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Gene Family: Mucins (MUC)

Mucin: Mucins are a family of high molecular weight, heavily glycosylated proteins ( glycoconjugates ) produced by epithelial tissues in most metazoans. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. They often take an inhibitory role. Some mucins are associated with controlling mineralization, including nacre formation in mollusks, calcification in echinoderms and bone formation in vertebrates. They bind to pathogens as part of the immune system. Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer. Although some mucins are membrane -bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted onto mucosal surfaces or secreted to become a component of saliva. [Source: Wikipedia]

Genes contained within the family: 21

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MUC1 mucin 1, cell surface associated PUM, MCKD1 CD227, PEM, ADMCKD, ADMCKD1, MCKD, MCD 1q22
MUC2 mucin 2, oligomeric mucus/gel-forming 11p15.5
MUC3A mucin 3A, cell surface associated MUC3 7q22.1
MUC3B mucin 3B, cell surface associated 7q22 not on reference assembly
MUC4 mucin 4, cell surface associated 3q29
MUC5AC mucin 5AC, oligomeric mucus/gel-forming MUC5 11p15.5
MUC5B mucin 5B, oligomeric mucus/gel-forming MUC5 MG1 11p15.5
MUC6 mucin 6, oligomeric mucus/gel-forming 11p15.5
MUC7 mucin 7, secreted FLJ27047, MG2 4q13.3
MUC8 mucin 8 12q24.33
OVGP1 oviductal glycoprotein 1 MUC9 CHIT5 1p13.2
MUC12 mucin 12, cell surface associated MUC11 7q22.1
MUC13 mucin 13, cell surface associated DRCC1 3q21.2
EMCN endomucin MUC14 4q24
MUC15 mucin 15, cell surface associated 11p14.3
MUC16 mucin 16, cell surface associated CA125, FLJ14303 19p13.2
MUC17 mucin 17, cell surface associated 7q22.1
MUC19 mucin 19, oligomeric FLJ35746 12q12
MUC20 mucin 20, cell surface associated FLJ14408, KIAA1359 3q29
MUC21 mucin 21, cell surface associated C6orf205 bCX31G15.2 6p21.33
MUC22 mucin 22 PBMUCL1 6p21.33

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