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Gene Family: Membrane associated guanylate kinases

Also known as : "MAGUKs"

Membrane-associated guanylate kinase: The membrane-associated guanylate kinases (MAGUK) are a superfamily of proteins. The MAGUKs are defined by their inclusion of PDZ, SH3 and GUK domains, although many of them also contain regions homologous of CaMKII, WW and L27 domains. The GUK domain that they have is structurally very similar to that of the guanylate kinases, however it is known to be catalytically inactive as the P-Loop which binds ATP is absent. It is thought that the MAGUKs have subfunctionalized the GUK domain for their own purposes, primarily based on its ability to form protein-protein interactions with cytoskeleton proteins, microtubule / actin based machinery and molecules involved in signal transduction. The PDZ domain which are contained in the MAGUKs in varying numbers. PDZ domains are short peptide binding sequences commonly found at the C-terminus of interacting proteins. Copies within each of the family members often have different binding partners, due to amino acid differences between the copies. The SH3 domain is again a protein-protein interaction domain. Its family generally bind to PXXP sites, but in MAGUKs it is known to bind to other sites as well. One of the most well known features is that it can form an intramolecular bond with the GUK domain, creating what is known as a GUK-SH3 'closed' state. [Source: Wikipedia]

Genes contained within the family: 26

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 CACNLB1 17q12
CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 MYSB, CACNLB2 10p12
CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 CACNLB3 12q13.12
CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 EJM4 2q23.3
CARD10 caspase recruitment domain family member 10 CARMA3, BIMP1 22q13.1
CARD11 caspase recruitment domain family member 11 CARMA1, BIMP3 7p22.2
CARD14 caspase recruitment domain family member 14 PSORS2 CARMA2, BIMP2 17q25.3
CASK calcium/calmodulin dependent serine protein kinase TNRC8 LIN2, CAGH39, FGS4 Xp11.4
DLG1 discs large MAGUK scaffold protein 1 SAP97, SAP-97, hdlg, DLGH1, dJ1061C18.1.1 3q29
DLG2 discs large MAGUK scaffold protein 2 PSD-93, PSD93, chapsyn-110, PPP1R58 11q14.1
DLG3 discs large MAGUK scaffold protein 3 NE-Dlg, SAP102, SAP-102, NEDLG, KIAA1232, MRX90, PPP1R82 Xq13.1
DLG4 discs large MAGUK scaffold protein 4 PSD-95, PSD95, SAP90, SAP-90 17p13.1
DLG5 discs large MAGUK scaffold protein 5 P-dlg, KIAA0583 10q22.3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 BAIAP1 BAP1, MAGI-1, TNRC19, AIP3, WWP3 3p14.1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 AIP1, ARIP1, KIAA0705, ACVRIP1, MAGI-2 7q21.11
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 MAGI-3 1p13.2
MPP1 membrane palmitoylated protein 1 DXS552E PEMP Xq28
MPP2 membrane palmitoylated protein 2 DLG2 DKFZp761D0712 17q21.31
MPP3 membrane palmitoylated protein 3 DLG3 17q21.31
MPP4 membrane palmitoylated protein 4 DLG6 2q33.1
MPP5 membrane palmitoylated protein 5 PALS1, FLJ12615 14q23.3
MPP6 membrane palmitoylated protein 6 PALS2, VAM-1, p55T 7p15.3
MPP7 membrane palmitoylated protein 7 FLJ32798 10p12.1
TJP1 tight junction protein 1 ZO-1, MGC133289, DKFZp686M05161 15q13.1
TJP2 tight junction protein 2 DFNA51 ZO-2, X104, ZO2 9q21.11
TJP3 tight junction protein 3 ZO-3 19p13.3

Comments

This membrane-associated guanylate kinase family is based on PMID:17678554 and includes the non-canonical CACNB and MAGI subfamilies. Both these subfamilies contain a GUK domain but the CACNB proteins lack PDZ domains and MAGI proteins lack the SH3 domain.

Publications

17678554