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Gene Family: Guanylate cyclases, soluble (GUCY1)

Also known as : "Soluble guanylyl cyclases", "sGCs"
A subset of : Guanylate cyclases

Soluble guanylyl cyclase: Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide, NO. It is soluble, i.e. completely intracellular. Most notably, this enzyme is involved in vasodilation. In humans, it is encoded by the genes GUCY1A2, GUCY1A3, GUCY1B2 and GUCY1B3. It is classified under EC number 4.6.1.2. [Source: Wikipedia]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2 GUC1A2 GC-SA2 11q22.3
GUCY1A3 guanylate cyclase 1 soluble subunit alpha GUC1A3 GC-SA3 4q32.1
GUCY1B2 guanylate cyclase 1 soluble subunit beta 2 (pseudogene) GC-SB2 13q14.3
GUCY1B3 guanylate cyclase 1 soluble subunit beta GUC1B3 GC-SB3, GC-S-beta-1 4q32.1