Skip to Navigation

Gene Family: Calpains (CAPN)

Also known as : "CANP", "Ca2+-activated neutral protease", "CASF", "CDP", "KAF", "intracellular Ca2+-dependent cysteine proteases"

Calpain: A calpain (EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium -dependent, non- lysosomal cysteine proteases ( proteolytic enzymes ) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin. [Source: Wikipedia]

Genes contained within the family: 15

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CAPN1 calpain 1 muCANP, muCL, CANP, CANPL1 11q13.1
CAPN2 calpain 2 mCANP, CANPml, CANPL2 1q41
CAPN3 calpain 3 LGMD2, LGMD2A CANP3, p94, nCL-1 15q15.1
CAPN5 calpain 5 VRNI nCL-3, HTRA3, ADNIV 11q13.5
CAPN6 calpain 6 CAPNX, CalpM, CANPX Xq23
CAPN7 calpain 7 PalBH 3p25.1
CAPN8 calpain 8 nCL-2 1q41
CAPN9 calpain 9 nCL-4, GC36 1q42.2
CAPN10 calpain 10 2q37.3
CAPN11 calpain 11 6p21.1
CAPN12 calpain 12 19q13.2
CAPN13 calpain 13 FLJ23523 2p23.1
CAPN14 calpain 14 2p23.1
CAPN15 calpain 15 SOLH 16p13.3
ADGB androglobin C6orf103 CAPN16, FLJ23121, dJ408K24.1 6q24.3

Publications

21670566