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New gene family pages: beta release

Please go to our new look gene family pages and send us your feedback. More information can be found in our current newsletter.

In April we plan to have the official release of the new family pages which will be replacing the old family pages across our site, and will be linked from symbol reports. The old gene family pages will be archived and remain on the site for up to 6 months after the full release.

Chloride channels

1. Chloride channels, voltage-sensitive
2. Cystic fibrosis transmembrane conductance regulators  
For all Ion channels, see our Ion channels page  
3. Calcium activated chloride channels (CaCC)
3.1 Anoctamins 
3.2 Bestrophins
4. Chloride intracelluar channels  specialist advisor

 Click on the Approved Gene Symbol to retrieve the complete gene record


Chloride channels, voltage-sensitive :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CLCN1 chloride channel, voltage-sensitive 1 CLC1, ClC-1 7q12
CLCN2 chloride channel, voltage-sensitive 2 CLC2, EJM6, ClC-2 3q27.1
CLCN3 chloride channel, voltage-sensitive 3 CLC3, ClC-3 4q
CLCN4 chloride channel, voltage-sensitive 4 CLC4, ClC-4 Xp22.3
CLCN5 chloride channel, voltage-sensitive 5 NPHL2, NPHL1 DENTS, XLRH, hClC-K2, hCIC-K2, CLC5, XRN, ClC-5 Xp11.23-p11.22
CLCN6 chloride channel, voltage-sensitive 6 CLC-6, KIAA0046, ClC-6 1p36
CLCN7 chloride channel, voltage-sensitive 7 CLC-7, OPTA2, CLC7, ClC-7, PPP1R63 16p13
CLCNKA chloride channel, voltage-sensitive Ka hClC-Ka 1p36
CLCNKB chloride channel, voltage-sensitive Kb hClC-Kb 1p36

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  Cystic fibrosis transmembrane conductance regulators :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) CF, ABCC7 MRP7, ABC35, TNR-CFTR, dJ760C5.1, CFTR/MRP 7q31.2

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Calcium activated chloride channels 

Anoctamins :  Some members of this family have been shown to support CaCC activity.

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ANO1 anoctamin 1, calcium activated chloride channel ORAOV2, TMEM16A TAOS2, FLJ10261, DOG1 11q13.2
ANO2 anoctamin 2, calcium activated chloride channel C12orf3, TMEM16B 12p13.3
ANO3 anoctamin 3 C11orf25, TMEM16C GENX-3947, DYT23 11p14.2
ANO4 anoctamin 4 TMEM16D FLJ34221, FLJ34272, FLJ35277 12q23.3
ANO5 anoctamin 5 TMEM16E, LGMD2L GDD1 11p15.1
ANO6 anoctamin 6 TMEM16F DKFZp313M0720 12q12-q13.11
ANO7 anoctamin 7 PCANAP5, TMEM16G NGEP, PCANAP5L, IPCA-5 2q37.3
ANO8 anoctamin 8 KIAA1623, TMEM16H 19p13.12
ANO9 anoctamin 9 TP53I5, TMEM16J PIG5 11p15.5
ANO10 anoctamin 10 TMEM16K FLJ10375, MGC47890, SCAR10 3p22.1-p21.33

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Bestrophins :  These genes are putative calcium-activated chloride channels.

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BEST1 bestrophin 1 VMD2 BMD, BEST, RP50 11q12
BEST2 bestrophin 2 VMD2L1 FLJ20132 19p13.13
BEST3 bestrophin 3 VMD2L3 MGC40411, MGC13168 12q15
BEST4 bestrophin 4 VMD2L2 1p34.1

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Chloride intracelluar channels :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CLIC1 chloride intracellular channel 1 NCC27, p64CLCP 6p21.3
CLIC2 chloride intracellular channel 2 XAP121 Xq28
CLIC3 chloride intracellular channel 3 9q34.3
CLIC4 chloride intracellular channel 4 DKFZP566G223, CLIC4L, P64H1, H1, huH1, p64H1 1p
CLIC5 chloride intracellular channel 5 DFNB102 6p12.3
CLIC6 chloride intracellular channel 6 CLIC1L CLIC5 21q22.12

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This online database does not include our confidential data. If you would like to create a new gene symbol and name, the only way to confirm it as unique is by contacting us.