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Gene Family: M10 matrix metallopeptidases (MMP)

Also known as : "matrix metalloproteinase", "MMPs", "matrixins"

Matrix metalloproteinases: Matrix metalloproteinases (MMPs) are zinc -dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively, these enzymes are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand ), and chemokine dispersion), differentiation, angiogenesis, apoptosis, and host defense. They were first described in vertebrates (1962), including humans, but have since been found in invertebrates and plants. They are distinguished from other endopeptidases by their dependence on metal ions as cofactors, their ability to degrade extracellular matrix, and their specific evolutionary DNA sequence. [Source: Wikipedia]

Genes contained within the family: 24

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MMP1 matrix metallopeptidase 1 CLG 11q22.2
MMP2 matrix metallopeptidase 2 CLG4, CLG4A TBE-1 16q12.2
MMP3 matrix metallopeptidase 3 STMY1, STMY 11q22.2
MMP7 matrix metallopeptidase 7 MPSL1 PUMP-1 11q22.2
MMP8 matrix metallopeptidase 8 CLG1 11q22.2
MMP9 matrix metallopeptidase 9 CLG4B 20q13.12
MMP10 matrix metallopeptidase 10 STMY2 11q22.2
MMP11 matrix metallopeptidase 11 STMY3 22q11.23
MMP12 matrix metallopeptidase 12 HME 11q22.2
MMP13 matrix metallopeptidase 13 CLG3 11q22.2
MMP14 matrix metallopeptidase 14 MT1-MMP 14q11.2
MMP15 matrix metallopeptidase 15 MT2-MMP, MTMMP2, SMCP-2 16q21
MMP16 matrix metallopeptidase 16 C8orf57 MT3-MMP, DKFZp761D112 8q21.3
MMP17 matrix metallopeptidase 17 MT4-MMP 12q24.33
MMP19 matrix metallopeptidase 19 MMP18 RASI-1 12q13.2
MMP20 matrix metallopeptidase 20 11q22.2
MMP21 matrix metallopeptidase 21 10q26.2
MMP23A matrix metallopeptidase 23A (pseudogene) MMP21 MIFR 1p36.33
MMP23B matrix metallopeptidase 23B MMP22 MIFR, MIFR-1 1p36.33
MMP24 matrix metallopeptidase 24 MT5-MMP 20q11.22
MMP25 matrix metallopeptidase 25 MMPL1, MMP20 MT6-MMP 16p13.3
MMP26 matrix metallopeptidase 26 endometase, MGC126590, MGC126592 11p15.4
MMP27 matrix metallopeptidase 27 11q22.2
MMP28 matrix metallopeptidase 28 MMP-25, MM28, EPILYSIN, MMP-28 17q12

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