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Gene Family: Small Cajal body-specific RNAs (SCARNA)

A subset of : Small nucleolar RNAs

Small Cajal body-specific RNA: Small Cajal body-specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) that specifically localise to the Cajal body, a nuclear organelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs or snurps). ScaRNAs guide the modification ( methylation and pseudouridylation ) of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. The first scaRNA identified was U85. It is unlike typical snoRNAs in that it is a composite CACA box snoRNAs and can guide both pseudouridylation and 2'-O-methylation. Not all scaRNAs are composite C/D and H/ACA box snoRNA and most scaRNAs are structurally and functionally indistinguishable from snoRNAs, directing ribosomal RNA (rRNA) modification in the nucleolus. [Source: Wikipedia]

Genes contained within the family: 27

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SCARNA1 small Cajal body-specific RNA 1 ACA35 1p35.3
SCARNA2 small Cajal body-specific RNA 2 mgU2-25/61, HBII-382 1q13.1
SCARNA3 small Cajal body-specific RNA 3 HBI-100 1q25.1
SCARNA4 small Cajal body-specific RNA 4 ACA26 1q22
SCARNA5 small Cajal body-specific RNA 5 U87 2q37.1
SCARNA6 small Cajal body-specific RNA 6 U88 2q37.1
SCARNA7 small Cajal body-specific RNA 7 U90 3q25.22
SCARNA8 small Cajal body-specific RNA 8 U92 9p22.1
SCARNA9 small Cajal body-specific RNA 9 mgU2-19/30, Z32 11q21
SCARNA9L small Cajal body-specific RNA 9-like Xp22.12
SCARNA10 small Cajal body-specific RNA 10 U85 12p13.31
SCARNA11 small Cajal body-specific RNA 11 ACA57 12p13.31
SCARNA12 small Cajal body-specific RNA 12 U89 12p13.31
SCARNA13 small Cajal body-specific RNA 13 U93 14q32.12
SCARNA14 small Cajal body-specific RNA 14 U100 15q22.31
SCARNA15 small Cajal body-specific RNA 15 ACA45 15q25.2
SCARNA16 small Cajal body-specific RNA 16 ACA47 17q25.2
SCARNA17 small Cajal body-specific RNA 17 mgU12-22/U4-8, U91 18q21.1
SCARNA18 small Cajal body-specific RNA 18 U109, SCARNA18A 5q14.2
SCARNA20 small Cajal body-specific RNA 20 ACA66 17q23.2
SCARNA21 small Cajal body-specific RNA 21 ACA68, SCARNA21A 17p13.1
SCARNA22 small Cajal body-specific RNA 22 ACA11 4p16.3
SCARNA23 small Cajal body-specific RNA 23 ACA12 Xp22.11
SCARNA26A small Cajal body-specific RNA 26A 1q22
SCARNA26B small Cajal body-specific RNA 26B 1q22
SCARNA27 small Cajal body-specific RNA 27 6p24.3
SCARNA28 small Cajal body-specific RNA 28 ZL1 7q22.1

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