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Gene Family: Histone deacetylase superfamily (HDAC, SIRT)

Also known as : "Lysine deacetylases", "KDACs", "Histone deacetylases"

Histone deacetylase: Histone deacetylases (EC, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an epsilon-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins. [Source: Wikipedia]

Family contains the following subsets

Genes contained within subsets