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Gene Family: Protein phosphatase 1 regulatory subunits (PPP1R)

Also known as : "PP1-interacting proteins", "PIPs"

Protein phosphatase 1 regulatory subunits: PPP1R subunits (also known as PP1-interacting proteins, or PIPs) direct the substrate specificity of protein phosphatase 1 catalytic (PPP1C) subunits. The large number of PPP1Rs reflects the wide substrate range of the serine/threonine phosphatase holoenzymes. [Source: HGNC]

Genes contained within the family: 181

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 12q13.2
PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B DARPP-32, FLJ20940 17q12
PPP1R1C protein phosphatase 1 regulatory inhibitor subunit 1C Inhibitor-1-like 2q31.3-q32.1
PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 IPP2 3q29
PPP1R3A protein phosphatase 1 regulatory subunit 3A PPP1R3 GM 7q31.1
PPP1R3B protein phosphatase 1 regulatory subunit 3B GL, FLJ14005, PPP1R4 8p23.1
PPP1R3C protein phosphatase 1 regulatory subunit 3C PPP1R5 PTG 10q23.32
PPP1R3D protein phosphatase 1 regulatory subunit 3D PPP1R6 20q13.33
PPP1R3E protein phosphatase 1 regulatory subunit 3E FLJ00089 14q11.2
PPP1R3F protein phosphatase 1 regulatory subunit 3F Hb2E Xp11.23
PPP1R3G protein phosphatase 1 regulatory subunit 3G 6p25.1
PPP1R7 protein phosphatase 1 regulatory subunit 7 sds22 2q37.3
PPP1R8 protein phosphatase 1 regulatory subunit 8 ard-1, NIPP-1, PRO2047, ARD1, NIPP1 1p35.3
PPP1R9A protein phosphatase 1 regulatory subunit 9A Neurabin-I, KIAA1222, FLJ20068 7q21.3
PPP1R9B protein phosphatase 1 regulatory subunit 9B PPP1R6, PPP1R9 Spn, SPINO 17q21.33
PPP1R10 protein phosphatase 1 regulatory subunit 10 PNUTS, FB19, CAT53, p99 6p21.33
PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 TCTE5 HCGV, Tctex5, HCG-V, CFAP255 6p22.1
PPP1R12A protein phosphatase 1 regulatory subunit 12A MYPT1 MBS, M130 12q21.2-q21.31
PPP1R12B protein phosphatase 1 regulatory subunit 12B MYPT2 MGC87886, MGC131980, PP1bp55 1q32.1
PPP1R12C protein phosphatase 1 regulatory subunit 12C LENG3 DKFZP434D0412, p84, MBS85, p85 19q13.42
TP53BP2 tumor protein p53 binding protein 2 ASPP2, 53BP2, PPP1R13A 1q41
PPP1R13B protein phosphatase 1 regulatory subunit 13B p53BP2-like, KIAA0771, p85, ASPP1 14q32.33
PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A PPP1INL CPI-17 19q13.1
PPP1R14B protein phosphatase 1 regulatory inhibitor subunit 14B PLCB3N SOM172, PNG, PHI-1 11q13.1
PPP1R14C protein phosphatase 1 regulatory inhibitor subunit 14C CPI17-like, NY-BR-81, KEPI 6q25.1
PPP1R14D protein phosphatase 1 regulatory inhibitor subunit 14D CPI17-like, FLJ20251, GBPI-1, MGC119014, MGC119016 15q15.1
PPP1R15A protein phosphatase 1 regulatory subunit 15A GADD34 19q13.2
PPP1R15B protein phosphatase 1 regulatory subunit 15B FLJ14744 1q32.1
PPP1R16A protein phosphatase 1 regulatory subunit 16A MGC14333, MYPT3 8q24.3
PPP1R16B protein phosphatase 1 regulatory subunit 16B KIAA0823, TIMAP, ANKRD4 20q11.23
PPP1R17 protein phosphatase 1 regulatory subunit 17 C7orf16 GSBS 7p14.3
PPP1R18 protein phosphatase 1 regulatory subunit 18 KIAA1949 phostensin 6p21.33
URI1 URI1, prefoldin like chaperone C19orf2 URI, FLJ10575, RMP, NNX3, PPP1R19 19q12
CCDC8 coiled-coil domain containing 8 3M3, PPP1R20, DKFZp564K0322 19q13.32
PPP1R21 protein phosphatase 1 regulatory subunit 21 CCDC128, KLRAQ1 FLJ16566 2p16.3
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 PPP1R22, MINOS3, FLJ20420, Mic19 7q32.3-q33
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 CHCM1, PPP1R23, Mic25, MGC13016 3q21.3
CSMD1 CUB and Sushi multiple domains 1 KIAA1890, PPP1R24 8p23.2
DDX31 DEAD-box helicase 31 FLJ14578, PPP1R25, FLJ13633, FLJ23349 9q34.13
PPP1R26 protein phosphatase 1 regulatory subunit 26 KIAA0649 9q34.3
PPP1R27 protein phosphatase 1 regulatory subunit 27 DYSFIP1 toonin 17q25.3
ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 PPP1R28 7p22.3
ELFN2 extracellular leucine rich repeat and fibronectin type III domain containing 2 PPP1R29, LRRC62 dJ63G5.3, KIAA1904 22q13.1
GPATCH2 G-patch domain containing 2 GPATC2 PPP1R30, FLJ10252, CT110, Pfa1 1q41
HYDIN HYDIN, axonemal central pair apparatus protein KIAA1864, CILD5, PPP1R31, DKFZp434D0513 16q22.2
PPP1R32 protein phosphatase 1 regulatory subunit 32 C11orf66 IIIG9, FLJ32771 11q12.2
ARFGEF3 ARFGEF family member 3 C6orf92, KIAA1244 BIG3, PPP1R33, dJ171N11.1 6q23.3-q24.1
MARF1 meiosis regulator and mRNA stability factor 1 KIAA0430 Marf1, PPP1R34, LMKB, LKAP 16p13.11
PPP1R35 protein phosphatase 1 regulatory subunit 35 C7orf47 MGC22793 7q22.1
PPP1R36 protein phosphatase 1 regulatory subunit 36 C14orf50 14q23.3
PPP1R37 protein phosphatase 1 regulatory subunit 37 LRRC68 19q13.32
SH2D4A SH2 domain containing 4A SH2A, FLJ20967, PPP1R38 8p21.3
SH3RF2 SH3 domain containing ring finger 2 PPP1R39 FLJ23654, RNF158, Hepp1, POSHER 5q32
TRIM42 tripartite motif containing 42 PPP1R40, T4A1, FLJ40097 3q23
ZCCHC9 zinc finger CCHC-type containing 9 PPP1R41, DKFZp761J139 5q14.1
PPP1R42 protein phosphatase 1 regulatory subunit 42 LRRC67 dtr, TLLR 8q13.1
AKAP1 A-kinase anchoring protein 1 PRKA1 AKAP121, TDRD17, SAKAP84, PPP1R43, D-AKAP1, AKAP149, AKAP84, S-AKAP84 17q22
AKAP11 A-kinase anchoring protein 11 PRKA11, AKAP220, PPP1R44, DKFZp781I12161, KIAA0629, FLJ11304 13q14.11
AKAP9 A-kinase anchoring protein 9 YOTIAO, CG-NAP, PRKA9, PPP1R45, MU-RMS-40.16A, LQT11, HYPERION, KIAA0803, AKAP450, AKAP350 7q21.2
APC APC, WNT signaling pathway regulator DP3, DP2.5, DP2, PPP1R46 5q22.2
AURKA aurora kinase A STK15, STK6 STK7, BTAK, AurA, ARK1, PPP1R47, AIK 20q13.2
AURKB aurora kinase B STK12 ARK2, STK5, AIM-1, AurB, IPL1, Aik2, PPP1R48 17p13.1
AXIN1 axin 1 PPP1R49 16p13.3
BCL2 BCL2, apoptosis regulator PPP1R50, Bcl-2 18q21.33
BCL2L1 BCL2 like 1 BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS, PPP1R52 20q11.21
BCL2L2 BCL2 like 2 KIAA0271, BCL-W, PPP1R51 14q11.2
BRCA1 BRCA1, DNA repair associated RNF53, PPP1R53, BRCC1, FANCS 17q21.31
CASC1 cancer susceptibility 1 FLJ10921, PPP1R54, LAS1 12p12.1
KNL1 kinetochore scaffold 1 MCPH4, CASC5 D40, Spc7, hKNL-1, AF15Q14, KIAA1570, PPP1R55, hSpc105, CT29 15q15.1
CASP9 caspase 9 ICE-LAP6, MCH6, PPP1R56, APAF-3 1p36.21
CASP2 caspase 2 NEDD2 ICH1, PPP1R57, MGC2181 7q34
DLG2 discs large MAGUK scaffold protein 2 PSD93, PPP1R58, PSD-93, chapsyn-110 11q14.1
CD2BP2 CD2 cytoplasmic tail binding protein 2 Snu40, LIN1, PPP1R59, U5-52K 16p11.2
CDC25C cell division cycle 25C CDC25 PPP1R60 5q31.2
CENPE centromere protein E KIF10, PPP1R61 4q24
CEP192 centrosomal protein 192 PPP1R62, FLJ10352, KIAA1569 18p11.21
CLCN7 chloride voltage-gated channel 7 CLC-7, CLC7, ClC-7, OPTA2, PPP1R63 16p13.3
CNST consortin, connexin sorting protein C1orf71 FLJ32001, PPP1R64 1q44
ANKRD28 ankyrin repeat domain 28 PP6-ARS-A, PPP1R65, KIAA0379, PITK 3p25.1
DZIP3 DAZ interacting zinc finger protein 3 PPP1R66, hRUL138 3q13.13
EIF2S2 eukaryotic translation initiation factor 2 subunit beta EIF2 EIF2beta, PPP1R67 20q11.22
ELL elongation factor for RNA polymerase II C19orf17 ELL1, Men, PPP1R68 19p13.11
ZFYVE16 zinc finger FYVE-type containing 16 PPP1R69, KIAA0305 5q14.1
SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 Bif-1, KIAA0491, CGI-61, PPP1R70 1p22.3
PTK2 protein tyrosine kinase 2 FAK1, PPP1R71, FADK, FAK 8q24.3
CSRNP2 cysteine and serine rich nuclear protein 2 C12orf22, FAM130A1 TAIP-12, PPP1R72, C12ORF2 12q13.12
CSRNP3 cysteine and serine rich nuclear protein 3 FAM130A2 PPP1R73, FLJ32093, TAIP-2 2q24.3
FER FER tyrosine kinase TYK3, PPP1R74 5q21.3
FARP1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 MGC87400, PPP1R75, CDEP, PLEKHC2 13q32.2
FKBP15 FK506 binding protein 15 KIAA0674 FKBP133, WAFL, PPP1R76 9q32
AATK apoptosis associated tyrosine kinase AATYK1, PPP1R77, LMTK1, AATYK, KIAA0641, LMR1 17q25.3
AHCYL1 adenosylhomocysteinase like 1 IRBIT, XPVKONA, PPP1R78 1p13.3
ANKRD42 ankyrin repeat domain 42 SARP, FLJ37874, PPP1R79 11q14.1
CAMSAP3 calmodulin regulated spectrin associated protein family member 3 KIAA1543 Nezha, PPP1R80 19p13.2
CDCA2 cell division cycle associated 2 PPP1R81, Repo-Man 8p21.2
DLG3 discs large MAGUK scaffold protein 3 KIAA1232, MRX90, SAP102, SAP-102, NE-Dlg, NEDLG, PPP1R82 Xq13.1
EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 PRKR PKR, EIF2AK1, PPP1R83 2p22.2
GPR12 G protein-coupled receptor 12 GPCR21, PPP1R84 13q12.13
GRM1 glutamate metabotropic receptor 1 mGlu1, PPP1R85, MGLUR1, GPRC1A 6q24.3
GRM5 glutamate metabotropic receptor 5 mGlu5, GPRC1E, PPP1R86, MGLUR5 11q14.2-q14.3
GRM7 glutamate metabotropic receptor 7 mGlu7, GPRC1G, PPP1R87, MGLUR7, GLUR7 3p26.1
GRXCR1 glutaredoxin and cysteine rich domain containing 1 DFNB25 PPP1R88 4p13
HCFC1 host cell factor C1 HFC1, MRX3 VCAF, PPP1R89, MGC70925, HCF-1, CFF, HCF1 Xq28
HDAC6 histone deacetylase 6 FLJ16239, JM21, PPP1R90, HD6, KIAA0901 Xp11.23
HSPB6 heat shock protein family B (small) member 6 PPP1R91, FLJ32389, Hsp20 19q13.12
IKZF1 IKAROS family zinc finger 1 ZNFN1A1 Hs.54452, hIk-1, IKAROS, PPP1R92, LyF-1 7p12.2
ITGA2B integrin subunit alpha 2b GP2B PPP1R93, CD41B, CD41 17q21.31
ITPR1 inositol 1,4,5-trisphosphate receptor type 1 SCA15, SCA16, SCA29 PPP1R94, IP3R1, Insp3r1, ACV 3p26.1
ITPR3 inositol 1,4,5-trisphosphate receptor type 3 IP3R3 6p21.31
KCNA6 potassium voltage-gated channel subfamily A member 6 PPP1R96, Kv1.6, HBK2 12p13
KCNK10 potassium two pore domain channel subfamily K member 10 PPP1R97, K2p10.1, TREK2, TREK-2 14q31.3
KIF18A kinesin family member 18A DKFZP434G2226, PPP1R99 11p14.1
LMTK2 lemur tyrosine kinase 2 KIAA1079, PPP1R100, BREK, cprk, KPI2, AATYK2, LMR2, KPI-2 7q21.3
LMTK3 lemur tyrosine kinase 3 KIAA1883, TYKLM3, PPP1R101, LMR3 19q13.33
MAP1B microtubule associated protein 1B PPP1R102, MAP5 5q13.2
MAPT microtubule associated protein tau DDPAC, MAPTL PPP1R103, MTBT2, tau, FTDP-17, MGC138549, TAU, MSTD, FLJ31424, MTBT1, PPND 17q21.31
MCM7 minichromosome maintenance complex component 7 MCM2 PPP1R104, CDC47 7q22.1
MKI67 marker of proliferation Ki-67 MIB-, PPP1R105 10q26.2
MPHOSPH10 M-phase phosphoprotein 10 PPP1R106, CT90, MPP10, MPP10P 2p13.3
MYO16 myosin XVI PPP1R107, KIAA0865, NYAP3, Myo16b, MYR8 13q33.3
MYO1D myosin ID KIAA0727, PPP1R108, myr4 17q11.2
NCOR1 nuclear receptor corepressor 1 hCIT529I10, KIAA1047, PPP1R109, MGC104216, TRAC1, N-CoR, hN-CoR 17p12-p11.2
NEFL neurofilament light CMT1F, PPP1R110, NF68, CMT2E, NFL 8p21.2
NEK2 NIMA related kinase 2 NLK1, PPP1R111, RP67, NEK2A 1q32.3
NOC2L NOC2 like nucleolar associated transcriptional repressor NET15, NIR, PPP1R112, NET7, DKFZP564C186 1p36.33
NOM1 nucleolar protein with MIF4G domain 1 C7orf3 PPP1R113, SGD1 7q36.3
NONO non-POU domain containing octamer binding P54, NRB54, PPP1R114, P54NRB, NMT55 Xq13.1
OCLN occludin PPP1R115 5q13.2
OPN3 opsin 3 ECPN PPP1R116, NMO-1, encephalopsin, ERO 1q43
ORC5 origin recognition complex subunit 5 ORC5L ORC5T, Orc5p, PPP1R117 7q22.1-q22.2
PARD3 par-3 family cell polarity regulator PARD3A, ASIP, Bazooka, PAR3, Baz, PPP1R118 10p11.22-p11.21
PCDH11X protocadherin 11 X-linked PCDH11 PPP1R119, PCDH-X, PCDHX Xq21.31
PCDH7 protocadherin 7 BH-Pcdh, PPP1R120 4p15.1
PCIF1 PDX1 C-terminal inhibiting factor 1 C20orf67 bA465L10.1, PPP1R121 20q13.12
PFKM phosphofructokinase, muscle PFKX PPP1R122, PFK-1 12q13.11
PHACTR3 phosphatase and actin regulator 3 C20orf101 PPP1R123 20q13.32-q13.33
PHACTR4 phosphatase and actin regulator 4 PPP1R124, FLJ13171 1p35.3
PHRF1 PHD and ring finger domains 1 RNF221 PPP1R125, KIAA1542 11p15.5
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 PPP1R126, MYT1 16p13.3
PLCL1 phospholipase C like 1 (inactive) PLCE PLCL, PRIP, PLC-L, PPP1R127 2q33.1
POLD3 DNA polymerase delta 3, accessory subunit PPP1R128, KIAA0039, P66, P68 11q13.4
PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 DEPDC2 PPP1R129, P-REX2, FLJ12987, DEP.2 8q13.2
RB1CC1 RB1 inducible coiled-coil 1 PPP1R131, DRAGOU14, FIP200, ATG17, Cc1, KIAA0203 8q11.23
RBM26 RNA binding motif protein 26 C13orf10 ZC3H17, FLJ20957, PRO1777, PPP1R132, ARRS2, SE70-2 13q31.1
RIMBP2 RIMS binding protein 2 PPP1R133, RIM-BP2, KIAA0318, RBP2, MGC15831 12q24.33
RPGRIP1L RPGRIP1 like PPP1R134, MKS5, JBTS7, FTM, NPHP8, CORS3, KIAA1005 16q12.2
RPL5 ribosomal protein L5 L5, PPP1R135 1p22.1
RRP1B ribosomal RNA processing 1B KIAA0179 RRP1, Nnp1, PPP1R136 21q22.3
RYR1 ryanodine receptor 1 MHS, MHS1, CCO PPP1R137, RYR 19q13.2
SACS sacsin molecular chaperone SPAX6, DNAJC29, DKFZp686B15167, KIAA0730, ARSACS, PPP1R138 13q12.12
SFI1 SFI1 centrin binding protein KIAA0542, PISD, PPP1R139 22q12.2
SFPQ splicing factor proline and glutamine rich PPP1R140, PSF 1p34.3
SLC12A2 solute carrier family 12 member 2 PPP1R141, NKCC1, BSC2, BSC 5q23.3
SLC7A14 solute carrier family 7 member 14 PPP1R142, KIAA1613 3q26.2
SLC9A1 solute carrier family 9 member A1 APNH, NHE1 PPP1R143 1p36.11
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 SNF5L1 Sfh1p, Snr1, RDT, hSNFS, PPP1R144, Ini1, BAF47 22q11.23
SPATA2 spermatogenesis associated 2 PD1, KIAA0757, tamo, PPP1R145 20q13.13
SPOCD1 SPOC domain containing 1 PPP1R146, FLJ25348 1p35.2
SPRED1 sprouty related EVH1 domain containing 1 PPP1R147, FLJ33903 15q14
SPZ1 spermatogenic leucine zipper 1 FLJ25709, PPP1R148, NYD-TSP1 5q14.1
SRSF10 serine and arginine rich splicing factor 10 FUSIP2, FUSIP1, SFRS13A TASR2, SRp38, PPP1R149, TASR1, SFRS13, SRrp40 1p36.11
STAU1 staufen double-stranded RNA binding protein 1 STAU PPP1R150 20q13.13
SYTL2 synaptotagmin like 2 CHR11SYT, exophilin-4, MGC102768, FLJ20163, PPP1R151, SGA72M, KIAA1597, FLJ21219, SLP2 11q14.1
TMEM132C transmembrane protein 132C DKFZp761O2018, PPP1R152 12q24.32
TMEM132D transmembrane protein 132D MOLT, KIAA1944, PPP1R153 12q24.33
TMEM225 transmembrane protein 225 PPP1R154, PMP22CD, SPATA47 11q24.1
TNS1 tensin 1 TNS, MXRA6 DKFZp586K0617, PPP1R155 2q35
TRA2B transformer 2 beta homolog SFRS10 PPP1R156, Htra2-beta 3q27.2
TRIM28 tripartite motif containing 28 RNF96, TIF1B, TF1B, PPP1R157, KAP1 19q13.4
TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein C20orf188 TRRP4AP, PPP1R158, dJ756N5.2, DKFZp586C1223, DKFZP727M231 20q11.22
TRPC5 transient receptor potential cation channel subfamily C member 5 PPP1R159 Xq23
TSC2 tuberous sclerosis 2 TSC4 tuberin, LAM, PPP1R160 16p13.3
TSKS testis specific serine kinase substrate TSSKS, PPP1R161 19q13.33
UBN1 ubinuclein 1 16p13.3
VDR vitamin D receptor PPP1R163, NR1I1 12q13.11
VPS54 VPS54, GARP complex subunit PPP1R164, HCC8 2p15-p14
WBP11 WW domain binding protein 11 SIPP1, NPWBP, PPP1R165 12p12.3
WDR81 WD repeat domain 81 PPP1R166, FLJ33817, CAMRQ2, SORF-2 17p13.3
WNK1 WNK lysine deficient protein kinase 1 PRKWNK1, HSN2 HSAN2, PPP1R167 12p13.33
WWC1 WW and C2 domain containing 1 KIBRA, PPP1R168, KIAA0869 5q34
YLPM1 YLP motif containing 1 C14orf170 PPP1R169, ZAP 14q24.3


Please see our Protein phosphatases, catalytic subunits page to view the PPP1C genes, along with all other PPP genes.

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