Skip to Navigation

Gene Family: Mitogen-activated protein kinases (MAPK)

Mitogen-activated protein kinase: Mitogen-activated protein kinases also known as MAP kinases are serinetyrosine-specific protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group. The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis - among many others. MAP kinases are found in eukaryotes only, but they are fairly diverse and encountered in all animals, fungi and plants, and even in an array of unicellular eukaryotes. [Source: Wikipedia]

Genes contained within the family: 13

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MAPK1 mitogen-activated protein kinase 1 PRKM2, PRKM1 ERK, ERK2, p41mapk, MAPK2 22q11.22
MAPK3 mitogen-activated protein kinase 3 PRKM3 ERK1, p44mapk, p44erk1 16p11.2
MAPK4 mitogen-activated protein kinase 4 PRKM4 Erk3-related, Erk4 18q21.1-q21.2
MAPK6 mitogen-activated protein kinase 6 PRKM6 ERK3, p97MAPK, HsT17250 15q21.2
MAPK7 mitogen-activated protein kinase 7 PRKM7 BMK1, ERK5 17p11.2
MAPK8 mitogen-activated protein kinase 8 PRKM8 JNK, JNK1, SAPK1 10q11.22
MAPK9 mitogen-activated protein kinase 9 PRKM9 JNK2, p54a, SAPK 5q35.3
MAPK10 mitogen-activated protein kinase 10 PRKM10 JNK3, p493F12, p54bSAPK 4q21.3
MAPK11 mitogen-activated protein kinase 11 PRKM11 p38-2, p38Beta, SAPK2 22q13.33
MAPK12 mitogen-activated protein kinase 12 SAPK3 ERK6, PRKM12, p38gamma, SAPK-3 22q13.33
MAPK13 mitogen-activated protein kinase 13 PRKM13 SAPK4, p38delta 6p21.31
MAPK14 mitogen-activated protein kinase 14 CSPB1, CSBP1, CSBP2 PRKM14, p38, Mxi2, PRKM15 6p21.31
MAPK15 mitogen-activated protein kinase 15 ERK8, ERK7 8q24.3