182 dJ824F16.3 20p13
SAA1 serum amyloid A1 SAA PIG4, TP53I4 11p15.1
SCT secretin 11p15.5
SELPLG selectin P ligand PSGL-1, CD162 12q24
SPP1 secreted phosphoprotein 1 BNSP, OPN BSPI, ETA-1 4q22.1
SST somatostatin SMST 3q28
TAC1 tachykinin precursor 1 TAC2, NKNA NPK 7q21-q22
TAC3 tachykinin 3 NKNB ZNEUROK1, NKB 12q13.3
TAC4 tachykinin 4 (hemokinin) HK-1, Pptc, PPT-C 17q21.33
TGFB1 transforming growth factor beta 1 TGFB, DPD1 CED, TGFbeta 19q13.1
TGFB2 transforming growth factor beta 2 1q41
TGFB3 transforming growth factor beta 3 ARVD1, ARVD 14q24
THPO thrombopoietin MGDF TPO, MPLLG 3q27
TRH thyrotropin releasing hormone 3q13.3-q21
TSHB thyroid stimulating hormone beta 1p13
UCN urocortin UROC, UI 2p23.3
UCN2 urocortin 2 UCNI, SRP, URP, UCN-II 3p21.3
UCN3 urocortin 3 UCNIII, SPC 10p15.1
UTS2 urotensin 2 UII, U-II, UCN2, PRO1068 1p36
UTS2B urotensin 2B UTS2D URP, U2B 3q28
VCAM1 vascular cell adhesion molecule 1 CD106 1p32-p31
VIP vasoactive intestinal peptide 6q24-q27
VTN vitronectin VN 17q11.2
VWF von Willebrand factor F8VWF 12p13.3
WNT1 Wnt family member 1 INT1 12q13.12
WNT2 Wnt family member 2 INT1L1 IRP 7q31
WNT3 Wnt family member 3 INT4 MGC131950, MGC138321, MGC138323 17q21.31
WNT3A Wnt family member 3A 1q42
WNT4 Wnt family member 4 WNT-4 1p36.23-p35.1
WNT5A Wnt family member 5A hWNT5A 3p21-p14
WNT7B Wnt family member 7B 22q13
XCL1 X-C motif chemokine ligand 1 LTN, SCYC1 LPTN, ATAC, SCM-1a, SCM-1 1q24.2
XCL2 X-C motif chemokine ligand 2 SCYC2 SCM-1b 1q24.2

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