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Gene Family: EF-hand domain containing

Also known as : "EF hand domain containing"

EF hand: The EF hand is a helix-loop-helix structural domain or motif found in a large family of calcium-binding proteins. The EF-hand motif contains a helix-loop-helix topology, much like the spread thumb and forefinger of the human hand, in which the Ca 2+ ions are coordinated by ligands within the loop. The motif takes its name from traditional nomenclature used in describing the protein parvalbumin, which contains three such motifs and is probably involved in muscle relaxation via its calcium-binding activity. The EF-hand consists of two alpha helices linked by a short loop region (usually about 12 amino acids ) that usually binds calcium ions. [Source: Wikipedia]

Family contains the following subsets

Genes contained within the family: 219

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AIF1 allograft inflammatory factor 1 IRT-1, AIF-1, Em:AF129756.17, IBA1 6p21.33
AIF1L allograft inflammatory factor 1 like C9orf58 IBA2, FLJ12783 9q34.12-q34.13
ANKEF1 ankyrin repeat and EF-hand domain containing 1 ANKRD5 FLJ21669, dJ839B4.6 20p12.2
CABP1 calcium binding protein 1 12q24.31
CABP2 calcium binding protein 2 DFNB93 11q13.2
CABP4 calcium binding protein 4 CSNB2B 11q13.2
CABP5 calcium binding protein 5 CABP3 CaBP3 19q13.33
CABP7 calcium binding protein 7 MGC57793 22q12.2
CACNA1B calcium voltage-gated channel subunit alpha1 B CACNL1A5 Cav2.2, CACNN 9q34.3
CACNA1E calcium voltage-gated channel subunit alpha1 E CACNL1A6 Cav2.3, BII, CACH6 1q25.3
CALB1 calbindin 1 CALB 8q21.3
CALB2 calbindin 2 CAL2 16q22.2
CALML3 calmodulin like 3 CLP 10p15.1
CALML4 calmodulin like 4 MGC4809, NY-BR-20 15q23
CALML5 calmodulin like 5 CLSP 10p15.1
CALML6 calmodulin like 6 CAGLP 1p36.33
CALM1 calmodulin 1 CALML2 CAMI, PHKD, DD132 14q32.11
CALM2 calmodulin 2 PHKD, CAMII 2p21
CALM3 calmodulin 3 PHKD 19q13.32
CALN1 calneuron 1 CABP8 7q11.22
CALU calumenin 7q32.1
CAPNS1 calpain small subunit 1 CAPN4 CANP, CANPS, 30K, CDPS 19q13.12
CAPNS2 calpain small subunit 2 MGC12536, MGC14804 16q12.2
CAPN1 calpain 1 muCANP, muCL, CANP, CANPL1 11q13.1
CAPN2 calpain 2 mCANP, CANPml, CANPL2 1q41
CAPN3 calpain 3 LGMD2, LGMD2A CANP3, p94, nCL-1 15q15.1
CAPN8 calpain 8 nCL-2 1q41
CAPN9 calpain 9 nCL-4, GC36 1q42.2
CAPN11 calpain 11 6p21.1
CAPN12 calpain 12 19q13.2
CAPN14 calpain 14 2p23.1
CAPS calcyphosine CAPS1, MGC126562 19p13.3
CAPSL calcyphosine like MGC26610 5p13.2
CAPS2 calcyphosine 2 12q21.1-q21.2
CETN1 centrin 1 CETN CEN1 18p11.32
CETN2 centrin 2 CALT CEN2 Xq28
CETN3 centrin 3 CEN3 5q14.3
CGREF1 cell growth regulator with EF-hand domain 1 CGR11 2p23.3
CHP1 calcineurin like EF-hand protein 1 Sid470p, CHP, SLC9A1BP, p22, p24 15q15.1
CHP2 calcineurin like EF-hand protein 2 16p12.2
CIB1 calcium and integrin binding 1 SIP2-28, CIB, KIP 15q26.1
CIB2 calcium and integrin binding family member 2 DFNB48, USH1J KIP2 15q25.1
CIB3 calcium and integrin binding family member 3 KIP3 19p13.11
CIB4 calcium and integrin binding family member 4 2p23.3
CRACR2A calcium release activated channel regulator 2A EFCAB4B MGC4266 12p13.32
CRACR2B calcium release activated channel regulator 2B EFCAB4A MGC45840 11p15.5
CRNN cornulin C1orf10 SEP53 1q21.3
DGKA diacylglycerol kinase alpha DAGK, DAGK1 DGK-alpha 12q13.2
DGKB diacylglycerol kinase beta DAGK2 KIAA0718, DGK, DGK-BETA 7p21.2
DGKG diacylglycerol kinase gamma DAGK3 3q27.2-q27.3
DNAH7 dynein axonemal heavy chain 7 KIAA0944 2q32.3
DST dystonin BPAG1 BP240, KIAA0728, FLJ21489, FLJ13425, FLJ32235, FLJ30627, CATX-15, BPA, MACF2 6p12.1
DUOX1 dual oxidase 1 NOXEF1, THOX1, LNOX1 15q21.1
DUOX2 dual oxidase 2 P138-TOX, P138(TOX), THOX2, LNOX2 15q21.1
EFCAB1 EF-hand calcium binding domain 1 FLJ11767 8q11.21
EFCAB2 EF-hand calcium binding domain 2 MGC12458, DRC8, CFAP200 1q44
EFCAB3 EF-hand calcium binding domain 3 FLJ25818 17q23.2
EFCAB5 EF-hand calcium binding domain 5 FLJ46247 17q11.2
EFCAB6 EF-hand calcium binding domain 6 FLJ23588, DJBP, HSCBCIP1, KIAA1672, dJ185D5.1 22q13.2-q13.31
EFCAB7 EF-hand calcium binding domain 7 KIAA1799, RP4-534K7.1 1p31.3
EFCAB8 EF-hand calcium binding domain 8 20q11.21
EFCAB9 EF-hand calcium binding domain 9 5q35.1
EFCAB10 EF-hand calcium binding domain 10 7q22.3
EFCAB11 EF-hand calcium binding domain 11 C14orf143 14q32.11
EFCAB12 EF-hand calcium binding domain 12 C3orf25 3q21.3
EFCAB13 EF-hand calcium binding domain 13 C17orf57 FLJ40342 17q21.32
EFCAB14 EF-hand calcium binding domain 14 KIAA0494 1p33
EFCC1 EF-hand and coiled-coil domain containing 1 C3orf73, CCDC48 FLJ12057 3q21.3
EFHB EF-hand domain family member B FLJ25200, CFAP21 3p24.3
EFHC1 EF-hand domain containing 1 EJM1, EJM FLJ10466 6p12.2
EFHC2 EF-hand domain containing 2 MRX74 FLJ22843 Xp11.3
EFHD1 EF-hand domain family member D1 FLJ13612 2q37.1
EFHD2 EF-hand domain family member D2 MGC4342 1p36.21
EHD1 EH domain containing 1 PAST1 H-PAST, HPAST1, FLJ42622, FLJ44618 11q13.1
EHD2 EH domain containing 2 PAST2 19q13.33
EHD3 EH domain containing 3 PAST3 2p23.1
EHD4 EH domain containing 4 PAST4 15q15.1
EPS15 epidermal growth factor receptor pathway substrate 15 AF-1P, MLLT5 1p32.3
EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 eps15R 19p13.11
FKBP7 FK506 binding protein 7 FKBP23 2q31.2
FKBP9 FK506 binding protein 9 FKBP60, FKBP63 7p14.3
FKBP10 FK506 binding protein 10 hFKBP65, FLJ22041, FKBP6, FLJ20683, FLJ23833 17q21.2
FKBP14 FK506 binding protein 14 FLJ20731, FKBP22 7p14.3
FLG filaggrin 1q21.3
FLG2 filaggrin family member 2 IFPS 1q21.3
FSTL4 follistatin like 4 KIAA1061 5q31.1
FSTL5 follistatin like 5 DKFZp566D234, KIAA1263 4q32.2
GCA grancalcin GCL 2q24.2
GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits GNPTA KIAA1208, MGC4170 12q23.2
GPD2 glycerol-3-phosphate dehydrogenase 2 2q24.1
GUCA1A guanylate cyclase activator 1A GUCA, GUCA1, C6orf131 GCAP, GCAP1, COD3, dJ139D8.6, CORD14 6p21.1
GUCA1B guanylate cyclase activator 1B GCAP2, RP48 6p21.1
GUCA1C guanylate cyclase activator 1C GCAP3 3q13.13
HPCA hippocalcin 1p35.1
HPCAL1 hippocalcin like 1 BDR1, HLP2, VILIP-3 2p25.1
HPCAL4 hippocalcin like 4 HLP4, DKFZp761G122 1p34.2
HRNR hornerin S100a18, S100A16, FLG3 1q21.3
ITSN1 intersectin 1 SH3D1A, ITSN SH3P17, MGC134948, MGC134949 21q22.11
ITSN2 intersectin 2 SH3D1B KIAA1256, SWAP, SH3P18, SWA, PRO2015 2p23.3
KCNIP1 potassium voltage-gated channel interacting protein 1 KCHIP1 5q35.1
KCNIP2 potassium voltage-gated channel interacting protein 2 KCHIP2 10q24.32
KCNIP3 potassium voltage-gated channel interacting protein 3 CSEN DREAM, KCHIP3 2q11.1
KCNIP4 potassium voltage-gated channel interacting protein 4 CALP, KCHIP4, MGC44947 4p15.31-p15.2
LCP1 lymphocyte cytosolic protein 1 PLS2, CP64, L-PLASTIN, LC64P 13q14.13
LETM1 leucine zipper and EF-hand containing transmembrane protein 1 4p16.3
LETM2 leucine zipper and EF-hand containing transmembrane protein 2 FLJ25409 8p11.23
LPCAT1 lysophosphatidylcholine acyltransferase 1 AYTL2 FLJ12443, AGPAT9, AGPAT10 5p15.33
LPCAT2 lysophosphatidylcholine acyltransferase 2 AYTL1 FLJ20481, AGPAT11, LysoPAFAT 16q12.2
MACF1 microtubule-actin crosslinking factor 1 KIAA0465, ACF7, ABP620, KIAA1251, MACF, FLJ45612, FLJ46776 1p34.3
MCC mutated in colorectal cancers 5q22.2
MCFD2 multiple coagulation factor deficiency 2 F5F8D, LMAN1IP, SDNSF 2p21
MICU1 mitochondrial calcium uptake 1 CBARA1 CALC, EFHA3, FLJ12684 10q22.1
MICU2 mitochondrial calcium uptake 2 EFHA1 13q12.11
MICU3 mitochondrial calcium uptake family member 3 EFHA2 DKFZp313A0139 8p22
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle MRLC2, HUMMLC2B, MYL11 16p11.2
MYL1 myosin light chain 1 2q34
MYL2 myosin light chain 2 CMH10 12q24.11
MYL3 myosin light chain 3 CMH8, VLC1, MLC1V, MLC1SB 3p21.31
MYL4 myosin light chain 4 ALC1, AMLC, GT1, PRO1957 17q21.32
MYL5 myosin light chain 5 4p16.3
MYL6 myosin light chain 6 ESMLC, MLC3NM, MLC1SM 12q13.2
MYL6B myosin light chain 6B MLC1SA 12q13.2
MYL7 myosin light chain 7 MYLC2A, MYL2A 7p13
MYL9 myosin light chain 9 MYRL2, MLC2, LC20, MRLC1 20q11.23
MYL10 myosin light chain 10 MGC3479, MYLC2PL, PLRLC 7q22.1
MYL12A myosin light chain 12A MLCB, MYL2B, MRLC3, MRCL3 18p11.31
MYL12B myosin light chain 12B MRLC2 18p11.31
NCALD neurocalcin delta 8q22.3
NCS1 neuronal calcium sensor 1 FREQ NCS-1 9q34.11
NECAB1 N-terminal EF-hand calcium binding protein 1 EFCBP1 8q21.3
NECAB2 N-terminal EF-hand calcium binding protein 2 EFCBP2 16q23.3
NECAB3 N-terminal EF-hand calcium binding protein 3 SYTIP2, APBA2BP XB51, dJ63M2.4, NIP1, dJ63M2.5, EFCBP3 20q11.22
NIN ninein 14q22.1
NINL ninein like KIAA0980, NLP 20p11.21
NKD1 naked cuticle homolog 1 16q12.1
NKD2 naked cuticle homolog 2 Naked2 5p15.33
NOX5 NADPH oxidase 5 NOX5A, NOX5B 15q23
NUCB1 nucleobindin 1 NUC, Calnuc 19q13.33
NUCB2 nucleobindin 2 NEFA 11p15.1
OCM oncomodulin OCM1 7p22.1
OCM2 oncomodulin 2 7q21.3
PDCD6 programmed cell death 6 ALG-2, PEF1B 5p15.33
PEF1 penta-EF-hand domain containing 1 PEF1A 1p35.2
PKD2 polycystin 2, transient receptor potential cation channel PKD4, PC2, Pc-2, TRPP2 4q22.1
PLCD1 phospholipase C delta 1 3p22.2
PLCD4 phospholipase C delta 4 2q35
PLCG1 phospholipase C gamma 1 PLC1 PLC148, PLC-II, PLCgamma1, NCKAP3 20q12
PLCH1 phospholipase C eta 1 PLCL3 KIAA1069, MGC117152, DKFZp434C1372, PLCeta1 3q25.31
PLCH2 phospholipase C eta 2 PLCL4 KIAA0450, PLCeta2, RP3-395M20.1, PLC-eta2 1p36.32
PLCZ1 phospholipase C zeta 1 NYD-SP27, PLCzeta 12p12.3
PLS1 plastin 1 I-plastin, Plastin-1 3q23
PLS3 plastin 3 T-plastin Xq23
PPEF1 protein phosphatase with EF-hand domain 1 PPEF PPP7CA Xp22.13
PPEF2 protein phosphatase with EF-hand domain 2 PPP7CB 4q21.1
PPP2R3A protein phosphatase 2 regulatory subunit B''alpha PPP2R3 PR130, PR72 3q22.2-q22.3
PPP2R3B protein phosphatase 2 regulatory subunit B''beta PPP2R3L PPP2R3LY, PR48, PR70 Xp22.3 and Yp11.3
PPP3R1 protein phosphatase 3 regulatory subunit B, alpha CALNB1, CNB, CNB1 2p14
PPP3R2 protein phosphatase 3 regulatory subunit B, beta PPP3RL 9q31.1
PRKCSH protein kinase C substrate 80K-H G19P1, PCLD, PLD1 VASAP-60, GIIB 19p13.2
PVALB parvalbumin D22S749 22q12.3
RAB11FIP3 RAB11 family interacting protein 3 KIAA0665, Rab11-FIP3, eferin 16p13.3
RAB11FIP4 RAB11 family interacting protein 4 RAB11-FIP4, KIAA1821, MGC11316, FLJ00131 17q11.2
RASEF RAS and EF-hand domain containing RAB45 FLJ31614 9q21.32
RASGRP1 RAS guanyl releasing protein 1 CalDAG-GEFII, RASGRP 15q14
RASGRP2 RAS guanyl releasing protein 2 CALDAG-GEFI 11q13.1
RASGRP3 RAS guanyl releasing protein 3 KIAA0846, GRP3, CalDAG-GEFIII 2p22.3
RASGRP4 RAS guanyl releasing protein 4 19q13.1
RCN1 reticulocalbin 1 RCN Rcal, PIG20, FLJ37041 11p13
RCN2 reticulocalbin 2 ERC-55, E6BP, ERC55, TCBP49 15q24.3
RCN3 reticulocalbin 3 RLP49 19q13.33
RCVRN recoverin RCV1 17p13.1
REPS1 RALBP1 associated Eps domain containing 1 6q24.1
REPS2 RALBP1 associated Eps domain containing 2 POB1 Xp22.2
RHBDL3 rhomboid like 3 RHBDL4 VRHO 17q11.2
RHOT1 ras homolog family member T1 ARHT1 MIRO-1, FLJ11040 17q11.2
RHOT2 ras homolog family member T2 C16orf39, ARHT2 MIRO-2 16p13.3
RPTN repetin FLJ39117 1q21.3
RYR2 ryanodine receptor 2 ARVD2 ARVC2, VTSIP 1q43
RYR3 ryanodine receptor 3 15q13.3-q14
SCGN secretagogin, EF-hand calcium binding protein SECRET, DJ501N12.8, SEGN, CALBL 6p22.2
SDF4 stromal cell derived factor 4 Cab45 1p36.33
SELENON selenoprotein N SEPN1, RSMD1, MDRS1 SELN, RSS 1p36.11
SLC25A12 solute carrier family 25 member 12 Aralar 2q31.1
SLC25A13 solute carrier family 25 member 13 CTLN2 CITRIN, ARALAR2 7q21.3
SLC25A23 solute carrier family 25 member 23 FLJ30339, MGC2615, APC2 19p13.3
SLC25A24 solute carrier family 25 member 24 DKFZp586G0123, APC1 1p13.3
SLC25A25 solute carrier family 25 member 25 KIAA1896, PCSCL, MCSC 9q34.11
SPATA21 spermatogenesis associated 21 spergen-2, spergen2 1p36.13
SPTAN1 spectrin alpha, non-erythrocytic 1 9q34.11
SPTA1 spectrin alpha, erythrocytic 1 EL2 1q23.1
SRI sorcin 7q21.12
SWAP70 switching B-cell complex subunit SWAP70 KIAA0640, SWAP-70 11p15.4
S100A1 S100 calcium binding protein A1 S100A S100-alpha 1q21.3
S100A2 S100 calcium binding protein A2 S100L CAN19 1q21.3
S100A4 S100 calcium binding protein A4 MTS1, CAPL P9KA, 18A2, PEL98, 42A, FSP1 1q21.3
S100A5 S100 calcium binding protein A5 S100D 1q21.3
S100A6 S100 calcium binding protein A6 CACY 2A9, PRA, CABP 1q21.3
S100A7 S100 calcium binding protein A7 PSOR1 S100A7c 1q21.3
S100A7A S100 calcium binding protein A7A S100A15, S100A7L1 S100A7f 1q21.3
S100A7L2 S100 calcium binding protein A7 like 2 s100a7b 1q21.3
S100A8 S100 calcium binding protein A8 CAGA, CFAG P8, MRP8, 60B8AG, CGLA 1q21.3
S100A9 S100 calcium binding protein A9 CAGB, CFAG P14, MIF, NIF, LIAG, MRP14, MAC387, 60B8AG, CGLB 1q21.3
S100A11 S100 calcium binding protein A11 S100C 1q21.3
S100A12 S100 calcium binding protein A12 p6, MRP6, CGRP, CAAF1, CAGC, ENRAGE 1q21.3
S100A16 S100 calcium binding protein A16 S100F, DT1P1A7, MGC17528 1q21.3
S100B S100 calcium binding protein B S100beta 21q22.3
S100G S100 calcium binding protein G CALB3 CABP9K, CABP1 Xp22.2
S100P S100 calcium binding protein P 4p16.1
S100Z S100 calcium binding protein Z Gm625, S100-zeta 5q13.3
TBC1D8B TBC1 domain family member 8B FLJ20298, RP11-321G1.1, GRAMD8B Xq22.3
TBC1D9 TBC1 domain family member 9 KIAA0882, MDR1, GRAMD9 4q31.21
TBC1D9B TBC1 domain family member 9B KIAA0676, GRAMD9B 5q35.3
TCHH trichohyalin THH 1q21.3
TESC tescalcin TSC, FLJ20607, CHP3 12q24.22
TNNC1 troponin C1, slow skeletal and cardiac type TNNC 3p21.1
TNNC2 troponin C2, fast skeletal type 20q13.12
USP32 ubiquitin specific peptidase 32 NY-REN-60, USP10 17q23.3
VSNL1 visinin like 1 VILIP, HPCAL3, HUVISL1, HLP3, VILIP-1 2p24.2
ZZEF1 zinc finger ZZ-type and EF-hand domain containing 1 KIAA0399, ZZZ4, FLJ10821 17p13.2

Genes contained within subsets