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Gene Family: Nuclear hormone receptors (NR)

Also known as : "Zinc fingers, C4-type"
A subset of : Zinc fingers

Nuclear receptor: In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors generally only happens when a ligand - a molecule that affects the receptor's behavior -€” is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor, which, in turn, activates the receptor, resulting in up-regulation or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. As a consequence, nuclear receptors play key roles in both embryonic development and adult homeostasis. As discussed below, nuclear receptors may be classified according to either mechanism or homology. [Source: Wikipedia]

Genes contained within the family: 49

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
NR0B1 nuclear receptor subfamily 0 group B member 1 AHC, DSS DAX1, AHCH Xp21.2
NR0B2 nuclear receptor subfamily 0 group B member 2 SHP 1p36.11
THRA thyroid hormone receptor, alpha THRA1, THRA2, ERBA1 NR1A1, EAR-7.1/EAR-7.2, AR7, THRA3, ERBA 17q21.1
THRB thyroid hormone receptor beta ERBA2, PRTH ERBA-BETA, THR1, GRTH, NR1A2, THRB2, THRB1 3p24.2
RARA retinoic acid receptor alpha NR1B1, RAR 17q21.2
RARB retinoic acid receptor beta HAP, RRB2, NR1B2 3p24.2
RARG retinoic acid receptor gamma RARC, NR1B3 12q13.13
PPARA peroxisome proliferator activated receptor alpha PPAR hPPAR, NR1C1 22q13.31
PPARD peroxisome proliferator activated receptor delta NUCII, FAAR, NUC1, NR1C2 6p21.31
PPARG peroxisome proliferator activated receptor gamma NR1C3, PPARG2, PPARgamma, PPARG1 3p25.2
NR1D1 nuclear receptor subfamily 1 group D member 1 THRAL ear-1, hRev, Rev-ErbAalpha, THRA1 17q21.1
NR1D2 nuclear receptor subfamily 1 group D member 2 BD73, RVR, EAR-1r, HZF2, Hs.37288 3p24.2
RORA RAR related orphan receptor A NR1F1, ROR1, ROR3, ROR2, RZRA 15q22.2
RORB RAR related orphan receptor B RZRB, ROR-BETA, NR1F2 9q21.13
RORC RAR related orphan receptor C RORG, RZRG, NR1F3, TOR 1q21
NR1H2 nuclear receptor subfamily 1 group H member 2 UNR NER, NER-I, RIP15, LXR-b 19q13.3
NR1H3 nuclear receptor subfamily 1 group H member 3 LXR-a, RLD-1 11p11.2
NR1H4 nuclear receptor subfamily 1 group H member 4 FXR, RIP14, HRR1, HRR-1 12q23.1
NR1H5P nuclear receptor subfamily 1 group H member 5, pseudogene Fxrb, NR1H5 1p13.2
VDR vitamin D receptor PPP1R163, NR1I1 12q13.11
NR1I2 nuclear receptor subfamily 1 group I member 2 ONR1, PXR, BXR, SXR, PAR2 3q13.33
NR1I3 nuclear receptor subfamily 1 group I member 3 MB67, CAR1, CAR 1q23.3
HNF4A hepatocyte nuclear factor 4 alpha TCF14, MODY, MODY1 HNF4, NR2A1 20q13.12
HNF4G hepatocyte nuclear factor 4 gamma NR2A2 8q21.13
RXRA retinoid X receptor alpha NR2B1 9q34.2
RXRB retinoid X receptor beta RCoR-1, H-2RIIBP, NR2B2 6p21.32
RXRG retinoid X receptor gamma NR2B3 1q23.3
NR2C1 nuclear receptor subfamily 2 group C member 1 TR2 TR2-11 12q22
NR2C2 nuclear receptor subfamily 2 group C member 2 TR4 TAK1, TR2R1, hTAK1 3p25.1
NR2E1 nuclear receptor subfamily 2 group E member 1 TLX TLL, XTLL 6q21
NR2E3 nuclear receptor subfamily 2 group E member 3 PNR, rd7, RP37 15q23
NR2F1 nuclear receptor subfamily 2 group F member 1 ERBAL3, TFCOUP1 EAR-3, COUP-TFI, TCFCOUP1, SVP44 5q15
NR2F2 nuclear receptor subfamily 2 group F member 2 ARP1, TFCOUP2 COUP-TFII, COUPTFB, SVP40, NF-E3 15q26.2
NR2F6 nuclear receptor subfamily 2 group F member 6 ERBAL2 EAR-2 19p13.11
ESR1 estrogen receptor 1 ESR ER-alpha, NR3A1, Era 6q25.1-q25.2
ESR2 estrogen receptor 2 ER-beta, NR3A2, Erb 14q23.2-q23.3
ESRRA estrogen related receptor alpha ESRL1 NR3B1, ERRalpha, ERRa, ERR1 11q13.1
ESRRB estrogen related receptor beta ESRL2, DFNB35 ERR2, NR3B2, ERRb, ERRbeta 14q24.3
ESRRG estrogen related receptor gamma NR3B3 1q41
NR3C1 nuclear receptor subfamily 3 group C member 1 GRL GR 5q31.3
NR3C2 nuclear receptor subfamily 3 group C member 2 MLR MR 4q31
PGR progesterone receptor PR, NR3C3 11q22.1
AR androgen receptor DHTR, SBMA AIS, SMAX1, HUMARA, NR3C4 Xq12
NR4A1 nuclear receptor subfamily 4 group A member 1 HMR, GFRP1 TR3, N10, NAK-1, NGFIB, NUR77 12q13.13
NR4A2 nuclear receptor subfamily 4 group A member 2 NURR1 TINUR, NOT, RNR1, HZF-3 2q22-q23
NR4A3 nuclear receptor subfamily 4 group A member 3 CSMF, CHN, NOR1, MINOR 9q22
NR5A1 nuclear receptor subfamily 5 group A member 1 FTZF1 FTZ1, SF-1, ELP, AD4BP, hSF-1 9q33.3
NR5A2 nuclear receptor subfamily 5 group A member 2 FTF FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2 1q32.1
NR6A1 nuclear receptor subfamily 6 group A member 1 GCNF GCNF1, RTR, CT150 9q33.3

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