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Gene Family: ENAH/VASPs

Also known as : "ENA-VASPs", "ENA/VASPs"

ENAH/VASP: ENAH/VASPs are a family of closely related proteins involved in cell motility in vertebrate and invertebrate animals. ENAH/VASPs are modular proteins that are involved in actin polymerization, as well as interaction with other proteins. Within the cell, ENAH/VASP proteins are found at the leading edge of Lamellipodia and at the tips of filopodia. Ena, the founding member of the family was discovered in a Drosophila genetic screen for mutations that act as dominant suppressors of the abl non receptor tyrosine kinase. Invertebrate animals have one Ena homologue, whereas human and other mammals have three: ENAH, VASP and EVL. [Source: Wikipedia]

Genes contained within the family: 3

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ENAH ENAH, actin regulator FLJ10773, NDPP1, MENA 1q42.12
EVL Enah/Vasp-like RNB6 14q32.2
VASP vasodilator stimulated phosphoprotein 19q13.32