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Gene Family: Astacins

Also known as : "M12 metallopeptidases"

Astacins: In molecular biology, the astacins are a family of metallopeptidases. These metallopeptidases belong to the MEROPS peptidase family M12, subfamily M12A (astacin family, clan MA(M)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA, and the predicted active site residues for members of this family and thermolysin occur in the motif HEXXH. The astacin family of metalloendopeptidases (EC 3.4.24.21) encompasses a range of proteins found in hydra to humans, in mature and developmental systems. Their functions include activation of growth factors, degradation of polypeptides, and processing of extracellular proteins. The proteins are synthesised with N-terminal signal and pro-enzyme sequences, and many contain multiple domains C-terminal to the protease domain. They are either secreted from cells, or are associated with the plasma membrane. The astacin molecule adopts a kidney shape, with a deep active-site cleft between its N- and C-terminal domains. The zinc ion, which lies at the bottom of the cleft, exhibits a unique penta-coordinated mode of binding, involving 3 histidine residues, a tyrosine and a water molecule (which is also bound to the carboxylate side chain of Glu93). The N-terminal domain comprises 2 alpha-helices and a 5-stranded beta-sheet. The overall topology of this domain is shared by the archetypal zinc-endopeptidase thermolysin. Astacin protease domains also share common features with serralysins, matrix metalloendopeptidases, and snake venom proteases; they cleave peptide bonds in polypeptides such as insulin B chain and bradykinin, and in proteins such as casein and gelatin; and they have arylamidase activity. [Source: Wikipedia]

Genes contained within the family: 6

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ASTL astacin like metalloendopeptidase ovastacin, SAS1B 2q11.2
BMP1 bone morphogenetic protein 1 PCOLC 8p21.3
MEP1A meprin A subunit alpha PPHA 6p12.3
MEP1B meprin A subunit beta 18q12.2-q12.3
TLL1 tolloid like 1 4q32.3
TLL2 tolloid like 2 10q24.1

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