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Newer gene family pages are available

This is our older gene family page that is no longer maintained. Please go to our new look gene family index to view a complete list of our new maintained gene families. More information can be found in our gene families help page.

We have created a mapping file (Excel) that will map most of the old families to the new. However because we have changed the way we assign families and how we organise them, this file may not map all the old families.

Chloride channels

1. Chloride channels, voltage-sensitive
2. Cystic fibrosis transmembrane conductance regulators  
For all Ion channels, see our Ion channels page  
3. Calcium activated chloride channels (CaCC)
3.1 Anoctamins 
3.2 Bestrophins
4. Chloride intracelluar channels  specialist advisor

 Click on the Approved Gene Symbol to retrieve the complete gene record


Chloride channels, voltage-sensitive :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CLCN1 chloride voltage-gated channel 1 CLC1, ClC-1 7q34
CLCN2 chloride voltage-gated channel 2 CLC2, EJM6, ClC-2 3q27.1
CLCN3 chloride voltage-gated channel 3 CLC3, ClC-3 4q33
CLCN4 chloride voltage-gated channel 4 CLC4, ClC-4 Xp22.2
CLCN5 chloride voltage-gated channel 5 NPHL2, NPHL1 DENTS, XLRH, hClC-K2, hCIC-K2, CLC5, XRN, ClC-5 Xp11.23
CLCN6 chloride voltage-gated channel 6 CLC-6, KIAA0046, ClC-6 1p36.22
CLCN7 chloride voltage-gated channel 7 CLC-7, OPTA2, CLC7, ClC-7, PPP1R63 16p13.3
CLCNKA chloride voltage-gated channel Ka hClC-Ka 1p36.13
CLCNKB chloride voltage-gated channel Kb hClC-Kb 1p36.13

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  Cystic fibrosis transmembrane conductance regulators :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CFTR cystic fibrosis transmembrane conductance regulator CF, ABCC7 MRP7, ABC35, TNR-CFTR, dJ760C5.1, CFTR/MRP 7q31.2

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Calcium activated chloride channels 

Anoctamins :  Some members of this family have been shown to support CaCC activity.

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ANO1 anoctamin 1 ORAOV2, TMEM16A TAOS2, FLJ10261, DOG1 11q13.3
ANO2 anoctamin 2 C12orf3, TMEM16B 12p13.31
ANO3 anoctamin 3 C11orf25, TMEM16C GENX-3947, DYT23 11p14.2
ANO4 anoctamin 4 TMEM16D FLJ34221, FLJ34272, FLJ35277 12q23.1
ANO5 anoctamin 5 TMEM16E, LGMD2L GDD1 11p14.3
ANO6 anoctamin 6 TMEM16F DKFZp313M0720 12q12
ANO7 anoctamin 7 PCANAP5, TMEM16G NGEP, PCANAP5L, IPCA-5 2q37.3
ANO8 anoctamin 8 KIAA1623, TMEM16H 19p13.11
ANO9 anoctamin 9 TP53I5, TMEM16J PIG5 11p15.5
ANO10 anoctamin 10 TMEM16K FLJ10375, MGC47890, SCAR10 3p22.1-p21.33

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Bestrophins :  These genes are putative calcium-activated chloride channels.

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BEST1 bestrophin 1 VMD2 BMD, BEST, RP50 11q12.3
BEST2 bestrophin 2 VMD2L1 FLJ20132 19p13.13
BEST3 bestrophin 3 VMD2L3 MGC40411, MGC13168 12q15
BEST4 bestrophin 4 VMD2L2 1p34.1

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Chloride intracelluar channels :

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CLIC1 chloride intracellular channel 1 NCC27, p64CLCP, G6 6p21.33
CLIC2 chloride intracellular channel 2 XAP121 Xq28
CLIC3 chloride intracellular channel 3 9q34.3
CLIC4 chloride intracellular channel 4 DKFZP566G223, CLIC4L, P64H1, H1, huH1, p64H1 1p36.11
CLIC5 chloride intracellular channel 5 DFNB102 6p21.1
CLIC6 chloride intracellular channel 6 CLIC1L CLIC5 21q22.12

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This online database does not include our confidential data. If you would like to create a new gene symbol and name, the only way to confirm it as unique is by contacting us.