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Basic helix-loop-helix proteins

Click on the Approved Gene Symbol to retrieve the complete gene record

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
NEUROD2 neuronal differentiation 2 NDRF, bHLHa1 17q12
NEUROD6 neuronal differentiation 6 Atoh2, NEX1M, Math-2, bHLHa2, Nex1 7p15.1
NEUROD1 neuronal differentiation 1 NEUROD BETA2, BHF-1, NeuroD, bHLHa3, MODY6 2q32
NEUROD4 neuronal differentiation 4 Atoh3, ATH-3, MATH-3, bHLHa4 12q13.13
NEUROG1 neurogenin 1 NEUROD3 AKA, Math4C, ngn1, bHLHa6 5q23-q31
NEUROG3 neurogenin 3 Atoh5, Math4B, ngn3, bHLHa7 10q21.3
NEUROG2 neurogenin 2 Atoh4, Math4A, ngn-2, bHLHa8, NGN2 4q25
BHLHA9 basic helix-loop-helix family, member a9 bHLHa9, BHLHF42 17p13.3
ATOH7 atonal homolog 7 (Drosophila) Math5, bHLHa13 10q22.2
ATOH1 atonal homolog 1 (Drosophila) HATH1, MATH-1, Math1, bHLHa14 4q22
BHLHA15 basic helix-loop-helix family, member a15 BHLHB8 MIST1, bHLHa15 7q21.3
TAL1 T-cell acute lymphocytic leukemia 1 TCL5 SCL, bHLHa17 1p32
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 bHLHa18 19p13.2
TAL2 T-cell acute lymphocytic leukemia 2 bHLHa19 9q32
ATOH8 atonal homolog 8 (Drosophila) HATH6, FLJ14708, bHLHa21 2p11.2
MSC musculin ABF-1, bHLHa22 8q13.3
TCF21 transcription factor 21 POD1, bHLHa23 6q23.2
TCF23 transcription factor 23 OUT, bHLHa24 2p23.3
TCF24 transcription factor 24 bHLHa25 8q13.1
HAND2 heart and neural crest derivatives expressed 2 dHand, Thing2, Hed, bHLHa26 4q34.1
HAND1 heart and neural crest derivatives expressed 1 eHand, Thing1, Hxt, bHLHa27 5q33
PTF1A pancreas specific transcription factor, 1a PTF1-p48, bHLHa29 10p12.31
FERD3L Fer3-like bHLH transcription factor NATO3, N-TWIST, bHLHa31 7p21.3
NHLH2 nescient helix loop helix 2 HEN2 NSCL2, bHLHa34 1p12-p11
NHLH1 nescient helix loop helix 1 HEN1 NSCL, NSCL1, bHLHa35 1q22
TWIST1 twist family bHLH transcription factor 1 ACS3, BPES3, TWIST, CRS SCS, H-twist, BPES2, bHLHa38, CRS1 7p21
TWIST2 twist family bHLH transcription factor 2 DERMO1, Dermo-1, bHLHa39 2q37.3
TCF15 transcription factor 15 (basic helix-loop-helix) EC2, PARAXIS, bHLHa40 20p13
ASCL3 achaete-scute family bHLH transcription factor 3 bHLHa42, HASH3, Sgn1 11p15.3
ASCL4 achaete-scute family bHLH transcription factor 4 HASH4, bHLHa44 12q24.11
ASCL2 achaete-scute family bHLH transcription factor 2 ASH2, HASH2, bHLHa45 11p15.5
ASCL1 achaete-scute family bHLH transcription factor 1 ASH1, HASH1, bHLHa46 12q22-q23
ASCL5 achaete-scute family bHLH transcription factor 5 bHLHa47 1q32.1
SCX scleraxis basic helix-loop-helix transcription factor SCXA, SCXB bHLHa48, bHLHa41 8q24.3
BHLHB9 basic helix-loop-helix domain containing, class B, 9 p60TRP, KIAA1701, GASP3 Xq23
USF1 upstream transcription factor 1 UEF, MLTFI, bHLHb11 1q22-q23
USF2 upstream transcription factor 2, c-fos interacting FIP, bHLHb12 19q13
TCF4 transcription factor 4 SEF2-1B, ITF2, bHLHb19, E2-2 18q21.1
TCF12 transcription factor 12 HEB, HTF4, HsT17266, bHLHb20 15q21
TCF3 transcription factor 3 E2A, ITF1, MGC129647, MGC129648, bHLHb21, VDIR, E47 19p13.3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein dJ857M17.1.2, bHLHb24 20q11
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein HEIR-1, bHLHb25 1p36.13-p36.12
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein GIG8, bHLHb26 2p25
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein bHLHb27 6p22.3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, bHLHb31 8q21
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 bHLHb32, HERP1, HESR2 6q
HEYL hes-related family bHLH transcription factor with YRPW motif-like bHLHb33, HEY3, HESR3 1p34.3
HES7 hes family bHLH transcription factor 7 bHLHb37 17p13.1
HES5 hes family bHLH transcription factor 5 bHLHb38 1p36
HES1 hes family bHLH transcription factor 1 HRY FLJ20408, HES-1, Hes1, bHLHb39 3q28-q29
HES2 hes family bHLH transcription factor 2 bHLHb40 1p36.31
HES6 hes family bHLH transcription factor 6 bHLHb41 2q37.3
HES4 hes family bHLH transcription factor 4 bHLHb42 1p36
HES3 hes family bHLH transcription factor 3 bHLHb43 1p36.31
HELT helt bHLH transcription factor HESL, HCM1228, Mgn, bHLHb44, MEGANE 4q35.1
MYOD1 myogenic differentiation 1 MYF3 PUM, MYOD, bHLHc1 11p15
MYF5 myogenic factor 5 bHLHc2 12q21
MYOG myogenin (myogenic factor 4) MYF4 bHLHc3 1q31-q41
MYF6 myogenic factor 6 (herculin) MRF4, bHLHc4 12q21
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 MGC10676, bHLHc5 15q26.1
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 SCDO2, bHLHc6 15q26.1
FIGLA folliculogenesis specific basic helix-loop-helix bHLHc8 2p13.3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) AP-4, bHLHc41 16p13
SREBF1 sterol regulatory element binding transcription factor 1 SREBP1, bHLHd1, SREBP-1c 17p11.2
SREBF2 sterol regulatory element binding transcription factor 2 SREBP2, bHLHd2 22q13.2
MAX MYC associated factor X bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8 14q23
MLX MLX, MAX dimerization protein TCFL4 MAD7, MXD7, bHLHd13 17q21.1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 KIAA0307, bHLHe1 15q25.1
ARNT aryl hydrocarbon receptor nuclear translocator HIF-1beta, bHLHe2 1q21
ARNTL aryl hydrocarbon receptor nuclear translocator-like MOP3, JAP3, BMAL1, PASD3, bHLHe5 11p15
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 BMAL2, MOP9, CLIF, PASD9, bHLHe6 12p12.2-p11.2
NPAS2 neuronal PAS domain protein 2 MOP4, PASD4, bHLHe9 2q11.2
NPAS1 neuronal PAS domain protein 1 MOP5, PASD5, bHLHe11 19q13.2-q13.3
NPAS3 neuronal PAS domain protein 3 MOP6, PASD6, bHLHe12 14q13.1
SIM1 single-minded family bHLH transcription factor 1 bHLHe14 6q16.3
SIM2 single-minded family bHLH transcription factor 2 SIM MGC119447, bHLHe15 21q22.2
HIF3A hypoxia inducible factor 3, alpha subunit IPAS, MOP7, PASD7, bHLHe17 19q13
OLIG2 oligodendrocyte lineage transcription factor 2 PRKCBP2, BHLHB1 RACK17, OLIGO2, bHLHe19 21q22.11
OLIG3 oligodendrocyte transcription factor 3 Bhlhb7, bHLHe20 6q23.3
OLIG1 oligodendrocyte transcription factor 1 BHLHB6, bHLHe21 21q22.11
BHLHE22 basic helix-loop-helix family, member e22 TNRC20, BHLHB5 CAGL85, Beta3, bHLHe22 8q12.1
BHLHE23 basic helix-loop-helix family, member e23 BHLHB4 bA305P22.3, Beta4, bHLHe23 20q13.33
MITF microphthalmia-associated transcription factor WS2A, WS2 MI, bHLHe32 3p14.1-p12.3
TFE3 transcription factor binding to IGHM enhancer 3 TFEA, bHLHe33 Xp11.22
TFEC transcription factor EC TCFEC, TFECL, bHLHe34 7q31.2
TFEB transcription factor EB TCFEB, bHLHe35 6p21
MLXIP MLX interacting protein MONDOA, KIAA0867, MIR, bHLHe36 12q21.31
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog NMYC bHLHe37, N-myc, MYCNOT 2p24.3
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog MYCL1 LMYC, bHLHe38 1p34.3
MYC v-myc avian myelocytomatosis viral oncogene homolog c-Myc, bHLHe39, MYCC 8q24
BHLHE40 basic helix-loop-helix family, member e40 STRA13, BHLHB2 DEC1, bHLHe40 3p26
BHLHE41 basic helix-loop-helix family, member e41 BHLHB3 DEC2, SHARP-1, SHARP1, bHLHe41 12p12.1
EPAS1 endothelial PAS domain protein 1 MOP2, PASD2, HIF2A, HLF, bHLHe73 2p21-p16
AHR aryl hydrocarbon receptor bHLHe76 7p15
AHRR aryl-hydrocarbon receptor repressor AHH, AHHR KIAA1234, bHLHe77 5p15.33
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) MOP1, HIF-1alpha, PASD8, HIF1, bHLHe78 14q23.2
NPAS4 neuronal PAS domain protein 4 PASD10, NXF, Le-PAS, bHLHe79 11q13.2
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 C9orf157 NOHLH, TEB2, bA100C15.3, bHLHe80, SPATA27 9q34.3
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 FLJ20449, TEB1, bHLHe81, SPATA28 13q13.3
TCFL5 transcription factor-like 5 (basic helix-loop-helix) Figlb, E2BP-1, CHA, bHLHe82 20q13.33
NCOA1 nuclear receptor coactivator 1 SRC1, F-SRC-1, NCoA-1, KAT13A, RIP160, bHLHe74 2p23
NCOA3 nuclear receptor coactivator 3 RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3 20q12
NCOA2 nuclear receptor coactivator 2 TIF2, GRIP1, NCoA-2, KAT13C, bHLHe75 8q13.3
CLOCK clock circadian regulator KIAA0334, KAT13D, bHLHe8 4q12
MXD1 MAX dimerization protein 1 MAD MAD1, bHLHc58 2p13-p12
MXI1 MAX interactor 1, dimerization protein MXD2, MAD2, MXI, bHLHc11 10q24-q25
MXD3 MAX dimerization protein 3 MAD3, bHLHc13 5q35.3
MXD4 MAX dimerization protein 4 MAD4, MSTP149, MST149, bHLHc12 4p16.3
MNT MAX network transcriptional repressor ROX, MXD6, MAD6, bHLHd3 17p13.3

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For a review of this family, see Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. PMC2894270

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