Skip to Navigation

Gene Family: C2 domain containing

C2 domain: A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 Beta-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. Many other C2 domain families don't have calcium binding activity. [Source: Wikipedia]

Family contains the following subsets

Genes contained within the family: 38

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ABR active BCR-related MDB 17p13.3
AIDA axin interactor, dorsalization associated C1orf80 FLJ12806 1q41
BAIAP3 BAI1 associated protein 3 BAP3, KIAA0734 16p13.3
BCR BCR, RhoGEF and GTPase activating protein D22S11, BCR1 D22S662, CML, PHL, ALL 22q11.23
CADPS2 calcium dependent secretion activator 2 CAPS2 7q31.32
CAPN5 calpain 5 VRNI nCL-3, HTRA3, ADNIV 11q13.5
CAPN6 calpain 6 CAPNX, CalpM, CANPX Xq23
CCDC33 coiled-coil domain containing 33 FLJ32855, CT61 15q24.1
CC2D1A coiled-coil and C2 domain containing 1A FLJ20241, MRT3 19p13.12
CC2D1B coiled-coil and C2 domain containing 1B KIAA1836 1p32.3
C2CD2 C2 calcium dependent domain containing 2 C21orf25 TMEM24L, DKFZP586F0422, C21orf258 21q22.3
C2CD3 C2 calcium dependent domain containing 3 DKFZP586P0123 11q13.4
C2CD4A C2 calcium dependent domain containing 4A FAM148A NLF1 15q22.2
C2CD4B C2 calcium dependent domain containing 4B FAM148B NLF2 15q22.2
C2CD4C C2 calcium dependent domain containing 4C KIAA1957, FAM148C NLF3 19p13.3
C2CD4D C2 calcium dependent domain containing 4D FAM148D 1q21.3
C2CD5 C2 calcium dependent domain containing 5 KIAA0528 CDP138 12p12.1
C2CD6 C2 calcium dependent domain containing 6 ALS2CR11 FLJ25351 2q33.1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 KIAA0322, NEDL1 7p14.1-p13
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 KIAA1301, NEDL2 2q32.3
INPP4A inositol polyphosphate-4-phosphatase type I A INPP4 2q11.2
INPP4B inositol polyphosphate-4-phosphatase type II B 4q31.21
ITCH itchy E3 ubiquitin protein ligase AIP4 20q11.22
ITSN1 intersectin 1 SH3D1A, ITSN SH3P17, MGC134948, MGC134949 21q22.11
ITSN2 intersectin 2 SH3D1B KIAA1256, SWAP, SH3P18, SWA, PRO2015 2p23.3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase KIAA0439, RSP5, NEDD4-2 18q21.31
PCLO piccolo presynaptic cytomatrix protein KIAA0559, DKFZp779G1236, ACZ 7q21.11
PRF1 perforin 1 PFP, P1, HPLH2 10q22.1
RAB11FIP1 RAB11 family interacting protein 1 RCP, FLJ22622, FLJ22524, Rab11-FIP1 8p11.23
RAB11FIP2 RAB11 family interacting protein 2 KIAA0941, nRip11, Rab11-FIP2 10q26.11
RAB11FIP5 RAB11 family interacting protein 5 GAF1, KIAA0857, RIP11, pp75 2p13.2
RGS3 regulator of G protein signaling 3 C2PA, FLJ20370, PDZ-RGS3 9q32
RPGRIP1 RPGR interacting protein 1 RPGRIP RGI1, LCA6, CORD13 14q11.2
RPGRIP1L RPGRIP1 like KIAA1005, CORS3, JBTS7, MKS5, NPHP8, FTM, PPP1R134 16q12.2
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 17q23.3-q24.1
SYDE2 synapse defective Rho GTPase homolog 2 FLJ13815 1p22.3
TOLLIP toll interacting protein IL-1RAcPIP 11p15.5
UVRAG UV radiation resistance associated VPS38 11q13.5

Genes contained within subsets

Comments

The genes displayed in the gene table that is open by default on this page shows the C2 domain containing-encoding genes that are not grouped into further subsets. You can view all genes in the subsets on this page by clicking on the plus sign next to the text "Genes contained within subsets", or you can navigate through to the individual gene family page for each subset.

Publications

20713135