Skip to Navigation

Gene Family: Minor histocompatibility antigens

Also known as : "MHA", "mHAg", "MiHA", "mHags", " minor H antigen"

Minor histocompatibility antigen: Minor histocompatibility antigens (a.k.a. MHA) are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants. They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC). Minor histocompatibility antigens are due to normal proteins that are in themselves polymorphic in a given population. Even when a transplant donor and recipient are identical with respect to their major histocompatibility complex genes, the amino acid differences in minor proteins can cause the grafted tissue to be slowly rejected. [Source: Wikipedia]

Genes contained within the family: 51

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AKAP13 A-kinase anchoring protein 13 LBC Ht31, BRX, AKAP-Lbc, c-lbc, PROTO-LB, HA-3, ARHGEF13 15q25.3
APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B PHRBNL, FLJ21201 22q13.1
ARHGDIB Rho GDP dissociation inhibitor beta RAP1GN1, GDIA2, GDID4 Ly-GDI, RhoGDI2 12p12.3
BCAT2 branched chain amino acid transaminase 2 BCT2 BCAM 19q13.33
BCL2A1 BCL2 related protein A1 HBPA1 GRS, BFL1, BCL2L5, ACC-1, ACC-2, ACC2, ACC1 15q25.1
CD19 CD19 molecule 16p11.2
CENPM centromere protein M C22orf18 Pane1, CENP-M, MGC861 22q13.2
CTSH cathepsin H CPSB ACC-4, ACC-5, ACC4, ACC5 15q25.1
C19orf48 chromosome 19 open reading frame 48 MGC13170, BC006151 19q13.33
DDX3Y DEAD-box helicase 3, Y-linked DBY Yq11.221
DPH1 diphthamide biosynthesis 1 DPH2L, DPH2L1 OVCA1 17p13.3
EBI3 Epstein-Barr virus induced 3 IL27B, IL35B 19p13.3
ERAP1 endoplasmic reticulum aminopeptidase 1 ARTS-1, A-LAP, PILS-AP, KIAA0525, ERAAP1 5q15
ERBB2 erb-b2 receptor tyrosine kinase 2 NGL NEU, HER-2, CD340, HER2 17q12
GEMIN4 gem nuclear organelle associated protein 4 HHRF-1, DKFZP434B131, p97, DKFZP434D174, HC56, HCAP1 17p13.3
HEATR1 HEAT repeat containing 1 FLJ10359, BAP28, UTP10 1q43
ARHGAP45 Rho GTPase activating protein 45 HMHA1 KIAA0223, HA-1 19p13.3
HMHB1 histocompatibility minor HB-1 HB-1, HB-1Y 5q31.3
HMSD histocompatibility minor serpin domain containing C18orf53 ACC-6, ACC6 18q22.1
KDM5D lysine demethylase 5D HYA, HY, SMCY, JARID1D KIAA0234 Yq11.223
PUM3 pumilio RNA binding family member 3 KIAA0020 XTP5, PEN, PUF6, hPUF-A, HA-8 9p24.2
KIAA1551 KIAA1551 C12orf35 FLJ20696, FLJ10652, UTA2-1, GET 12p11.21
LY75 lymphocyte antigen 75 DEC-205, CLEC13B, CD205 2q24.2
MR1 major histocompatibility complex, class I-related HLALS 1q25.3
MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 MTHFC, MTHFD 14q23.3
MYO1G myosin IG HA-2 7p13
NUP133 nucleoporin 133 FLJ10814 1q42.13
PDCD11 programmed cell death 11 KIAA0185, ALG-4, RRP5 10q24.33
PI4K2B phosphatidylinositol 4-kinase type 2 beta PI4KIIB, FLJ11105, PIK42B 4p15.2
PKN3 protein kinase N3 PKNbeta, UTDP4-1 9q34.11
PRCP prolylcarboxypeptidase PCP, HUMPCP 11q14
PTK2B protein tyrosine kinase 2 beta FAK2 CAKB, PYK2, RAFTK, PTK, CADTK 8p21.2
P2RX5 purinergic receptor P2X 5 P2X5, LRH-1 17p13.2
RPS4Y1 ribosomal protein S4, Y-linked 1 RPS4Y MGC5070, MGC119100, S4 Yp11.2
SLC1A5 solute carrier family 1 member 5 RDRC, M7V1 AAAT, ASCT2 19q13.32
SLC19A1 solute carrier family 19 member 1 FOLT, RFC1 21q22.3
SON SON DNA binding protein C21orf50 DBP-5, NREBP, KIAA1019, BASS1, FLJ21099, FLJ33914 21q22.11
SP110 SP110 nuclear body protein IFI41, IFI75 2q37.1
SSR1 signal sequence receptor subunit 1 TRAPA 6p24.3
SWAP70 switching B-cell complex subunit SWAP70 KIAA0640, SWAP-70 11p15.4
TMSB4Y thymosin beta 4, Y-linked TB4Y Yq11.221
TOR3A torsin family 3 member A ADIR FLJ22345, ADIR2 1q25.2
TRIM22 tripartite motif containing 22 STAF50, GPSTAF50, RNF94 11p15.4
TRIM42 tripartite motif containing 42 FLJ40097, PPP1R40, T4A1 3q23
TRIP10 thyroid hormone receptor interactor 10 STOT STP, HSTP, CIP4 19p13.3
TYMP thymidine phosphorylase MNGIE, ECGF1 22q13.33
UGT2B17 UDP glucuronosyltransferase family 2 member B17 4q13.2
USP9Y ubiquitin specific peptidase 9, Y-linked DFFRY Yq11.221
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked KDM6AL, KDM6C Yq11.221
WNK1 WNK lysine deficient protein kinase 1 PRKWNK1, HSN2 HSAN2, PPP1R167 12p13.33
ZNF419 zinc finger protein 419 ZNF419A ZAPHIR 19q13.43